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| Product | Description | |
|---|---|---|
| Zegocractin | Zegocractin, also known as CM4620, is a selective Orai1 inhibitor, prevents Ca2+ entry in acinar cells. The intravenous administration of CM4620 reduces the severity of acute pancreatitis in the rat, a hitherto untested species. SOCE via STIM1/Orai complexes promotes activation and fibroinflammatory gene expression within pancreatic stellate cells. CM4620 also decreased myeloperoxidase activity and inflammatory cytokine expression in pancreas and lung tissues, fMLF peptide-induced oxidative burst in human neutrophils, and cytokine production in human peripheral blood mononuclear cells (PBMCs) and rodent PaSCs, indicating that Orai1/STIM1 channels participate in the inflammatory responses of these cell types during acute pancreatitis. Uses: Designed for use in research and industrial production. Additional or Alternative Names: CM-4620; CM 4620; CM4620; Zegocractin. Product Category: Inhibitors. Appearance: Solid powder. CAS No. 1713240-67-5. Molecular formula: C19H11ClF3N3O3. Mole weight: 421.76. Purity: >98%. IUPACName: N-(5-(6-chloro-2,2-difluorobenzo[d][1,3]dioxol-5-yl)pyrazin-2-yl)-2-fluoro-6-methylbenzamide. Canonical SMILES: O=C(NC1=NC=C(C2=C(Cl)C=C(OC(F)(F)O3)C3=C2)N=C1)C4=C(C)C=CC=C4F. Product ID: ACM1713240675. Alfa Chemistry ISO 9001:2015 Certified. |  |
| Zegocractin | Zegocractin is a selective Orai1 inhibitor that prevents Ca2+ entry in acinar cells. Synonyms: CM-4620; CM 4620; CM4620. Grades: >98%. CAS No. 1713240-67-5. Molecular formula: C19H11ClF3N3O3. Mole weight: 421.76. |  |
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