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| Product | Description | |
|---|---|---|
| VEGFR2 Kinase Inhibitor II | VEGFR2 kinase inhibitor II is a reversible and cell-permeable inhibitor of VEGFR2's kinase activity with IC50 value of 70 nM. It also less potently inhibits the platelet-derived growth factor receptor β (PDGFRβ) with IC50 value of 920 nM, and other related receptor as well as non-receptor tyrosine kinases. Synonyms: (Z)-5-Bromo-3-(4,5,6,7-tetrahydro-1H-indol-2-ylmethylene)-1,3-dihydroindol-2-one. Grades: ≥95%. CAS No. 288144-20-7. Molecular formula: C17H15BrN2O. Mole weight: 343.2. |  |
| VEGFR2 Kinase Inhibitor II - CAS 288144-20-7 | The VEGFR2 Kinase Inhibitor II, also referenced under CAS 288144-20-7, controls the biological activity of VEGFR2 Kinase. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications. Group: Fluorescence/luminescence spectroscopy. |  |
| PDGFRb/RAF Kinase Inhibitor | An orally bioavailable amino-triazole compound that is shown to bind to the inactive conformations of both PDGFRb and Raf kinases (allosteric, Type II inh), and acts as a potent inhibitor of Flt3, Kit, PDGFRa and PDGFRb (=52, 170, 300 and 520nM, respectively) with selectivity over B-Raf, p38a, FGFR2 and VEGFR2 (>10uM) in a multi-kinase panel. Completely blocks the phosphorylations of MEK-1/2 S217/S221, ERK-1/2 T202/Y204 in FGF-stimulated HUVECs, PDGFRb in PDGF-BB-stimulated VSMCs, ERK-1/2 T202/Y204 in 1205Lu-B Raf V600E cells, and C-Raf S338 at 10uM. Reduces FGF-induced angiogenesis in mouse Matrigel model (50mg/kg, i.p., bid) and selectively induces apoptosis in the endothelium; further, suppresses orthotopic renal cell carcinoma growth in mice (100mg/kg, p.o., qd). Group: Biochemicals. Alternative Names: 6- (4- (5- (3- (Trifluoromethyl) phenylamino) -4 H-1,2,4-triazol-3-yl)phenoxy)-2-(methylthio)pyrimidin-4-amine, PDGFR Tyrosine Kinase Inhibitor XXII. Grades: Highly Purified. Pack Sizes: 10mg. Molecular Formula: C??H??F?N?OS, Molecular Weight: 459.6. US Biological Life Sciences. |  Worldwide |
| VEGFR Tyrosine Kinase Inhibitor II | VEGFR tyrosine kinase inhibitor II is a pyridinyl-anthranilamide compound that potently inhibits the kinase activities of VEGFR2 (KDR), VEGFR1 (FLT1), and c-Kit (IC50 = 20, 180, and 240 nM, respectively). It is potential for cancer treatment for its inhibitory effect of tumor induced angiogenesis. Synonyms: N-(4-Chlorophenyl)-2-[(pyridin-4-ylmethyl)amino]benzamide. Grades: ≥98%. CAS No. 269390-69-4. Molecular formula: C19H16ClN3O. Mole weight: 337.8. | |
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