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| Product | Description | |
|---|---|---|
| ZM323881 | ZM323881 inhibits VEGF-A, EGF and bFEF induced HUVEC cell proliferation with IC50 of 8 nM, 1.9 μM and 1.6 μM, respectively. ZM323881 (10 nM) abolishes VEGF-A-mediated increases in vascular permeability in perfused mesenteric microvessels in male leopard. ZM323881 (10 nM) blocks the increase in intensity of the VEGF-R2 band in the lung of male leopard frogs. M323881 (1 μM) blocks activation of extracellular regulated-kinase, p38, Akt, and endothelial nitric oxide synthetase (eNOS) by VEGF, but did not inhibit p38 activation by the VEGFR-1-specific ligand, placental growth factor (PIGF) in human aortic endothelial cells (HAECs). ZM323881 (1 μM) also perturbes VEGF-induced membrane extension, cell migration, and tube formation by HAECs. ZM323881 (1 μM) reverses VEGF-stimulated phosphorylation of CrkII and its Src homology 2 (SH2)-binding protein p130Cas, which are known to play a pivotal role in regulating endothelial cell migration. ZM323881 (10 nM) completely blocks VEGF-induced VEGF promoter activity in SCC-9 cells. ZM323881 (10 nM) blocks VEGF stimulated Hif-1α protein accumulation in SCC-9 cells. ZM323881 (10 nM) blocks VEGF-induced Rac1 activation at 30 min in HUVECs. ZM323881 (10 nM) prevents Vav2 tyrosine phosphorylation in response to VEGF in HUVECs. Synonyms: ZM 323881; ZM-323881. Grades: >98%. CAS No. 193001-14-8. Molecular formula: C22H18FN3O2. Mole weight: 375.4. |  |
| ZM323881 HCl | ZM323881 is a potent and selective inhibitor of VEGF-R2 tyrosine kinase in vitro (IC(50) < 2 nM), compared with other receptor tyrosine kinases, including VEGF-R1 (IC(50)> 50 microM). ZM323881 inhibits VEGF-A-induced endothelial cell proliferation (IC(50) = 8 nM) and VEGF-R2 tyrosine phosphorylation in vitro. Group: Inhibitors. Alternative Names: ZM323881; ZM 323881; ZM-323881; ZM323881 HCl; ZM323881 hydrochloride. CAS No. 193000-39-4. Molecular formula: C22H19ClFN3O2. Mole weight: 411.12. Appearance: Solid powder. Purity: >98%. IUPACName: 5-((7-Benzyloxyquinazolin-4-yl)amino)-4-fluoro-2-methylphenol hydrochloride. Canonical SMILES: OC1=CC (NC2=C3C=CC (OCC4=CC=CC=C4)=CC3=NC=N2)=C (F)C=C1C. [H]Cl. Catalog: ACM193000394. |  |
| ZM323881 hydrochloride | Potent and selective inhibitor of VEGFR2 (IC50: 2 nM for VEGFR2 vs >50 mM for VEGFR1 respectively). Synonyms: ZM-323881 hydrochloride; ZM 323881 hydrochloride. Grades: >98%. CAS No. 193000-39-4. Molecular formula: C22H19ClFN3O2. Mole weight: 411.86. | |
| ZM323881 hydrochloride | ZM323881 hydrochloride is a potent and selective VEGFR2 inhibitor with an IC 50 of less than 2 nM. Uses: Scientific research. Group: Signaling pathways. CAS No. 193000-39-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-15467A. |  |
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