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| Product | Description | |
|---|---|---|
| Zipalertinib | Zipalertinib, also known as TAS6417, CLN-081, is a Novel EGFR Inhibitor Targeting Exon 20 Insertion Mutations. TAS6417 inhibited EGFR with various exon 20 insertion mutations more potently than it inhibited the WT. TAS6417 inhibited EGFR phosphorylation and downstream molecules in NSCLC cell lines expressing EGFR exon 20 insertions, resulting in caspase activation. These characteristics led to marked tumor regression in vivo in both a genetically engineered model and in a patient-derived xenograft model. Furthermore, TAS6417 provided a survival benefit with good tolerability in a lung orthotopic implantation mouse model. Uses: Designed for use in research and industrial production. Additional or Alternative Names: TAS6417; TAS-6417; TAS 6417; CLN-081; CLN081; CLN081; Zipalertinib. Product Category: Inhibitors. Appearance: Solid powder. CAS No. 1661854-97-2. Molecular formula: C23H20N6O. Mole weight: 396.45. Purity: >98%. IUPACName: (S)-N-(4-amino-6-methyl-5-(quinolin-3-yl)-8,9-dihydropyrimido[5,4-b]indolizin-8-yl)acrylamide. Canonical SMILES: NC1=C2C(N3C(C(C)=C[C@@H](C3)NC(C=C)=O)=C2C4=CC5=CC=CC=C5N=C4)=NC=N1. Product ID: ACM1661854972. Alfa Chemistry ISO 9001:2015 Certified. |  |
| Zipalertinib | Zipalertinib (TAS6417; CLN-081) is a highly effective, orally active and pan-mutation-selective EGFR tyrosine kinase inhibitor with a unique scaffold fitting into the ATP-binding site of the EGFR hinge region, with IC 50 values ranging from 1.1-8.0 nM [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: TAS6417; CLN-081. CAS No. 1661854-97-2. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-112299. |  |
| TAS6417 | TAS6417 is a novel EGFR inhibitor that targets EGFR exon 20 insertion mutations while sparing wild-type (WT) EGFR. TAS6417 inhibited EGFR phosphorylation and downstream molecules in NSCLC cell lines expressing EGFR exon 20 insertions, resulting in caspase activation. Synonyms: CLN-081; TPC-064; TAS 6417; TAS-6417; Zipalertinib. CAS No. 1661854-97-2. Molecular formula: C23H20N6O. Mole weight: 396.44. |  |
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