American Chemical Suppliers
A directory of where to buy chemicals in the USA, including: distributors, industrial manufacturers, bulk supplies and wholesalers of raw ingredients & finished goods.
Search for products or services, then visit the suppliers website for prices or more information.
Product | Description | |
---|---|---|
TAS-108 Quick inquiry Where to buy Suppliers range | TAS-108, also known as SR16234, is a synthetic, antiestrogenic steroidal compound with potential antitumor activity. TAS-108 binds to and inhibits estrogenic receptor alpha (ERa), mainly expressed in the mammary gland and uterus and upregulated in estrogen-dependent tumors. Blockage of ERa by TAS-108 prevents the binding and effects of estrogen and may lead to an inhibition of estrogen-dependent cancer cell proliferation. TAS-108 also is a partial agonist of the estrogenic receptor beta (ERb), expressed in many tissues including the central nervous system, urogenital tract, bone and cardiovascular system, thereby exerting a positive effect on these tissues. In addition, TAS-108 activates the co-repressor Silencing Mediator for Retinoid and Thyroid hormone receptor (SMRT), a protein that inhibits the activities of the estrogen receptors, which may contribute to the antitumor activity of TAS-108. Synonyms: TAS108; TAS 108; SR16234; SR 16234; SR-16234; (7alpha)-21-(4-((Diethylamino)methyl)-2-methoxyphenoxy)-7-methyl-19-norpregna-1,3,5(10)-trien-3-ol 2-hydroxy-1,2,3-propanetricarboxylate. Grades: >98%. CAS No. 229634-98-4. Molecular formula: C39H55NO10. Mole weight: 697.86. | |
TAS-115 Quick inquiry Where to buy Suppliers range | This active molecular is a c-MET and VEGFR inhibitor which is selective and specific in vitro. In vivo studies, TAS-115 suppressed the progression of MET-inactivated tumor completely through blocking angiogenesis without toxicity and it also induced marked tumor shrinkage and prolonged survival in animal model. In Dec 2013, Phase-I development was ongoing in Japan. In Dec 2014, Taiho Pharmaceutical completed a phase I trial for Solid tumours in Japan. In Apr 2016, preclinical data was presented. Uses: Solid tumours. Synonyms: TAS-115; TAS 115; TAS115; 4-(2-fluoro-4-(3-(2-phenylacetyl)thioureido)phenoxy)-7-methoxy-N-methylquinoline-6-carboxamide. Grades: 98%. CAS No. 1190836-34-0. Molecular formula: C27H23FN4O4S. Mole weight: 518.56. | |
TAS-116 Quick inquiry Where to buy Suppliers range | TAS-116 is a inhibitor of Hsp90. It induces significant cytotoxicity in MM cells even in the presence of BMSCs, associates with downregulation of phospho-Akt and phospho-ERK. In addition, neither exogenous IL-6 nor IGF-1 was able to protect against TAS-116. Importantly, TAS-116 did not induce cytotoxicity in BMSCs. TAS-116 enhanced bortezomib-induced cytotoxicity in MM.1S and RPMI-8226 cells, associated with decreased phospho-Akt, phospho-RelA (p65), phospho-IkBa, and phospho-IKKα/β; as well as increased CHOP and PARP cleavage. These results suggest that TAS-116 blocks bortezomib-induced canonical NF-κB pathway and augments bortezomib-induced endoplasmic reticulum (ER) stress. Synonyms: TAS116; TAS 116; TAS-116; 3-Ethyl-4-[3-(1-methylethyl)-4-[4-(1-methyl-1H-pyrazol-4-yl)-1H-imidazol-1-yl]-1H-pyrazolo[3,4-b]pyridin-1-yl]benzamide. Grades: >98%. CAS No. 1260533-36-5. Molecular formula: C25H26N8O. Mole weight: 454.54. | |
TAS 301 Quick inquiry Where to buy Suppliers range | TAS 301. Group: Biochemicals. Grades: Purified. CAS No. 193620-69-8. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
TAS-301 Quick inquiry Where to buy Suppliers range | TAS-301 is a potent and selective constrictive remodeling regulator on renarrowing after balloon overstretch injury of porcine coronary artery. TAS-103 inhibits smooth muscle cell migration and proliferation. Synonyms: TAS-301; TAS301; TAS301. Grades: 98%. CAS No. 193620-69-8. Molecular formula: C23H19NO3. Mole weight: 357.41. | |
TAS4464 Quick inquiry Where to buy Suppliers range | TAS4464 is a potent and selective NEDD8 activating enzyme (NAE) inhibitor with IC50 of 0.955 nM. It selectively inhibits NAE relative to the other E1s UAE and SAE. TAS4464 treatment inhibits cullin neddylation and subsequently induces the accumulation of CRL substrates such as CDT1, p27, and phosphorylated IkBa in human cancer cell lines. Synonyms: 7H-Pyrrolo[2,3-d]pyrimidin-4-amine, 7-[5-[(aminosulfonyl)amino]-5-deoxy-beta-D-ribofuranosyl]-5-[2-(2-ethoxy-6-fluorophenyl)ethynyl]-. CAS No. 1848959-10-3. Molecular formula: C21H23FN6O6S. Mole weight: 506.5. | |
TAS6417 Quick inquiry Where to buy Suppliers range | TAS6417 is a novel EGFR inhibitor that targets EGFR exon 20 insertion mutations while sparing wild-type (WT) EGFR. TAS6417 inhibited EGFR phosphorylation and downstream molecules in NSCLC cell lines expressing EGFR exon 20 insertions, resulting in caspase activation. Synonyms: CLN-081; TPC-064; TAS 6417; TAS-6417; Zipalertinib. CAS No. 1661854-97-2. Molecular formula: C23H20N6O. Mole weight: 396.44. | |
TaSe2 Crystal Quick inquiry Where to buy Suppliers range | TaSe2 Crystal. Group: Graphene-like Materials Series. Alternative Names: Tantalumdiselenide; tantalumselenide(tase2); TANTALUM SELENIDE;Tantalum(IV) selenide. Grades: 99.995%. CAS No. 12039-55-3. Molecular formula: Se2Ta. Mole weight: 338.87. | |
Taselisib Quick inquiry Where to buy Suppliers range | Taselisib, also known as GDC0032 or RG7606, is a selective, potent, orally bioavailable inhibitor of PI3Ka with a Ki = 0.2nM, and with reduced inhibitory activity against PI3K. This selectivity profile, and excellent pharmacokinetic and pharmaceutical properties, allowed for greater efficacy in vivo at the maximum tolerated dose relative to a pan Class I PI3K inhibitor in PIK3CA mutant xenografts. Notably, GDC-0032 preferentially inhibited PIK3CA mutant cells relative to cells with wild-type PI3K. GDC-0032 potently inhibits signal transduction downstream of PI3K and induces apoptosis at low concentrations in breast cancer cell lines and xenograft models that harbor PIK3CA mutations. Synonyms: GDC-0032; GDC0032; GDC 0032; RG7604; RG-7604; RG 7604; Taselisib. CAS No. 1282512-48-4. Molecular formula: C24H28N8O2. Mole weight: 460.542. | |
Tasidotin Quick inquiry Where to buy Suppliers range | Tasidotin. Group: Heterocyclic Organic Compound. Alternative Names: Tasidotin [INN], UNII-05G07285DK, CID9895066, CID 9895066, 192658-64-3. Grades: 96%. CAS No. 192658-64-3. Molecular formula: C32H59ClN6O5. Mole weight: 643.30. IUPAC Name: (2S)-N-tert-butyl-1-[(2S)-1-[(2S)-2-[[(2S)-2-[[(2S)-2-(dimethylamino)-3-methylbutanoyl]amino]-3-methylbutanoyl]-methylamino]-3-methylbutanoyl]pyrrolidine-2-carbonyl]pyrrolidine-2-carboxamide. Exact Mass: 606.44700. InChIKey: QMCOCIWNMHBIIA-LROMGURASA-N. H-Bond Donor: 2. H-Bond Acceptor: 6. | |
Tasidotin hydrochloride Quick inquiry Where to buy Suppliers range | Tasidotin, also know as ILX-651, is an orally active synthetic microtubule-targeted derivative of the marine depsipeptide dolastatin-15, is currently undergoing clinical evaluation for cancer treatment. Tasidotin inhibited proliferation of MCF7/GFP breast cancer cells with an IC(50) of 63 nmol/L and inhibited mitosis with an IC(50) of 72 nmol/L in the absence of detectable effects on spindle microtubule polymer mass. Tasidotin inhibited the polymerization of purified tubulin into microtubules weakly (IC(50) approximately 30 micromol/L). However, it strongly suppressed the dynamic instability behavior of the microtubules at their plus ends at concentrations approximately 5 to 10 times below those required to inhibit polymerization. Synonyms: ILX 651; ILX651; ILX-651. CAS No. 623174-20-9. Molecular formula: C32H59ClN6O5. Mole weight: 643.31. | |
Tasimelteon Quick inquiry Where to buy Suppliers range | Tasimelteon (trade name Hetlioz) is a drug approved by the FDA solely for the treatment of non-24-hour sleep-wake disorder (often designated as N24HSWD) in totally blind adults. It is a selective agonist for the melatonin receptors MT1 and MT2 in the suprachiasmatic nucleus of the brain, similar to other members of the melatonin receptor agonist class of which ramelteon (2005) and agomelatine (2009) were the first approved. Uses: Tasimelteon is a novel drug, used in the treatment of non-24 hour sleep-wake disorder. it helps to correct the circadian rhythm disorder often seen in patients who are visually impaired. Synonyms: BMS-214,778; BMS-214778; BMS214778; BMS 214778. VEC-162; VEC162; VEC 162. Trade name: Hetlioz. Grades: ≥ 99.0%. CAS No. 609799-22-6. Molecular formula: C15H19NO2. Mole weight: 245.32. | |
Tasimelteon Quick inquiry Where to buy Suppliers range | Tasimelteon. Group: Heterocyclic Organic Compound. Alternative Names: tasimelteon; (1R-trans) -N-[[2- (2, 3-Dihydro-4-benzofuranyl) cyclopropyl]methyl]propanamide; BMS 214778;MA 1;VEC 162; TasiMelteon/BMS214778; Tasimelteon (1R-trans) -N-[[2- (2, 3-Dihydro-4-benzofuranyl) cyclopropyl]methyl]propanamide; tasimelteon impurity A. CAS No. 609799-22-6. Product ID: ACM609799226. Molecular formula: C15H19NO2. Mole weight: 245.32. Density: 1.145. | |
TASIN-1 Quick inquiry Where to buy Suppliers range | TASIN-1 is an inhibitor of adenomatous polyposis coli (APC) that kills colorectal cancer cells that express APC by reducing cellular cholesterol levels. It also inhibits AKT activity through a cholesterol-dependent manner. Synonyms: 1'-[(4-Methoxyphenyl)sulfonyl]-4-methyl-1,4'-bipiperidine. Grades: ≥98%. CAS No. 792927-06-1. Molecular formula: C18H28N2O3S. Mole weight: 352.5. | |
Tasisulam Quick inquiry Where to buy Suppliers range | Tasisulam is a small molecule anticancer drug that induces apoptosis through intrinsic pathways. It leads to the release of cytochrome c and caspase-dependent cell death. Tasisulam can inhibit the process of mitosis and induce vascular normalization. Synonyms: LY 573636; LY573636; N-(2,4-Dichlorobenzoyl)-5-bromothiophene-2-sulfonamide. Grades: >98%. CAS No. 519055-62-0. Molecular formula: C11H6BrCl2NO3S2. Mole weight: 415.11. | |
Tasosartan Quick inquiry Where to buy Suppliers range | Tasosartan. Uses: For analytical and research use. Group: Enzyme Activators, Inhibitors & Substrates. Alternative Names: Pyrido[2,3-d]pyrimidin-7(6H)-one, 5,8-dihydro-2,4-dimethyl-8-[[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]- (9CI), Verdia, WAY-ANA 756,Pyrido[2,3-d]pyrimidin-7(6H)-one, 5,8-dihydro-2,4-dimethyl-8-[[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-, Tasosartan, 5,8-Dihydro-2,4-dimethyl-8-[[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]pyrido[2,3-d]pyrimidin-7(6H)-one. CAS No. 145733-36-4. Pack Sizes: 10MG. IUPAC Name: 2,4-dimethyl-8-[[4-[2-(1H-tetrazol-5-yl)phenyl]phenyl]methyl]-5,6-dihydropyrido[2,3-d]pyrimidin-7-one. Molecular formula: C23H21N7O. Mole weight: 411.46. Catalog: APS145733364. SMILES: Cc1nc (C)c2CCC (=O)N (Cc3ccc (cc3)c4ccccc4c5nnn[nH]5)c2n1. Format: Neat. Shipping: Room Temperature. | |
Tasosartan Quick inquiry Where to buy Suppliers range | Tasosartan. Group: Heterocyclic Organic Compound. Alternative Names: TASOSARTAN;2,4-Dimethyl-8-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]-5,6-dihydropyrido[6,5-d]pyrimidin-7-one. CAS No. 145733-36-4. Molecular formula: C23H21N7O. Mole weight: 411.46. | |
Tasosartan Quick inquiry Where to buy Suppliers range | Tasosartan, a pyrido-pyrimidin derivative, has been found to be an angiotensin II receptor antagonist that could have probable effect against hypertension. It has been discontinued for some security problems by Wyeth. Synonyms: TASOSARTAN;2,4-Dimethyl-8-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]-5,6-dihydropyrido[6,5-d]pyrimidin-7-one. Grades: 98%. CAS No. 145733-36-4. Molecular formula: C23H21N7O. Mole weight: 411.46. | |
TASP 0390325 Quick inquiry Where to buy Suppliers range | TASP 0390325 is a potent and selective vasopressin V1B receptor antagonist (IC50 = 2.22 nM for rat pituitary receptor) with no significant affinity for 85 other receptors, ion channels and transporters at 10 μM, including V1A and V2. TASP 0390325 increases ACTH levels in rats. TASP 0390325 has the potential use as antidepressant and anxiolytic. Synonyms: TASP0390325, TASP 0390325, TASP-0390325; 2-(3-Chloro-4-fluorophenyl)-N-(1-methylethyl)-6-[3-(4-morpholinyl)propoxy]-4-oxo-pyrido[2,3-d]pyrimidine-3(4H)-acetamide hydrochloride. Grades: ≥98% by HPLC. CAS No. 1642187-96-9. Molecular formula: C25H29ClFN5O4.HCl. Mole weight: 554.44. | |
TASP-0415914 Quick inquiry Where to buy Suppliers range | Potent, orally applicable PI3K y inhibitor. PI3Ky is required for for T-cell and B-cell as well as mast cell migration and degranulation. As such, these kinases are attractive targets for potential anti-infmamatory drugs. TASP-0415914 has shown excellent results in cell based assays. It is orally available and has performed will in murine in vivo models. PI3Ky IC(50) 29nm, AKT IC(50) 294nm. Group: Biochemicals. Grades: Highly Purified. CAS No. 1292300-75-4. Pack Sizes: 1mg, 5mg. Molecular Formula: C13H17N5O3S, Target: PI3Kγ. US Biological Life Sciences. | Worldwide |
TASP 0433864 Quick inquiry Where to buy Suppliers range | TASP 0433864 is a selective and positive allosteric modulator of mGlu2 receptor (EC50 = 199 and 206 nM for human and rat receptors, respectively) with no agonist activity at rat mGlu2 receptors. It displays weak activity against a range of neurotransmitter targets except 5-HT2B and MAO-B (72 and 92% inhibition at 10 μM, respectively). Synonyms: TASP0433864, TASP0433864, TASP0433864; (2S)-2-[[4-(1,1-Dimethylethyl)phenoxy]methyl]-2,3-dihydro-5-methylimidazo[2,1-b]oxazole-6-carboxamide. Grades: ≥98% by HPLC. CAS No. 1431980-60-7. Molecular formula: C18H23N3O3. Mole weight: 329.39. | |
Taspine Quick inquiry Where to buy Suppliers range | Taspine. Uses: For analytical and research use. Group: Phytochemicals. CAS No. 602-07-3. Pack Sizes: 5MG. Molecular formula: C20H19NO6. Mole weight: 369.37. Catalog: APS602073. SMILES: COc1ccc2C (=O)Oc3c (OC)cc (CCN (C)C)c4C (=O)Oc1c2c34. Format: Neat. Shipping: Room Temperature. | |
Taspine Quick inquiry Where to buy Suppliers range | Taspine is an alkaloid isolated from Radix et Rhizoma Leonticis. It shows various pharmaceutical properties: bacteriostatic, wound healing, cytotoxicity, immunosuppression, acetilcholinesterase inhibition, and inhibition of the activity of tumor angiogenesis. Used as human acid beta-glucosidase inhibitor and for the treatment of Gaucher disease. Group: Biochemicals. Alternative Names: 1-[2-(Dimethylamino)ethyl]-3,8-dimethoxy-[1]benzopyrano[5,4,3-cde][1]benzopyran-5,10-dione; Thaspine; NSC 688259; Taspin. Grades: Highly Purified. CAS No. 602-07-3. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
Taspoglutide Quick inquiry Where to buy Suppliers range | Taspoglutide is a long-acting glucagon-like peptide 1 (GLP-1) receptor agonist (EC50 = 0.06 nM) under investigation for treatment of type 2 diabetes. Synonyms: (N-((N-(L-histidyl)-2-aminoisobutyryl)-L-alpha-glutamyl-glycyl-L-threonyl-L-phenylalanyl-L-threonyl-L-seryl-L-alpha-aspartyl-L-valyl-L-seryl-L-seryl-L-tyrosyl-L-leucyl-L-alpha-glutamyl-glycyl-L-glutaminyl-L-alanyl-L-alanyl-L-lysyl-L-alpha-glutamyl-L-phenylalanyl-L-isoleucyl-L-alanyl-L-tryptophyl-L-leucyl-L-valyl-L-lysyl)-2-aminoisobutyryl)-L-argininamide; H-His-Aib-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Val-Ser-Ser-Tyr-Leu-Glu-Gly-Gln-Ala-Ala-Lys-Glu-Phe-Ile-Ala-Trp-Leu-Val-Lys-Aib-Arg-NH2. CAS No. 275371-94-3. Molecular formula: C152H232N40O45. Mole weight: 3339.71. | |
Taspoglutide Quick inquiry Where to buy Suppliers range | Taspoglutide is a pharmaceutical drug, a glucagon-like peptide-1 agonist (GLP-1 agonist), under investigation for treatment of type 2 diabetes being codeveloped by Ipsen and Roche. Uses: API. CAS No. 275371-94-3. Product ID: 10-101-176. | |
Taspoglutide trifluoroacetate salt Quick inquiry Where to buy Suppliers range | ≥95% (HPLC). Uses: For analytical and research use. Group: Fluorescence/Luminescence Spectroscopy. CAS No. 275371-94-3 (free base). Pack Sizes: 5MG, 25MG. Mole weight: 3339.71 (free base basis). Catalog: ALP275371943. Assay: ≥95% (HPLC). | |
Tasquinimod Quick inquiry Where to buy Suppliers range | Tasquinimod is a quinoline-3-carboxamide linomide analogue with antiangiogenic and potential antineoplastic activities. Tasquinimod has been shown to decrease blood vessel density but the exact mechanism of action is not known. This agent has also been shown to augment the antineoplastic effects of docetaxel and androgen ablation in a murine model of prostate cancer involving human prostate cancer xenografts. Uses: For research used only. Synonyms: ABR215050, ABR-215050, ABR 215050, Tasquinimod. Grades: 0.98. CAS No. 254964-60-8. Molecular formula: C20H17F3N2O4. Mole weight: 406.361. | |
Tasquinimod, 98% Quick inquiry Where to buy Suppliers range | Tasquinimod, 98%. Group: Cancer Research. CAS No. 254964-60-8. Pack Sizes: 5mg. ID EBT930. | |
TAT Quick inquiry Where to buy Suppliers range | TAT (YGRKKRRQRRR) is a HIV-1 virus-encoded Tat peptide, which can increase the yields and the solubility of heterologous proteins. Uses: Peptide Inhibitors. Product ID: R1705. | |
TAT 14 Quick inquiry Where to buy Suppliers range | TAT 14 is an Nrf2 activator and inhibits Nrf2/Keap1 interaction with neuroprotective activity. TAT 14 has been shown to induce upregulation of Nrf2 pathway downstream gene expression including heme-oxygenase 1 and suppress LPS-induced TNF-α expression in THP-1 cells. Synonyms: TAT14; TAT-14; H-Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-Leu-Gln-Leu-Asp-Glu-Glu-Thr-Gly-Glu-Phe-Leu-Pro-Ile-Gln-OH; L-tyrosyl-glycyl-L-arginyl-L-lysyl-L-lysyl-L-arginyl-L-arginyl-L-glutaminyl-L-arginyl-L-arginyl-L-arginyl-L-leucyl-L-glutaminyl-L-leucyl-L-alpha-aspartyl-L-alpha-glutamyl-L-alpha-glutamyl-L-threonyl-glycyl-L-alpha-glutamyl-L-phenylalanyl-L-leucyl-L-prolyl-L-isoleucyl-L-glutamine; TAT 14 Peptide (Nrf2 Activator III). Grades: ≥95%. CAS No. 1362661-34-4. Molecular formula: C137H230N48O39. Mole weight: 3173.59. | |
TAT 14 Quick inquiry Where to buy Suppliers range | TAT 14. Uses: HIV-TAT Family. CAS No. 1362661-34-4. Product ID: GR1229. | |
TAT 14 Quick inquiry Where to buy Suppliers range | TAT 14. Group: Biochemicals. Grades: Purified. CAS No. 1362661-34-4. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
TAT 2-4 Quick inquiry Where to buy Suppliers range | TAT 2-4 is a peptide derived from HIV-1 transactivator of transcription (Tat) protein. Uses: Peptide Inhibitors. CAS No. 1159916-66-1. Product ID: R1707. | |
TAT (47-57) Quick inquiry Where to buy Suppliers range | TAT (YGRKKRRQRRR) is derived from the transactivator of transcription (TAT) of human immunodeficiency virus-1 (HIV-1) and is a cell-penetrating peptide. TAT can increase the yields and the solubility of heterologous proteins. Uses: HIV-TAT Family. CAS No. 191936-91-1. Product ID: GR1204. | |
TAT (47-57), FAM-labeled Quick inquiry Where to buy Suppliers range | It is a fluorescent (FAM) labeled TAT peptide, Abs/Em=494/521 nm. TAT is the most characteristic fragment of HIV trans-activator protein (TAT). The arginine-rich TAT peptide penetrates the plasma membrane directly rather than through endocytosis. Synonyms: FAM-Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-OH; N-[(3',6'-Dihydroxy-3-oxo-3H-spiro[2-benzofuran-1,9'-xanthen]-5-yl)carbonyl]-L-tyrosylglycyl-L-arginyl-L-lysyl-L-lysyl-L-arginyl-L-arginyl-L-glutaminyl-L-arginyl-L-arginyl-L-arginine; 5-FAM-HIV-1 Tat Protein (47-57). Grades: ≥95%. CAS No. 1676104-81-6. Molecular formula: C85H128N32O20. Mole weight: 1918.16. | |
TAT (47-57), FAM-labeled Quick inquiry Where to buy Suppliers range | This is a fluorescent (FAM)-labeled TAT peptide, Abs/Em = 494/521 nm. Uses: HIV-TAT Family. Product ID: GR1209. | |
TAT (47-57) GGG-Cys(Npys) Quick inquiry Where to buy Suppliers range | This peptide corresponds to the protein transduction domain of the TAT protein and is synthesized with an activated cysteine residue C(Npys), wherein Npys is 3-Nitro-2-pyridinesulfenyl group and is used for activating S of cysteine and for rapid reaction when a thiol group is introduced. The N-terminus is rendered free for applications requiring certain conjugation reactions with a free N-terminal end, and a linker GGG is placed at the C-terminal end, and the peptide has been synthesized with the C(Npys) group. This kind of modification has been used to render this peptide as a cell penetrating and carrier peptide applicable in conjugation studies. Uses: HIV-TAT Family. Product ID: GR1208. | |
TAT (47-57) GGG-Cys(Npys) Quick inquiry Where to buy Suppliers range | It corresponds to the protein transduction domain of the TAT protein and is synthesized with an activated cysteine residue C(Npys), where Npys is 3-Nitro-2-pyridinesulfenyl group and is used for activating S of cysteine and for rapid reaction when a thiol group is introduced. The N-terminus is rendered free for applications requiring certain conjugation reactions with a free N-terminal end, and a linker GGG is placed at the C-terminal end, and the peptide has been synthesized with the C(Npys) group. This kind of modification has been used to render this peptide as a cell penetrating and carrier peptide applicable in conjugation studies. Synonyms: H-Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-Gly-Gly-Gly-Cys(Npys)-NH2. Grades: ≥95%. Molecular formula: C78H135N39O19S2. Mole weight: 1987.29. | |
TAT (47-57), TAMRA-labeled Quick inquiry Where to buy Suppliers range | This is a fluorescent (TAMRA)-labeled TAT peptide, Abs/Em=541/568. Uses: HIV-TAT Family. Product ID: GR1210. | |
TAT (47-57), TAMRA-labeled Quick inquiry Where to buy Suppliers range | It is a fluorescent (TAMRA)-labeled TAT peptide, Abs/Em=541/568 nm. TAT is the most characteristic fragment of HIV trans-activator protein (TAT). The arginine-rich TAT peptide penetrates the plasma membrane directly rather than through endocytosis. Synonyms: TAMRA-Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-OH. Grades: ≥95%. | |
TAT (48-57) Quick inquiry Where to buy Suppliers range | This peptide is amino acid residues 48 to 57 fragment of the basic domain of HIV Tat. It contains the protein transduction domain (PTD) of the HIV Tat protein. Uses: HIV-TAT Family. Product ID: GR1206. | |
TAT 48-57 Quick inquiry Where to buy Suppliers range | TAT (48-57) is a cell-permeable peptide, derived from HIV-1 transactivator of transcription (Tat) protein residue 48-57. Uses: Peptide Inhibitors. CAS No. 253141-50-3. Product ID: R1708. | |
TAT (48-57) TFA Quick inquiry Where to buy Suppliers range | TAT (48-57) (TFA) is a cell-permeable peptide, derived from HIV-1 transactivator of transcription (Tat) protein residue 48-57. Uses: Peptide Inhibitors. Product ID: R1706. | |
Tat-beclin 1 Quick inquiry Where to buy Suppliers range | Tat-beclin 1 is a region of the autophagy protein, beclin 1, binding to HIV-1 Nef and inducing autophagy. Synonyms: Tat-BECN1. CAS No. 1423821-88-8. Molecular formula: C164H251N57O45. Mole weight: 3741.1. | |
Tat-Beclin-1 Quick inquiry Where to buy Suppliers range | Beclin-1 peptide is the HIV-1 Nef binding portion of full-length human Beclin-1 protein (amino acids 267-299). Beclin-1 protein is an autophagy inducing agent that may trigger cellular adaptation, survival or cell death. When conjugated to the cell-permeable peptide, it can successfully enter cells and induce autophagy. RELATED PRODUCTS:Beclin-1, Cat# 65466Tat-Beclin-1, scrambled, Cat# 65468. Uses: HIV-TAT Family. Product ID: GR1214. | |
Tat-Beclin-1 Quick inquiry Where to buy Suppliers range | Beclin-1 peptide is the HIV-1 Nef binding portion of full-length human Beclin-1 protein (amino acids 267-299). Beclin-1 protein is an autophagy inducing agent that triggers cell adaptation, survival, or death. When combined with the cell-permeable peptide, it can successfully enter cells and induce autophagy. Synonyms: Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-Gly-Gly-Thr-Asn-Val-Phe-Asn-Ala-Thr-Phe-Glu-Ile-Trp-His-Asp-Gly-Glu-Phe-Gly-Thr-OH; Tat-BECN1. Grades: ≥95%. Molecular formula: C164H251N57O45. Mole weight: 3741.15. | |
Tat-Beclin-1, scrambled Quick inquiry Where to buy Suppliers range | Beclin-1 peptide is the HIV-1 Nef binding portion of full-length human Beclin-1 protein (amino acids 267-299). Beclin-1 protein is an autophagy inducing agent that triggers cell adaptation, survival, or death. When combined with the cell-permeable peptide, it can successfully enter cells and induce autophagy. Tat-Beclin-1, scrambled will not induce autophagy and can be used as a negative control. Synonyms: H-Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-Gly-Gly-Val-Gly-Asn-Asp-Phe-Phe-Ile-Asn-His-Glu-Thr-Thr-Gly-Phe-Ala-Thr-Glu-Trp-OH. Grades: ≥95% by HPLC. Molecular formula: C164H251N57O45. Mole weight: 3741.15. | |
Tat-Beclin-1, scrambled Quick inquiry Where to buy Suppliers range | Beclin-1 peptide is the HIV-1 Nef binding portion of full-length human Beclin-1 protein (amino acids 267-299). Beclin-1 protein is an autophagy inducing agent that may trigger cellular adaptation, survival or cell death. When conjugated to the cell-permeable peptide, it can successfully enter cells and induce autophagy. Tat-Beclin-1, scrambled will not induce autophagy and can be used as a negative control. RELATED PRODUCTS:Tat-Beclin-1, Cat# 65467Beclin-1, Cat# 65466. Uses: HIV-TAT Family. Product ID: GR1215. | |
TAT- C (48-57) Quick inquiry Where to buy Suppliers range | This peptide is amino acids 48 to 57 fragment of TAT with an additional cysteine residue at the N-terminus. This peptide contains the protein transduction domain (PTD) of the HIV Tat protein that inhibits HSV-1 entry. The addition of a cysteine residue to the N-terminus of the Tat-PTD (Tat-C peptide) improves the antiviral activity against HSV-1 and HSV-2. Tat-C acts extracellularly, blocking entry of adsorbed virus immediately without eluting virions. Uses: HIV-TAT Family. Product ID: GR1207. | |
TAT-C (48-57) Quick inquiry Where to buy Suppliers range | It is amino acids 48 to 57 fragment of TAT with an additional cysteine residue at the N-terminus. The peptide contains a protein transduction domain (PTD) that inhibits HSV-1 entry into the HIV Tat protein. The addition of cysteine residue to the N-terminus of the Tat-PTD (Tat-C peptide) improves the antiviral activity against HSV-1 and HSV-2. Tat-C acts extracellular and immediately blocks the entry of adsorptive virus without eluting virions. Synonyms: H-Cys-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-OH; (Cys47)-HIV-1 tat Protein (47-57); L-cysteinyl-glycyl-L-arginyl-L-lysyl-L-lysyl-L-arginyl-L-arginyl-L-glutaminyl-L-arginyl-L-arginyl-L-arginine. Grades: ≥95%. CAS No. 627079-23-6. Molecular formula: C58H114N32O13S. Mole weight: 1499.82. | |
TAT-cyclo-CLLFVY Quick inquiry Where to buy Suppliers range | TAT-cyclo-CLLFVY has been found to be a HIF-1 dimerization inhibitor and could block protein-protein interaction of recombinant HIF-1&alpha. Synonyms: TAT-cyclo-CLLFVY; 1446322-66-2; AKOS027470216; PD079835. Grades: ≥95% by HPLC. CAS No. 1446322-66-2. Molecular formula: C111H188N42O24S2. Mole weight: 2559.10. | |
TAT-cyclo-CLLFVY Quick inquiry Where to buy Suppliers range | TAT-cyclo-CLLFVY is a selective HIF-1 dimerization inhibitor. TAT-cyclo-CLLFVY blocks protein-protein interaction of recombinant HIF-1α, but not HIF-2α, with HIF-1β (IC50=1.3 μM). TAT-cyclo-CLLFVY inhibits hypoxia-induced HIF-1 activity and decreases VEGF and CAIX expression in osteosarcoma and breast cancer cells in vitro. TAT-cyclo-CLLFVY also reduces the tubularization of hypoxic HUVECs. Uses: HIV-TAT Family. CAS No. 1446322-66-2. Product ID: GR1228. | |
TAT-Gap19 Quick inquiry Where to buy Suppliers range | TAT-Gap19. Uses: HIV-TAT Family. CAS No. 1507930-54-2. Product ID: GR1230. | |
TAT-Gap19 Quick inquiry Where to buy Suppliers range | TAT-Gap19 is a brain penetrating Cx43 hemichannel blocker (IC50 ~7 μM) with no significant affinity for gap junctions or Panx1 channels. Synonyms: H-Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-Lys-Gln-Ile-Glu-Ile-Lys-Lys-Phe-Lys-OH; L-tyrosyl-glycyl-L-arginyl-L-lysyl-L-lysyl-L-arginyl-L-arginyl-L-glutaminyl-L-arginyl-L-arginyl-L-arginyl-L-lysyl-L-glutaminyl-L-isoleucyl-L-alpha-glutamyl-L-isoleucyl-L-lysyl-L-lysyl-L-phenylalanyl-L-lysine. Grades: 97%. CAS No. 1507930-54-2. Molecular formula: C119H212N46O26. Mole weight: 2703.28. | |
TAT-Gap19 trifluoroacetate salt Quick inquiry Where to buy Suppliers range | ≥95% (HPLC). Uses: For analytical and research use. Group: Fluorescence/Luminescence Spectroscopy. CAS No. 1507930-54-2 (free base). Pack Sizes: 1MG. Mole weight: 2703.25 (free base basis). Catalog: ALP1507930542. Assay: ≥95% (HPLC). | |
TAT-GluA2 3Y acetate Quick inquiry Where to buy Suppliers range | TAT-GluA2 3Y acetate is a cell-penetrating peptide containing tyrosine residues. It inhibits the phosphorylation of alpha-amino-3-hydroxy-5-methyl-isoxazole-4-propionic acid (AMPA) receptor endocytosis. Synonyms: H-Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-Tyr-Lys-Glu-Gly-Tyr-Asn-Val-Tyr-Gly-OH.CH3CO2H; L-tyrosyl-glycyl-L-arginyl-L-lysyl-L-lysyl-L-arginyl-L-arginyl-L-glutaminyl-L-arginyl-L-arginyl-L-arginyl-L-tyrosyl-L-lysyl-L-alpha-glutamyl-glycyl-L-tyrosyl-L-asparagyl-L-valyl-L-tyrosyl-glycine acetic acid. Grades: ≥95%. Molecular formula: C117H189N43O31. Mole weight: 2694.07. | |
TAT-GluR23A Fusion Peptide Quick inquiry Where to buy Suppliers range | TAT-GluR23A Fusion Peptide is a control inactive peptide that acts as a mutant counterpart to glutamate receptor endocytosis inhibitor (GluR23Y), linked to an 11 amino acid cell permeable HIV Trans-activator of Transcription (TAT) protein transduction domain (PTD). GluR23A is derived from GluR23Y amino acid 869-877, which is substituted for Tyr by Ala and lacks necessary phosphorylation sites. Synonyms: H-Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-Ala-Lys-Glu-Gly-Ala-Asn-Val-Ala-Gly-OH. Grades: ≥95%. Molecular formula: C97H173N43O26. Mole weight: 2357.71. | |
TAT-GluR23A Fusion Peptide Quick inquiry Where to buy Suppliers range | This is a control inactive peptide used as a mutant counterpart to glutamate receptor endocytosis inhibitor (GluR23Y), connected to an 11 amino acid cell permeable HIV Trans-Activator of Transcription (TAT) protein transduction domain (PTD). GluR23A is derived from GluR23Y amino acids 869 to 877, with Ala substituted for Tyr, and thus lacking essential phosphorylation sites. Uses: HIV-TAT Family. Product ID: GR1216. | |
Tat-GluR23Y Quick inquiry Where to buy Suppliers range | This is a peptide containing tyrosine residues and blocks phosphorylation of alpha-amino-3-hydroxy-5-methyl-isoxazole-4-propionic acid (AMPA) receptor endocytosis. Uses: HIV-TAT Family. Product ID: GR1217. | |
TAT-GluR23Y Quick inquiry Where to buy Suppliers range | TAT-GluR23Y is a cell penetrating peptide containing tyrosine residues. It inhibits the phosphorylation of alpha-amino-3-hydroxy-5-methyl-isoxazole-4-propionic acid (AMPA) receptor endocytosis. Synonyms: H-Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-Tyr-Lys-Glu-Gly-Tyr-Asn-Val-Tyr-Gly-OH; Tat-GluR23Y; L-tyrosyl-glycyl-L-arginyl-L-lysyl-L-lysyl-L-arginyl-L-arginyl-L-glutaminyl-L-arginyl-L-arginyl-L-arginyl-L-tyrosyl-L-lysyl-L-alpha-glutamyl-glycyl-L-tyrosyl-L-asparagyl-L-valyl-L-tyrosyl-glycine; TAT-GluA2 3Y. Grades: ≥95%. CAS No. 1404188-93-7. Molecular formula: C115H185N43O29. Mole weight: 2634.01. | |
Tat-GluR23Y, scrambled Quick inquiry Where to buy Suppliers range | This is a control peptide for Tat-GluR23Y. However, the scrambled version does not have blockade properties. Uses: HIV-TAT Family. Product ID: GR1218. | |
TAT-GluR23Y, scrambled Quick inquiry Where to buy Suppliers range | TAT-GluR23Y, scrambled is a control peptide. The synthetic peptide (Tat-Glur23Y), containing tyrosine residues, blocks phosphorylation of AMPA receptor endocytosis. However, the scrambled version does not have blockade properties. Previous studies show that Tat-Glur23Y, scrambled increases stress levels in mice, while Tat-Glur23Y reduces stress when administered. Synonyms: H-Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-Val-Tyr-Lys-Tyr-Gly-Gly-Tyr-Asn-Glu-OH; Tat-GluR23Y, scrambled. Grades: ≥95%. Molecular formula: C115H185N43O29. Mole weight: 2634.01. | |
TAT-HA2 Fusion Peptide Quick inquiry Where to buy Suppliers range | This is a peptide composed of amino acids 1 to 20 of influenza A virus hemagglutinin protein (HA2) connected to a 10 amino acid cell permeable HIV Trans-Activator of Transcription (TAT) protein transduction domain (PTD). TAT-HA2 is capable of being used as a large macromolecule drug delivery peptide. The TAT PTD binds to the cell surface and penetrates the membrane via lipid raft-dependent macropinocytosis. Endosomal escape and transduction of the fusion peptide are enhanced by the HA2 domain, which is a pH-sensitive lipid membrane destabilizing sequence. Uses: HIV-TAT Family. Product ID: GR1219. | |
TAT-HA2 Fusion Peptide Quick inquiry Where to buy Suppliers range | It is a cell penetrating peptide consisting of amino acids 1 to 20 of influenza A virus hemagglutinin protein (HA2), which is linked to a 10 amino acid cell permeable HIV Trans-activator of Transcription (TAT) protein transduction domain (PTD). TAT-HA2 can be used as a large molecule drug delivery peptide. TAT PTD binds to the cell surface and penetrates the cell membrane through lipid raft dependent macropinocytosis. The HA2 domain is a pH-sensitive lipid membrane destabilizing sequence that enhances endosomal escape and transduction of the fusion peptide. Synonyms: H-Arg-Arg-Arg-Gln-Arg-Arg-Lys-Lys-Arg-Gly-Gly-Asp-Ile-Met-Gly-Glu-Trp-Gly-Asn-Glu-Ile-Phe-Gly-Ala-Ile-Ala-Gly-Phe-Leu-Gly-OH. Grades: ≥95%. Molecular formula: C149H243N53O39S. Mole weight: 3432.98. | |
Tati Nickel Ore Quick inquiry Where to buy Suppliers range | Tati Nickel Ore. Uses: For analytical and research use. Group: Process Materials, Geological, Cement & Soils. Catalog: APS013113. | |
Tatm Quick inquiry Where to buy Suppliers range | Tatm. Group: Heterocyclic Organic Compound. Alternative Names: MANNOSE TRIFLATE;MANNOSE TRIFLATE F;BETA-D-MANNOPYRANOSE 1,3,4,6-TETRAACETATE 2-TRIFLATE;BETA-D-MANNOPYRANOSE, 1,3,4,6-TETRAACETATE 2-(TRIFLUOROMETHANE-SULFONATE);BETA-D-MANNOPYRANOSE 1,3,4,6-TETRA-O-ACETATE 2-O-TRIFLUOROMETHANESULFONATE;1,3,4,6-TETRA-O-ACETYL-2-O-TRIFLUORO-METHANESULFONYL-BETA-D-MANNOPYRANOSE;1,3,4,6-TETRA-O-ACETYL-2-O-TRIFLUOROMETHANSULFONYL-BETA-D-MANNOPYRANOSE;1,3,4,6-TETRA-O-ACETYL-2-O-TRIFLUOROMETHYLSULFONYL-B-D-MANNOPYRANOSE. CAS No. 92051-23-5. Molecular formula: C15H19F3O12S. Mole weight: 480.36. Melting Point: 118-122°C. Hazard statements: Xi. | |
TAT-NR2B9c Quick inquiry Where to buy Suppliers range | Tat-NR2B9c (NA-1) is an peptide that inhibits PSD-95, thus disrupting binding to N-methyl-D-aspartate receptors (NMDARs) and neuronal nitric oxide synthases (nNOS) and reducing excitoxicity induced by cerebral ischemia. Uses: API. CAS No. 500992-11-0. Product ID: 10-101-142. | |
Tat-NR2Bct Quick inquiry Where to buy Suppliers range | This is a membrane-permeable postsynaptic density (PSD)-95-binding (decoy) peptide Tat-NR2Bct. It can transduce into neurons in cell culture. Uses: HIV-TAT Family. Product ID: GR1220. | |
TAT-NSF222 Fusion Peptide Quick inquiry Where to buy Suppliers range | This sequence is a N-ethylmaleimide sensitive factor (NSF) peptide that connects to the 11 amino acid cell permeable human immunodeficiency virus (HIV) transactivating regulatory protein (TAT) domain by Gly-Gly-Gly spacer. The peptide contains the NSF domain extending from 222 to 243 amino acids, which is located directly at the amino terminus of the Walker A motif in the NSF D1 domain. ATPase assay shows that TAT-NSF222 inhibits the activity of NSF ATPase. Synonyms: H-Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-Gly-Gly-Gly-Leu-Asp-Lys-Glu-Phe-Asn-Ser-Ile-Phe-Arg-Arg-Ala-Phe-Ala-Ser-Arg-Val-Phe-Pro-Pro-Glu-OH. Grades: ≥95%. Molecular formula: C187H301N67O47. Mole weight: 4239.89. | |
TAT-NSF222 Fusion Peptide Quick inquiry Where to buy Suppliers range | This sequence is N-ethyl-maleimide-sensitive factor (NSF) peptide connected to 11 amino acid cell permeable human immunodeficiency virus (HIV) transactivating regulatory protein (TAT) domain by Gly-Gly-Gly spacer. This peptide contains NSF domain extending from amino acids 222 to 243, which is directly amino-terminal of the Walker A motif of the D1 domain of NSF. ATPase assay shows that TAT-NSF222 inhibits NSF ATPase activity. Uses: HIV-TAT Family. Product ID: GR1221. |