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| Product | Description | |
|---|---|---|
| Zoniporide | Zoniporide, also called as CP-597,396, is a potent and selective Na(+)/H(+) exchanger (NHE) with high aqueous solubility and acceptable pharmacokinetics for intravenous administration. Zoniporide displays selectivity over other NHE isoforms (Ki values are 14, 2200 and 220000 nM for human NHE1, human NHE2 and rat NHE3 respectively). Synonyms: N-Carbamimidoyl-5-cyclopropyl-1-(quinolin-5-yl)-1H-pyrazole-4-carboxamide; N-(5-Cyclopropyl-1-quinolin-5-yl-1H-pyrazole-4-carbonyl)-guanidine. Grades: >98%. CAS No. 241800-98-6. Molecular formula: C17H16N6O. Mole weight: 320.35. |  |
| Zoniporide | Zoniporide (CP-597396) is a potent and selective NHE-1 inhibitor with cardioprotective activity. Zoniporide inhibits 22 Na + uptake by human NHE-1 -expressing fibroblasts in a concentration-dependent manner ( IC 50 =14 nM). Zoniporide inhibits platelet swelling in vitro with an IC 50 of 0.059 μM. Zoniporide can be used in the study of cardiovascular disease [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: CP-597396. CAS No. 241800-98-6. Pack Sizes: 5 mg; 10 mg. Product ID: HY-105064. |  |
| Zoniporide dihydrochloride | Zoniporide dihydrochloride is a potent sodium-hydrogen exchanger isoform 1 (NHE1) inhibitor with selectivity over other NHE isoforms (Ki = 14, 2200 and 220000 nM for human NHE1, human NHE2 and rat NHE3, respectively). Zoniporide inhibits NHE1-dependent 22Na+ uptake in vitro (IC50 = 14 nM) and protects against cardiac ischemia-reperfusion injury. Zoniporide also exhibits inhibitory effects on MMP2/9 in breast cancer cells. Synonyms: [1-(Quinolin-5-yl)-5-cyclopropyl-1H-pyrazole-4-carbonyl]guanidine dihydrochloride; CP 597396. Grades: ≥99% by HPLC. CAS No. 241799-10-0. Molecular formula: C17H16N6O.2HCl. Mole weight: 393.27. | |
| Zoniporide hydrochloride | Zoniporide hydrochloride is a potent and selective inhibitor of Na+/H+ exchanger isoform 1 (NHE-1), which is mostly expressed in the heart. Zoniporide inhibits NHE1-dependent Na+ uptake (IC50: 14 nM) and protects from cardiac ischemia-reperfusion injury (EC50 = 0.25 nM). Synonyms: N-(aminoiminomethyl)-5-cyclopropyl-1-(5-quinolinyl)-1H-pyrazole-4-carboxamide monohydrochloride. Grades: 99%. CAS No. 241800-97-5. Molecular formula: C17H16N6O.HCl. Mole weight: 356.81. | |
| Zoniporide Hydrochloride | Zoniporide is a potent and selective inhibitor of human sodium-hydrogen exchanger isoform1(NHE-1) and protects against cardiac ischemia-reperfusion injury. Group: Biochemicals. Alternative Names: N-(Aminoiminomethyl)-5-cyclopropyl-1-(5-quinolinyl)-1H-pyrazole-4-carboxamide Hydrochloride;CP 597396 Hydrochloride; N-[5-Cyclopropyl-1-(quinolin-5-yl)-1H-pyrazole-4-carbonyl]guanidine Hydrochloride; [1-(Quinolin-5-yl)-5-cyclopropyl-1H-pyrazole-4-carbonyl]guanidine Hydrochloride. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. |  Worldwide |
| Zoniporide hydrochloride hydrate | Zoniporide (CP-597396) hydrochloride hydrate is a potent and selective inhibitor of sodium-hydrogen exchanger type 1 (NHE-1). Zoniporide hydrochloride hydrate inhibits human NHE-1 ( IC 50=14 nM), and has >150-fold selectivity versus other NHE isoforms. Zoniporide hydrochloride hydrate potently inhibits ex vivo NHE-1-dependent swelling of human platelets (IC 50 =59 nM) [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: CP-597396 hydrochloride hydrate. CAS No. 863406-85-3. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-105064D. | |
| 2-Oxo-Zoniporide, HCl | 2-Oxo-Zoniporide is an metabolite of Zoniporide, a potent and selective inhibitor of human sodium-hydrogen exchanger isoform1(NHE-1) and protects against cardiac ischemia-reperfusion injury. Group: Biochemicals. Alternative Names: N-(Aminoiminomethyl)-5-cyclopropyl-1-(1,2-dihydro-2-oxo-5-quinolinyl)-1H-pyrazole-4-carboxamide Hydrochloride. Grades: Highly Purified. CAS No. 372078-42-7. Pack Sizes: 1mg. Molecular Formula: C17H17ClN6O2, Molecular Weight: 372.81. US Biological Life Sciences. | Worldwide |
| 5-Cyclopropyl-1-(1,2-dihydro-2-oxo-5-quinolinyl)-1H-pyrazole-4-carboxylic Acid | 5-Cyclopropyl-1-(1,2-dihydro-2-oxo-5-quinolinyl)-1H-pyrazole-4-carboxylic Acid is an intermediate in the synthesis of Zoniporide (Z680000), a potent and selective inhibitor of human sodium-hydrogen exchanger used to protect against cardiac ischemia-reperfusion injury. Group: Biochemicals. Grades: Highly Purified. CAS No. 372078-47-2. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
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