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| Product | Description | |
|---|---|---|
| Vinflunine | Vinflunine is an antitumor agent that inhibits the mitochondrial membrane potential, resulting in the breakdown of intracellular ATP and cell death. Vinflunine has been shown to be effective against a number of carcinoma cell lines, including those from solid tumours (e.g., breast cancer) and those from blood cells (e.g., leukemia). Vinflunine has also been shown to be effective against angiogenic processes in vitro assays and in vivo trials. Vinflunine is active against natural compounds such as p-hydroxybenzoic acid, which are involved in the production of collagen and other proteins essential for tumor growth. In addition, vinflunine has been shown to cause significant cytotoxicity against tumors in vivo. Group: Other alkaloids. CAS No. 162652-95-1. Canonical SMILES: CC[C@@]12C=CCN3[C@H]1[C@]4 (CC3)[C@@H] ([C@] (C2OC (=O)C) (C (=O)OC)O)N (C5=CC (=C (C=C45)[C@]6 (CC7CC (CN (C7)CC8=C6NC9=CC=CC=C89)C (C) (F)F)C (=O)OC)OC)C. Catalog: ACM162652951. |  |
| Vinflunine | Vinflunine is a new vinca alkaloid uniquely fluorinated with the properties of mitotic-arresting and tubulin-interacting activity. Synonyms: Vinflunine; 162652-95-1; Javlor; UNII-5BF646324K; 20',20'-difluoro-3',4'-dihydrovinorelbine. Grades: 0.98. CAS No. 162652-95-1. Molecular formula: C45H54F2N4O8. Mole weight: 816.944. |  |
| Vinflunine ditartrate | Vinflunine, a semisynthetic derivative of Vinorelbine, is the first fluorinated microtubule inhibitor belonging to the Vinca alkaloids family endowed with unique antitumor properties. Uses: Semisynthetic vinca alkaloid with microtubule destabilizing and antiangiogenic activity; derivative of vinorelbine. antineoplastic. Synonyms: 4'-Deoxy-20',20'-difluoro-5'-norvincaleukoblastine Ditartrate; 20',20'-Difluoro-3',4'-dihydrovinorelbine Ditartrate; BMS 710485; F 12158; Javlor. Grades: >98%. CAS No. 194468-36-5. Molecular formula: C53H66F2N4O20. Mole weight: 1117.10. | |
| Vinflunine ditartrate | Vinflunine ditartrate is the first fluorinated microtubule inhibitor belonging to the Vinca alkaloids family. Vinflunine ditartrate has anti-angiogenic, vascular-disrupting and anti-metastatic activities. Vinflunine ditartrate can be used for the research of transitional cell carcinoma of the urothelial tract, non-small cell lung cancer, and carcinoma of the breast. Group: Inhibitors. Alternative Names: 4'-Deoxy-20',20'-difluoro-5'-norvincaleukoblastine Ditartrate; 20',20'-Difluoro-3',4'-dihydrovinorelbine Ditartrate; BMS 710485; F 12158; Javlor. CAS No. 194468-36-5. Molecular formula: C53H66F2N4O20. Mole weight: 1117.1. Appearance: White Solid. Canonical SMILES: OC ([C@H] (O)[C@@H] (O)C (O)=O)=O. OC ([C@H] (O)[C@@H] (O)C (O)=O)=O. CC[C@@]1 (C=CCN2CC3)[C@@]2 ([H])[C@@]3 (C (C=C ([C@] (C4=C5C (C=CC=C6)=C6N4) (CC (C[C@@H] (C (F) (F)C)C7) ([H])CN7C5)C (OC)=O)C (OC)=C8)=C8N9C)[C@]9 ([H])[C@] (C (OC)=O) (O)[C@@H]1OC (C)=O. Catalog: ACM194468365. | |
| Vinflunine Ditartrate | Vinflunine is a semisynthetic Vinca alkaloid with microtubule destabilizing and antiangiogenic activity. Vinflunine is a derivative of Vinorelbine. Vinflunine is used as an antineoplastic. Group: Biochemicals. Alternative Names: (2 β,3 β,4 β,5α,12 β,19α)-4-(Acetyloxy)-6,7-didehydro-15-[(2R,4R,6S,8S)-4-(1,1-difluoroethyl)-1,3,4,5,6,7,8,9-octahydro-8-(methoxycarbonyl)-2,6-methano-2H-azecino[4,3-b]indol-8-yl]-3-hydroxy-16-methoxy-1-methylaspidospermidine-3-carboxylic Acid Methyl Ester (2R,3R)-2,3-Dihydroxybutanedioate; 4'-Deoxy-20',20'-difluoro-5'-nor-vincaleukoblastine Ditartrate; 20',20'-Difluoro-3',4'-dihydrovinorelbine Ditartrate; BMS 710485; F 12158; Javlor. Grades: Highly Purified. CAS No. 194468-36-5. Pack Sizes: 5mg. US Biological Life Sciences. |  Worldwide |
| Vinflunine Liposome | Vinflunine is a novel fluorinated vinca alkaloid derivative that exerts antitumor effects by inhibiting the cell proliferation of microtubule proteins. This product is a PEGylated pre-formulated liposome with vinflunine ditartrate. It is only for research purposes. Group: Drug-loaded liposome. Categories: liposomes, niosomes, ethosomes, and transfersomes. |  |
| Vinflunine tartrate | Vinflunine is a section, particle drug that belongs to the class of cancer drugs. It has been shown to have synergistic effects in combination with other drugs. Vinflunine has been shown to inhibit HDAC activity and induce apoptosis in human nasopharyngeal carcinoma and cervical cancer cells. Vinflunine is also a backup molecule for the treatment of hematological malignancies. This drug has been shown to have an acidic pH, which may make it unsuitable for oral administration. Vinflunine is used as a chitosan gel carrier for topical application. Group: Other alkaloids. CAS No. 1201898-17-0. Molecular formula: C45H54F2N4O8·xC4H6O6. Canonical SMILES: CC[C@@]12C=CCN3[C@@H]1[C@]4 (CC3)[C@H] ([C@] ([C@@H]2OC (=O)C) (C (=O)OC)O)N (C5=CC (=C (C=C45)[C@]6 (C[C@H]7C[C@H] (CN (C7)CC8=C6NC9=CC=CC=C89)C (C) (F)F)C (=O)OC)OC)C. [C@@H] ([C@H] (C (=O)O)O) (C (=O)O)O. Catalog: ACM1201898170. | |
| Vinflunine Tartrate | Vinflunine induces apoptosis in neuroblastoma SK-N-SH cells through a postmitotic G1 arrest and a mitochondrial pathway in a concentration-dependent manner with an IC50 with 50 nM. Grades: >98%. CAS No. 1201898-17-0. Molecular formula: C45H54F2N4O8.xC4H6O6. Mole weight: 967.02. | |
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