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| Product | Description | |
|---|---|---|
| VEGFR Tyrosine Kinase Inhibitor II | VEGFR tyrosine kinase inhibitor II is a pyridinyl-anthranilamide compound that potently inhibits the kinase activities of VEGFR2 (KDR), VEGFR1 (FLT1), and c-Kit (IC50 = 20, 180, and 240 nM, respectively). It is potential for cancer treatment for its inhibitory effect of tumor induced angiogenesis. Synonyms: N-(4-Chlorophenyl)-2-[(pyridin-4-ylmethyl)amino]benzamide. Grades: ≥98%. CAS No. 269390-69-4. Molecular formula: C19H16ClN3O. Mole weight: 337.8. |  |
| VEGFR Tyrosine Kinase Inhibitor II - CAS 269390-69-4 | The VEGFR Tyrosine Kinase Inhibitor II, also referenced under CAS 269390-69-4, controls the biological activity of VEGFR Tyrosine Kinase. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications. Group: Fluorescence/luminescence spectroscopy. |  |
| 4SC-203 | 4SC-203 is a multikinase inhibitor with potential antineoplastic activity. Multikinase inhibitor 4SC-203 selectively inhibits FMS-related tyrosine kinase 3 (FLT3/STK1), FLT3 mutated forms, and vascular endothelial growth factor receptors (VEGFRs). This may result in the inhibition of angiogenesis and cell proliferation in tumor cells in which these kinases are upregulated. FLT3 (FLK2), a class III tyrosine kinase receptor, is overexpressed or mutated in most B lineage and acute myeloid leukemias (AML). VEGFRs, tyrosine kinase receptors, are overexpressed in a variety of tumor cell types and play key roles in angiogenesis. Uses: Designed for use in research and industrial production. Additional or Alternative Names: 4SC203; 4SC-203; 4SC 203; SC71710; SC-71710; SC 71710. Product Category: Inhibitors. Appearance: Solid powder. CAS No. 895533-09-2. Molecular formula: C33H38N8O4S. Mole weight: 642.77. Purity: >98%. IUPACName: 1-(2-methoxy-5-methylphenyl)-3-(6-((6-methoxy-7-(3-(4-methylpiperazin-1-yl)propoxy)quinazolin-4-yl)amino)benzo[d]thiazol-2-yl)urea. Canonical SMILES: O=C(NC1=NC2=CC=C(NC3=C4C=C(OC)C(OCCCN5CCN(C)CC5)=CC4=NC=N3)C=C2S1)NC6=CC(C)=CC=C6OC. Product ID: ACM895533092. Alfa Chemistry ISO 9001:2015 Certified. |  |
| PDGFRb/RAF Kinase Inhibitor | An orally bioavailable amino-triazole compound that is shown to bind to the inactive conformations of both PDGFRb and Raf kinases (allosteric, Type II inh), and acts as a potent inhibitor of Flt3, Kit, PDGFRa and PDGFRb (=52, 170, 300 and 520nM, respectively) with selectivity over B-Raf, p38a, FGFR2 and VEGFR2 (>10uM) in a multi-kinase panel. Completely blocks the phosphorylations of MEK-1/2 S217/S221, ERK-1/2 T202/Y204 in FGF-stimulated HUVECs, PDGFRb in PDGF-BB-stimulated VSMCs, ERK-1/2 T202/Y204 in 1205Lu-B Raf V600E cells, and C-Raf S338 at 10uM. Reduces FGF-induced angiogenesis in mouse Matrigel model (50mg/kg, i.p., bid) and selectively induces apoptosis in the endothelium; further, suppresses orthotopic renal cell carcinoma growth in mice (100mg/kg, p.o., qd). Group: Biochemicals. Alternative Names: 6- (4- (5- (3- (Trifluoromethyl) phenylamino) -4 H-1,2,4-triazol-3-yl)phenoxy)-2-(methylthio)pyrimidin-4-amine, PDGFR Tyrosine Kinase Inhibitor XXII. Grades: Highly Purified. Pack Sizes: 10mg. Molecular Formula: C??H??F?N?OS, Molecular Weight: 459.6. US Biological Life Sciences. |  Worldwide |
| VEGFR2 Kinase Inhibitor II | VEGFR2 kinase inhibitor II is a reversible and cell-permeable inhibitor of VEGFR2's kinase activity with IC50 value of 70 nM. It also less potently inhibits the platelet-derived growth factor receptor β (PDGFRβ) with IC50 value of 920 nM, and other related receptor as well as non-receptor tyrosine kinases. Synonyms: (Z)-5-Bromo-3-(4,5,6,7-tetrahydro-1H-indol-2-ylmethylene)-1,3-dihydroindol-2-one. Grades: ≥95%. CAS No. 288144-20-7. Molecular formula: C17H15BrN2O. Mole weight: 343.2. | |
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