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| Product | Description | |
|---|---|---|
| Xevinapant | Xevinapant (AT-406) is a potent and orally bioavailable Smac mimetic and an antagonist of IAPs , and it binds to XIAP, cIAP1, and cIAP2 proteins with K i of 66.4, 1.9, and 5.1 nM, respectively. Uses: Scientific research. Group: Signaling pathways. Alternative Names: AT-406; Debio 1143; SM-406. CAS No. 1071992-99-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg. Product ID: HY-15454. |  |
| Xevinapant | Xevinapant Inhibitor. Uses: Scientific use. Product Category: T6763. CAS No. 1071992-99-8. |  |
| Xevinapant hydrochloride | Xevinapant (AT-406) hydrochloride is a potent and orally bioavailable Smac mimetic and an antagonist of the inhibitor of apoptosis proteins (IAPs). Xevinapant hydrochloride binds to XIAP, cIAP1, and cIAP2 proteins with K i s of 66.4, 1.9, and 5.1 nM, respectively. Xevinapant hydrochloride effectively antagonizes XIAP BIR3 protein in a cell-free functional assay, induces rapid degradation of cellular cIAP1 protein, and inhibits cancer cell growth in various human cancer cell lines. Xevinapant hydrochloride is highly effective in induction of apoptosis in xenograft tumors [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: AT-406 hydrochloride; Debio 1143 hydrochloride; SM-406 hydrochloride. CAS No. 1071992-57-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg. Product ID: HY-13208. | |
| AT-406 hydrochloride | AT-406 hydrochloride, a potent and orally bioavailable smac mimetic and an antagonist of apoptosis proteins (IAPs) inhibitor, binds to XIAP, cIAP1 and cIAP2 proteins with Kis of 66.4, 1.9 and 5.1 nM, respectively. It can effectively antagonize XIAP BIR3 protein in a cell-free functional assay, induce rapid degradation of cellular cIAP1 protein, and inhibit the growth of various human cancer cell lines. It can effectively induce the apoptosis in xenograft tumors. Synonyms: Xevinapant hydrochloride; Debio 1143 hydrochloride; SM-406 hydrochloride; (5S,8S,10aR)-N-benzhydryl-5-((S)-2-(methylamino)propanamido)-3-(3-methylbutanoyl)-6-oxodecahydropyrrolo[1,2-a][1,5]diazocine-8-carboxamide hydrochloride; (5S,8S,10aR)-N-(Diphenylmethyl)-5-[(N-methyl-L-alanyl)amino]-3-(3-methylbutanoyl)-6-oxodecahydropyrrolo[1,2-a][1,5]diazocine-8-carboxamide hydrochloride (1:1). Grade: ≥98%. CAS No. 1071992-57-8. Molecular formula: C32H44ClN5O4. Mole weight: 598.18. |  |
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