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| Product | Description | |
|---|---|---|
| XEN445 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. |  |
| XEN445 | XEN445 is a potent and selective endothelial lipase inhibitor with IC50 of 0.237 μM. Synonyms: XEN445; XEN 445; XEN-445. Grades: >98%. CAS No. 1515856-92-4. Molecular formula: C18H17F3N2O3. Mole weight: 366.33. |  |
| XEN445 | XEN445 is potent and selective endothelial lipase inhibitor, that showed good ADME and PK properties, and demonstrated in vivo efficacy in raising plasma HDLc concentrations in mice. Endothelial lipase (EL) activity has been implicated in HDL metabolism and in atherosclerotic plaque development; inhibitors are proposed to be efficacious in the treatment of dyslipidemia related cardiovascular disease. Uses: Designed for use in research and industrial production. Additional or Alternative Names: XEN445; XEN 445; XEN-445. Product Category: Inhibitors. Appearance: White to off-white solid powder. CAS No. 1515856-92-4. Molecular formula: C18H17F3N2O3. Mole weight: 366.33. Purity: >98%. IUPACName: (S)-2-(3-(pyridin-2-ylmethoxy)pyrrolidin-1-yl)-5-(trifluoromethyl)benzoic acid. Canonical SMILES: O=C(O)C1=CC(C(F)(F)F)=CC=C1N2C[C@@H](OCC3=NC=CC=C3)CC2. Product ID: ACM1515856924. Alfa Chemistry ISO 9001:2015 Certified. |  |
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