A directory of where to buy chemicals in the USA, including: distributors, industrial manufacturers, bulk supplies and wholesalers of raw ingredients & finished goods.
VUF 10460. Group: Biochemicals. Grades: Purified. CAS No. 1028327-66-3. Pack Sizes: 10mg, 50mg. US Biological Life Sciences.
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VUF 11207 fumarate
VUF 11207 fumarate is a potent ACKR3 (CXCR7) agonist. Synonyms: VUF 11207 fumarate; VUF11207 fumarate; VUF-11207 fumarate; N-[(2E)-3-(2-Fluorophenyl)-2-methyl-2-propen-1-yl]-3,4,5-trimethoxy-N-[2-(1-methyl-2-pyrrolidinyl)ethyl]benzamide fumarate. CAS No. 1785665-61-3. Molecular formula: C27H35FN2O4.C4H4O4. Mole weight: 586.65.
VUF 11207 fumarate
VUF 11207 fumarate. Group: Biochemicals. Grades: Purified. Pack Sizes: 10mg, 50mg. US Biological Life Sciences.
Worldwide
VUF 11207 trifluoroacetate salt
VUF 11207 is a potent agonist of the G protein-coupled chemokine receptor 7 (CXCR7). It also reduces CXCR7 cell surface expression (EC50 = 14.1 nM) in vitro. Synonyms: VUF11207 TFA salt. Grades: ≥95%. Molecular formula: C27H35FN2O4·CF3COOH. Mole weight: 584.6.
VUF 11222
VUF 11222 is a high affinity non-peptide CXCR3 agonist (pKi = 7.2). Synonyms: VUF-11222, VUF 11222, VUF11222; 2'-Bromo-N-[[(1R,5S)-6,6-dimethylbicyclo[3.1.1]hept-2-en-2-yl]methyl]-N,N-dimethyl-[1,1'-biphenyl]-4-methanaminium iodide. CAS No. 1414376-84-3. Molecular formula: C25H31BrIN. Mole weight: 552.33.
VUF 5574
VUF 5574 is a potent and competitive antagonist for the human adenosine A3 receptor (Ki = 4 nM) that displays ≥ 2500-fold selectivity over A1 and A2A receptors. Synonyms: VUF5574, VUF 5574, VUF-5574; N-(2-Methoxyphenyl)-N'-[2-(3-pyrindinyl)-4-quinazolinyl]-urea; 1-(2-Methoxyphenyl)-3-(2-(pyridin-3-yl)quinazolin-4-yl)urea. Grades: ≥98% by HPLC. CAS No. 280570-45-8. Molecular formula: C21H17N5O2. Mole weight: 371.39.
VUF 5574
VUF 5574. Group: Biochemicals. Grades: Purified. CAS No. 280570-45-8. Pack Sizes: 10mg, 50mg. US Biological Life Sciences.
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VUF 5681 dihydrobromide
VUF 5681 dihydrobromide. Group: Biochemicals. Grades: Purified. CAS No. 639089-06-8. Pack Sizes: 10mg, 50mg. US Biological Life Sciences.
Worldwide
VUF 5681 dihydrobromide
VUF 5681 dihydrobromide is a potent histamine H3 receptor silent antagonist (pKi = 8.35). Synonyms: VUF 5681 dihydrobromide; VUF5681 dihydrobromide; VUF-5681 dihydrobromide; 4-[3-(1H-Imidazol-4-yl)propyl]piperidine dihydrobromide. Grades: ≥98% by HPLC. CAS No. 639089-06-8. Molecular formula: C11H19N3.2HBr. Mole weight: 355.11.
VUF 8430 dihydrobromide
VUF 8430 dihydrobromide. Group: Biochemicals. Grades: Purified. CAS No. 100130-32-3. Pack Sizes: 10mg, 50mg. US Biological Life Sciences.
Worldwide
VUF 8430 dihydrobromide
VUF 8430 dihydrobromide is a high affinity (pKi = 7.5) and potent histamine H4 receptor full agonist (pEC50 = 7.3). VUF 8430 also has moderate affinity for H3 receptors (pKi = 6.0) and weak partial agonist activity at H2 receptors. Synonyms: VUF8430 dihydrobromide; VUF-8430 dihydrobromide; VUF 8430 dihydrobromide; 2-[(Aminoiminomethyl)amino]ethyl carbamimidothioic acid ester dihydrobromide; S-(2-guanidylethyl)-isothiourea; S,2-Guanidinoethylisothiuronium bromide hydrobromide. CAS No. 100130-32-3. Molecular formula: C4H11N5S.2HBr. Mole weight: 323.05.
VUF 8430 (dihydrobromide) is a potent and selective histamine H4 receptor agonist with a K i of 31.6 nM and an EC 50 of 50 nM [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 100130-32-3. Pack Sizes: 5 mg; 10 mg. Product ID: HY-107555.
vulcanization agents
vulcanization agents. Group: Polymers.
VULM 1457
VULM 1457 is an Acyl-CoA that acts as a cholesterol acyltransferase (ACAT) inhibitor. VULM 1457 has been shown to reduce cholesterol levels in the plasma and liver of diabetic-hypercholesterolemic rats. Synonyms: VULM 1457; VULM1457; VULM-1457; N-[2,6-bis(1-Methylethyl)phenyl]-N'-[4-[(4-nitrophenyl)thio]phenyl]urea. Grades: ≥99% by HPLC. CAS No. 228544-65-8. Molecular formula: C25H27N3O3S. Mole weight: 449.57.
VULM 1457
VULM 1457. Group: Biochemicals. Grades: Purified. CAS No. 228544-65-8. Pack Sizes: 10mg, 50mg. US Biological Life Sciences.
Worldwide
Vulpinic acid
Vulpinic acid. Group: Biochemicals. Alternative Names: (a-E) -a- (3-Hydroxy-5-oxo-4-phenyl-2 (5H) -furanylidene) benzeneacetic Acid Methyl Ester. Grades: Highly Purified. CAS No. 521-52-8. Pack Sizes: 500mg, 1g, 2g, 5g, 10g. Molecular Formula: C19H14O5. US Biological Life Sciences.
Worldwide
VUN32779
VUN32779, also known as 7-benzyl-4-(2-methylbenzyl)-1,2,6,7,8,9-hexahydroimidazo[1,2-a]pyrido[3,4-e]pyrimidin-5(4H)-one is a chemical reagent for research use. Group: Others. Alternative Names: VUN32779; VUN 32779; VUN-32779. CAS No. 1616632-77-9. Molecular formula: C24H26N4O. Mole weight: 386.5. Appearance: Solid powder. Purity: >98%. IUPACName: 7-benzyl-4-(2-methylbenzyl)-1,2,6,7,8,9-hexahydroimidazo[1,2-a]pyrido[3,4-e]pyrimidin-5(4H)-one. Canonical SMILES: O=C1N (CC2=CC=CC=C2C)C3=NCCN3C4=C1CN (CC5=CC=CC=C5)CC4. Catalog: ACM1616632779.
VUN73874
VUN73874, also known as GOT1 inhibitor 2c, is a glutamate-oxaloacetate transaminase 1 (GOT1)? inhibitor. This compound was first reported in Bioorg Med Chem Lett. 2018 Sep 1;28(16):2675-2678. Group: Inhibitors. Alternative Names: GOT1 inhibitor 2c; VUN73874; VUN-73874; VUN 73874. CAS No. 732973-87-4. Molecular formula: C19H19ClN4O. Mole weight: 354.84. Appearance: Solid powder. Purity: >98%. IUPACName: N-(4-Chlorophenyl)-4-(1H-indol-4-yl)piperazine-1-carboxamide. Canonical SMILES: O=C (N1CCN (C2=CC=CC3=C2C=CN3)CC1)NC4=CC=C (Cl)C=C4. Catalog: ACM732973874.
Vunakizumab
Vunakizumab (Anti-Human IL17A Recombinant Antibody) is a recombinant human IgGκ monoclonal antibody that targets IL-17A and inhibits its interaction with the IL-17 receptor. Vunakizumab can be used to study autoimmune diseases such as psoriatic arthritis, ankylosing spondylitis, multiple sclerosis and inflammatory arthritis [1]. Uses: Scientific research. Group: Inhibitory antibodies. Alternative Names: Anti-Human IL17A Recombinant Antibody. CAS No. 1792181-33-9. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99335.
VUT-MK142
VUT-MK142 is a potent new cardiomyogenic synthetic agent promoting the differentiation of pre-cardiac mesoderm into cardiomyocytes, which may be useful to differentiate stem cells into cardiomyocytes for cardiac repair [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1313491-22-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-122610.
VV116
VV116, also known as JT001, is an oral drug candidate of nucleoside analog against SARS-CoV-2. VV116 is a deuterated, tri-isobutyrate ester prodrug of the RDV parent nucleoside, and is rapidly metabolized into the parent nucleoside (116-N1) in the body. 116-N1 is intracellularly converted to the nucleoside triphosphate active form, which would interfere with the function of RNA-dependent RNA polymerase of SARS-CoV-2, thus exerting antiviral effects (Fig. 1). VV116 showed potent activity against a panel of SARS-CoV-2 variants (alpha, beta, delta, and omicron) and excellent therapeutic efficacy in the mice model. Group: Others. Alternative Names: VV116; VV 116; VV-116; JT001; JT-001; JT 001. CAS No. 2647442-33-7. Molecular formula: C24H30DN5O7. Mole weight: 502.55. Appearance: Solid powder. Purity: >98%. IUPACName: (2R, 3R, 4R, 5R) -2- (4-amino-5-deuteropyrrolo[2, 1-f][1, 2, 4]triazin-7-yl) -2-cyano-5- ( (isobutyryloxy) methyl) tetrahydrofuran-3, 4-diyl bis(2-methylpropanoate). Canonical SMILES: CC (C (OC[C@H]1O[C@] (C#N) ([C@@H] ([C@@H]1OC (C (C)C)=O)OC (C (C)C)=O)C2=CC ([2H])=C3N2N=CN=C3N)=O)C. Catalog: ACM2647442337.
Vv-AMP1
Vv-AMP1 is an antibacterial peptide isolated from Vit is vinifera. It has activity against fungi. Synonyms: Arg-Thr-Cys-Glu-Ser-Gln-Ser-His-Arg-Phe-Lys-Gly-Thr-Cys-Val-Arg-Gln-Ser-Asn-Cys-Ala-Ala-Val-Cys-Gln-Thr-Glu-Gly-Phe-His-Gly-Gly-Asn-Cys-Arg-Gly-Phe-Arg-Arg-Arg-Cys-Phe-Cys-Thr-Lys-His-Cys. Molecular formula: C216H343N81O64S8. Mole weight: 5355.08.
VX-11e
VX-11e is a potent, selective, and orally bioavailable inhibitor of ERK, which is extracellular signal-regulated kinases. It is an antitumor agent and potently blocks proliferation of HT29 cells. Synonyms: VX-11e; VX 11e; VX11e; VTX-11e; VTX11e; VTX 11e; ERK-11e; ERK 11e; ERK11e. Grades: >98%. CAS No. 896720-20-0. Molecular formula: C24H20Cl2FN5O2. Mole weight: 500.35.
VX-148
VX-148 is a novel, uncompetitive IMPDH inhibitor with a K(I) value of 6 nM against IMPDH type II enzyme. VX-148 is slightly more potent than mycophenolic acid and VX-497 in inhibiting the proliferation of mitogen-stimulated primary human lymphocytes (IC(50) value of ~80 nM). VX-148 does not inhibit proliferation of nonlymphoid cell types such as fibroblasts, indicating selectivity for inhibition of IMPDH activity. VX-148 significantly prolongs skin graft survival at 100 mg/kg b.i.d. in mice. Synonyms: VX148; VX 148; (R)-1-cyanobutan-2-yl ( (S) -1- (3- (3- (4-cyano-3-methoxyphenyl) ureido) phenyl) ethyl) carbamate. Grades: 98%. CAS No. 297730-05-3. Molecular formula: C23H25N5O4. Mole weight: 435.48.
VX-150
VX-150 is a NaV1.8 blocker that is currently in phase II clinical trial for the treatment of patients with acute pain. Study shows that VX-150 significantly alleviates postoperative pain. Synonyms: Benzamide, N-[1,2-dihydro-2-oxo-1-[(phosphonooxy)methyl]-4-pyridinyl]-2-(4-fluoro-2-methylphenoxy)-4-(trifluoromethyl)-; N-[1,2-Dihydro-2-oxo-1-[(phosphonooxy)methyl]-4-pyridinyl]-2-(4-fluoro-2-methylphenoxy)-4-(trifluoromethyl)benzamide; VX 150; VX150; (4-(2-(4-Fluoro-2-methylphenoxy)-4-(trifluoromethyl)benzamido)-2-oxopyridin-1(2H)-yl)methyl dihydrogen phosphate. Grades: ≥95%. CAS No. 1793080-72-4. Molecular formula: C21H17F4N2O7P. Mole weight: 516.33.
VX-166
VX-166 is a caspase inhibitor and can be used as a novel potential treatment for sepsis. VX-166 can also reduce fibrosis in an animal model of nonalcoholic steatohepatitis. Uses: Sepsis. Synonyms: VX166, VX 166, VX-166; (S)-3-((S)-2-(3-((methoxycarbonyl)amino)-2-oxopyridin-1(2H)-yl)butanamido)-4-oxo-5-(2,3,5,6-tetrafluorophenoxy)pentanoic acid. Grades: 98%. CAS No. 800408-39-3. Molecular formula: C22H21F4N3O8. Mole weight: 531.41.
VX-222 (VCH-222, Lomibuvir)
VX-222 (VCH-222) is a novel, potent and selective inhibitor of HCV polymerase with IC50 of 0.94-1.2 μM, 15.3-fold less effective for mutant M423T, and 108-fold less effective for mutant I482L. Phase 2. Synonyms: 2-Thiophenecarboxylic acid, 5-(3,3-dimethyl-1-butyn-1-yl)-3-[(cis-4-hydroxycyclohexyl)[(trans-4-methylcyclohexyl)carbonyl]amino]-; 5-(3,3-Dimethyl-1-butyn-1-yl)-3-[(cis-4-hydroxycyclohexyl)[(trans-4-methylcyclohexyl)carbonyl]amino]-2-thiophenecarboxylic acid; Lomibuvir; VCH 222; VX 222; VX222. Grades: >98%. CAS No. 1026785-59-0. Molecular formula: C25H35NO4S. Mole weight: 445.61.
VX-661
VX-661 is a cystic fibrosis transmembrane conductance regulator (CFTR) potentiator used in combination with Ivacaftor in the treatment of cystic fibrosis. Synonyms: 1-(2,2-Difluoro-1,3-benzodioxol-5-yl)-N-[1-[(2R)-2,3-dihydroxypropyl]-6-fluoro-2-(2-hydroxy-1,1-dimethylethyl)-1H-indol-5-yl]cyclopropanecarboxamide; VX 661; VX661; Tezacaftor. Grades: 98%. CAS No. 1152311-62-0. Molecular formula: C26H27F3N2O6. Mole weight: 520.50.
VX 702
VX 702. Group: Biochemicals. Grades: Purified. CAS No. 479543-46-9. Pack Sizes: 10mg. US Biological Life Sciences.
Worldwide
VX-702
VX-702 is a highly selective inhibitor of p38α MAPK, 14-fold higher potency against the p38α versus p38&beta. Synonyms: VX-702; VX 702; VX702. Grades: >98%. CAS No. 745833-23-2. Molecular formula: C19H12F4N4O2. Mole weight: 404.3.
VX-702
VX-702. Group: Biochemicals. Alternative Names: 6-[(Aminocarbonyl)(2,6-difluorophenyl)amino]-2-(2,4-difluorophenyl)-3-pyridinecarboxamide. Grades: Highly Purified. CAS No. 745833-23-2. Pack Sizes: 2mg, 5mg, 10mg, 25mg, 50mg. Molecular Formula: C19H12F4N4O2. US Biological Life Sciences.
Worldwide
VX 745
VX 745 is a potent and selective inhibitor of p38α mitogen-activated protein (MAP) kinase. VX 745 is a potential anti-inflammatory agents. Studies suggest that VX 745 may be useful in the treatment of Werner syndrome. Group: Biochemicals. Alternative Names: 5-(2,6-Dichlorophenyl)-2-[(2,4-difluorophenyl)thio]-6H-pyrimido[1,6-b]pyridazin-6-one. Grades: Highly Purified. CAS No. 209410-46-8. Pack Sizes: 25mg. US Biological Life Sciences.
Worldwide
VX-745
VX 745 is a potent and selective inhibitor of p38α mitogen-activated protein (MAP) kinase. VX 745 is a potential anti-inflammatory agents. Studies suggest that VX 745 may be useful in the treatment of Werner syndrome. Synonyms: VX-745; VX 745; VX745; VRT-031745, VD-31745; VRT 031745, VD 31745; VRT031745, VD31745; Neflamapimod. Grades: 0.97. CAS No. 209410-46-8. Molecular formula: C19H9Cl2F2N3OS. Mole weight: 436.258.
VX-765
VX-765. Group: Biochemicals. Alternative Names: N-(4-Amino-3-chlorobenzoyl)-3-methyl-L-valyl-N-[(2R,3S)-2-ethoxytetrahydro-5-oxo-3-furanyl]-L-prolinamide; Belnacasan. Grades: Highly Purified. CAS No. 273404-37-8. Pack Sizes: 5mg. Molecular Formula: C24H33ClN4O6, Molecular Weight: 509. US Biological Life Sciences.
Worldwide
VX-787
VX-787, a pyrrolopyridine derivative, has been found to be an antiviral agent and is still under Phase II trial against Influenza A virus infection. Synonyms: VX-787; VX 787; VX787; JNJ-872; JNJ 872; JNJ872; VRT-0928787; VRT 0928787; VRT0928787;pimodivir; (2S,3S)-3-((5-Fluoro-2-(5-fluoro-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-4-yl)amino)bicyclo[2.2.2]octane-2-carboxylic Acid. Grades: 98%. CAS No. 1629869-44-8. Molecular formula: C20H19F2N5O2. Mole weight: 399.40.
VY-3-135 is a potent ACSS2 inhibitor. VY-3-135 acts as a transition-state mimetic to block ACSS2 activity in vitro and in vivo. Pharmacologic inhibition of ACSS2 as a single agent impaired breast tumor growth. The aqueous solubility of VY-3-135 was 21.7 μM. The aqueous solubility of VY-3-135 was 21.7 μM. VY-3-135 is a potent low nanomolar inhibitor of ACSS2 in cancer cells in vitro. VY-3-135 potently inhibits ACSS2 dependent fatty acid metabolism but has no effect on gene expression in tumors. Group: Inhibitors. Alternative Names: VY-3-135; VY3-135; VY 3-135; VY-3135; VY3135; VY 3135. CAS No. 1824637-41-3. Molecular formula: C26H27N3O3. Mole weight: 429.52. Appearance: Solid powder. Purity: >98%. IUPACName: (R)-1-Ethyl-2-(hydroxydiphenylmethyl)-N-(2-hydroxypropyl)-1H-benzo[d]imidazole-6-carboxamide. Canonical SMILES: O=C (C1=CC=C2C (N (CC)C (C (C3=CC=CC=C3) (O)C4=CC=CC=C4)=N2)=C1)NC[C@H] (O)C. Catalog: ACM1824637413.
VZHE-039
VZHE-039 is a structurally-enhanced allosteric hemoglobin effector. Study in vitro showed that VZHE-039 inhibited sickling of SS erythrocytes in a dose-dependent manner. The result of in vivo studies showed that AUCtrap increased supra-proportionally with dose after I.P. administration; the limited sampling schedule suggested an I.P. bioavailability of >20%. VZHE-039 is promisingly to be a novel anti-sickling drug. Uses: Potential anti-sickling drug. Synonyms: VZHE-039; VZHE039.