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| Product | Description | |
|---|---|---|
| Upadacitinib | Upadacitinib (ABT-494) is a potent, orally active and selective Janus kinase 1 ( JAK1 ) inhibitor ( IC 50 =43 nM). Upadacitinib (ABT-494) displays approximately 74 fold selective for JAK1 over JAK2 (200 nM) in cellular assays dependent on specific, relevant cytokines. Upadacitinib (ABT-494) can be used for several autoimmune disorders research [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: ABT-494. CAS No. 1310726-60-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 200 mg. Product ID: HY-19569. |  |
| Upadacitinib | Upadacitinib is a selective JAK inhibitor under the development of AbbVie.ABT-494 is nearly 74 fold selective for Jak1 over Jak2 in cellular assays dependent on specific, relevant cytokines. Preliminary evidence suggests that ABT-494 may spare Jak2 and Jak3 dependent signaling compared to tofacitinib. Phase II for the treatment of Atopic dermatitis and Crohn's disease, Phase III for the treatment of Rheumatoid arthritis and Ulcerative colitis was on-going. Uses: Rheumatoid arthritis; ulcerative colitis;atopic dermatitis; crohn's disease. Synonyms: UNII-4RA0KN46E0;ABT494;(3S,4R)-3-ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]pyrazin-8-yl)-N-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide. Grades: 98%. CAS No. 1310726-60-3. Molecular formula: C17H19F3N6O. Mole weight: 380.37. |  |
| Upadacitinib Impurity 63 | Upadacitinib Impurity 63. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: N-(2,2,2-trifluoroethyl)-1H-imidazole-1-carboxamide. CAS No. 1046861-47-5. Molecular formula: C6H6F3N3O. Mole weight: 193.13. Catalog: APB1046861475. |  |
| Upadacitinib Impurity 89 | Upadacitinib Impurity 89. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: 5H-pyrrolo[2,3-b]pyrazin-2-amine. CAS No. 1504066-86-7. Molecular formula: C6H6N4. Mole weight: 134.14. Catalog: APB1504066867. | |
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