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| Product | Description | |
|---|---|---|
| Zatebradine | Zatebradine is a potent HCN channels antagonist. It could decrease the heartbeat in a reversible manner. Its IC50 value is 10 uM of 92% inhibition of the hHCN1. It reduced the activity of oriens-lacunosum moleculare interneurons in wild-type and decreased the frequency of spontaneous inhibitory currents in postsynaptic CA1 pyramidal cells. It is a specific bradycardic agent. Uses: Zatebradine could decrease the heartbeat in a reversible manner. it is a specific bradycardic agent. Synonyms: 2H-3-Benzazepin-2-one, 3-[3-[[2- (3, 4-dimethoxyphenyl) ethyl]methylamino]propyl]-1, 3, 4, 5-tetrahydro-7, 8-dimethoxy-; Zatebradinum; Zatebradina; 3-[3-[2- (3, 4-dimethoxyphenyl) ethyl-methylamino]propyl]-7, 8-dimethoxy-2, 5-dihydro-1H-3-benzazepin-4-one; UL-FS49. Grades: >98%. CAS No. 85175-67-3. Molecular formula: C26H36N2O5. Mole weight: 456.57. |  |
| Zatebradine hydrochloride | Zatebradine hydrochloride. Group: Biochemicals. Grades: Purified. CAS No. 91940-87-3. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. |  Worldwide |
| Zatebradine hydrochloride | Zatebradine hydrochloride is a potent HCN channels antagonist. It could decrease the heartbeat in a reversible manner. It is a bradycardic compound that blocks hyperpolarization-activated inward current through cyclic nucleotide-gated cation channels in sinoatrial node cells. It can block voltage-gated outward K+ currents and related neuronal hyperpolarization-activated inward current channels, but exhibits little or no activity for L-type Ca2+ currents. It is also a sinus node inhibitor. It displays negative chronotropic activity in isolated guinea pig atria. It was developed by Boehringer Ingelheim. Uses: Zatebradine hydrochloride could decrease the heartbeat in a reversible manner. it is also a sinus node inhibitor. Synonyms: Zatebradine HCl; Zatebradine Hydrochloride; UL-FS49; UL FS49; ULFS49;;UL-FS-49CL;UL-FS49;3-[3-[2-(3,4-dimethoxyphenyl)ethyl-methylamino]propyl]-7,8-dimethoxy-2,5-dihydro-1H-3-benzazepin-4-one hydrochloride;2H-3-Benzazepin-2-one, 3- (3- ( (2- (3, 4-dimethoxyphenyl) ethyl) methylamino) propyl) -1, 3, 4, 5-tetrahydro-7, 8-dimethoxy-, monohydrochloride. Grades: >98 %. CAS No. 91940-87-3. Molecular formula: C26H37ClN2O5. Mole weight: 493.04. | |
| 3-(3-Chloropropyl)-7,8-dimethoxy-1H-3-benzazepin-2(3H)-one | 3-(3-Chloropropyl)-7,8-dimethoxy-1H-3-benzazepin-2(3H)-one is a reactant used in the synthesis of Zatebradine analogues as potential blockers od hyperpolarization-activated current. Group: Biochemicals. Grades: Highly Purified. CAS No. 85175-59-3. Pack Sizes: 100mg, 250mg. Molecular Formula: C15H18ClNO3. US Biological Life Sciences. | Worldwide |
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