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| Product | Description | |
|---|---|---|
| Wiskostatin | Wiskostatin. Group: Biochemicals. Grades: Purified. CAS No. 253449-04-6. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. |  Worldwide |
| Wiskostatin | Wiskostatin is a cell-permeable and selective inhibitor of neural Wiskott-Aldrich syndrome protein (N-WASP). Wiskostatin directly interacts with the regulatory GTPase-binding domain of N-WASP and inhibits its activation. Wiskostatin blocks the activation of Arp2/3 complex and inhibits actin polymerization. Synonyms: 3,6-Dibromo-α-[(dimethylamino)methyl]-9H-cabazole-9-ethanol; 1-(3,6-dibromocarbazol-9-yl)-3-(dimethylamino)propan-2-ol. Grades: ≥99% by HPLC. CAS No. 253449-04-6. Molecular formula: C17H18Br2N2O. Mole weight: 426.15. |  |
| Wiskostatin | Wiskostatin is a potent and selective inhibitor of neuronal Wiskott-Aldrich syndrome protein (N-WASP)-mediated actin polymerization by stabilization of the closed, autoinhibited conformation, thereby preventing Arp2/3 complex activation. Wiskostatin is also a dynamin inhibitor with an IC50 value of 20.7 ?M and a potent inhibitor of clathrin-mediated endocytosis with an IC50 value of 6.9 ?M. Wiskostatin causes a rapid, profound, and irreversible decrease in cellular ATP levels. Wiskostatin also induces disassembly of podosomes in a murine monocyte cell line[1][2][3][4][5]. Uses: Scientific research. Group: Signaling pathways. CAS No. 253449-04-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-12534. |  |
| Clathrin-IN-4 | Clathrin-IN-4 (compound 8b), a Wiskostatin (HY-12534) analogue, is a potent inhibitor of clathrin mediated endocytosis with an IC 50 of 2.1 μM. Clathrin-IN-4 is a dynamin I GTPase activity inhibitor with an IC 50 of 9.1 μM [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 762242-59-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-152218. | |
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