Find where to buy products from suppliers in the USA, including: distributors, industrial manufacturers in America, bulk supplies and wholesalers of raw ingredients & finished goods.
Search for products or services, then visit the American suppliers website for prices, SDS or more information. You can also view suppliers in Australia, NZ or the UK.
| Product | Description | |
|---|---|---|
| Voreloxin Hydrochloride | Voreloxin Hydrochloride is a first-in-class topoisomerase II inhibitor that intercalates DNA and induces site-selective DNA DSB, G2 arrest, and apoptosis. Uses: Scientific research. Group: Signaling pathways. Alternative Names: SNS-595 Hydrochloride; Vosaroxin Hydrochloride; AG 7352 Hydrochloride. CAS No. 175519-16-1. Pack Sizes: 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-16518. |  |
| Voreloxin Hydrochloride | Vosaroxin intercalates into DNA in a site-specific manner and blocks the re-ligation process carried out by topoisomerase II during DNA replication. As a result, inhibition of DNA replication, RNA and protein synthesis occurs, followed by cell cycle arrest at G2 phase and induced p53-independent apoptosis. This agent shows a favorable toxicity profile in several aspects: it does not generate reactive oxygen species, as do anthracyclines, reducing the risk of cardiotoxicity; it is not a P-glycoprotein (P-gp) substrate, and thereby evades the common mechanism for multidrug resistance; and it has limited distribution to normal tissues and a more chemically stable molecular structure. Synonyms: Voreloxin Hydrochloride. Grades: >98%. CAS No. 175519-16-1. Molecular formula: C18H20ClN5O4S. Mole weight: 437.9. |  |
Our database is helping our users find suppliers everyday.
