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| Product | Description | |
|---|---|---|
| W146 | W146. Group: Biochemicals. Grades: Purified. CAS No. 909725-61-7. Pack Sizes: 1mg. US Biological Life Sciences. |  Worldwide |
| W146 | W146 is a potent and selective sphingosine-1-phosphate receptor (S1P1) antagonist (Ki = 18 nM) with no effect at S1P2, S1P3 or S1P5. W146 potentiates capillary leakage and restores lymphocyte egress in vivo. Synonyms: W146; W 146; W-146; [(3R)-3-amino-4-[(3-hexylphenyl)amino]-4-oxobutyl]-phosphonic acid; (R)-3-Amino-4-(3-hexylphenylamino)-4-oxobutylphosphonic acid. Grades: ≥98% by HPLC. CAS No. 909725-61-7. Molecular formula: C16H27N2O4P. Mole weight: 342.37. |  |
| W146 hydrate | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. |  |
| W146 trifluoroacetate salt | W146 is a S1P1 receptor antagonist that exhibits Ki value of 77 nM for the human receptor in a GTP-γS binding assay with equipotency at the murine S1P1 receptor (2a = W146; 2b = W140 in supplemental material). Synonyms: W146 TFA salt; [(3R)-3-Amino-4-(3-hexylanilino)-4-oxobutyl]phosphonic acid (TFA salt); [3-azaniumyl-4-(3-hexylanilino)-4-oxobutyl]-hydroxyphosphinate. Grades: ≥95%. CAS No. 909725-62-8. Molecular formula: C18H28F3N2O6P. Mole weight: 456.39. | |
| W140 trifluoroacetate salt | W140 is an inactive enantiomer of W146, a selective S1P1 antagonist (Ki = 77 nM), binding to the S1P1 receptor with a Ki of 4.6 μM (2a = W146; 2b = W140 in supplemental material). Synonyms: W140 TFA salt; (S)-3-amino-4-(3-hexylphenylamino)-4-oxobutylphosphonic acid (TFA salt); Phosphonic acid, [(3S)-3-amino-4-[(3-hexylphenyl)amino]-4-oxobutyl]-, mono(trifluoroacetate); 2,2,2-trifluoroacetic acid. Grades: ≥95%. CAS No. 909725-64-0. Molecular formula: C18H28F3N2O6P. Mole weight: 456.39. | |
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