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ZJ 43. Group: Biochemicals. Alternative Names: N- [ [ [ (1S) -1-Carboxy-3-methylbutyl] amino] carbonyl] -L-glutamic Acid. Grades: Highly Purified. CAS No. 723331-20-2. Pack Sizes: 10mg. Molecular Formula: C12H20N2O7, Molecular Weight: 304.3. US Biological Life Sciences.
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ZJ 43
ZJ 43 is a potent inhibitor of glutamate carboxypeptidase II and III (GCP II and III/NAAG peptidase/NAALADase) (Ki = 0.8 and 23 nM, respectively). It inhibits the hydrolysis of NAAG (IC50 = 2.4 nM) and decreases the deleterious effects of excessive extracellular glutamate. ZJ 43 has been shown to reduce neuronal degeneration in a rat model of traumatic brain injury (TBI) and reduce locomotor activity in the PCP-model of schizophrenia. Synonyms: ZJ 43; ZJ43; ZJ-43; N-[[[(1S)-1-Carboxy-3-methylbutyl]amino]carbonyl]-L-glutamic acid; (2S) -2- [ [ (1S) -1-carboxy-3-methylbutyl] carbamoylamino] pentanedioic acid. CAS No. 723331-20-2. Molecular formula: C12H20N2O7. Mole weight: 304.3.