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| Product | Description | |
|---|---|---|
| XL413 | XL413 is a potent and selective Cdc7 inhibitor with an IC50 of 3.7 nM, with a 60-fold selectivity against CK2,10-fold selectivity against PIM, and 300-fold selectivity against a panel of over 100 protein kinases. Synonyms: BMS-863233; BMS863233; BMS 863233; XL-413; XL413; XL 413. Grades: >98%. CAS No. 1169558-38-6. Molecular formula: C14H12ClN3O2. Mole weight: 289.72. |  |
| XL413 hydrochloride | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. |  |
| XL413 hydrochloride | XL413 is a potent and selective inhibitor of Cdc7 with IC50 value of 3.4 nM. It exhibits >60, >10, and >300-fold selectivity for Cdc7 over CK2, PIM1, and a panel of over 100 protein kinases, respectively. Synonyms: 8-Chloro-2-[(2S)-pyrrolidin-2-yl]-4aH-[1]benzofuro[3,2-d]pyrimidin-4-one hydrochloride. Grades: ≥98%. CAS No. 2062200-97-7. Molecular formula: C14H12ClN3O2·HCl. Mole weight: 326.18. | |
| BMS-863233 HCl | BMS-863233, also known as XL-413, is an orally bioavailable cell division cycle 7 homolog (CDC7) kinase inhibitor with potential antineoplastic activity. CDC7 kinase inhibitor BMS-863233 binds to and inhibits the activity of CDC7, which may result in the inhibition of DNA replication and mitosis, the induction of tumor cell apoptosis, and the inhibition of tumor cell proliferation in CDC7-overexpressing tumor cells. CDC7, a serine-threonine kinase overexpressed in a variety of tumor cell types, plays an essential role in the initiation of DNA replication by activating origins of replication. Check for active clinical trials or closed clinical trials using this agent. Synonyms: BMS-863233; BMS863233; BMS 863233; XL-413; XL413; XL 413. CAS No. 1169562-71-3. Molecular formula: C14H13Cl2N3O2. Mole weight: 289.72. | |
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