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| Product | Description | |
|---|---|---|
| WYE 687 dihydrochloride | WYE 687 is an ATP-competitive inhibitor of mTOR with IC50 value of 7 nM. It was shown to inhibit phosphorylation of mTORC1 and mTORC2 substrates including S6K, SGK and Akt. It also blocks VEGF secretion and HIF-1α expression. Synonyms: N-[4-[4-(4-Morpholinyl)-1-[1-(3-pyridinylmethyl)-4-piperidinyl]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]phenyl]-carbamic acid methyl ester dihydrochloride. Grades: ≥98% by HPLC. CAS No. 1702364-87-1. Molecular formula: C28H32N8O32HCl. Mole weight: 601.53. |  |
| WYE 687 Dihydrochloride (Potent and Selective mTOR Inhibitor, N-[4-[4-(4-Morpholinyl)-1-[1-(3-pyr idinylmethyl)-4-piperidinyl]-1H-pyrazolo[3,4-d]pyr imidin-6-yl]phenyl]-carbamic acid methyl ester hydrochloride) | Potent, ATP-competitive inhibitor of mammalian target of rapamycin (mTOR) (IC50 = 7nm). Displays selectivity for mTOR over PI 3-Kalpha (~100-fold) and PI 3-Kgamma (~500-fold). Inhibits phosphorylation of mTORC1 and mTORC2 substrates including S6K, SGK and Akt; blocks VEGF secretion and HIF-1alpha expression. Exhibits antiproliferative effects in cancer cell lines through G1 cell cycle arrest and selective apoptosis. Group: Biochemicals. Grades: Highly Purified. CAS No. 1062161-90-3. Pack Sizes: 10mg. US Biological Life Sciences. |  Worldwide |
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