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| Product | Description | |
|---|---|---|
| VER-155008 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. |  |
| VER-155008 | VER-155008 is an adenosine-derived inhibitor of heat shock protein 70 (Hsp70; IC50 = 0.5 μM) that is selective over Hsp90. It targets the nucleotide-binding domain (NBD) of Hsp70 and similarly binds the NBDs of Hsp70 cognates Hsc70 (Ki = 10 μM) and glucose-regulated protein 78 (Grp78; KD = 80 nM). VER-155008 inhibits the proliferation of human breast and colon cancer cell lines, inducing apoptosis or caspase-independent cell death. It induces the proteasome-dependent degradation of Hsp90 client proteins and potentiates the apoptotic activity of Hsp90 inhibitors. VER-15508 also triggers paraptosis in anaplastic thyroid carcinoma cells. Synonyms: 8-(3,4-Dichlorobenzyl)amino-5'-O-(4-cyanobenzyl)adenosine; C07; VER 155008; VER155008; 5'-O-[(4-Cyanophenyl)methyl]-8-[[(3,4-dichlorophenyl)methyl]amino]-Adenosine; 4-((((2R,3S,4R,5R)-5-(6-amino-8-(3,4-dichlorobenzylamino)-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methoxy)methyl)benzonitrile. Grades: ≥95%. CAS No. 1134156-31-2. Molecular formula: C25H23Cl2N7O4. Mole weight: 556.40. |  |
| VER-155008 | VER-155008 is an inhibitor of Hsp70, with IC50s of 0.5 ?M, 2.6 ?M, and 2.6 ?M for Hsp70, Hsc70 and Grp7, respectively, and with a Kd of 0.3 ?M for Hsp70. Uses: Scientific research. Group: Signaling pathways. CAS No. 1134156-31-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-10941. |  |
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