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| Product | Description | |
|---|---|---|
| YMU1 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. |  |
| YMU1 | YMU1 is a human thymidylate kinase (hTMPK; IC50 value 1.65 μM) inhibitor yet not has inhibitory effect on the activity of purified thymidine kinase 1 (TK1). YMU1 stabilizes the conformation of ligand-induced degradation (LID) region of hTMPK and blocks the catalytic site or ATP-binding site. Synonyms: ethyl 4-[2-(4,6-dimethyl-3-oxo-[1,2]thiazolo[5,4-b]pyridin-2-yl)acetyl]piperazine-1-carboxylate. Grades: 99%. CAS No. 902589-96-2. Molecular formula: C17H22N4O4S. Mole weight: 378.45. |  |
| YMU1 | YMU1 is a human thymidylate kinase (hTMPK) inhibitor that lacks inhibitory effect on the activity of purified thymidine kinase 1 (TK1). YMU1 stabilizes the conformation of ligand-induced degradation (LID) region of hTMPK and blocks the catalytic site or ATP-binding site. Blocking hTMPK by YMU1 attenuates the ATP binding-induced closed conformation that is required for phosphorylation of dTMP and sensitizes cancer cells for low-dose doxorubicin chemotherapy. Uses: Designed for use in research and industrial production. Additional or Alternative Names: YMU1; YMU 1; YMU-1. Product Category: Inhibitors. Appearance: Solid powder. CAS No. 902589-96-2. Molecular formula: C17H22N4O4S. Mole weight: 378.45. Purity: >98%. IUPACName: ethyl 4-(2-(4,6-dimethyl-3-oxoisothiazolo[5,4-b]pyridin-2(3H)-yl)acetyl)piperazine-1-carboxylate. Canonical SMILES: O=C(N1CCN(C(CN2SC3=NC(C)=CC(C)=C3C2=O)=O)CC1)OCC. Product ID: ACM902589962. Alfa Chemistry ISO 9001:2015 Certified. Categories: YMusic. |  |
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