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| Product | Description | |
|---|---|---|
| wyosine | Wyosine is a compound commonly found in transfer RNA (tRNA) molecules. It plays a significant role in stabilizing the anticodon loop of tRNA aiding in accurate protein synthesis. Wyosine has been studied in various diseases, such as cancer and viral infections, due to its involvement in tRNA function and cellular processes. Synonyms: 9H-Imidazo[1,2-a]purin-9-one, 3,4-dihydro-4,6-dimethyl-3-b-D-ribofuranosyl-; {3H-Diimidazo[1,2-a:4',5'-d]pyrimidin-9-one} 4,9-dihydro-4,6-dimethyl-3-B-D-ribofuranosyl-; 3-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]-4,6-dimethyl-imidazo[1,2-a]purin-9-one. CAS No. 52662-10-9. Molecular formula: C14H17N5O5. Mole weight: 335.32. |  |
| methylwyosine | By inhibiting the activity of Wybutosine biosynthesis, Methylwyosine facilitates targeted therapy for leukemia and lymphomas. Its mechanism of action involves disrupting the function of Wyosine synthase, a crucial enzyme in nucleic acid synthesis, ultimately impeding tumor growth and progression. Synonyms: 9H-Imidazo[1,2-a]purin-9-one, 3,4-dihydro-4,6,7-trimethyl-3-b-D-ribofuranosyl-; 3-Ribofuranosyl-4,9-dihydro-4,6,7-trimethyl-9-oxoimidazo(1,2-a)purine; 4,6,7-Trimethyl-3-pentofuranosyl-3,4-dihydro-9H-imidazo[1,2-a]purin-9-one. CAS No. 108274-04-0. Molecular formula: C15H19N5O5. Mole weight: 349.35. | |
| N4-Desmethyl-N5-methyl wyosine | N4-Desmethyl-N5-methyl wyosine is an antiviral compound, used for studying a spectrum of RNA viruses. Synonyms: 5-Methyl-4-desomethylwyosine; 5,6-dimethyl-3-β-D-ribofuranosyl-3,6-dihydro-imidazo[1,2-a]purin-9-one; 9H-Imidazo[1,2-a]purin-9-one, 3,5-dihydro-5,6-dimethyl-3-β-D-ribofuranosyl-; 3-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-5,6-dimethyl-5H-imidazo[1,2-a]purin-9-one. Grades: ≥95%. CAS No. 59327-63-8. Molecular formula: C14H17N5O5. Mole weight: 335.32. | |
| tRNA 4-demethylwyosine synthase (AdoMet-dependent) | This enzyme, which is a member of the superfamily of S-adenosyl-L-methionine-dependent radical (radical AdoMet) enzymes, binds two [4Fe-4S] clusters. Carbons C2 and C3 from pyruvate are incorporated into 4-demethylwyosine. The enzyme is found in eukaryotes where it is part of the pathway for wybutosine synthesis, and in archaea, where it is involved in the biosynthesis of archaeal wye bases, such as wyosine, isowyosine, and methylwyosine. Group: Enzymes. Synonyms: TYW1. Enzyme Commission Number: EC 4.1.3.44. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4921; tRNA 4-demethylwyosine synthase (AdoMet-dependent); EC 4.1.3.44; TYW1. Cat No: EXWM-4921. |  |
| tRNAPhe (7-(3-amino-3-carboxypropyl)wyosine37-C2)-hydroxylase | Requires Fe2+. The enzyme is not active with wybutosine. Group: Enzymes. Synonyms: TYW5; tRNA yW-synthesizing enzyme 5. Enzyme Commission Number: EC 1.14.11.42. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0661; tRNAPhe (7-(3-amino-3-carboxypropyl)wyosine37-C2)-hydroxylase; EC 1.14.11.42; TYW5; tRNA yW-synthesizing enzyme 5. Cat No: EXWM-0661. | |
| tRNAPhe [7-(3-amino-3-carboxypropyl)wyosine37-O]-methyltransferase | The enzyme is found only in eukaryotes, where it is involved in the biosynthesis of wybutosine, a hypermodified tricyclic base found at position 37 of certain tRNAs. The modification is important for translational reading-frame maintenance. In some species that produce hydroxywybutosine the enzyme uses 7-(2-hydroxy-3-amino-3-carboxypropyl)wyosine37 in tRNAPhe as substrate. The enzyme also has the activity of EC 2.3.1.231, tRNAPhe 7-[(3S)-4-methoxy-(3-amino-3-carboxypropyl)wyosine37-O]-carbonyltransferase. Group: Enzymes. Synonyms: TYW4 (ambiguous); tRNA-yW synthesizing enzyme-4 (ambiguous). Enzyme Commission Number: EC 2.1.1.290. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-1897; tRNAPhe [7-(3-amino-3-carboxypropyl)wyosine37-O]-methyltransferase; EC 2.1.1.290; TYW4 (ambiguous); tRNA-yW synthesizing enzyme-4 (ambiguous). Cat No: EXWM-1897. | |
| tRNAPhe {7-[3-amino-3-(methoxycarbonyl)propyl]wyosine37-N}-methoxycarbonyltransferase | The enzyme is found only in eukaryotes, where it is involved in the biosynthesis of wybutosine, a hypermodified tricyclic base found at position 37 of certain tRNAs. The modification is important for translational reading-frame maintenance. In some species that produce hydroxywybutosine the enzyme uses 7-[2-hydroxy-3-amino-3-(methoxycarbonyl)propyl]wyosine37 in tRNAPhe as substrate. The enzyme also has the activity of EC 2.1.1.290, tRNAPhe [7-(3-amino-3-carboxypropyl)wyosine37-O]-methyltransferase. Group: Enzymes. Synonyms: TYW4 (ambiguous); tRNA-yW synthesizing enzyme-4 (ambiguous). Enzyme Commission Number: EC 2.3.1.231. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2179; tRNAPhe {7-[3-amino-3-(methoxycarbonyl)propyl]wyosine37-N}-methoxycarbonyltransferase; EC 2.3.1.231; TYW4 (ambiguous); tRNA-yW synthesizing enzyme-4 (ambiguous). Cat No: EXWM-2179. | |
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