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| Product | Description | |
|---|---|---|
| (-)-Indolactam V | (-)-Indolactam V is an indole alkaloid compound which activates protein kinase C (PKC), which strongly directs human ES cell-derived definitive endoderm into pancreatic endoderm. It is weak tumor promoter. It binds to PKC regulatory domains of mouse skin PKCη and rat brain PKCγ with Ki values of 3.4 nM and 1 μM, respectively. It induces differentiation of human embryonic stem cells into pancreatic progenitors through activation of PKC signaling at 1 μM. It may be used as an effective diabetes therapy. It may share an RA-dependent signaling pathway, allowing ultimately to streamline the process of efficient pancreatic endoderm derivation. It was predicted to be a biosynthetic intermediate and was confirmed via in vitro prenylation by LtxC due to the structural relatedness of the lyngbyatoxins and teleocidin. It induces differentiation of a substantial number of Pdx1-expressing cells from human ESCs. Uses: (-)-indolactam v induces differentiation of human embryonic stem cells into pancreatic progenitors through activation of pkc signaling. it may be used as an effective diabetes therapy. Synonyms: (2S-(2R*,5R*))-ethyl)-1-methyl-2-(1-methylethyl);3h-pyrrolo(4,3,2-gh)-1,4-benzodiazonin-3-one,1,2,4,5,6,8-hexahydro-5-(hydroxym;(2S,5S)-1,2,4,5,6,8-Hexahydro-5-(hydroxymethyl)-1-methyl-2-(1-methylethyl)-3H-pyrrolo[4,3,2-gh]-1,4-benzodiazonin-3-one;3H-Pyrrolo(4,3,2-gh)-1,4-benzodiazonin-3-one, 1,2,4,5,6,8-hexahydro-5-(hydroxymethyl)-1-methyl-2-(1-methylethyl)-, (2S-(2R*,5R*))-;Indolactam V. Grades: >98%. CAS No. 90365-57-4. Molecular formula: C17H23N3O2. Mole weight: 301.38. |  |
| (-)-Indolactam V | (-)-Indolactam V is a PKC activator shown to effect differentiation in embryonic stem cells leading to development of pancreatic precursors. It is active in the mouse model. Group: Biochemicals. Grades: Highly Purified. CAS No. 90365-57-4. Pack Sizes: 300ug, 1mg. Molecular Formula: C17H23N3O2. US Biological Life Sciences. |  Worldwide |
| (-)-Indolactam V | (-)-Indolactam V is a PKC activator, with K i s of 3.36 nM, 1.03 μM for η-CRD2 (PKCη surrogate peptide), γ-CRD2 (PKCγ surrogate peptide), and K d s of 5.5 nM (η-C1B), 7.7 nM (ε-C1B), 8.3 nM (δ-C1B), 18.9 nM (β-C1A-long), 20.8 nM (α-C1A-long), 137 nM (β-C1B), 138 nM (γ-C1A), 213 nM (γ-C1B), and has antitumor activity. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Indolactam V. CAS No. 90365-57-4. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-12307. |  |
| (-)-Indolactam V ((2S,5S)-1,2,4,5,6,8-Hexahydro-5-(hydroxymethyl)-1-methyl-2-(1-methylethyl)-3H-pyrrolo[4,3,2-gh]-1,4-benzodiazonin-3-one) | Cell-permeable. A protein kinase C (PKC) activator and a tumor promoter. Directs differentiation of human embryonic stem cells (ESCs) into pancreatic progenitors. Group: Biochemicals. Grades: Highly Purified. CAS No. 90365-57-4. Pack Sizes: 250ug, 1mg. US Biological Life Sciences. | Worldwide |
| (?)-Indolactam V | ?96% (HPLC). Group: Fluorescence/luminescence spectroscopy. |  |
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