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| Product | Description | |
|---|---|---|
| YM155 | YM155. Group: Biochemicals. Alternative Names: 4,9-Dihydro-1-(2-methoxyethyl)-2-methyl-4,9-dioxo-3-(2-pyrazinylmethyl)-1H-naphth[2,3-d]imidazolium Bromide; Sepantronium bromide; YM 155. Grades: Highly Purified. CAS No. 781661-94-7. Pack Sizes: 10mg. Molecular Formula: C20H19BrN4O3, Molecular Weight: 443.29. US Biological Life Sciences. |  Worldwide |
| Survivin Inhibitor, YM155 (Survivin Inhibitor I, Interleukin Enhancer-Binding Factor 3 Inhibitor) | A cell-permeable imidazolium derivative that suppresses survivin expression, blocks survivin promoter activity, and induces apoptosis in a variety of tumor cell lines (IC50 = 540nM) in a dose-dependent manner. The main target of YM155 appears to be the interleukin enhancer-binding factor 3 (ILF3/NF110) with shorter C-terminal lengths associated with reduced binding. Exhibits potent anti-tumor effects without any severe systemic toxicity in murine models. Reported to induce tumor regression by suppressing intratumor survivin levels in PC3-xenograph tumor models (by 47% and 80% at 1 and 5mg/kg, respectively. Group: Biochemicals. Grades: Highly Purified. CAS No. 781661-94-7. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| Sepantronium | Sepantronium, also known as YM-155, is a small-molecule proapoptotic agent with potential antineoplastic activity. Survivin inhibitor YM155 selectively inhibits survivin expression in tumor cells, resulting in inhibition of survivin antiapoptotic activity (via the extrinsic or intrinsic apoptotic pathways) and tumor cell apoptosis. Survivin, a member of the inhibitor of apoptosis (IAP) gene family, is expressed during embryonal development and is absent in most normal, terminally differentiated tissues; upregulated in a variety of human cancers, its expression in tumors is associated with a more aggressive phenotype, shorter survival times, and a decreased response to chemotherapy. Uses: For research used only. Synonyms: YM155; YM 155; YM-155; Sepantronium bromide. Grades: >98%. CAS No. 781661-94-7. Molecular formula: C20H19BrN4O3. Mole weight: 443.29386. |  |
| YM-155 hydrochloride | YM155 is a potent survivin suppressant by inhibiting Survivin promoter activity with IC50 of 0.54 nM. Synonyms: YM155 hydrochloride; YM 155 hydrochloride. Grades: >98%. CAS No. 355406-09-6. Molecular formula: C20H19ClN4O3. Mole weight: 398.84. | |
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