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| Product | Description | |
|---|---|---|
| ZM 449829 | ZM 449829 is a potent and selective inhibitor of Janus tyrosine kinase 3 (JAK3) which binds competitively to the JAK3 ATP site (pIC50 = 6.8, 5.0, 4.7, and < 5.0 for JAK3, EGFR, JAK1 and CDK4, respectively). ZM 449829 inhibits STAT-5 phosphorylation and T cell proliferation. Synonyms: ZM 449829; ZM449829; ZM-449829; 1-(2-Naphthalenyl)-2-propen-1-one; JAK3 inhibitor V. Grades: ≥98% by HPLC. CAS No. 4452-6-6. Molecular formula: C13H10O. Mole weight: 182.22. |  |
| ZM 449829 | ZM 449829 is a potent, selective and ATP competitive inhibitor of JAK3 , with a pIC 50 of 6.8. ZM 449829 will be useful pharmacological tools for the investigation of the JAK3 [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 4452-6-6. Pack Sizes: 5 mg; 10 mg; 25 mg. Product ID: HY-13450. |  |
| ZM 39923 HCl | ZM 39923 HCl is a potent and selective inhibitor of JAK3, and also inhibits EGFR, JAK1 and CDK4. It breaks down in neutral buffer (t½ = 36 mins, pH 7.43, 25°C) to form ZM 449829. Synonyms: ZM 39923 hydrochloride; JAK3 Inhibitor IV; 3-[benzyl(propan-2-yl)amino]-1-naphthalen-2-ylpropan-1-one hydrochloride. Grades: >98%. CAS No. 1021868-92-7. Molecular formula: C23H25NO.HCl. Mole weight: 367.91. | |
| ZM 39923 hydrochloride | ZM 39923 hydrochloride is a potent and selective inhibitor of Janus tyrosine kinase 3 (JAK3) (pIC50 = 7.1, 5.6, 4.4, and < 5.0 for JAK3, EGFR, JAK1 and CDK4, respectively). ZM 39923 breaks down in neutral buffer (t½ = 36 mins, pH 7.43, 25°C) to produce an active analog, ZM 449829. Synonyms: ZM 39923; ZM-39923; ZM39923 HCl; 3-benzylisopropylamino-1-naphthalen-2-yl-propan-1-one hydrochloride; JAK3 Inhibitor IV. Grades: ≥99% by HPLC. CAS No. 58753-54-1. Molecular formula: C23H25NO.HCl. Mole weight: 367.92. | |
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