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| Product | Description | |
|---|---|---|
| Zamifenacin | Zamifenacin is a Muscarinic M3 receptor antagonist originated by Pfizer. pKi value is 8.52 for M3 receptor, 7.93 for M2 receptor, 7.90 for M1 receptor and 7.78 for M4 receptor. It can reduce colonic motor activity in patients with irritable bowel syndrome. But clinical trials for Irritable bowel syndrome was discontinued. Uses: Irritable bowel syndrome. Synonyms: UNII-Y88Q418Y7M;UK 76654; UK76654; UK-76654; Zamifenacin AC1MJ6I5;(3R)-3-benzhydryloxy-1-[2-(1,3-benzodioxol-5-yl)ethyl]piperidine;127308-98-9 (Zamifenacin fumarate). Grades: 95%. CAS No. 127308-82-1. Molecular formula: C27H29NO3. Mole weight: 415.53. |  |
| Zamifenacin fumarate | Zamifenacin fumarate is a selective M3 muscarinic receptor antagonist (pKi = 8.52, 7.93, 7.90 and 7.78 for M3, M2, M1 and M4 receptors, respectively). Zamifenacin fumarate exhibits higher affinity for ileal M3 receptors (pKi = 9.3) than oesophageal and tracheal M3 receptors (pKi = 8.8 and 8.2 respectively). Synonyms: (3R)-1-[2-(1-,3-Benzodioxol-5-yl)ethyl]-3-(diphenylmethoxy)piperidine fumarate. Grades: ≥99% by HPLC. CAS No. 127308-98-9. Molecular formula: C27H29NO3.C4H4O4. Mole weight: 531.6. | |
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