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| Product | Description | |
|---|---|---|
| Zaprinast | Zaprinast. Group: Biochemicals. Grades: Purified. CAS No. 37762-06-4. Pack Sizes: 25mg. US Biological Life Sciences. |  Worldwide |
| Zaprinast | Zaprinast is a cyclic-GMP phosphodiesterase inhibitor with selectivity for PDE6, 5, 11 and 9 (IC50 = 0.15, 0.76, 12.0 and 29.0 μM, respectively). C-GMP acts as a mediator of signal transduction that relaxes vascular smooth muscles and increases blood flow. Therefore zaprinast exhibits vasodilating, relaxant, and diuretic effects. Zaprinast also acts as a putative GPR35 agonist. Synonyms: 2-(2-Propyloxyphenyl)-8-azapurin-6-one; 5-(2-propoxyphenyl)-2,3-dihydrotriazolo[4,5-d]pyrimidin-7-one. Grades: ≥99% by HPLC. CAS No. 37762-06-4. Molecular formula: C13H13N5O2. Mole weight: 271.28. |  |
| Zaprinast | Zaprinast (M&B 22948) is a selective inhibitor of cGMP-selective Phosphodiesterase (PDE5). Zaprinast causes a significant increase in cGMP levels in myocytes. Zaprinast is a G protein-coupled receptor 35 (GPR35) agonist which activates rat GPR35 strongly and activates human GPR35 moderately. Zaprinast reduces vessel remodeling through antiproliferative and proapoptotic effects [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: M&B 22948. CAS No. 37762-06-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-B1816. |  |
| Zaprinast (1,4-Dihydro-5-(2-propoxyphenyl)-7H-1,2,3-triazolo(4,5-d)pyrimidin-7-one, M&B 22948) | Cell-permeable. A selective inhibitor of cGMP-specific phosphodiesterase (PDE V) (IC50 = 0.45uM). Inhibits PDE IX only at higher concentrations (IC50 = 35uM). Group: Biochemicals. Alternative Names: 1,4-Dihydro-5-(2-propoxyphenyl)-7H-1,2,3-triazolo(4,5-d)pyrimidin-7-one, M&B 22948. Grades: Highly Purified. CAS No. 37762-06-4. Pack Sizes: 25mg. US Biological Life Sciences. | Worldwide |
| Zaprinast (1,4-Dihydro-5-[2-propoxyphenyl]-7H-1,2,3-triazolo[4,5-d]pyrimidine-7-one) | A selective inhibitor of cyclic-GMP phosphodiesterase (PDE V, calmodulin insensitive). Since cGMP mediates the vasorelaxant action of nitric oxide, as well as the natriuretic and diuretic effect of a. Group: Biochemicals. Alternative Names: 1,4-Dihydro-5-[2-propoxyphenyl]-7H-1,2,3-triazolo[4,5-d]pyrimidine-7-one. Grades: Highly Purified. CAS No. 37762-06-4. Pack Sizes: 100mg. US Biological Life Sciences. | Worldwide |
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