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| Product | Description | |
|---|---|---|
| WP1066 | WP1066 is a JAK2 and STAT3 inhibitor. It was shown to inhibit proliferation and induce apoptosis in erythroid human cells carrying the JAK2 V617F mutation. Synonyms: (E)-3-(6-bromopyridin-2-yl)-2-cyano-N-[(1S)-1-phenylethyl]prop-2-enamide. Grades: >98%. CAS No. 857064-38-1. Molecular formula: C17H14BrN3O. Mole weight: 356.223. |  |
| WP1066 | WP1066 is an inhibitor of JAK2 and STAT3 , and also shows effect on STAT5 and ERK1/2, without affecting JAK1 and JAK3. Uses: Scientific research. Group: Signaling pathways. CAS No. 857064-38-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg. Product ID: HY-15312. |  |
| WP1066 ((2E)-3-(6-Bromo-2-pyridinyl)-2-cyano-N-[(1S)-1-phenylethy]-2-propenamide) | A potent, cell-permeable JAK2 inhibitor. A novel analog of the JAK2 inhibitor AG490 that blocks STAT3 and phosphoinositide-3-kinase pathways. It is significantly more potent and active against human malignant glioma cells in vitro and in vivo than AG 490. Similar to AG490, WP1066 inhibits the phosphorylation of JAK2, but unlike AG490, WP1066 also degrades JAK2 protein, thus blocking its downstream signal transducer and activator of transcription (STAT) and phosphoinositide-3-kinase pathways to results in the activation of the caspase pathway. Group: Biochemicals. Grades: Purified. CAS No. 857064-38-1. Pack Sizes: 5mg. US Biological Life Sciences. |  Worldwide |
| WP1130 (Degrasyn) | A cell-permeable tyrphostin compound that acts as a partially selective deubiquitinase (DUB) inhibitor and suppresses JAK-Stat signaling pathway. Reported to cause accumulation of polyubiquitinated p53, JAK2 and Bcr-Abl, and reduce c-Myc and MCL-1 protein levels in several tumor cells and downregulate Stat3 and NF-kB activities (IC50 < 1uM in MCL cells) leading to tumor cell apoptosis (IC50 ~1.2uM in Z138 cells). Suggested to modify active site cysteine of DUB and inhibit USP5, UCH-L1, USP9x, USP14, and UCH37 activities (≥80% inhibition at 5uM) without affecting 20S proteasome. Reported to exert stronger antiproliferative and antitumor properties than STAT3 Inhibitor III, WP1066 in xenograft mouse models of CML and melanoma. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
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