American Chemical Suppliers
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Product | Description | |
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VTP-27999 Hydrochloride Quick inquiry Where to buy Suppliers range | VTP-27999 Hcl is an alkyl amine Renin inhibitor; VTP-27999 is useful for Hypertension and End-Organ Diseases. Synonyms: VTP27999 Hydrochloride; VTP 27999 Hydrochloride. Grades: >98%. CAS No. 1264191-73-2. Molecular formula: C26H42Cl2N4O5. Mole weight: 561.54. | |
VTP-37948 Quick inquiry Where to buy Suppliers range | VTP-37948, also called BI 1181181, being clinically developed with Boehringer Ingelheim and Vitae Pharmaceuticals, is an inhibitor targeted to the catalytic site of the enzymes BACE1 and BACE2 designed for treating Alzheimer's disease. Synonyms: BI 1181181; BI-1181181; VTP-37948; BI1181181; VTP37948; VTP 37948. | |
VTP50469 Quick inquiry Where to buy Suppliers range | VTP50469 Inhibitor. Uses: Scientific use. Product Category: T13336. CAS No. 2169916-18-9. | |
VTP50469 Quick inquiry Where to buy Suppliers range | VTP50469 is a Menin-MLL interaction inhibitor, effective against MLL rearrangement and NPM1c+ leukemia. It has effective anti-leukemia activity. Grades: ≥98% by HPLC. CAS No. 2169916-18-9. Molecular formula: C32H47FN6O4S. Mole weight: 630.82. | |
VTX-27 Quick inquiry Where to buy Suppliers range | Selective PKC inhibitor. VTX-27 is a potent and selective inhibitor of the PKCth enzyme, with over 1000-fold against classical isoforms and over 10,000-fold against atypical isoforms. Group: Biochemicals. Grades: Highly Purified. CAS No. 1321924-70-2. Pack Sizes: 1mg, 5mg. Molecular Formula: C20H24ClFN6O, Form: Supplied as a. US Biological Life Sciences. | Worldwide |
V type AAO Template(hole depth:260 nm) Quick inquiry Where to buy Suppliers range | V type AAO Template(hole depth:260 nm). Group: Inorganic Nanomaterials. CAS No. 11092-32-3. | |
V type AAO Template(hole depth :500 nm) Quick inquiry Where to buy Suppliers range | V type AAO Template(hole depth :500 nm). Group: Inorganic Nanomaterials. CAS No. 11092-32-3. | |
V type AAO Template(pore diameter: 450 nm) Quick inquiry Where to buy Suppliers range | V type AAO Template(pore diameter: 450 nm). Group: Inorganic Nanomaterials. CAS No. 11092-32-3. | |
V type AAO Template(pore diameter: 90-40 nm) Quick inquiry Where to buy Suppliers range | V type AAO Template(pore diameter: 90-40 nm). Group: Inorganic Nanomaterials. CAS No. 11092-32-3. | |
VU0029251 Quick inquiry Where to buy Suppliers range | VU002925 1is a partial antagonist of metabotropic glutamate receptor 5 (mGluR5) with Ki value of 1.07 μM. Synonyms: 10-methylsulfanyl-7-thia-9,11-diazatricyclo[6.4.0.02,6]dodeca-1(12),2(6),8,10-tetraen-12-amine. CAS No. 330819-85-7. Molecular formula: C10H11N3S2. Mole weight: 237.3. | |
VU 0029767 Quick inquiry Where to buy Suppliers range | VU 0029767 is a positive allosteric modulator of M1, a member of the muscarinic acetylcholine family of GPCRs (mAChRs). VU 0029767 enhances the competitive effect of ACh for M1. VU0029767 potentiates ACh-mediated intracellular calcium mobilization, but not phospholipase D activation. Synonyms: VU0029767, VU 0029767, VU-0029767; 2-(4-ethoxyanilino)-N'-[(Z)-(2-oxonaphthalen-1-ylidene)methyl]acetohydrazide. Grades: 98%. CAS No. 326001-01-8. Molecular formula: C21H21N3O3. Mole weight: 363.41. | |
VU0071063 Quick inquiry Where to buy Suppliers range | VU0071063 is a potent and selective Kir6.2/SUR1 potassium channel activator. It inhibits glucose-stimulated calcium entry in isolated mouse pancreatic β-cells. Synonyms: 7-[(4-tert-butylphenyl)methyl]-1,3-dimethyl-2,3,6,7-tetrahydro-1H-purine-2,6-dione. Grades: ≥98%. CAS No. 333415-38-6. Molecular formula: C18H22N4O2. Mole weight: 326.4. | |
VU0119498 Quick inquiry Where to buy Suppliers range | VU0119498 is an M1 muscarinic receptor agonist (EC50 = 3.1 μM) and pan-mAChR M3, M5 positive allosteric modulator (PAM), and a neuroprotective agent. It has anti-diabetic activity. Synonyms: 1-[(4-Bromophenyl)Methyl]Indole-2,3-Dione; N-4-Bromobenzylisatin; 1-(4-Bromobenzyl)-1H-Indole-2,3-Dione. Grades: 98%. CAS No. 79183-37-2. Molecular formula: C15H10BrNO2. Mole weight: 316.15. | |
VU 0134992 Quick inquiry Where to buy Suppliers range | VU 0134992 is a Kir4.1 potassium channel blocker with IC50 value of 0.97 μM. Synonyms: 2-(2-Bromo-4-isopropylphenoxy)-N-(2,2,6,6-tetramethylpiperidin-4-yl)acetamide. Grades: ≥98% by HPLC. CAS No. 755002-90-5. Molecular formula: C20H31BrN2O2. Mole weight: 411.38. | |
VU0152099 Quick inquiry Where to buy Suppliers range | VU0152099 is a potent and selective allosteric potentiator of M4 mAChR with an EC50 of 380 ± 93 nM. VU0152099 has no agonist activity but potentiated responses of M4 to acetylcholine. Synonyms: VU 0152099; VU-0152099. Grades: 98%. CAS No. 612514-42-8. Molecular formula: C18H17N3O3S. Mole weight: 355.41. | |
VU0152100 Quick inquiry Where to buy Suppliers range | ≥98% (HPLC). Uses: For analytical and research use. Group: Fluorescence/Luminescence Spectroscopy. CAS No. 409351-28-6. Pack Sizes: 5MG, 25MG. Mole weight: 341.43. Catalog: AP409351286. Assay: ≥98% (HPLC). | |
VU0152100 Quick inquiry Where to buy Suppliers range | VU0152100 is a selective and positive allosteric modulators of M4 receptor. It has shown a potent positive allosteric modulators that increase the response of the M4 receptor to the endogenous agonist ACh in in vitro study. And it has been revealed to enhance receptor activation by increasing the affinity of M4 for acetylcholine. Synonyms: VU0152100, VU-0152100, VU 0152100, VU152100, VU 152100, VU-152100. Grades: >98%. CAS No. 409351-28-6. Molecular formula: C18H19N3O2S. Mole weight: 341.43. | |
VU 0155041 Quick inquiry Where to buy Suppliers range | VU 0155041 is a potent positive allosteric modulator at mGlu4 receptors (EC50 = 798 and 693 nM at human and rat mGlu4 receptors, respectively). VU 0155041 displays no activity for 67 G protein-coupled receptors, ion channels, and transporters, and lacks antagonist activity at NMDA receptors in striatal medium spiny neurons at a concentration of 10 μM. VU 0155041 is active in in vivo models of Parkinson's disease following i.c.v. administration. Synonyms: VU0155041, VU 0155041, VU-0155041; cis-2-[[ (3, 5-Dichlorophenyl) amino]carbonyl]cyclohexanecarboxylic acid; (1R,2S)-2-[(3,5-dichlorophenyl)carbamoyl]cyclohexane-1-carboxylic acid. Grades: ≥99% by HPLC. CAS No. 1093757-42-6. Molecular formula: C14H15Cl2NO3. Mole weight: 316.18. | |
VU 0155041 Quick inquiry Where to buy Suppliers range | VU 0155041. Group: Biochemicals. Grades: Purified. CAS No. 1093757-42-6. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
VU 0155041 sodium salt Quick inquiry Where to buy Suppliers range | VU 0155041 sodium salt is a potent positive allosteric modulator at mGlu4 receptors (EC50 = 798 and 693 nM at human and rat mGlu4 receptors, respectively). VU 0155041 displays no activity for 67 G protein-coupled receptors, ion channels, and transporters, and lacks antagonist activity at NMDA receptors in striatal medium spiny neurons at a concentration of 10 μM. VU 0155041 is active in in vivo models of Parkinson's disease following i.c.v. administration. Synonyms: VU 0155041 sodium salt; VU0155041 sodium salt; VU-0155041 sodium salt; cis-2-[[ (3, 5-Dichlorophenyl) amino]carbonyl]cyclohexanecarboxylic acid sodium salt. Grades: ≥98% by HPLC. CAS No. 1259372-69-4. Molecular formula: C14H14Cl2NNaO3. Mole weight: 338.16. | |
VU 0155041 sodium salt Quick inquiry Where to buy Suppliers range | VU 0155041 sodium salt. Group: Biochemicals. Grades: Purified. CAS No. 1259372-69-4. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
VU0155041, Sodium Salt (cis-2- (3, 5-Dichlorophenyl carbamoyl ) cyclohexane carboxyl ic Acid Sodium Salt) Quick inquiry Where to buy Suppliers range | A highly potent, selective positive allosteric modulator for mGlu receptor subtype 4 (EC50 = 0.8 and 0.7uM at human and rat mGlu4 receptors respectively). Does not interact with other mGluR subtypes. Significant antiparkinsonian effects in two preclinical rodent models of Parkinson's disease when administered intracerebroventri cularlly (icv). Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
VU 0155069 Quick inquiry Where to buy Suppliers range | VU 0155069 is a potent and selective phospholipase D1 (PLD1) inhibitor (IC50 = 46 and 933 nM for PLD1 and PLD2, respectively). VU 0155069 has been shown to inhibit migration of human and mouse breast cancer cell lines in transwell assays. Synonyms: VU-0155069; VU 0155069; VU0155069; N-[(1S)-2-[4-(5-Chloro-2,3-dihydro-2-oxo-1H-benzimidazol-1-yl)-1-piperidinyl]-1-methylethyl-2-naphthalenecarboxamide. Grades: ≥98% by HPLC. CAS No. 1130067-06-9. Molecular formula: C26H27ClN4O2. Mole weight: 462.98. | |
VU 0155069 Quick inquiry Where to buy Suppliers range | VU 0155069. Group: Biochemicals. Grades: Purified. CAS No. 1130067-06-9. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
VU0155069 Quick inquiry Where to buy Suppliers range | ≥98% (HPLC). Uses: For analytical and research use. Group: Fluorescence/Luminescence Spectroscopy. CAS No. 1130067-06-9. Pack Sizes: 5MG, 25MG. Mole weight: 462.97. Catalog: AP1130067069. Assay: ≥98% (HPLC). | |
VU 0238429 Quick inquiry Where to buy Suppliers range | VU 0238429. Group: Biochemicals. Grades: Purified. CAS No. 1160247-92-6. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
VU 0238429 Quick inquiry Where to buy Suppliers range | VU 0238429 is a selective positive allosteric modulator of M5 muscarinic acetylcholine receptor (EC50 = 1.16, >30 and >30 μM at M5, M1 and M3 receptors, respectively) with no activity at M2 and M4 receptors. Synonyms: VU0238429, VU 0238429, VU-0238429; 1-(4-Methoxybenzyl)-5-trifluoromethoxyisatin; 1-[(4-methoxyphenyl)methyl]-5-(trifluoromethoxy)indole-2,3-dione. Grades: ≥99% by HPLC. CAS No. 1160247-92-6. Molecular formula: C17H12F3NO4. Mole weight: 351.28. | |
VU0238429 Quick inquiry Where to buy Suppliers range | solubility: ≥20 mg/mL in DMSO. Uses: For analytical and research use. Group: Fluorescence/Luminescence Spectroscopy. CAS No. 1160247-92-6. Pack Sizes: 5MG, 25MG. Mole weight: 351.28. Catalog: AP1160247926. Assay: ≥98% (HPLC). | |
VU0238441 Quick inquiry Where to buy Suppliers range | VU0238441 is a pan muscarinic acetylcholine receptor (mAChR) positive allosteric modulator (PAM) with EC50s of 3.2 μM, 2.8 μM, 2.2 μM, 2.1 μM, >10 μM for M1, M2, M3, M5 and M4, respectively. Synonyms: 1H-Indole-2,3-dione, 7-chloro-1-[[4-(trifluoromethyl)phenyl]methyl]-. Grades: 98%. CAS No. 85511-68-8. Molecular formula: C16H9ClF3NO2. Mole weight: 339.69. | |
VU 0240551 Quick inquiry Where to buy Suppliers range | VU 0240551. Group: Biochemicals. Grades: Purified. CAS No. 893990-34-6. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
VU-0240551 Quick inquiry Where to buy Suppliers range | VU 0240551 is a small-molecule inhibitor of neuronal K-Cl cotransporter(KCC2) with IC50 value of 560nM, which is a potassium-chloride exchanger expressed specifically in neurons. It also inhibits hERG and L-type Ca2+ channels. It is primarily responsible for maintaining intracellular Cl- concentrations including regulating an excess or lack of ions following periods of under or overstimulation, as well as general dendritic development. It was discovered in a high-throughput screen, followed by directed medicinal chemistry. It is selective for KCC2 and shows minimal effect on NKCC1. It binds competitively to the K+ site and binds noncompetitively to the Cl- site. It is the only small molecule with specificity for a KCC family member. It significantly inhibits KCC2-mediated K+ uptake at concentration of 10μM. It is also found to inhibit KCC3 in the micromolar range. It exerts significant effects on Adenosine A1 and A3 receptors, L- type Ca2+ channel and K+ channel hERG when treated with some other GPCRs, ion channels and transporters. Uses: Vu 0240551 is primarily responsible for maintaining intracellular cl- concentrations including regulating an excess or lack of ions following periods of under or overstimulation, as well as general dendritic development. Synonyms: VU0240551, VU 0240551, VU- 0240551; N-(4-Methyl-2-thiazolyl)-2-[(6-phenyl-3-pyridazinyl)thio]acetamide;VU 0240551. Grades: >99 %. CAS No. 893990-34-6. Molecular formula: C16H14N4OS2. Mole weight: 342.43. | |
VU 0255035 Quick inquiry Where to buy Suppliers range | VU 0255035. Group: Biochemicals. Grades: Purified. CAS No. 1135243-19-4. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
VU 0255035 Quick inquiry Where to buy Suppliers range | VU 0255035 is a highly selective M1 muscarinic acetylcholine receptor antagonist (Ki = 14.87 nM) with 75-fold greater selectivity for the M1 orthosteric site over the other receptor subtypes. VU 0255035 has been shown to reduce pilocarpine-induced seizures in mice. Synonyms: VU0255035, VU 0255035, VU-0255035; N-[3-Oxo-3-[4-(4-pyridinyl)-1-piperazinyl]propyl]-2,1,3-benzothiadiazole-4-sulfonamide. Grades: ≥99% by HPLC. CAS No. 1135243-19-4. Molecular formula: C18H20N6O3S2. Mole weight: 432.52. | |
VU0255035 hydrate Quick inquiry Where to buy Suppliers range | ≥98% (HPLC). Uses: For analytical and research use. Group: Fluorescence/Luminescence Spectroscopy. CAS No. 1135243-19-4 (anhydrous). Pack Sizes: 5MG, 25MG. Mole weight: 432.52 (anhydrous basis). Catalog: ALP1135243194. Assay: ≥98% (HPLC). | |
VU 0285683 Quick inquiry Where to buy Suppliers range | VU 0285683. Group: Biochemicals. Alternative Names: 3-(2-Pyridyl)-5-(3-fluoro-5-cyanophenyl)-1,2,4-oxadiazole. Grades: Highly Purified. CAS No. 327056-22-4. Pack Sizes: 10mg. Molecular Formula: C14H7FN4O, Molecular Weight: 266.23. US Biological Life Sciences. | Worldwide |
VU 0285683 Quick inquiry Where to buy Suppliers range | VU 0285683 is a negative allosteric modulator of mGlu5 receptors with high affinity for the MPEP binding site. VU 0285683 exhibits anxiolytic activity in rodent models of anxiety. Synonyms: VU0285683, VU 0285683, VU-0285683; 3-Fluoro-5-[3-(2-pyridinyl)-1,2,4-oxadiazol-5-yl]-benzonitrile. Grades: ≥98% by HPLC. CAS No. 327056-22-4. Molecular formula: C14H7FN4O. Mole weight: 266.23. | |
VU 0357017 hydrochloride Quick inquiry Where to buy Suppliers range | VU 0357017 hydrochloride. Group: Biochemicals. Grades: Purified. CAS No. 1135242-13-5. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
VU 0357017 hydrochloride Quick inquiry Where to buy Suppliers range | The hydrochloride salt form of VU0357017 which is a selective M1 agonist and has been found to be probably effective in the treatment of hippocampal-dependent cognitive function deficits. EC50=477 ± 172 nM. Synonyms: VU0357017; VU-0357017; VU 0357017; CID 25010775; CID25010775; CID-25010775; 4-[[2-[(2-Methylbenzoyl)amino]ethyl]amino]-1-piperidinecarboxylic Acid Ethyl Ester Hydrochloride. Grades: >98%. CAS No. 1135242-13-5. Molecular formula: C18H27N3O3.HCl. Mole weight: 369.89. | |
VU0357017 monohydrochloride Quick inquiry Where to buy Suppliers range | ≥98% (HPLC). Uses: For analytical and research use. Group: Fluorescence/Luminescence Spectroscopy. CAS No. 1135242-13-5. Pack Sizes: 5MG, 25MG. Mole weight: 369.89. Catalog: AP1135242135. Assay: ≥98% (HPLC). | |
VU 0357121 Quick inquiry Where to buy Suppliers range | VU0357121 is a novel positive allosteric modulator (PAM) of mGlu5 with EC50 of 33 nM, is inactive or very weakly antagonizing at other mGlu receptor subtypes. Synonyms: VU-0357121, VU0357121, VU 0357121. Grades: >98%. CAS No. 433967-28-3. Molecular formula: C17H17F2NO2. Mole weight: 305.32. | |
VU 0357121 Quick inquiry Where to buy Suppliers range | VU 0357121. Group: Biochemicals. Alternative Names: 4-Butoxy-N-(2,4-difluorophenyl)-benzamide. Grades: Highly Purified. CAS No. 433967-28-3. Pack Sizes: 25mg. Molecular Formula: C17H17F2NO2, Molecular Weight: 305.32. US Biological Life Sciences. | Worldwide |
VU0357121 Quick inquiry Where to buy Suppliers range | ≥98% (HPLC). Uses: For analytical and research use. Group: Fluorescence/Luminescence Spectroscopy. CAS No. 433967-28-3. Pack Sizes: 5MG. Mole weight: 305.32. Catalog: AP433967283. Assay: ≥98% (HPLC). | |
VU0359595 Quick inquiry Where to buy Suppliers range | VU0359595 is an inhibitor of Phospholipase D1 (PLD1) (IC50 = 3.7 nM) exhibiting >1,700-fold selectivity for PLD1 over PLD2 (IC50 = 6.4 μM). It may function via interacting with an allosteric site of PLD. Synonyms: CID-53361951; ML-270; (1R,2R)-N-([S]-1-{4-[5-bromo-2-oxo-2,3-dihydro-1H-benzo(d)imidazol-1-yl]piperidin-1-yl}propan-2-yl)-2-phenylcyclopropanecarboxamide. Grades: ≥95%. CAS No. 1246303-14-9. Molecular formula: C25H29BrN4O2. Mole weight: 497.43. | |
VU 0360172 Quick inquiry Where to buy Suppliers range | VU 0360172. Group: Biochemicals. Alternative Names: N-Cyclobutyl-6-[2-(3-fluorophenyl)ethynyl]-3-pyridinecarboxamide Hydrochloride. Grades: Highly Purified. CAS No. 1309976-62-2. Pack Sizes: 10mg. Molecular Formula: C18H16ClFN2O, Molecular Weight: 330.78. US Biological Life Sciences. | Worldwide |
VU 0360172 hydrochloride Quick inquiry Where to buy Suppliers range | VU 0360172 hydrochloride is a positive allosteric modulator of mGlu5 receptors (EC50 = 16 nM; Ki = 195 nM) with potential antipsychotic-like activity. VU 0360172 has no significant activity at mGlu1, mGlu2 or mGlu4 receptors. VU 0360172 has been shown to decrease spontaneous spike and wave discharges without affecting motor behavior in a rat model of absence epilepsy. Synonyms: VU 0360172 hydrochloride; VU0360172 hydrochloride; VU-0360172 hydrochloride; N-Cyclobutyl-6-[2-(3-fluorophenyl)ethynyl]-3-pyridinecarboxamide hydrochloride. Grades: ≥98% by HPLC. CAS No. 1309976-62-2. Molecular formula: C18H15FN2O.HCl. Mole weight: 330.78. | |
VU 0360172 hydrochloride Quick inquiry Where to buy Suppliers range | VU 0360172 hydrochloride. Group: Biochemicals. Grades: Purified. CAS No. 1309976-62-2. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
VU 0360223 Quick inquiry Where to buy Suppliers range | VU 0360223 is a potent mGlu5 negative allosteric modulator (IC50 = 61 nM) that has no activity at mGlu1-4 and mGlu7-8. Synonyms: VU 0360223; VU0360223; VU-0360223; 3-Fluoro-5-(2-methyl-5-benzothiazolyl)-benzonitrile. Grades: ≥99% by HPLC. CAS No. 1274859-33-4. Molecular formula: C15H9FN2S. Mole weight: 268.31. | |
VU 0360223 Quick inquiry Where to buy Suppliers range | VU 0360223. Group: Biochemicals. Grades: Purified. CAS No. 1274859-33-4. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
VU 0361737 Quick inquiry Where to buy Suppliers range | VU 0361737. Group: Biochemicals. Grades: Purified. CAS No. 1161205-04-4. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
VU 0361737 Quick inquiry Where to buy Suppliers range | VU 0361737 is a selective positive allosteric modulator (PAM) for mGlu4 receptor with EC50 of 240 nM and 110 nM at human and rat receptors, respectively, displaying weak activity at mGlu5 and mGlu8 receptors, and being inactive at mGlu1, mGlu2, mGlu3, mGlu6 and mGlu7 receptors. Synonyms: VU 0361737, VU-0361737, VU0361737. CAS No. 1161205-04-4. Molecular formula: C13H11ClN2O2. Mole weight: 262.693. | |
VU0361737 Quick inquiry Where to buy Suppliers range | ≥98% (HPLC). Uses: For analytical and research use. Group: Fluorescence/Luminescence Spectroscopy. CAS No. 1161205-04-4. Pack Sizes: 5MG, 25MG. Mole weight: 262.69. Catalog: AP1161205044. Assay: ≥98% (HPLC). | |
VU 0364439 Quick inquiry Where to buy Suppliers range | VU 0364439 is a mGlu4 positive allosteric modulator (PAM), with EC50 of 19.8 nM. Synonyms: VU0364439, VU-0364439, VU 0364439. CAS No. 1246086-78-1. Molecular formula: C18H13Cl2N3O3S. Mole weight: 422.28. | |
VU 0364439 Quick inquiry Where to buy Suppliers range | VU 0364439. Group: Biochemicals. Grades: Purified. CAS No. 1246086-78-1. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
VU0364572 trifluoroacetate salt Quick inquiry Where to buy Suppliers range | VU0364572 is an allosteric agonist of the muscarinic acetylcholine receptor 1 (M1) with EC50 value of 0.2 mM. It induces increases in Ca2+ mobilization and ERK1/2 phosphorylation in CHO cells transfected with the human M1 receptor, but exhibits no effect on β-arrestin recruitment. Synonyms: VU0364572 TFA salt; ethyl 4-[(3R)-3-[(2-methylbenzoyl)amino]piperidin-1-yl]piperidine-1-carboxylate;2,2,2-trifluoroacetic acid. Grades: ≥98%. CAS No. 1240514-89-9. Molecular formula: C21H31N3O3·CF3COOH. Mole weight: 487.5. | |
VU 0364739 hydrochloride Quick inquiry Where to buy Suppliers range | VU 0364739 hydrochloride. Group: Biochemicals. Grades: Purified. CAS No. 1244640-48-9. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
VU 0364739 hydrochloride Quick inquiry Where to buy Suppliers range | VU 0364739 hydrochloride is a potent and selective phospholipase D2 (PLD2) inhibitor (IC50 = 20 nM), displaying 75-fold selectivity over PLD1 (IC50 = 1500 nM). Synonyms: VU0364739; VU-0364739; VU 0364739; ML-271; ML271, ML 271; VU0364739 HCl; VU0364739 hydrochloride; N-[2-[1-(3-Fluorophenyl)-4-oxo-1,3,8-triazaspiro[4.5]dec-8-yl]ethyl]-2-naphthalenecarboxamide. Grades: ≥98% by HPLC. CAS No. 1244640-48-9. Molecular formula: C26H27FN4O2.HCl. Mole weight: 482.98. | |
VU 0364770 Quick inquiry Where to buy Suppliers range | VU 0364770 is systemically active positive allosteric modulator (PAM) of metabotropic glutamate receptor subtype 4 (mGluR4) (EC50: 290 nM). It showed efficacy alone or when administered in combination with L-DOPA or an adenosine 2A (A2A) receptor antagonist, in several rodent PD models. Synonyms: VU0364770; VU-0364770; N-(3-chlorophenyl)picolinamide; N-(3-chlorophenyl)-2-pyridinecarboxamide. Grades: >98%. CAS No. 61350-00-3. Molecular formula: C12H9ClN2O. Mole weight: 232.67. | |
VU 0364770 Quick inquiry Where to buy Suppliers range | VU 0364770. Group: Biochemicals. Grades: Purified. CAS No. 61350-00-3. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
VU 0365114 Quick inquiry Where to buy Suppliers range | VU 0365114 is a selective positive allosteric modulator of M5 muscarinic acetylcholine receptor (mAChR) (EC50 = 2.7 μM for human M5, and >30 μM for M1, M2, M3 and M4, receptors). Synonyms: VU 0365114; VU0365114; VU-0365114; 1-[(1,1'-Biphenyl)-4-ylmethyl]-5-(trifluoromethoxy)-1H-indole-2,3-dione; 1-[(4-phenylphenyl)methyl]-5-(trifluoromethoxy)indole-2,3-dione. Grades: ≥98% by HPLC. CAS No. 1208222-39-2. Molecular formula: C22H14F3NO3. Mole weight: 397.35. | |
VU 0365114 Quick inquiry Where to buy Suppliers range | VU 0365114. Group: Biochemicals. Grades: Purified. CAS No. 1208222-39-2. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
VU0405601 Quick inquiry Where to buy Suppliers range | ≥98% (HPLC). Uses: For analytical and research use. Group: Fluorescence/Luminescence Spectroscopy. CAS No. 712325-30-9. Pack Sizes: 5MG, 25MG. Mole weight: 357.20. Catalog: AP712325309. Assay: ≥98% (HPLC). | |
VU 0409106 Quick inquiry Where to buy Suppliers range | VU 0409106 is a potent and selective mGlu5 negative allosteric modulator (IC50 = 49 nM for human mGlu5) with selectivity over a panel of GPCRs and ion channels. VU 0409106 exhibits no significant nonspecific binding in rat brain homogenates in vitro. Synonyms: VU0409106, VU 0409106, VU-0409106; 3-Fluoro-N-(4-methyl-2-thiazolyl)-5-(5-pyrimidinyloxy)benzamide. Grades: ≥98% by HPLC. CAS No. 1276617-62-9. Molecular formula: C15H11FN4O2S. Mole weight: 330.34. | |
VU 0409551 Quick inquiry Where to buy Suppliers range | VU0409551 is a selectively glutamate receptor subtype 5 (mGlu5) positive allosteric modulator with EC50 value of 260 nM. VU0409551 shows distinct stimulus bias and selectively potentiates mGlu5 coupling to Gαq-mediated signaling. It exhibits wake-promoting, antipsychotic-like and cognition-enhancing effects in animal models. Synonyms: VU0409551; VU-0409551; VU 0409551; JNJ-46778212; JNJ 46778212; JNJ46778212;(4-fluorophenyl)(2-(phenoxymethyl)-6,7-dihydrooxazolo[5,4-c]pyridin-5(4H)-yl)methanone. Grades: 98%. CAS No. 1363281-27-9. Molecular formula: C20H17FN2O3. Mole weight: 352.37. | |
VU 0422288 Quick inquiry Where to buy Suppliers range | VU 0422288 is a group III mGlu receptor positive allosteric modulator (EC50 = 108, 125 and 146 nM for mGlu4, mGlu8 and mGlu7, respectively) with selectivity over a panel of 68 other GPCRs, ion channels and transporters. VU 0422288 has been shown to potentiate mGlu7-mediated reductions in excitatory post synaptic potentials in hippocampal slices. Synonyms: VU0422288; VU-0422288; VU 0422288; ML 396; ML-396; ML396; N-[3-Chloro-4-[(5-chloro-2-pyridinyl)oxy]phenyl]-2-pyridinecarboxamide. Grades: ≥98% by HPLC. CAS No. 1630936-95-6. Molecular formula: C17H11Cl2N3O2. Mole weight: 360.19. | |
VU0453379 Quick inquiry Where to buy Suppliers range | VU0453379 is a highly selective and central nervous system (CNS) permeability positive allosteric modulator (PAM) of glucagon-like peptide-1R (GLP-1R) with an EC50 of 1.3 μM. Synonyms: VU-0453379; VU 0453379. Grades: ≥98% by HPLC. CAS No. 1638646-27-1. Molecular formula: C26H34N4O2. Mole weight: 434.6. | |
VU 0463271 Quick inquiry Where to buy Suppliers range | VU 0463271. Group: Biochemicals. Grades: Purified. CAS No. 1391737-01-1. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
VU 0463271 Quick inquiry Where to buy Suppliers range | VU 0463271 is a potent and selective inhibitor of KCC2, which is a neuronal K-Cl cotransporter (IC50 = 61 nM). VU 0463271 exhibits >100-fold selectivity versus the Na-K-2Cl cotransporter 1 (NKCC1) and no activity against a panel of 68 GPCRs, ion channels and transporters. Synonyms: VU0463271; VU-0463271; VU 0463271; N-Cyclopropyl-N-(4-methyl-2-thiazolyl)-2-[(6-phenyl-3-pyridazinyl)thio]acetamide. Grades: ≥98% by HPLC. CAS No. 1391737-01-1. Molecular formula: C19H18N4OS2. Mole weight: 382.5. | |
VU0467154 Quick inquiry Where to buy Suppliers range | VU0467154 is a positive allosteric modulator of the M4 muscarinic acetylcholine receptor. It potentiates acetylcholine responses in CHO cells expressing M4 receptors (EC50s = 17.7, 630, and 1,000 nM for rat, human, and cynomolgus monkey receptors, respectively). Synonyms: 5-Amino-3, 4-dimethyl-N-[[4- (trifluoromethylsulfonyl) phenyl]methyl]thieno[2, 3-c]pyridazine-6-carboxamide. Grades: ≥95%. CAS No. 1451993-15-9. Molecular formula: C17H15F3N4O3S2. Mole weight: 444.45. | |
VU 0469650 hydrochloride Quick inquiry Where to buy Suppliers range | VU 0469650 hydrochloride is a potent and selective negative allosteric modulator of mGlu1 (IC50 = 99 nM), displaying >100-fold selectivity for mGlu1 over mGlu2-8 and 68 other GPCRs, ion channels, kinases and transporters. Synonyms: VU 0469650 hydrochloride, VU 0469650 HCl, VU 0469650, VU0469650, VU-0469650; 3-[(3R)-3-Methyl-4-(tricyclo[3.3.1.13,7]dec-1-ylcarbonyl)-1-piperazinyl]-2-pyridinecarbonitrile hydrochloride. Grades: ≥98% by HPLC. CAS No. 1443748-47-7. Molecular formula: C22H28N4O.HCl. Mole weight: 400.94. | |
VU-0483605 Quick inquiry Where to buy Suppliers range | VU-0483605, an isoindol derivative, has been found to be a mGluR1 positive allosteric modulator and probably be effective against schizophrenia. EC50: 356 and 390 nM for rat and human receptors, respectively. Synonyms: CHEMBL3628116; VU0483605, VU-0483605, VU 048360; AOB6248; SYN5042; AOB 6248; SYN 5042; AOB-6248; SYN-5042; 3-chloro-N-[3-chloro-4-(4-chloro-1,3-dioxoisoindol-2-yl)phenyl]pyridine-2-carboxamide. Grades: 98%. CAS No. 1623101-11-0. Molecular formula: C20H10Cl3N3O3. Mole weight: 446.67. |