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| Product | Description | |
|---|---|---|
| Volasertib | BI 6727 (Volasertib) is a small highly potent Polo-like kinase inhibitor (Plk) with an IC50 of 0.87 nM and EC50 of 11-37 nM on a panel of cancer cell lines, which exhibited significant anti-proliferative in multiple cancer models, including a model of taxane-resistant colorectal cancer. BI 6727 (Volasertib) caused programmed cell death in colon and non-small cell lung cancer cells both in vitro and in vivo. Synonyms: Volasertib; BI-6727; BI6727; BI 6727. Grades: 0.98. CAS No. 755038-65-4. Molecular formula: C34H50N8O3. Mole weight: 618.827. |  |
| Volasertib | Volasertib (BI 6727) is an orally active, highly potent and ATP-competitive Polo-like kinase 1 (PLK1) inhibitor with an IC 50 of 0.87 nM. Volasertib inhibits PLK2 and PLK3 with IC 50 s of 5 and 56 nM, respectively. Volasertib induces mitotic arrest and apoptosis. Volasertib, a dihydropteridinone derivative, shows marked antitumor activity in multiple cancer models [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: BI 6727. CAS No. 755038-65-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-12137. |  |
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