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| Product | Description | |
|---|---|---|
| Vonoprazan | Vonoprazan is a novel P-CAB (potassium-competitive acid blocker) that reversibly inhibits H+/K+ ATPase with IC50 of 19 nM (pH 6.5), controls gastric acid secretion. It is used to treat acid-related diseases. It can be used for the treatment of gastroduodenal ulcer (including some drug-induced peptic ulcers) and reflux esophagitis, and can be combined with antibiotics for the eradication of Helicobacter pylori. It is a pyrrole derivative with a chemical structure that is completely different from the P-CABs developed to date in vitro. It inhibits basal gastric acid secretion in a dose-dependent manner, and the ID50 value is 1.26 mg/kg in vivo. It shows a potent and longer-lasting inhibitory effect on the histamine-stimulated gastric acid secretion in rats and dogs. It shows significant antisecretory activity through high accumulation and slow clearance from the gastric tissue. It is unaffected by the gastric secretory state. It was developed by Takeda and Otsuda together. It has been listed. Uses: Vonoprazan is used to treat acid-related diseases. it can be used for the treatment of gastroduodenal ulcer (including some drug-induced peptic ulcers) and reflux esophagitis, and can be combined with antibiotics for the eradication of helicobacter pylori. Synonyms: TAK-438 free base;TAK438 free base; TAK 438 free base; Takecab;1-[5-(2-Fluorophenyl)-1-[(pyridin-3-yl)sulfonyl]-1H-pyrrol-3-yl]-N-methylmethanamine;1H-Pyrrole-3-methanamine,5-(2-fluorophenyl)-N-methyl-1-(3-pyridinylsulfonyl). Grades: >98 %. CAS No. 881681-00-1. Molecular formula: C17H16FN3O2S. Mole weight: 345.39. |  |
| Vonoprazan | Vonoprazan (TAK-438 free base), a proton pump inhibitor (PPI), is a potent and orally active potassium-competitive acid blocker (P-CAB) , with antisecretory activity. Vonoprazan inhibits H + ,K + -ATPase activity in porcine gastric microsomes with an IC 50 of 19 nM at pH 6.5. Vonoprazan is developed for the research of acid-related diseases, such as gastroesophageal reflux disease and peptic ulcer disease. Vonoprazan can be used for eradication of Helicobacter pylori [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: TAK-438 free base. CAS No. 881681-00-1. Pack Sizes: 10 mM * 1 mL; 100 mg; 250 mg. Product ID: HY-100007. |  |
| Vonoprazan Fumarate | TAK-438 is a novel P-CAB (potassium-competitive acid blocker) that reversibly inhibits H+/K+, ATPase with IC50 of 19 nM (pH 6.5), controls gastric acid secretion. Synonyms: TAK438; TAK-438; TAK 438. Grades: 98%. CAS No. 881681-01-2. Molecular formula: C17H16FN3O2S.C4H4O4. Mole weight: 461.46. | |
| Vonoprazan Fumarate | Vonoprazan Fumarate (TAK-438), a proton pump inhibitor (PPI), is a potent and orally active potassium-competitive acid blocker (P-CAB) , with antisecretory activity. Vonoprazan Fumarate inhibits H + ,K + -ATPase activity in porcine gastric microsomes with an IC 50 of 19 nM at pH 6.5. Vonoprazan Fumarate is developed for the research of acid-related diseases, such as gastroesophageal reflux disease and peptic ulcer disease [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: TAK-438. CAS No. 881681-01-2. Pack Sizes: 10 mM * 1 mL; 100 mg; 500 mg. Product ID: HY-15295. | |
| Vonoprazan Fumarate Impurity 4 | One of the impurities of Vonoprazan, which is a potassium-competitive acid blocker and has been found to be effective in the treatment of gastroduodenal ulcer and reflux esophagitis. Grades: 95%. CAS No. 2169271-28-5. Molecular formula: C16H13FN2O3S. Mole weight: 332.35. | |
| Vonoprazan Impuirty 8 | One of the impurities of Vonoprazan, which is a potassium-competitive acid blocker and has been found to be effective in the treatment of gastroduodenal ulcer and reflux esophagitis. Molecular formula: C21H20FN3O6S. Mole weight: 461.47. | |
| Vonoprazan Impurity 1 | One of the impurities of Vonoprazan, which is a potassium-competitive acid blocker and has been found to be effective in the treatment of gastroduodenal ulcer and reflux esophagitis. Synonyms: N-methyl(5-phenyl-1-(pyridin-3-ylsulfonyl)-1H-pyrrol-3-yl)methanamine fumarate salt. CAS No. 881732-90-7. Molecular formula: C17H17N3O2S. Mole weight: 327.41. | |
| Vonoprazan Impurity 10 | One of the impurities of Vonoprazan, which is a potassium-competitive acid blocker and has been found to be effective in the treatment of gastroduodenal ulcer and reflux esophagitis. Molecular formula: C34H30N6O4S2. Mole weight: '688.78. | |
| Vonoprazan Impurity 11 | One of the impurities of Vonoprazan, which is a potassium-competitive acid blocker and has been found to be effective in the treatment of gastroduodenal ulcer and reflux esophagitis. Synonyms: 1-(5-(2-Fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrol-3-yl)-N-((5-(2-fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrol-3-yl)methyl)-N-methylmethanamine. CAS No. 2250243-23-1. Molecular formula: C33H27F2N5O4S2. Mole weight: 659.74. | |
| Vonoprazan Impurity 12 | One of the impurities of Vonoprazan, which is a potassium-competitive acid blocker and has been found to be effective in the treatment of gastroduodenal ulcer and reflux esophagitis. Molecular formula: C11H7ClFNO. Mole weight: 223.64. | |
| Vonoprazan Impurity 13 | One of the impurities of Vonoprazan, which is a potassium-competitive acid blocker and has been found to be effective in the treatment of gastroduodenal ulcer and reflux esophagitis. Molecular formula: C16H10ClFN2O3S. Mole weight: 364.79. | |
| Vonoprazan Impurity 14 | One of the impurities of Vonoprazan, which is a potassium-competitive acid blocker and has been found to be effective in the treatment of gastroduodenal ulcer and reflux esophagitis. Synonyms: 1H-Pyrrole-3-carboxaldehyde, 5-(2-fluorophenyl)-1-(3-pyridinylsulfonyl)-; 5-(2-Fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrole-3-carbaldehyde; 5-(2-Fluorophenyl)-1-(3-pyridinylsulfonyl)-1H-pyrrole-3-carboxaldehyde. Grades: ≥95%. CAS No. 881677-11-8. Molecular formula: C16H11FN2O3S. Mole weight: 330.34. | |
| Vonoprazan Impurity 15 | One of the impurities of Vonoprazan, which is a potassium-competitive acid blocker and has been found to be effective in the treatment of gastroduodenal ulcer and reflux esophagitis. Molecular formula: C17H16FN3O3S. Mole weight: '361.40. | |
| Vonoprazan Impurity 17 | One of the impurities of Vonoprazan, which is a potassium-competitive acid blocker and has been found to be effective in the treatment of gastroduodenal ulcer and reflux esophagitis. Synonyms: 1883595-38-7; 5-(2-Fluorophenyl)-1H-pyrrole-3-carboxylic acid1H-Pyrrole-3-carboxylic acid, 5-(2-fluorophenyl)-Vonoprazan Impurity 17CS-0163877. Grades: 95%. CAS No. 1883595-38-7. Molecular formula: C11H8FNO2. Mole weight: 205.18. | |
| Vonoprazan Impurity 19 | One of the impurities of Vonoprazan, which is a potassium-competitive acid blocker and has been found to be effective in the treatment of gastroduodenal ulcer and reflux esophagitis. Grades: 95%. CAS No. 881674-58-4. Molecular formula: C11H10FNO. Mole weight: 191.20. | |
| Vonoprazan Impurity 2 | One of the impurities of Vonoprazan, which is a potassium-competitive acid blocker and has been found to be effective in the treatment of gastroduodenal ulcer and reflux esophagitis. Synonyms: 1-(5-(4-Fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrol-3-yl)-N-methylmethanamine; 1H-Pyrrole-3-methanamine, 5-(4-fluorophenyl)-N-methyl-1-(3-pyridinylsulfonyl)-; SCHEMBL1580664; CHEMBL2079304; 1-[5-(4-fluorophenyl)-1-pyridin-3-ylsulfonylpyrrol-3-yl]-N-methylmethanamine. CAS No. 881733-36-4. Molecular formula: C17H16FN3O2S. Mole weight: 345.4. | |
| Vonoprazan Impurity 23 | One of the impurities of Vonoprazan, which is a potassium-competitive acid blocker and has been found to be effective in the treatment of gastroduodenal ulcer and reflux esophagitis. Synonyms: 1-(5-(2-Fluorophenyl)-1H-pyrrol-3-yl)-N-methylmethanamine. Grades: 95%. CAS No. 1610043-62-3. Molecular formula: C12H13FN2. Mole weight: 204.24. | |
| Vonoprazan Impurity 24 | One of the impurities of Vonoprazan, which is a potassium-competitive acid blocker and has been found to be effective in the treatment of gastroduodenal ulcer and reflux esophagitis. Synonyms: Vonoprazan N-Oxide Impurity. Grades: 95%. CAS No. 1883595-39-8. Molecular formula: C17H14FN3O3S. Mole weight: 359.37. | |
| Vonoprazan Impurity 27 | Vonoprazan Impurity 27. Uses: For analytical and research use. Group: Impurity standards. CAS No. 122453-85-4. Molecular formula: C11H8N2. Mole weight: 168.2. Catalog: APB122453854. |  |
| Vonoprazan Impurity 28 | One of the impurities of Vonoprazan, which is a potassium-competitive acid blocker and has been found to be effective in the treatment of gastroduodenal ulcer and reflux esophagitis. Synonyms: 2-phenyl-4-formylpyrrole; 5-Phenylpyrrole-3-carbaldehyde. Grades: 95 %. CAS No. 56448-22-7. Molecular formula: C11H9NO. Mole weight: 171.19. | |
| Vonoprazan Impurity 29 | One of the impurities of Vonoprazan, which is a potassium-competitive acid blocker and has been found to be effective in the treatment of gastroduodenal ulcer and reflux esophagitis. Synonyms: 881676-90-0; 5-Phenyl-1-(pyridin-3-ylsulfonyl)-1H-pyrrole-3-carbaldehyde5-phenyl-1-pyridin-3-ylsulfonylpyrrole-3-carbaldehyde; Vonoprazan Impurity 29; SCHEMBL1156702. Grades: 95%. CAS No. 881676-90-0. Molecular formula: C16H12N2O3S. Mole weight: 312.34. | |
| Vonoprazan Impurity 3 | One of the impurities of Vonoprazan, which is a potassium-competitive acid blocker and has been found to be effective in the treatment of gastroduodenal ulcer and reflux esophagitis. CAS No. 928325-41-1. Molecular formula: C17H15F2N3O2S. Mole weight: 363.39. | |
| Vonoprazan Impurity 34 | Vonoprazan Impurity 34. Uses: For analytical and research use. Group: Impurity standards. CAS No. 1240948-72-4. Molecular formula: C11H6ClFN2. Mole weight: 220.63. Catalog: APB1240948724. | |
| Vonoprazan Impurity 36 | Vonoprazan Impurity 36. Uses: For analytical and research use. Group: Impurity standards. CAS No. 1060802-18-7. Molecular formula: C5H3Cl2NO2S. Mole weight: 212.04. Catalog: APB1060802187. | |
| Vonoprazan Impurity 4 | One of the impurities of Vonoprazan, which is a potassium-competitive acid blocker and has been found to be effective in the treatment of gastroduodenal ulcer and reflux esophagitis. Molecular formula: C16H13ClFN3O2S. C4H4O4. Mole weight: 481.89. | |
| Vonoprazan Impurity 5 | One of the impurities of Vonoprazan, which is a potassium-competitive acid blocker and has been found to be effective in the treatment of gastroduodenal ulcer and reflux esophagitis. Molecular formula: C17H18FN3O2S. Mole weight: 347.41. | |
| Vonoprazan Impurity 51 | Vonoprazan Impurity 51. Uses: For analytical and research use. Group: Impurity standards. CAS No. 1240949-51-2. Molecular formula: C11H7FN2. Mole weight: 186.19. Catalog: APB1240949512. | |
| Vonoprazan Impurity 6 | One of the impurities of Vonoprazan, which is a potassium-competitive acid blocker and has been found to be effective in the treatment of gastroduodenal ulcer and reflux esophagitis. Molecular formula: C17H20FN3O3S. Mole weight: 365.43. | |
| Vonoprazan Impurity 64 | Vonoprazan Impurity 64. Uses: For analytical and research use. Group: Impurity standards. CAS No. 1240948-77-9. Molecular formula: C11H7FN2. Mole weight: 186.19. Catalog: APB1240948779. | |
| Vonoprazan Impurity 67 | One of the impurities of Vonoprazan, which is a potassium-competitive acid blocker and has been found to be effective in the treatment of gastroduodenal ulcer and reflux esophagitis. Synonyms: N,N-Dimethylmethanamine Vonoprazan. Grades: 95%. CAS No. 1885094-62-1. Molecular formula: C18H18FN3O2S. Mole weight: 359.42. | |
| Vonoprazan Impurity 7 | One of the impurities of Vonoprazan, which is a potassium-competitive acid blocker and has been found to be effective in the treatment of gastroduodenal ulcer and reflux esophagitis. Molecular formula: C17H20FN3O2S. Mole weight: 349.43. | |
| Vonoprazan Impurity 9 | One of the impurities of Vonoprazan, which is a potassium-competitive acid blocker and has been found to be effective in the treatment of gastroduodenal ulcer and reflux esophagitis. Molecular formula: C17H16N3O3S. Mole weight: 361.4. | |
| Vonoprazan Impurity F | One of the impurities of Vonoprazan, which is a potassium-competitive acid blocker and has been found to be effective in the treatment of gastroduodenal ulcer and reflux esophagitis. Molecular formula: C18H18FN3O2S. Mole weight: 359.43. | |
| 2-Chloro Vonoprazan | One of the impurities of Vonoprazan, which is a potassium-competitive acid blocker and has been found to be effective in the treatment of gastroduodenal ulcer and reflux esophagitis. Synonyms: 2-Chloro Vonoprazan; 928325-68-2; 1-(2-Chloro-5-(2-fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrol-3-yl)-N-methylmethanamine; 1-[2-chloro-5-(2-fluorophenyl)-1-pyridin-3-ylsulfonylpyrrol-3-yl]-N-methylmethanamine; SCHEMBL1580961; CS-0164589; 1-(2-chloro-5-(2-fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrol-3-yl)-N-methylmethanamine? (Vonoprazan Impurity pound(c). Grades: 95%. CAS No. 928325-68-2. Molecular formula: C17H15ClFN3O2S. Mole weight: 379.84. | |
| 1-Methyl-4-sulfopyridinium Hydroxide Inner Salt | One of the impurities of Vonoprazan, which is a potassium-competitive acid blocker and has been found to be effective in the treatment of gastroduodenal ulcer and reflux esophagitis. Synonyms: 1-methyl-4-sulfopyridin-1-ium hydroxide; 4416-69-7. Grades: 95%. CAS No. 4416-69-7. Molecular formula: C6H7NO3S. Mole weight: 173.19. | |
| 2'-Fluoroacetophenone | 2'-Fluoroacetophenone (Vonoprazan Impurity 31). Group: Biochemicals. Grades: Highly Purified. CAS No. 445-27-2. Pack Sizes: 500mg, 1g. Molecular Formula: C8H7FO, Molecular Weight: 138.139999999999. US Biological Life Sciences. |  Worldwide |
| 5-(2-Fluorophenyl)-1-(3-pyridinylsulfonyl)-1H-pyrrole-3-carbonitrile | One of the impurities of Vonoprazan, which is a potassium-competitive acid blocker and has been found to be effective in the treatment of gastroduodenal ulcer and reflux esophagitis. Grades: 95%. CAS No. 1807642-39-2. Molecular formula: C16H10FN3O2S. Mole weight: 327.33. | |
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