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| Product | Description | |
|---|---|---|
| UNC569 | Mer proto-oncogene tyrosine kinase (MerTK) is expressed in the retinal pigment epithelium (RPE), regulates phagocytosis of shed photoreceptor outer segments (POS). UNC569 is a specific MerTK inhibitor. Synonyms: 1-[(Trans-4-Aminocyclohexyl)methyl]-N-Butyl-3-(4-Fluorophenyl)-1h-Pyrazolo[3,4-D]pyrimidin-6-Amine. Grades: 98%. CAS No. 1350547-65-7. Molecular formula: C22H29FN6. Mole weight: 396.50. |  |
| Mer RTK Inhibitor, UNC569 | Mer RTK Inhibitor, UNC569, 1350547-65-7 is a potent, reversible and ATP-competitive inhibitor of Mer receptor tyrosine kinase (IC50 = 2.9 nM; Ki = 4.3 nM). Group: Fluorescence/luminescence spectroscopy. |  |
| Mer RTK Inhibitor, UNC569 (1- ( (trans-4-Aminocyclohexyl) methyl) -N-butyl-3- (4-fluorophenyl) -1H-pyrazolo[3, 4-d]pyrimidin-6-amine, MERTK Inhibitor I, RP38 Inhibitor I, TAM Family RTK Inhibitor I) | An orally bioavailable pyrazolopyrimidine compound that acts as a potent, reversible and ATP-competitive inhibitor of Mer receptor tyrosine kinase (IC50=2.9nM; Ki=4.3nM) with ~10-fold greater selectivity over other TAM family kinases (IC50=37 and 48nM for Axl and Tyro3, respectively). Also shown to affect the activities of Flt3, MAPKAPK2, RET and Ret-Y791F at 30nM by 82%, 92%, 59% and 56% in a 72 kinase panel, and block Mer auto-phosphorylation in human Pre-B leukemia 697 cells with an IC50 of 141nM. Exhibits desirable pharmacokinetic profile and efficacy in mice. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. |  Worldwide |
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