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| Product | Description | |
|---|---|---|
| Vernakalant Hydrochloride | Vernakalant hydrochloride is a mixed voltage- and frequency-dependent Na + and atria-preferred K + channel blocker. IC 50 for block by Vernakalant of wild-type and mutant Kv1.5 channels Fractional block is 13.35±0.93 μM, 0.61±0.03 μM, and 1.63±0.09 μM for Kv1.5 channel wt , Kv1.5 channel I508F , Kv1.5 channel T479A , respectively. Uses: Scientific research. Group: Signaling pathways. Alternative Names: RSD1235 hydrochloride. CAS No. 748810-28-8. Pack Sizes: 10 mM * 1 mL; 2 mg; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-14183. |  |
| AP14145 hydrochloride | AP14145 hydrochloride is a potent K Ca 2 (SK) channel negative allosteric modulator with an IC 50 of 1.1 μM for K Ca 2.2 (SK2) and K Ca 2.3 (SK3) channels. AP14145 hydrochloride inhibition strongly depends on two amino acids, S508 and A533 in the channel. AP14145 hydrochloride prolonged atrial effective refractory period (AERP) in rats and demonstrates antiarrhythmic effects in a Vernakalant-resistant porcine model of atrial fibrillation (AF) [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2387505-59-9. Pack Sizes: 5 mg. Product ID: HY-120355A. | |
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