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| Product | Description | |
|---|---|---|
| WS6 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. |  |
| WS6 | WS6 induces R7T1 cell proliferation with EC50 of 0.28 μM, and promotes β cell proliferation in rodent and human primary islets. Synonyms: WS6; WS-6; WS 6. Grades: >98%. CAS No. 1421227-53-3. Molecular formula: C29H31F3N6O3. Mole weight: 568.59. |  |
| WS6 | WS6 is an IkB kinase and EBP1 inhibitor, with IC 50 values of 0.24 nM, 0.21 nM, and 40.48 nM in MV4-11, MOLM13, and K562 cells, respectively. WS6 promotes the proliferation of alpha and beta cells in the pancreas, has antioxidant and anti-inflammatory activities, and can alleviate depression like behavior in rats [1][2][4]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1421227-53-3. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 50 mg. Product ID: HY-12461. |  |
| EBP1 Inhibitor, WS6 (N- (6- (4- (2- (4- ( (4- methyl piperazin-1-yl) methyl ) -3- (trifluoro methyl ) phenylamino) -2-oxoethyl) phenoxy) pyrimidin-4-yl) cyclopropane carboxamide, xHCl, Erb3 Binding Protein-1 Inhibitor, IKK Inhibitor XV, PA2G4 Inhibitor) | A cell-permeable phenoxypyrimidin-cyclopropane carboxamide compound that effectively stimulates the growth of primary beta cells in cultured primary rat and human islets in vitro (ECmax in 4 d = 200 and 400nM, respectively) and in the murine type 1 diabetes (T1D) model RIP-DTA in vivo (170% of control pancreas Ki-67-positive beta cells in 1 wk; 5mg/kg i.p. q.o.d.) by interacting with IKKε and EBP1/PA2G4/Erb3 binding protein-1 and blocking the known suppressor function of EBP1 toward E2F-mediated transcription. Likewise, dual inhibition of EBP1 (with shRNA) and IKK (1uM) is shown to fully recapitulate the proliferating effect of WS6 in R7T1 cells. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. Molecular Formula: C??H??F?N?O?; xHCl. US Biological Life Sciences. |  Worldwide |
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