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| Product | Description | |
|---|---|---|
| ZZW-115 | ZZW-115 is a potent NUPR1 inhibitor. ZZW-115 induces ferroptosis in a mitochondria-dependent manner. ZZW-115 induces ROS accumulation followed by a ferroptotic cell death, which could be prevented by ferrostatin-1 (Fer-1) and ROS-scavenging agents. In addition, ZZW-115-treatment increases the accumulation of hydroperoxided lipids in these cells. ZZW-115-induced mitochondrial morphological changes, compatible with the ferroptotic process, as well as mitochondrial network disorganization and strong mitochondrial metabolic dysfunction, which are rescued by both Fer-1 and N-acetylcysteine (NAC). Of note, the expression of TFAM, a key regulator of mitochondrial biogenesis, is downregulated by ZZW-115. Uses: Designed for use in research and industrial production. Additional or Alternative Names: ZZW-115; ZZW 115; ZZW115. Product Category: Inhibitors. Appearance: Solid powder. CAS No. 801991-87-7. Molecular formula: C24H31F3N4S. Mole weight: 464.6. Purity: >98%. IUPACName: N,N-dimethyl-2-(4-(3-(2-(trifluoromethyl)-10H-phenothiazin-10-yl)propyl)piperazin-1-yl)ethan-1-amine. Canonical SMILES: FC(C(C=C1N2CCCN3CCN(CCN(C)C)CC3)=CC=C1SC4=C2C=CC=C4)(F)F. Product ID: ACM801991877. Alfa Chemistry ISO 9001:2015 Certified. |  |
| ZZW-115 hydrochloride | ZZW-115 hydrochloride is a potent NUPR1 inhibitor, with a K d of 2.1 μM. ZZW-115 hydrochloride induces tumor cell death by necroptosis and apoptosis. Anticancer activity [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 10122-45-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-111838A. |  |
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