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| Product | Description | |
|---|---|---|
| Y15 | Y15 is a novel small molecule FAK phosphorylation inhibitor. It is a direct inhibitor of FAK1 autophosphorylation, blocking phosphorylation of Y397. Besides, it promotes cell detachment and inhibits cell adhesion of cells in culture. It has been used to demonstrate a role for FAK in the regulation of aortic stiffness. Synonyms: 1,2,4,5-benzenetetramine tetrahydrochloride; Y15 hydrochloride; Y15 tetrahydrochloride; Y 15; Y-15 FAK Inhibitor 14. Grades: >98%. CAS No. 4506-66-5. Molecular formula: C6H14Cl4N4. Mole weight: 284.01. |  |
| Y15 | Y15. Uses: Designed for use in research and industrial production. Additional or Alternative Names: 1,2,4,5-benzenetetramine tetrahydrochloride. Product Category: Amide & Amine Monomers. Appearance: Light Green to Green Solid Powder. CAS No. 4506-66-5. Molecular formula: C6H14Cl4N4. Mole weight: 284.01 g/mol. Purity: 0.98. Product ID: ACM-MO-4506665. Alfa Chemistry ISO 9001:2015 Certified. |  |
| Y15 hydrochloride | Y15 hydrochloride, also known as FAK Inhibitor 14, is a direct FAK autophosphorylation inhibitor, blocking phosphorylation of Y397 with an IC50 value of about 1 μM. Y15 decreases viability, clonogenicity, and cell attachment in thyroid cancer cell lines and synergizes with targeted therapeutics. Y15 was shown to decrease cancer growth in vitro and in vivo. Uses: Designed for use in research and industrial production. Additional or Alternative Names: Y15 hydrochloride; Y15 tetrahydrochloride; Y 15; Y-15. FAK Inhibitor 14. Product Category: Inhibitors. Appearance: Light green to green solid powder. CAS No. 4506-66-5. Molecular formula: C6H14Cl4N4. Mole weight: 284.01. Purity: >97%. IUPACName: 1,2,4,5-benzenetetramine tetrahydrochloride. Canonical SMILES: NC1=CC(N)=C(N)C=C1N.[H]Cl.[H]Cl.[H]Cl.[H]Cl. Product ID: ACM4506665. Alfa Chemistry ISO 9001:2015 Certified. | |
| SAR-020106 | SAR-020106 is an ATP-competitive, potent, and selective CHK1 inhibitor on the isolated human enzyme. This compound abrogates an etoposide-induced G(2) arrest with an IC(50) of 55 nmol/L in HT29 cells, and significantly enhances the cell killing of gemcitabine and SN38 by 3.0- to 29-fold in several colon tumor lines in vitro and in a p53-dependent fashion. Biomarker studies have shown that SAR-020106 inhibits cytotoxic drug-induced autophosphorylation of CHK1 at S296 and blocks the phosphorylation of CDK1 at Y15 in a dose-dependent fashion both in vitro and in vivo. SAR-020106 can enhance antitumor activity with selected anticancer drugs in vivo and may therefore have clinical utility. Synonyms: SAR020106; SAR 020106; SAR-20106; SAR20106; SAR 20106. Grades: 98%. CAS No. 1184843-57-9. Molecular formula: C19H19ClN6O. Mole weight: 382.852. | |
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