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| Product | Description | |
|---|---|---|
| WS3 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. |  |
| WS3 | WS3 induces proliferation of the mouse β cell line R7T1 with EC50 of 0.074 μM. Synonyms: WS3; WS-3; WS 3. Grades: >98%. CAS No. 1421227-52-2. Molecular formula: C28H30F3N7O3. Mole weight: 569.58. |  |
| Cell Proliferation Inducer, WS3 (N- (6- (4- (3- (4- ( (4- methyl piperazin-1-yl) methyl ) -3- (trifluoro methyl ) phenyl) ureido) phenoxy) pyrimidin-4-yl) cyclopropane carboxamide Hydrochloride) | A cell-permeable, diarylurea analog that can reversibly induce cell proliferation of primary retinal pigment epithelial (RPE) cells from rodents and from fetal and adult human donors (~25nM). Its action suggested to be mediated through Erb3 binding protein 1 (Ebp1). Non-proliferating RPE cells at passage 6 appear to respond well to WS3 treatment, whereas actively proliferating cells in passage 1 to 4 do not exhibit any increase in proliferation. These cells can differentiate into functional monolayer following WS3 withdrawal. However, WS3-expanded adult human RPE cells differentiate less effectively when compared to stem cell-derived RPE cells. The expanded RPE cells are shown to preserve vision when transplanted into rodent models of retinal degeneration. Also shown to induce proliferation of mouse R7T1 beta cells (EC50 = 74nM). Not reported to induce any genetic changes or tumorigenic events. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. Molecular Formula: C??H??F?N?O? HCl. US Biological Life Sciences. |  Worldwide |
| N-Ethyl-p-menthane-3-carboxamide | WS 3 is a cooling agent that acts as an agonist at TRPM8 receptors (EC50 = 3.7 μM). Uses: Cooling agent. Synonyms: WS 3; WS3; WS-3; N-Ethyl-5-methyl-2-(1-methylethyl)cyclohexanecarboxamide; N-Ethyl-p-menthane-3-carboxamide; Ethyl menthane carboxamide. Grades: ≥99% by HPLC. CAS No. 39711-79-0. Molecular formula: C13H25NO. Mole weight: 211.34. | |
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