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Product | Description | |
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Vernakalant Quick inquiry Where to buy Suppliers range | Vernakalant is an drug under regulatory for the treatment for conversion of atrial fibrillation. It blocks atrial potassium channels, thereby prolonging repolarization. It differs from typical class III agents and is more effective at high heart rates. It also slightly blocks the hERG potassium channel, leading to a prolonged QT interval. It also blocks atrial sodium channels. It was initially developed by Cardiome Pharma, and the intravenous formulation was bought for further development by Merck in April 2009. In September 2012, Merck terminated its agreements with Cardiome and has consequently returned all rights of the drug back to Cardiome. The drug (under brand name Brinavess) was approved in Europe on 1 September 2010. An oral formulation underwent Phase II clinical trials between 2005 and 2008. Uses: Vernakalant is an drug under regulatory for the treatment for conversion of atrial fibrillation. it blocks atrial potassium channels, thereby prolonging repolarization. it also slightly blocks the herg potassium channel, leading to a prolonged qt interval. it also blocks atrial sodium channels. Synonyms: Brinavess; RSD1235; (3R) -1-[ (1R, 2R) -2-[2- (3, 4-dimethoxyphenyl) ethoxy]cyclohexyl]pyrrolidin-3-ol. Grades: 95%. CAS No. 794466-70-9. Molecular formula: C20H31NO4. Mole weight: 349.47. | |
Vernakalant ((3R,1'R,2'R)-Isomer) HCl Quick inquiry Where to buy Suppliers range | Vernakalant hydrochloride, also known as RSD1235, is a novel, relatively atrial-selective antiarrhythmic drug which can terminate acute atrial fibrillation (AF) in humans at 2 to 5 mg/kg. It belongs mixed ion channel blocker. It may be more atrial-selective than available agents in treatment of antiarrhythmic. It blocks atrial potassium channels, thereby prolonging repolarization. It also blocks atrial sodium channels. It also slightly blocks the hERG potassium channel, leading to a prolonged QT interval, which may theoretically increase the risk of ventricular tachycardia, though this does not seem to be clinically relevant. It is more effective at high heart rates. It was initially developed by Cardiome Pharma, and the intravenous formulation was bought for further development by Merck in April 2009. In September 2012, Merck terminated its agreements with Cardiome and has consequently returned all rights of the drug back to Cardiome. The drug (under brand name Brinavess) was approved in Europe on 1 September 2010. An oral formulation underwent Phase II clinical trials between 2005 and 2008. Uses: Vernakalant hydrochloride blocks atrial potassium channels, thereby prolonging repolarization. it also blocks atrial sodium channels. it also slightly blocks the herg potassium channel, leading to a prolonged qt interval, which may theoretically increase the risk of ventricular tachycardia, though this does not seem to be clinically relevant. it is more effective at high heart rates. Synonyms: RSD1235, RSD-1235, RSD 1235, Vernakalant HCl, Kynapid, Brinavess; D06665;(3R)-1-[(1R,2R)-2-[2-(3,4-Dimethoxyphenyl)ethoxy]cyclohexyl]-3-pyrrolidinol monohydrochloride;RSD 1235 hydrochloride;Vernakalant ((3R,1'R,2'R)-Isomer) HCl. Grades: 98%. CAS No. 748810-28-8. Molecular formula: C20H32NO4Cl. Mole weight: 385.93. | |
Vernakalant Impurity 1 ((3S,1'S,2'S)-Isomer) HCl Quick inquiry Where to buy Suppliers range | An impurity of Vernakalant. Vernakalant is a medication used for the treatment of acute conversion of atrial fibrillation. Vernakalant blocks cardiac transient outward potassium current with increased potency as the heart rate increases. CAS No. 795282-00-7. Molecular formula: C20H31NO4. HCl. Mole weight: 385.93. | |
Vernakalant Impurity 2 ((3S,1'R,2'R)-Isomer) HCl Quick inquiry Where to buy Suppliers range | An impurity of Vernakalant. Vernakalant is a medication used for the treatment of acute conversion of atrial fibrillation. Vernakalant blocks cardiac transient outward potassium current with increased potency as the heart rate increases. CAS No. 795281-99-1. Molecular formula: C20H31NO4. HCl. Mole weight: 385.93. | |
Vernakalant Impurity 3 ((3S,1'R,2'S)-Isomer) Quick inquiry Where to buy Suppliers range | An impurity of Vernakalant. Vernakalant is a medication used for the treatment of acute conversion of atrial fibrillation. Vernakalant blocks cardiac transient outward potassium current with increased potency as the heart rate increases. CAS No. 795282-30-3. Molecular formula: C20H31NO4. Mole weight: 349.47. | |
Vernakalant Impurity 4 ((3S,1'S,2'R)-Isomer) Quick inquiry Where to buy Suppliers range | An impurity of Vernakalant. Vernakalant is a medication used for the treatment of acute conversion of atrial fibrillation. Vernakalant blocks cardiac transient outward potassium current with increased potency as the heart rate increases. CAS No. 795282-28-9. Molecular formula: C20H31NO4. Mole weight: 349.47. | |
Vernakalant Impurity 5 ((3R,1'S,2'S)-Isomer) HCl Quick inquiry Where to buy Suppliers range | An impurity of Vernakalant. Vernakalant is a medication used for the treatment of acute conversion of atrial fibrillation. Vernakalant blocks cardiac transient outward potassium current with increased potency as the heart rate increases. CAS No. 795281-93-5. Molecular formula: C20H31NO4. HCl. Mole weight: 385.93. | |
Vernakalant Impurity 7 ((3R,1'R,2'S)-Isomer) Quick inquiry Where to buy Suppliers range | An impurity of Vernakalant. Vernakalant is a medication used for the treatment of acute conversion of atrial fibrillation. Vernakalant blocks cardiac transient outward potassium current with increased potency as the heart rate increases. CAS No. 795282-29-0. Molecular formula: C20H31NO4. Mole weight: 349.47. | |
Vernakalant Impurity 8 ((3R,1'S,2'R)-Isomer) Quick inquiry Where to buy Suppliers range | An impurity of Vernakalant. Vernakalant is a medication used for the treatment of acute conversion of atrial fibrillation. Vernakalant blocks cardiac transient outward potassium current with increased potency as the heart rate increases. CAS No. 795282-27-8. Molecular formula: C20H31NO4. Mole weight: 349.47. |