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| Product | Description | |
|---|---|---|
| Y-27632 | Y-27632 Inhibitor. Uses: Scientific use. Product Category: T1725. CAS No. 129830-38-2. |  |
| Y-27632 | Y-27632 is an orally active, ATP-competitive inhibitor of ROCK-I and ROCK-II , with K i s of 220 and 300 nM, respectively. Y-27632 attenuates Doxorubicin-induced apoptosis of human cardiac stem cells. Y-27632 also suppresses dissociation-induced apoptosis of murine prostate stem/progenitor cells. Y-27632 primes human induced pluripotent stem cells (hIPSCs) to selectively differentiate towards mesendodermal lineage via epithelial-mesenchymal transition-like modulation [1] [2] [3] [4] [5] [6] [7]. Uses: Scientific research. Group: Signaling pathways. CAS No. 146986-50-7. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 50 mg; 100 mg; 200 mg; 500 mg. Product ID: HY-10071. |  |
| Y-27632 - CAS 146986-50-7 | Y-27632A, CAS 146986-50-7, is a cell-permeable, reversible, inhibitor of Rho kinases (Ki = 140 nM for p160ROCK). Enhances survival & cloning efficiency of ESC without affecting their pluripotency. Group: Fluorescence/luminescence spectroscopy. |  |
| Y-27632-d4 Dihydrochloride Hydrate (ROCK Inhibitor) | A labeled Rho kinase inhibitor (ROCK) for the treatment of ischemia-reperfusion disorders. Group: Biochemicals. Alternative Names: trans-4-[(1R)-1-Aminoethyl]-N-4-pyridinyl-cyclohexanecarboxamide-d4 Dihydrochloride Monohydrate. Grades: Highly Purified. Pack Sizes: 1mg. US Biological Life Sciences. |  Worldwide |
| Y-27632 dihydrochloride | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| Y-27632 dihydrochloride | Y-27632 dihydrochloride is an orally active and ATP-competitive ROCK ( Rho-kinase ) inhibitor (ROCK-I K i =220 nM; ROCK-II K i =300 nM). Y-27632 dihydrochloride shows antiepileptic effects [1] [2] [3] [4]. Uses: Scientific research. Group: Signaling pathways. CAS No. 129830-38-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 200 mg. Product ID: HY-10583. | |
| Y-27632 Dihydrochloride | Y-27632 is a selective inhibitor of Rho-associated coiled-coil forming protein serine/threonine kinase (ROCK) family of protein kinases that selectively competes with ATP for binding to the catalytic site. It is reported to diminish dissociation-induced apoptosis, increase cloning efficiency, and facilitate subcloning after gene transfer in human embryonic stem cells (hES). Group: Biochemicals. Alternative Names: trans-4- [ (1R) -1-Aminoethyl] -N-4-pyridinylcyclohexane carboxamide Dihydrochloride; (+) - (R) -trans-4- (1-aminoethyl) -N- (4-pyridyl) cyclohexanecarboxamide Dihydrochloride; (+) -trans-N- (4-Pyridyl) -4- [ (R) -1-aminoethyl] cyclohexanecarboxamide Dihydrochloride. Grades: Highly Purified. CAS No. 129830-38-2. Pack Sizes: 10mg, 25mg, 50mg. Molecular Formula: C??H??N?O; 2(HCl), Molecular Weight: 320.3. US Biological Life Sciences. | Worldwide |
| Y-27632 dihydrochloride (GMP) | Y-27632 dihydrochloride (GMP) is the GMP level of Y-27632 dihydrochloride (HY-10583). GMP guidelines are used to produce Y-27632 dihydrochloride (GMP). GMP small molecules works appropriately as an auxiliary reagent for cell research manufacture. Y-27632 dihydrochloride is an orally active and ATP-competitive ROCK (Rho-kinase) inhibitor with antiepileptic effect[1][2][3][4]. Uses: Scientific research. Group: Signaling pathways. CAS No. 129830-38-2. Pack Sizes: 10 mg; 50 mg; 100 mg. Product ID: HY-10583G. | |
| Y-27632 (dihydrochloride) (Standard) | Y-27632 (dihydrochloride) (Standard) is the analytical standard of Y-27632 (dihydrochloride). Y-27632 dihydrochloride is an orally active and ATP-competitive ROCK ( Rho-kinase ) inhibitor (ROCK-I K i =220 nM; ROCK-II K i =300 nM). Y-27632 dihydrochloride shows antiepileptic effects [1] [2] [3] [4]. Uses: Scientific research. Group: Signaling pathways. CAS No. 129830-38-2. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-10583R. | |
| InSolution Y-27632 | Y-27632A, CAS 146986-50-7, is a cell-permeable, reversible, inhibitor of Rho kinases (Ki = 140 nM for p160ROCK). Enhances survival & cloning efficiency of ESC without affecting their pluripotency. Group: Fluorescence/luminescence spectroscopy. | |
| InSolution Y-27632 in DMSO | Y-27632 is a 10 mM solution in DMSO. A highly potent, cell-permeable, reversible, and selective inhibitor of Rho-associated protein kinases (Ki = 140 nM for p160ROCK). Group: Fluorescence/luminescence spectroscopy. | |
| InSolution Y-27632 in DMSO | Y-27632 is a 10 mM solution in DMSO. A highly potent, cell-permeable, reversible, and selective inhibitor of Rho-associated protein kinases (Ki = 140 nM for p160ROCK). Uses: For analytical and research use. Group: Fluorescence/luminescence spectroscopy. Pack Sizes: 1MG. Mole weight: 247.34. Catalog: IAR42415742. Assay: ?95% (HPLC). | |
| N-tert-Butyloxycarbonyl Y-27632-d4 (ROCK Inhibitor) | Protected Y-27632-d4. A labeled Rho kinase inhibitor (ROCK) for the treatment of ischemia-reperfusion disorders. Group: Biochemicals. Alternative Names: trans-4-[ (R) -1-[ (tert-Butyloxycarbonyl) amino]ethyl]-N- (4-pyridyl) cyclohexanecarboxamide-d4; [ (1R) -1- [trans-4- [ (4-Pyridinyl-d4-amino) carbonyl] cyclohexyl] ethyl] -carbamic Acid 1,1-Dimethyethyl Ester. Grades: Highly Purified. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| Rock inhibitor y-27632 | Rock inhibitor y-27632. Uses: Designed for use in research and industrial production. Additional or Alternative Names: 4-[(1R)-1-aminoethyl]-N-pyridin-4-ylcyclohexane-1-carboxamide. Appearance: white solid. CAS No. 146986-50-7. Molecular formula: C14H21N3O·2HCl. Mole weight: 320.26. Purity: 98%+. IUPACName: 4-[(1R)-1-aminoethyl]-N-pyridin-4-ylcyclohexane-1-carboxamide. Canonical SMILES: CC(C1CCC(CC1)C(=O)NC2=CC=NC=C2)N. Density: 1.136 g/cm³. Product ID: ACM146986507. Alfa Chemistry ISO 9001:2015 Certified. Categories: 129830-38-2. |  |
| (1R)-trans-4-[N-Boc-1-aminoethyl]-N-4-pyridinyl-cyclohexanecarboxamide | Protected Y-27632, a Rho kinase inhibitor (ROCK) for the treatment of ischemia-reperfusion disorders. Group: Biochemicals. Alternative Names: [ (1R) -1- [trans-4- [ (4-Pyridinylamino) carbonyl] cyclohexyl] ethyl] carbamic Acid 1,1-Dimethylethyl Ester; N-Boc-Y-27632. Grades: Highly Purified. CAS No. 671816-04-9. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
| Pro-survival Compound, DDD00033325 | A cell-permeable, pyrrolidine small molecule that promotes single human embryonic stem cell survival up to 20-fold over background (EC50=3.9uM), with equal or higher potency than Y-27632 in 5 cell lines (SA461, SA181, SA167, SA121 and SA002) tested at 10uM. An in vitro high-content screening assay, which profiles a panel of more than 70 protein kinases, indicates that this small molecule is more selective than Y-27632 and only displays an inhibitory effect toward ROCK2 (> 83% inhibition, ROCK1 was not included in the panel) and PRK2 (76% inhibition) at 10uM. Furthermore, it exhibits less cytotoxicity at a greater concentration of 30uM than Y-27632 without marked adverse effects for up to 120 hours. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. Molecular Formula: C??H??N?, Molecular Weight: 293.37. US Biological Life Sciences. | Worldwide |
| Rho Kinase Inhibitor (H-1152, H-1152P, (S) - (+) -2-Methyl-1- [ (4-methyl-5-isoquinolinyl) sulfonyl] homopiperazine, 2HCl, ROCK Inhibitor) | A cell-permeable isoquinolinesulfonamid e compound that acts as a highly specific, reversible, potent, and ATP-competitive inhibitor of G-protein Rho-associated kinase (ROCK; Ki=1.6nM). Inhibits other serine/threonine kinases only at higher concentrations (Ki=630nM for PKA, 9.27 uM for PKC, and 10.1uM for MLCK). Shown to selectively block lysophosphatidic acid-induced, but not PDBu-induced, phosphorylation of myristoylated alanine-rich C kinase substrate (MARCKS) in NT-2 cells (IC50=2.5uM). Reported to be a more potent and selective inhibitor than Y-27632. Group: Biochemicals. Grades: Highly Purified. CAS No. 872543-07-6. Pack Sizes: 1mg, 5mg. US Biological Life Sciences. | Worldwide |
| Y-33075 | Y-33075 is a selective ROCK inhibitor derived from Y-27632, and is more potent than Y-27632, with an IC50 of 3.6 nM. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Y-39983 free base. CAS No. 199433-58-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg. Product ID: HY-10067. | |
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