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| Product | Description | |
|---|---|---|
| Z-Val-Trp-OH | Z-Val-Trp-OH. Group: Biochemicals. Grades: Highly Purified. CAS No. 18904-53-5. Pack Sizes: 2g. US Biological Life Sciences. |  Worldwide |
| Z-Val-Trp-OH | Synonyms: (S)-2-((S)-2-(benzyloxycarbonylamino)-3-methylbutanamido)-3-(1H-indol-3-yl)propanoic acid; Z Val Trp OH. Grades: ≥ 99% (TLC). CAS No. 18904-53-5. Molecular formula: C24H27N3O5. Mole weight: 437.50. |  |
| Z-Val-Trp-OH 99+% | Z-Val-Trp-OH 99+%. Group: Biochemicals. Grades: Reagent Grade. Pack Sizes: 1g, 2.5g. US Biological Life Sciences. | Worldwide |
| z-Val-trp-ome | z-Val-trp-ome. Uses: Designed for use in research and industrial production. Additional or Alternative Names: Z-VAL-TRP-OME. Product Category: Heterocyclic Organic Compound. CAS No. 17430-65-8. Molecular formula: C25H29N3O5. Mole weight: 451.51. Product ID: ACM17430658. Alfa Chemistry ISO 9001:2015 Certified. |  |
| z-Val-tyr-oh | z-Val-tyr-oh. Uses: Designed for use in research and industrial production. Additional or Alternative Names: Z-VAL-TYR-OH. Product Category: Heterocyclic Organic Compound. CAS No. 862-26-0. Molecular formula: C22H26N2O6. Mole weight: 414.45. Purity: 0.96. IUPACName: (2S)-3-(4-hydroxyphenyl)-2-[[(2S)-3-methyl-2-(phenylmethoxycarbonylamino)butanoyl]amino]propanoic acid. Canonical SMILES: CC(C)C(C(=O)NC(CC1=CC=C(C=C1)O)C(=O)O)NC(=O)OCC2=CC=CC=C2. Product ID: ACM862260. Alfa Chemistry ISO 9001:2015 Certified. | |
| Z-Val-Val-Arg-AMC | Z-Val-Val-Arg-AMC is a peptide used as a selective azadipeptide nitrile inhibitor for cathepsin K. Synonyms: benzyl (S)-1-((S)-1-((S)-5-guanidino-1-(4-methyl-2-oxo-2H-chromen-7-ylamino)-1-oxopentan-2-ylamino)-3-methyl-1-oxobutan-2-ylamino)-3-methyl-1-oxobutan-2-ylcarbamate; Z Val Val Arg AMC. Grades: 95%. CAS No. 124485-41-2. Molecular formula: C34H45N7O7. Mole weight: 663.77. | |
| Z-Val-Val-Arg-AMC | Substrate for Cathepsin S. Group: Biochemicals. Alternative Names: Benzyloxycarbonyl-L-Valyl-L-Valyl-L-Arginine 4-Methyl-Coumaryl-7-Amide, Z-Val-Val-Arg-AMC, Z-VVR-AMC, Z-VVR-MCA. Grades: Highly Purified. CAS No. 124485-41-2. Pack Sizes: 10mg, 25mg, 50mg. Molecular Formula: C34H45N7O7 HCl, Molecular Weight: 722.22. US Biological Life Sciences. | Worldwide |
| Z-Val-Val-Arg-AMC | Z-Val-Val-Arg-AMC is a fluorescent peptide substrate that can be used to test the activity of cathepsins [1]. Uses: Scientific research. Group: Peptides. CAS No. 124485-41-2. Pack Sizes: 5 mg; 10 mg; 25 mg. Product ID: HY-137367. |  |
| Z-Val-Val-OH | Synonyms: Z-VAL-VAL-OH; Z-L-VALYL-L-VALINE. CAS No. 19542-54-2. Molecular formula: C18H26N2O5. Mole weight: 350.42. | |
| Z-VDVAD-FMK | Z-VDVAD-FMK is a special inhibitor of caspase-2. Z-VDVAD-FMK produces a reduction in Lovastatin-induced apoptosis[1][2][3]. Uses: Scientific research. Group: Peptides. Alternative Names: Z-VD(OMe)VAD(OMe)-FMK. CAS No. 210344-92-6. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-P1008. | |
| Z-VDVAD-FMK | Z-VDVAD-FMK is a cell-permeant and irreversible caspase-2 inhibitor and can inhibits apoptosis in various cell lines. Synonyms: Z-VD(OMe)VAD(OMe)-FMK; Z-Val-Asp(OMe)-Val-Ala-Asp(OMe)-fluoromethyl ketone; benzyloxycarbonyl-Val-Asp(OMe)-Val-Ala-Asp(OMe)-fluoromethylketone; L-Alaninamide, N-[(phenylmethoxy)carbonyl]-L-valyl-L-|A-aspartyl-L-valyl-N-[(1S)-3-fluoro-1-(2-methoxy-2-oxoethyl)-2-oxopropyl]-, methyl ester; Z-Val-Asp(OMe)-Val-Ala-Asp(OMe)-FMK. Grades: ≥95%. CAS No. 210344-92-6. Molecular formula: C32H46FN5O11. Mole weight: 695.74. | |
| Z-VEID-FMK | Z-VEID-FMK (Z-VE(OMe)ID(OMe)-FMK) is a selective and irreversible caspase-6 peptide inhibitor. Z-VEID-FMK alleviates the drug-induced augmentation of caspase-6 activity, DNA fragmentation, and cell apoptosis [1] [2]. Uses: Scientific research. Group: Peptides. Alternative Names: Z-VE(OMe)ID(OMe)-FMK. CAS No. 210344-96-0. Pack Sizes: 5 mg; 10 mg. Product ID: HY-P1007. | |
| Z-VRPR-FMK trifluoroacetate salt | Z-VRPR-FMK trifluoroacetate salt is an irreversible and cell-permeable MALT1 inhibitor. Z-VRPR-FMK dose-dependently inhibits T cell activation-induced cleavage of Bcl-10. Z-VRPR-FMK reduces NF-κB-dependent gene expression in lymphocytes. Synonyms: Z-Val-Arg-Pro-DL-Arg-FMK. Grades: >90%. Molecular formula: C31H49FN10O6.CF3CO2H. Mole weight: 790.81. | |
| Z-VRPR-FMK (Z-Val-Arg-Pro-DL-Arg-FMK. TFA) | Selective cell permeable and irreversible MALT1 inhibitor. Inhibits NF-kappaB-dependent gene expression and affects the growth, proliferation and survival of activated B cell-like diffuse large B cell lymphomas (ABC-DLBCL) and germinal center B cell like diffuse large B cell lymphoma (GCB-DLBCL) cell lines. Shown to inhibit the autoprocessing activity of MCA2ac (calcium dependent) in Trypanosoma brucei. Group: Biochemicals. Grades: Purified. CAS No. 1381885-28-4 (free base). Pack Sizes: 500ug, 1mg. US Biological Life Sciences. | Worldwide |
| ZW4864 | ZW4864 is an orally active and selective ? catenin/B-Cell lymphoma 9 protein protein interaction (? catenin/BCL9 PPI) inhibitor. ZW4864 inhibits ? catenin/BCL9 PPI with a Ki value of 0.76 ?M and an IC50 value of 0.87 ?M[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2632259-93-7. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-132300. | |
| ZX-29 | ZX-29 is a potent and selective ALK inhibitor for ALK, ALK L1196M and ALK G1202R mutations, respectively. ZX-29 is inactive against EGFR. ZX-29 induces apoptosis by inducing endoplasmic reticulum (ER) stress and overcomes cell resistance caused by an ALK mutation. ZX-29 also induces protective autophagy and has antitumor effect. Uses: Designed for use in research and industrial production. Additional or Alternative Names: ZX-29; ZX29; ZX 29. Product Category: Inhibitors. Appearance: Solid powder. CAS No. 2254805-62-2. Molecular formula: C23H28ClN7O3S. Mole weight: 518.03. Purity: >98%. IUPACName: N-(2-((5-chloro-2-((2-methoxy-4-(4-methylpiperazin-1-yl)phenyl)amino)pyrimidin-4-yl)amino)phenyl)methanesulfonamide. Canonical SMILES: CS(=O)(NC1=CC=CC=C1NC2=NC(NC3=CC=C(N4CCN(C)CC4)C=C3OC)=NC=C2Cl)=O. Product ID: ACM2254805622. Alfa Chemistry ISO 9001:2015 Certified. Categories: ZH-29. | |
| ZXH 3-26 | ZXH 3-26 is a potent and selective BRD4 degrader (DC50 ~ 5 nM). Synonyms: methyl 2-((6S)-4-(4-chlorophenyl)-2-((5-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)pentyl)carbamoyl)-3,9-dimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetate; Methyl {(6S)-4-(4-chlorophenyl)-2-[(5-{[2-(2,6-dioxo-3-piperidinyl)-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl]amino}pentyl)carbamoyl]-3,9-dimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl}acetate; 6H-Thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetic acid, 4-(4-chlorophenyl)-2-[[[5-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]pentyl]amino]carbonyl]-3,9-dimethyl-, methyl ester, (6S)-; Methyl (6S)-4-(4-chlorophenyl)-2-[[[5-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]pentyl]amino]carbonyl]-3,9-dimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetate; ZXH 3-26. Grades: ≥98% by HPLC. CAS No. 2243076-67-5. Molecular formula: C38H37ClN8O7S. Mole weight: 785.27. | |
| ZXH-3-26 | ZXH-3-26 is a PROTAC connected by ligands for Cereblon and BRD4 with a DC50/5h of 5 nM. The DC50/5h refers to half-maximal degradation after 5 hours of treatment of ~ 5 nM[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2243076-67-5. Pack Sizes: 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-122826. | |
| ZY-444 | ZY-444 is a small molecule that suppresses breast cancer progression by targeting pyruvate carboxylase. Uses: Scientific research. Group: Signaling pathways. CAS No. 1802650-31-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-142870. | |
| Zygadenine | Zygadenine. Uses: Designed for use in research and industrial production. Additional or Alternative Names: Zygadenine;4α,9-Epoxycevane-3β,4,14,15α,16β,20-hexol. Product Category: Heterocyclic Organic Compound. CAS No. 545-45-9. Product ID: ACM545459. Alfa Chemistry ISO 9001:2015 Certified. | |
| Zygosporin D | Zygosporin D is produced by the strain of Zygosporium masonii MFC-612 and Zygosporium mycophylum MFC-702. It is cytotoxic to HeLa cells with ED50 of 0.4 μg/mL. It has anti-tumor and anti-inflammatory properties. Synonyms: Desacetylcytochalasin D; Deactylzygosporin A; (7S,13E,16S,18R,19E,21R)-7,18,21-Trihydroxy-16,18-dimethyl-10-phenyl[11]cytochalasa-6(12),13,19-triene-1,17-dione; 1H-Cycloundec[d]isoindole-1,11(2H)-dione, 3,3a,4,5,6,6a,9,10,12,15-decahydro-6,12,15-trihydroxy-4,10,12-trimethyl-5-methylene-3-(phenylmethyl)-, (3S, 3aR, 4S, 6S, 6aR, 7E, 10S, 12R, 13E, 15R, 15aR)-. CAS No. 25374-67-8. Molecular formula: C28H35NO5. Mole weight: 465.58. | |
| Zygosporin E | Zygosporin E is produced by the strain of Zygosporium masonii MFC-612 and Zygosporium mycophylum MFC-702. It is cytotoxic to HeLa cells with ED50 of 0.4 μg/mL. It has anti-tumor and anti-inflammatory properties. Synonyms: (7S,13E,16S,18S,19E,21R)-21-Acetoxy-7-hydroxy-16,18-dimethyl-10-phenyl[11]cytochalasa-6(12),13,19-triene-1,17-dione; 1H-Cycloundec[d]isoindole-1,11(2H)-dione, 15-(acetyloxy)-3,3a,4,5,6,6a,9,10,12,15-decahydro-6-hydroxy-4,10,12-trimethyl-5-methylene-3-(phenylmethyl)-, (3S, 3aR, 4S, 6S, 6aR, 7E, 10S, 12S, 13E, 15R, 15aR)-; Z-Val-Lys-Met 7-amido-4-methylcoumarin; Z-Val-Lys-Met-MCA. CAS No. 26399-27-9. Molecular formula: C30H37NO5. Mole weight: 491.62. | |
| Zygosporin F | Zygosporin F is produced by the strain of Zygosporium masonii MFC-612 and Zygosporium mycophylum MFC-702. It is cytotoxic to HeLa cells with ED50 of >10 μg/mL. It has anti-tumor and anti-inflammatory properties. Synonyms: Zygosporin E acetate; 7-Acetylcytochalasin D; (7S,13E,16S,18R,19E,21R)-7,21-Diacetoxy-18-hydroxy-16,18-dimethyl-10-phenyl[11]cytochalasa-6(12),13,19-triene-1,17-dione; 1H-Cycloundec[d]isoindole-1,11(2H)-dione, 6,15-bis(acetyloxy)-3,3a,4,5,6,6a,9,10,12,15-decahydro-12-hydroxy-4,10,12-trimethyl-5-methylene-3-(phenylmethyl)-, (3S, 3aR, 4S, 6S, 6aR, 7E, 10S, 12R, 13E, 15R, 15aR)-. CAS No. 25374-68-9. Molecular formula: C32H39NO7. Mole weight: 549.65. | |
| Zygosporin G | Zygosporin G is produced by the strain of Zygosporium masonii MFC-612 and Zygosporium mycophylum MFC-702. It is cytotoxic to HeLa cells with ED50 of 0.68 μg/mL. It has anti-tumor and anti-inflammatory properties. Synonyms: (13E,16S,18R,19E,21R)-21-(Acetyloxy)-18-hydroxy-16,18-dimethyl-10-phenyl[11]cytochalasa-6,13,19-triene-1,17-dione; 1H-Cycloundec[d]isoindole-1,11(2H)-dione, 15-(acetyloxy)-3, 3a, 4, 6a, 9, 10, 12, 15-octahydro-12-hydroxy-4, 5, 10, 12-tetramethyl-3-(phenylmethyl)-, (3S, 3aR, 4S, 6aS, 7E, 10S, 12R, 13E, 15R, 15aS)-. CAS No. 25374-69-0. Molecular formula: C30H37NO5. Mole weight: 491.62. | |
| Zymosan | Zymosan. CAS No. 58856-93-2. Product ID: 4-00301. Source : from Saccharomyces cerevisiae. |  |
| Zymosan | Zymosan. Group: Polymers. Alternative Names: ZYMOSAN; ZYMOSAN A; zymosans; Zymosan [immunological; Zymosan [immunological reagent]. CAS No. 9010-72-4. |  |
| Zymosan A | Zymosan A (Zymosan A from Saccharomyces cerevisiae) is a TLR2 agonist, that targeting TLRs can prevent and suppress IR-induced intestinal injury. Zymosan A exhibits a significant radioprotective effect, and protects IR-induced intestinal injury in mice. Zymosan A promotes the regeneration of intestinal stem cells (ISCs), after IR injury [1]. Uses: Scientific research. Group: Biochemical assay reagents. Alternative Names: Zymosan A from Saccharomyces cerevisiae. CAS No. 58856-93-2. Pack Sizes: 50 mg; 100 mg. Product ID: HY-W250113. | |
| Zymosan A from Saccharomyces cerevisiae | for inducing inflamatory response. Group: Fluorescence/luminescence spectroscopy. |  |
| Zymostenol | Zymostenol is an intermediate in the biosynthesis of cholesterol. It is an agonist of retinoic acid receptor-related orphan receptor γ (RORγ). Synonyms: Δ8-Cholesterol; (5α)-cholest-8-en-3β-ol; 3β-Hydroxy-5α-cholest-8(9)-ene; (3β,5α)-Cholest-8-en-3-ol. Grades: ≥95%. CAS No. 566-97-2. Molecular formula: C27H46O. Mole weight: 386.65. | |
| Zymostenol | Zymostenol is a late-stage precursor in the biosynthesis of cholesterol.1 It is an agonist of retinoic acid receptor-related orphan receptor γ (RORγ) with an EC50 value of 1uM in a RORγ coactivator recruitment assay in the presence of ursolic acid. It increases the number of myelin basic protein-positive oligodendrocytes generated from oligodendrocyte precursor cells in vitro.2 Zymostenol accumulates in cells following administration of microsomal antiestrogen-binding site (AEBS) ligands, such as tamoxifen, which are associated with cell differentiation and a protective type of autophagy.3,4 When used alone at a concentration of 20uM, zymostenol halts the cell cycle at the G0/G1 phase and increases the levels of free sterols, esterified sterols, and triacylglycerols in MCF-7 cells.3. Group: Biochemicals. Alternative Names: 5α-Cholest-8-en-3 β-ol; 3 β-Hydroxy-5α-cholest-8(9)-ene; Dihydrozymosterol; Δ8-Cholestenol; (3 β,5α)-Cholest-8-en-3-ol. Grades: Highly Purified. CAS No. 566-97-2. Pack Sizes: 5mg, 10mg, 25mg. Molecular Formula: C27H46O, Molecular Weight: 386.65. US Biological Life Sciences. | Worldwide |
| Zymostenol | Zymostenol (5a-Cholest-8-en-3b-ol) is a late-stage precursor in the biosynthesis of cholesterol. Zymostenol is a RORγ agonist ( EC 50 : 1 μM) [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: 5a-Cholest-8-en-3b-ol. CAS No. 566-97-2. Pack Sizes: 1 mg. Product ID: HY-113345. | |
| zymostenol-d7 | zymostenol-d7. Group: Others. Purity: >99%. Mole weight: 393.697. Stability: 6 Months. Storage: -20°C. Avanti Polar Lipids; lipid products; sterols; sterols products; singnal transduction; cell pathways; zymostenol-d7; zymostenol-d7. Cat No: STEZ-074. |  |
| Zymostenol-d7 | Zymostenol-d 7 is deuterium labeled 5a-Cholest-8-en-3b-ol. Uses: Scientific research. Group: Isotope-labeled compounds. Alternative Names: 5a-Cholest-8-en-3b-ol-d7. CAS No. 2260669-19-8. Pack Sizes: 1 mg. Product ID: HY-113345S. | |
| Zymosterol | Zymosterol is a Cholesterol (HY-N0322) biosynthesis metabolite. Zymosterol, a precursor of Cholesterol, is found mostly in the plasma membrane. Zymosterol circulates within the cell [1] [2]. Uses: Scientific research. Group: Natural products. CAS No. 128-33-6. Pack Sizes: 1 mg; 5 mg. Product ID: HY-114297. | |
| Z-YVAD-CMK trifluoroacetate salt | Z-YVAD-CMK is an inhibitor of caspase-1 and caspase-3. It exhibits anti-apoptotic, anti-inflammatory and neuroprotective effects. Synonyms: Benxyloxycarbonyl-Tyr-Val-Ala-Asp-Chloromethylketone; Caspase-1 Inhibitor IV. Grades: ≥95%. Molecular formula: C30H37ClN4O9·xCF3COOH. Mole weight: 633.09. | |
| Z-YVAD-FMK | Z-YVAD-FMK Inhibitor. Uses: Scientific use. Product Category: TP1466. CAS No. 210344-97-1. |  |
| Z-YVAD-FMK | Z-YVAD-FMK is a cell-permeant and irreversible caspase-1 inhibitor with anti-inflammatory activity. Synonyms: Caspase-1 Inhibitor; Z-YVAD fluoromethylketone; Z-YVAD-FMK; Caspase-1 Inhibitor VI; Z-Tyr-Val-Ala-Asp(OMe)-FMK; Z-Tyr-Val-Ala-Asp(OMe)-fluoromethyl ketone; benzyloxycarbonyl-Tyr-Val-Ala-Asp(OMe)-fluoromethylketone; methyl (5S,8S,11S,14S)-14-(2-fluoroacetyl)-5-(4-hydroxybenzyl)-8-isopropyl-11-methyl-3,6,9,12-tetraoxo-1-phenyl-2-oxa-4,7,10,13-tetraazahexadecan-16-oate. Grades: ≥95%. CAS No. 210344-97-1. Molecular formula: C31H39FN4O9. Mole weight: 630.67. | |
| Z-YVAD-FMK | Z-YVAD-FMK is a cell-permeable caspase-1 and -4 inhibitor with anti-inflammatory and anti-tumor activities[1]. Uses: Scientific research. Group: Peptides. CAS No. 210344-97-1. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P1009. | |
| z,z-Dienestrol | z,z-Dienestrol. Uses: Designed for use in research and industrial production. Additional or Alternative Names: (z,z)-dienestrol;4,4'-(1,2-diethylidene-1,2-ethanediyl)bis-,(z,z)-pheno;beta-dienestrol;cis,cis-dienestrol;isodienestrol;(Z,Z)-Dienoestrol;4,4'-[(1Z,2Z)-1,2-Diethylidene-1,2-ethanediyl]bisphenol;4,4'-[(2Z,4Z)-2,4-Hexadiene-3,4-diyl]bisphenol. Product Category: Heterocyclic Organic Compound. Appearance: White Solid. CAS No. 35495-11-5. Molecular formula: C18H18O2. Mole weight: 266.338. Density: 1.129g/cm³. Product ID: ACM35495115. Alfa Chemistry ISO 9001:2015 Certified. | |
| Z,Z-Dienestrol | Z,Z-Dienestrol. Group: Biochemicals. Alternative Names: 3,4-Bis(4-hydroxyphenyl)-2,4-hexadiene; b-Dienestrol; 4,4'-[(1Z,2Z)-1,2-Diethylidene-1,2-ethanediyl]bisphenol. Grades: Highly Purified. CAS No. 35495-11-5. Pack Sizes: 2mg, 5mg, 10mg, 25mg, 50mg. Molecular Formula: C18H18O2. US Biological Life Sciences. | Worldwide |
| Z,Z-Dienestrol (3,4-Bis(4-hydroxyphenyl)-2,4-hexadiene) | A metabolite of Diethylstilbestrol. Group: Biochemicals. Alternative Names: 3,4-Bis(4-hydroxyphenyl)-2,4-hexadiene. Grades: Highly Purified. CAS No. 35495-11-5. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
| Z,Z-Dienestrol-d6 | A labeled metabolite of Diethylstilbestrol. Group: Biochemicals. Alternative Names: 3,4-Bis(4-hydroxyphenyl)-2,4-hexadiene-d6; β-Dienestrol-d6; 4,4'-[(1Z,2Z)-1,2-Diethylidene-1,2-ethanediyl]bisphenol-d6. Grades: Highly Purified. CAS No. 91297-99-3. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| Z,Z-Dienestrol Diacetate | Protected Z,Z-Dienestrol. A metabolite of Diethylstilbestrol. Group: Biochemicals. Alternative Names: β-Dienestrol diacetate; 4, 4'- (Diethylideneethylene) diphenol Diacetate; (Z,Z)-4,4'-(1,2-diethylidene-1,2-ethanediyl)bisphenol Diacetate. Grades: Highly Purified. CAS No. 24705-62-2. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| ZZW-115 | ZZW-115 is a potent NUPR1 inhibitor. ZZW-115 induces ferroptosis in a mitochondria-dependent manner. ZZW-115 induces ROS accumulation followed by a ferroptotic cell death, which could be prevented by ferrostatin-1 (Fer-1) and ROS-scavenging agents. In addition, ZZW-115-treatment increases the accumulation of hydroperoxided lipids in these cells. ZZW-115-induced mitochondrial morphological changes, compatible with the ferroptotic process, as well as mitochondrial network disorganization and strong mitochondrial metabolic dysfunction, which are rescued by both Fer-1 and N-acetylcysteine (NAC). Of note, the expression of TFAM, a key regulator of mitochondrial biogenesis, is downregulated by ZZW-115. Uses: Designed for use in research and industrial production. Additional or Alternative Names: ZZW-115; ZZW 115; ZZW115. Product Category: Inhibitors. Appearance: Solid powder. CAS No. 801991-87-7. Molecular formula: C24H31F3N4S. Mole weight: 464.6. Purity: >98%. IUPACName: N,N-dimethyl-2-(4-(3-(2-(trifluoromethyl)-10H-phenothiazin-10-yl)propyl)piperazin-1-yl)ethan-1-amine. Canonical SMILES: FC(C(C=C1N2CCCN3CCN(CCN(C)C)CC3)=CC=C1SC4=C2C=CC=C4)(F)F. Product ID: ACM801991877. Alfa Chemistry ISO 9001:2015 Certified. | |
| ZZW-115 hydrochloride | ZZW-115 hydrochloride is a potent NUPR1 inhibitor, with a K d of 2.1 μM. ZZW-115 hydrochloride induces tumor cell death by necroptosis and apoptosis. Anticancer activity [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 10122-45-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-111838A. | |
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