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| Product | Description | |
|---|---|---|
| VU 0255035 | VU 0255035 is a highly selective M1 muscarinic acetylcholine receptor antagonist (Ki = 14.87 nM) with 75-fold greater selectivity for the M1 orthosteric site over the other receptor subtypes. VU 0255035 has been shown to reduce pilocarpine-induced seizures in mice. Synonyms: VU0255035, VU 0255035, VU-0255035; N-[3-Oxo-3-[4-(4-pyridinyl)-1-piperazinyl]propyl]-2,1,3-benzothiadiazole-4-sulfonamide. Grades: ≥99% by HPLC. CAS No. 1135243-19-4. Molecular formula: C18H20N6O3S2. Mole weight: 432.52. |  |
| VU0255035 hydrate | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. |  |
| VU 0285683 | VU 0285683. Group: Biochemicals. Alternative Names: 3-(2-Pyridyl)-5-(3-fluoro-5-cyanophenyl)-1,2,4-oxadiazole. Grades: Highly Purified. CAS No. 327056-22-4. Pack Sizes: 10mg. Molecular Formula: C14H7FN4O, Molecular Weight: 266.23. US Biological Life Sciences. |  Worldwide |
| VU 0285683 | VU 0285683 is a negative allosteric modulator of mGlu5 receptors with high affinity for the MPEP binding site. VU 0285683 exhibits anxiolytic activity in rodent models of anxiety. Synonyms: VU0285683, VU 0285683, VU-0285683; 3-Fluoro-5-[3-(2-pyridinyl)-1,2,4-oxadiazol-5-yl]-benzonitrile. Grades: ≥98% by HPLC. CAS No. 327056-22-4. Molecular formula: C14H7FN4O. Mole weight: 266.23. | |
| VU 0357017 hydrochloride | The hydrochloride salt form of VU0357017 which is a selective M1 agonist and has been found to be probably effective in the treatment of hippocampal-dependent cognitive function deficits. EC50=477 ± 172 nM. Synonyms: VU0357017; VU-0357017; VU 0357017; CID 25010775; CID25010775; CID-25010775; 4-[[2-[(2-Methylbenzoyl)amino]ethyl]amino]-1-piperidinecarboxylic Acid Ethyl Ester Hydrochloride. Grades: >98%. CAS No. 1135242-13-5. Molecular formula: C18H27N3O3.HCl. Mole weight: 369.89. | |
| VU 0357017 hydrochloride | VU 0357017 hydrochloride. Group: Biochemicals. Grades: Purified. CAS No. 1135242-13-5. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| VU0357017 monohydrochloride | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| VU0357121 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| VU 0357121 | VU0357121 is a novel positive allosteric modulator (PAM) of mGlu5 with EC50 of 33 nM, is inactive or very weakly antagonizing at other mGlu receptor subtypes. Synonyms: VU-0357121, VU0357121, VU 0357121. Grades: >98%. CAS No. 433967-28-3. Molecular formula: C17H17F2NO2. Mole weight: 305.32. | |
| VU 0357121 | VU 0357121. Group: Biochemicals. Alternative Names: 4-Butoxy-N-(2,4-difluorophenyl)-benzamide. Grades: Highly Purified. CAS No. 433967-28-3. Pack Sizes: 25mg. Molecular Formula: C17H17F2NO2, Molecular Weight: 305.32. US Biological Life Sciences. | Worldwide |
| VU0359595 | VU0359595 is an inhibitor of Phospholipase D1 (PLD1) (IC50 = 3.7 nM) exhibiting >1,700-fold selectivity for PLD1 over PLD2 (IC50 = 6.4 μM). It may function via interacting with an allosteric site of PLD. Synonyms: CID-53361951; ML-270; (1R,2R)-N-([S]-1-{4-[5-bromo-2-oxo-2,3-dihydro-1H-benzo(d)imidazol-1-yl]piperidin-1-yl}propan-2-yl)-2-phenylcyclopropanecarboxamide. Grades: ≥95%. CAS No. 1246303-14-9. Molecular formula: C25H29BrN4O2. Mole weight: 497.43. | |
| VU0359595 | ?97% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| VU0360172 | VU0360172 is a potent and selective mGlu5 receptor positive allosteric modulator with an EC 50 value of 16 nM and a K i of 195 nM, respectively. VU0360172 stimulates polyphosphoinositide (PI) hydrolysis in vivo , which is abrogated in mGlu5 receptors gene deleted mice [1]. VU0360172 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. Uses: Scientific research. Group: Signaling pathways. CAS No. 1310012-12-4. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-120589. |  |
| VU 0360172 | VU 0360172. Group: Biochemicals. Alternative Names: N-Cyclobutyl-6-[2-(3-fluorophenyl)ethynyl]-3-pyridinecarboxamide Hydrochloride. Grades: Highly Purified. CAS No. 1309976-62-2. Pack Sizes: 10mg. Molecular Formula: C18H16ClFN2O, Molecular Weight: 330.78. US Biological Life Sciences. | Worldwide |
| VU 0360172 hydrochloride | VU 0360172 hydrochloride is a positive allosteric modulator of mGlu5 receptors (EC50 = 16 nM; Ki = 195 nM) with potential antipsychotic-like activity. VU 0360172 has no significant activity at mGlu1, mGlu2 or mGlu4 receptors. VU 0360172 has been shown to decrease spontaneous spike and wave discharges without affecting motor behavior in a rat model of absence epilepsy. Synonyms: VU 0360172 hydrochloride; VU0360172 hydrochloride; VU-0360172 hydrochloride; N-Cyclobutyl-6-[2-(3-fluorophenyl)ethynyl]-3-pyridinecarboxamide hydrochloride. Grades: ≥98% by HPLC. CAS No. 1309976-62-2. Molecular formula: C18H15FN2O.HCl. Mole weight: 330.78. | |
| VU 0360172 hydrochloride | VU 0360172 hydrochloride. Group: Biochemicals. Grades: Purified. CAS No. 1309976-62-2. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| VU 0360223 | VU 0360223 is a potent mGlu5 negative allosteric modulator (IC50 = 61 nM) that has no activity at mGlu1-4 and mGlu7-8. Synonyms: VU 0360223; VU0360223; VU-0360223; 3-Fluoro-5-(2-methyl-5-benzothiazolyl)-benzonitrile. Grades: ≥99% by HPLC. CAS No. 1274859-33-4. Molecular formula: C15H9FN2S. Mole weight: 268.31. | |
| VU 0360223 | VU 0360223. Group: Biochemicals. Grades: Purified. CAS No. 1274859-33-4. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| VU0361737 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| VU 0361737 | VU 0361737 is a selective positive allosteric modulator (PAM) for mGlu4 receptor with EC50 of 240 nM and 110 nM at human and rat receptors, respectively, displaying weak activity at mGlu5 and mGlu8 receptors, and being inactive at mGlu1, mGlu2, mGlu3, mGlu6 and mGlu7 receptors. Synonyms: VU 0361737, VU-0361737, VU0361737. CAS No. 1161205-04-4. Molecular formula: C13H11ClN2O2. Mole weight: 262.693. | |
| VU 0361737 | VU 0361737. Group: Biochemicals. Grades: Purified. CAS No. 1161205-04-4. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| VU0364289 | VU0364289 is a highly selective mGlu5 positive allosteric modulator (PAM) (binds to the MPEP (HY-14609A) site), with an EC 50 of 1.6 μM. VU0364289 can reverse amphetamine-induced hyperlocomotion in a dose-dependent manner, which can be used for schizophrenia and other psychiatric research [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1242443-29-3. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-120727. | |
| VU0364439 | VU0364439 is a positive allosteric modulator (PAM) of mGlu4 receptors (EC50 = 19.8 nM in vitro for human mGlu4). Uses: Designed for use in research and industrial production. Additional or Alternative Names: VU0364439, VU-0364439, VU 0364439. Product Category: Others. Appearance: Solid powder. CAS No. 1246086-78-1. Molecular formula: C18H13Cl2N3O3S. Mole weight: 422.28. Purity: >98%. IUPACName: N-[3-Chloro-4-[[(2-chlorophenyl)amino]sulfonyl]phenyl]-2-pyridinecarboxamide. Canonical SMILES: O=C(C1=NC=CC=C1)NC2=CC=C(S(=O)(NC3=CC=CC=C3Cl)=O)C(Cl)=C2. Product ID: ACM1246086781. Alfa Chemistry ISO 9001:2015 Certified. Categories: CS-1000. |  |
| VU 0364439 | VU 0364439 is a mGlu4 positive allosteric modulator (PAM), with EC50 of 19.8 nM. Synonyms: VU0364439, VU-0364439, VU 0364439. CAS No. 1246086-78-1. Molecular formula: C18H13Cl2N3O3S. Mole weight: 422.28. | |
| VU 0364439 | VU 0364439. Group: Biochemicals. Grades: Purified. CAS No. 1246086-78-1. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| VU0364572 trifluoroacetate salt | VU0364572 is an allosteric agonist of the muscarinic acetylcholine receptor 1 (M1) with EC50 value of 0.2 mM. It induces increases in Ca2+ mobilization and ERK1/2 phosphorylation in CHO cells transfected with the human M1 receptor, but exhibits no effect on β-arrestin recruitment. Synonyms: VU0364572 TFA salt; ethyl 4-[(3R)-3-[(2-methylbenzoyl)amino]piperidin-1-yl]piperidine-1-carboxylate;2,2,2-trifluoroacetic acid. Grades: ≥98%. CAS No. 1240514-89-9. Molecular formula: C21H31N3O3·CF3COOH. Mole weight: 487.5. | |
| VU 0364739 hydrochloride | VU 0364739 hydrochloride is a potent and selective phospholipase D2 (PLD2) inhibitor (IC50 = 20 nM), displaying 75-fold selectivity over PLD1 (IC50 = 1500 nM). Synonyms: VU0364739; VU-0364739; VU 0364739; ML-271; ML271, ML 271; VU0364739 HCl; VU0364739 hydrochloride; N-[2-[1-(3-Fluorophenyl)-4-oxo-1,3,8-triazaspiro[4.5]dec-8-yl]ethyl]-2-naphthalenecarboxamide. Grades: ≥98% by HPLC. CAS No. 1244640-48-9. Molecular formula: C26H27FN4O2.HCl. Mole weight: 482.98. | |
| VU 0364739 hydrochloride | VU 0364739 hydrochloride. Group: Biochemicals. Grades: Purified. CAS No. 1244640-48-9. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| VU0364770 | VU0364770 is a selective and potent positive allosteric modulator ( PAM ) of mGlu4. VU0346770 exhibits EC 50 s of 290 nM and 1.1 μM at rat mGlu4 and human mGlu4 receptor , respectively. VU0364770 exhibits antagonist activity at mGlu5 with a potency of 17.9 μM and PAM activity at mGlu6 with a potency of 6.8 μM. VU0364770 also possesses activity at MAO with K i values of 8.5 and 0.72 μM for human MAO-A and human MAO-B, respectively [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 61350-00-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-100588. | |
| VU 0364770 | VU 0364770 is systemically active positive allosteric modulator (PAM) of metabotropic glutamate receptor subtype 4 (mGluR4) (EC50: 290 nM). It showed efficacy alone or when administered in combination with L-DOPA or an adenosine 2A (A2A) receptor antagonist, in several rodent PD models. Synonyms: VU0364770; VU-0364770; N-(3-chlorophenyl)picolinamide; N-(3-chlorophenyl)-2-pyridinecarboxamide. Grades: >98%. CAS No. 61350-00-3. Molecular formula: C12H9ClN2O. Mole weight: 232.67. | |
| VU 0364770 | VU 0364770. Group: Biochemicals. Grades: Purified. CAS No. 61350-00-3. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| VU0364770 hydrochloride | VU0364770 hydrochloride is a selective and potent positive allosteric modulator ( PAM ) of mGlu4. VU0346770 hydrochloride exhibits EC 50 s of 290 nM and 1.1 μM at rat mGlu4 and human mGlu4 receptor , respectively. VU0364770 hydrochloride exhibits antagonist activity at mGlu5 with a potency of 17.9 μM and PAM activity at mGlu6 with a potency of 6.8 μM. VU0364770 hydrochloride also possesses activity at MAO with K i values of 8.5 and 0.72 μM for human MAO-A and human MAO-B, respectively [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1414842-70-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-100588A. | |
| VU 0365114 | VU 0365114 is a selective positive allosteric modulator of M5 muscarinic acetylcholine receptor (mAChR) (EC50 = 2.7 μM for human M5, and >30 μM for M1, M2, M3 and M4, receptors). Synonyms: VU 0365114; VU0365114; VU-0365114; 1-[(1,1'-Biphenyl)-4-ylmethyl]-5-(trifluoromethoxy)-1H-indole-2,3-dione; 1-[(4-phenylphenyl)methyl]-5-(trifluoromethoxy)indole-2,3-dione. Grades: ≥98% by HPLC. CAS No. 1208222-39-2. Molecular formula: C22H14F3NO3. Mole weight: 397.35. | |
| VU 0365114 | VU 0365114. Group: Biochemicals. Grades: Purified. CAS No. 1208222-39-2. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| VU0405601 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| VU 0409106 | VU 0409106 is a potent and selective mGlu5 negative allosteric modulator (IC50 = 49 nM for human mGlu5) with selectivity over a panel of GPCRs and ion channels. VU 0409106 exhibits no significant nonspecific binding in rat brain homogenates in vitro. Synonyms: VU0409106, VU 0409106, VU-0409106; 3-Fluoro-N-(4-methyl-2-thiazolyl)-5-(5-pyrimidinyloxy)benzamide. Grades: ≥98% by HPLC. CAS No. 1276617-62-9. Molecular formula: C15H11FN4O2S. Mole weight: 330.34. | |
| VU 0409551 | VU0409551 is a selectively glutamate receptor subtype 5 (mGlu5) positive allosteric modulator with EC50 value of 260 nM. VU0409551 shows distinct stimulus bias and selectively potentiates mGlu5 coupling to Gαq-mediated signaling. It exhibits wake-promoting, antipsychotic-like and cognition-enhancing effects in animal models. Synonyms: VU0409551; VU-0409551; VU 0409551; JNJ-46778212; JNJ 46778212; JNJ46778212;(4-fluorophenyl)(2-(phenoxymethyl)-6,7-dihydrooxazolo[5,4-c]pyridin-5(4H)-yl)methanone. Grades: 98%. CAS No. 1363281-27-9. Molecular formula: C20H17FN2O3. Mole weight: 352.37. | |
| VU0420373 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| VU 0422288 | VU 0422288 is a group III mGlu receptor positive allosteric modulator (EC50 = 108, 125 and 146 nM for mGlu4, mGlu8 and mGlu7, respectively) with selectivity over a panel of 68 other GPCRs, ion channels and transporters. VU 0422288 has been shown to potentiate mGlu7-mediated reductions in excitatory post synaptic potentials in hippocampal slices. Synonyms: VU0422288; VU-0422288; VU 0422288; ML 396; ML-396; ML396; N-[3-Chloro-4-[(5-chloro-2-pyridinyl)oxy]phenyl]-2-pyridinecarboxamide. Grades: ≥98% by HPLC. CAS No. 1630936-95-6. Molecular formula: C17H11Cl2N3O2. Mole weight: 360.19. | |
| VU0453379 | VU0453379 is a highly selective and central nervous system (CNS) permeability positive allosteric modulator (PAM) of glucagon-like peptide-1R (GLP-1R) with an EC50 of 1.3 μM. Synonyms: VU-0453379; VU 0453379. Grades: ≥98% by HPLC. CAS No. 1638646-27-1. Molecular formula: C26H34N4O2. Mole weight: 434.6. | |
| VU0463271 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| VU 0463271 | VU 0463271 is a potent and selective inhibitor of KCC2, which is a neuronal K-Cl cotransporter (IC50 = 61 nM). VU 0463271 exhibits >100-fold selectivity versus the Na-K-2Cl cotransporter 1 (NKCC1) and no activity against a panel of 68 GPCRs, ion channels and transporters. Synonyms: VU0463271; VU-0463271; VU 0463271; N-Cyclopropyl-N-(4-methyl-2-thiazolyl)-2-[(6-phenyl-3-pyridazinyl)thio]acetamide. Grades: ≥98% by HPLC. CAS No. 1391737-01-1. Molecular formula: C19H18N4OS2. Mole weight: 382.5. | |
| VU 0463271 | VU 0463271. Group: Biochemicals. Grades: Purified. CAS No. 1391737-01-1. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| VU0463597 | VU0463597, also known as ML-289, is a negative allosteric modulator of mGlu3 (IC50 = 0.66 μM) that displays 15-fold selectivity over mGlu2 and inactivity against mGlu5.1. Uses: Designed for use in research and industrial production. Additional or Alternative Names: VU0463597, VU 0463597, VU-0463597, ML-289, ML 289; ML289. Product Category: Others. Appearance: Solid powder. CAS No. 1382481-79-9. Molecular formula: C22H23NO3. Mole weight: 349.43. Purity: >98%. IUPACName: [(3R)-1-({4-[2-(4-methoxyphenyl)ethynyl]phenyl}carbonyl)piperidin-3-yl]methanol. Canonical SMILES: OC[C@H]1CN(C(C2=CC=C(C#CC3=CC=C(OC)C=C3)C=C2)=O)CCC1. Product ID: ACM1382481799. Alfa Chemistry ISO 9001:2015 Certified. | |
| VU0467154 | VU0467154 is a positive allosteric modulator of the M4 muscarinic acetylcholine receptor. It potentiates acetylcholine responses in CHO cells expressing M4 receptors (EC50s = 17.7, 630, and 1,000 nM for rat, human, and cynomolgus monkey receptors, respectively). Synonyms: 5-Amino-3, 4-dimethyl-N-[[4- (trifluoromethylsulfonyl) phenyl]methyl]thieno[2, 3-c]pyridazine-6-carboxamide. Grades: ≥95%. CAS No. 1451993-15-9. Molecular formula: C17H15F3N4O3S2. Mole weight: 444.45. | |
| VU 0469650 hydrochloride | VU 0469650 hydrochloride is a potent and selective negative allosteric modulator of mGlu1 (IC50 = 99 nM), displaying >100-fold selectivity for mGlu1 over mGlu2-8 and 68 other GPCRs, ion channels, kinases and transporters. Synonyms: VU 0469650 hydrochloride, VU 0469650 HCl, VU 0469650, VU0469650, VU-0469650; 3-[(3R)-3-Methyl-4-(tricyclo[3.3.1.13,7]dec-1-ylcarbonyl)-1-piperazinyl]-2-pyridinecarbonitrile hydrochloride. Grades: ≥98% by HPLC. CAS No. 1443748-47-7. Molecular formula: C22H28N4O.HCl. Mole weight: 400.94. | |
| VU-0483605 | VU-0483605, an isoindol derivative, has been found to be a mGluR1 positive allosteric modulator and probably be effective against schizophrenia. EC50: 356 and 390 nM for rat and human receptors, respectively. Synonyms: CHEMBL3628116; VU0483605, VU-0483605, VU 048360; AOB6248; SYN5042; AOB 6248; SYN 5042; AOB-6248; SYN-5042; 3-chloro-N-[3-chloro-4-(4-chloro-1,3-dioxoisoindol-2-yl)phenyl]pyridine-2-carboxamide. Grades: 98%. CAS No. 1623101-11-0. Molecular formula: C20H10Cl3N3O3. Mole weight: 446.67. | |
| VU0486321 | VU0486321 is a compound in a class of mGlu1 positive allosteric modulators (PAMs). VU0486321 maintains acceptable mGlu1 PAM potency, DMPK profile, CNS permeability, and mGluR selectivity. Uses: Scientific research. Group: Signaling pathways. CAS No. 1816301-67-3. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-118179. | |
| VU0486846 | VU0486846 is an orally active and selective muscarinic acetylcholine receptor M1 positive allosteric modulator (PAM) [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1788055-11-7. Pack Sizes: 1 mg; 5 mg. Product ID: HY-121806. | |
| VU 0650991 | VU 0650991 is a selective and non-competitive glucagon-like peptide-1 (GLP-1) receptor antagonist with IC50 value of 650 nM. Synonyms: GLP-1R Antagonist 1; 7-(4-Chlorophenyl)-5,8-dihydro-1,3-dimethyl-5,5-bis(trifluoromethyl)pyrimido[4,5-d]pyrimidine-2,4(1H,3H)-dione. Grades: ≥98% by HPLC. CAS No. 488097-06-9. Molecular formula: C16H11ClF6N4O2. Mole weight: 440.73. | |
| VU 10010 | VU 10010 is a selective allosteric potentiator at M4 acetylcholine receptors (EC50 = 33 and 0.7 nM for ACh in the absence and presence of VU10010 respectively). VU 10010 binds to an allosteric site on the receptor increasing affinity for ACh and coupling to G-proteins. Synonyms: VU 10010; VU10010; VU-10010; 3-Amino-N-[(4-chlorophenyl)methyl]-4,6-dimethylthieno[2,3-b]pyridine-2-carboxamide. Grades: ≥99% by HPLC. CAS No. 633283-39-3. Molecular formula: C17H16ClN3OS. Mole weight: 345.85. | |
| VU 10010 | VU 10010. Group: Biochemicals. Grades: Purified. CAS No. 633283-39-3. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| VU 152100 | VU 152100. Group: Biochemicals. Grades: Purified. CAS No. 409351-28-6. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| VU 1545 | VU 1545. Group: Biochemicals. Grades: Purified. CAS No. 890764-63-3. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| VU 1545 | VU 1545 is a metabotropic glutamate receptor 5 (mGlu5) positive allosteric modulator (EC50 = 9.6 nM, Ki = 156 nM at rat mGlu5). Synonyms: VU-1545, VU 1545, VU1545; N-[1-(2-Fluorophenyl)-3-phenyl-1H-pyrazol-5-yl]-4-nitrobenzamide. Grades: ≥98% by HPLC. CAS No. 890764-63-3. Molecular formula: C22H15FN4O3. Mole weight: 402.38. | |
| VU 29 | VU 29. Group: Biochemicals. Grades: Purified. CAS No. 890764-36-0. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| VU 29 | VU 29 is a potent positive allosteric potentiator at the rat mGlu5 receptor (EC50 = 9 nM) with selectivity for mGlu5 over mGlu1 and mGlu2 receptors (EC50 = 557 nM and 1.51 μM for mGlu1 and mGlu2, respectively). VU 29 binds to the MPEP allosteric site (Ki app = 244 nM). VU 29 was shown to potentiate both DHPG-induced LTP and threshold θ-burst stimulation (TBS)-induced LTP in rat hippocampal slices. Synonyms: N-(1,3-Diphenyl-1H-pyrazolo-5-yl)-4-nitrobenzamide; DPAP; VU-29; VU 29; VU29; 4-nitro-N-(1,3-diphenyl-1H-pyrazol-5-yl)benzamide. Grades: ≥99% by HPLC. CAS No. 890764-36-0. Molecular formula: C22H16N4O3. Mole weight: 384.39. | |
| VU-29 | VU-29 is a positive allosteric modulator of metabotropic glutamate 5 (mGlu5) receptor ( EC 50 =9 nM and K i =244 nM for rmGluR5). VU-29 is selective for mGluR5 relative to other mGluR subtypes (EC 50 : rmGluR1/rmGluR2=557 nM/1.5 μM; hmGluR4=154 nM) [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 890764-36-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-107508. | |
| VU590 | VU590 is a potent and moderately selective ROMK (Kir1.1) inhibitor, with an IC 50 of 290 nM. VU590 also inhibits Kir7.1 , with an IC 50 of 8 μM. VU590 is not a good probe of ROMK function in the kidney [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 313505-85-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-108595. | |
| VU 590 dihydrochloride | VU 590 dihydrochloride. Group: Biochemicals. Grades: Purified. CAS No. 313505-85-0. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| VU 590 dihydrochloride | VU 590 dihydrochloride is a selective renal outer medullary potassium channel (Kir1.1, ROMK) inhibitor (IC50 = 294 nM). VU 590 displays no effect upon Kir2.1 or Kir4.1. It also inhibits the inward retifying K+ channel Kir7.1. Synonyms: VU590 HCl; VU590 dihydrochloride; VU590; VU-590; VU 590; CID-4536383; CID 4536383; CID4536383; ML 111; ML111 ; ML-111; 7,13-Bis[(4-nitrophenyl)methyl]-1,4,10-trioxa-7,13-diazacyclopentadecane dihydrochloride. Grades: ≥97% by HPLC. CAS No. 1783987-83-6. Molecular formula: C24H32N4O7.2HCl. Mole weight: 561.46. | |
| VU591 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| VU 591 hydrochloride | VU 591 hydrochloride is a selective renal outer medullary potassium channel (Kir1.1, ROMK) antagonist (IC50 = 300 nM). VU 591 exhibits no effect on Kir7.1 at concentrations up to 10 μM and no inhibition of Kir2.1, Kir2.3 or Kir4.1. Synonyms: VU 591 hydrochloride; VU591 hydrochloride; VU-591 hydrochloride; 6-Nitro-2-[(6-nitro-1H-benzimidazol-2-yl)methoxymethyl]-1H-benzimidazole hydrochloride. Grades: ≥99% by HPLC. CAS No. 1315380-70-1. Molecular formula: C16H12N6O5.HCl. Mole weight: 404.76. | |
| VU 591 hydrochloride | VU 591 hydrochloride. Group: Biochemicals. Grades: Purified. CAS No. 1315380-70-1. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| VU6001221 | VU6001221 is a choline transporter (CHT) inhibitor (IC50 value of 270 nM) with comparable potency for choline uptake inhibition as ML352, as well as improved PK and CNS penetration. For the first time, VU6001221 allowed evaluation of a CHT inhibitor in a standard preclinical rodent cognition model, namely novel object recognition (NOR). Synonyms: VU 6001221; VU-6001221. Grades: 98%. CAS No. 2002495-17-0. Molecular formula: C20H26ClN3O3. Mole weight: 391.89. | |
| VU 6008667 | VU 6008667 is a selective negative allosteric modulator (NAM) of M5 muscarinic acetylcholine receptor (mAChR) (IC50 values of 1.2 and 1.6 μM in human and rat M5, respectively). Moreover, VU6008667 has high CNS penetration and exhibits a desired short half-life in rats (t1/2 = 2.3 h) for addiction studies. Synonyms: VU 6008667; VU6008667; VU-6008667. Grades: 99%. CAS No. 2092923-21-0. Molecular formula: C24H17ClF2N2O2. Mole weight: 438.85. | |
| VU6036720 | VU6036720 is a potent and specific in vitro inhibitor of Kir4.1/5.1. VU6036720 can inhibit Kir4.1/5.1 channels with an IC 50 value of 0.24 μM. VU6036720 can be used for the research of brain and kidney [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 3026597-12-3. Pack Sizes: 5 mg; 10 mg. Product ID: HY-148304. | |
| VUAA1 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| Vudalimab | Vudalimab is a humanized bispecific monoclonal antibody targeting both PD-1 and CTLA-4. Vudalimab inhibits the PD-1- and CTLA4-mediated downregulation of T-cell activation and proliferation. CAS No. 2329669-72-7. | |
| Vudalimab | Vudalimab is a potent dual PD-1 and CTLA-4 inhibitor as a fully humanized bispecific monoclonal antibody. Vudalimab targets immune checkpoint receptors PD-1 and CTLA-4 and promotes tumor-selective T-cell activation [1]. Uses: Scientific research. Group: Inhibitory antibodies. CAS No. 2329669-72-7. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99166. | |
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