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| Product | Description | |
|---|---|---|
| (-)-Xestospongin C | (-)-Xestospongin C. Group: Biochemicals. Grades: Purified. CAS No. 88903-69-9. Pack Sizes: 10ug. US Biological Life Sciences. |  Worldwide |
| (-)-Xestospongin C | (-)-Xestospongin C is a potent and reversible inhibitor of IP3 receptor that reguates calcium release. (-)-Xestospongin C has been found to inhibit bradykinin-induced Ca2+ release in PC12 cells and attenuate PHP-induced IL-2 production in Jurkat T cells, but exhibits no effect on ryanodine receptor-mediated Ca2+ release in PC12 cells. Synonyms: (1R,4aR,11R,12aS,13S,16aS,23R,24aS)-Eicosahydro-5H,17H-1,23:11,13-diethano-2H,14H-[1,11]dioxacycloeicosino[2,3-b:12,13-b']dipyridine; Xestospongin C. CAS No. 88903-69-9. Molecular formula: C28H50N2O2. Mole weight: 446.71. |  |
| Xestospongin c | Xestospongin C ((-)-Xestospongin C) is a selective, reversible inositol 1,4,5-trisphosphate receptor (IP3R) inhibitor. Xestospongin C acts as an inhibitor of the sarcoplasmic/endoplasmic reticulum Ca2+ ATPase (SERCA) pump of internal stores. Xestospongin C blocks IP3-induced Ca2+ release from cerebellar microsomes with an IC50 of 358 nM. Xestospongin C is a valuable tool for investigating the structure and function of IP3Rs and Ca2+ signaling in neuronal and nonneuronal cells. Uses: Designed for use in research and industrial production. Additional or Alternative Names: [1R-(1R*,4AR*,11R*,12AS*,13S*,16AS*,23R*,24AS*)]-EICOSAHYDRO-5H,17H-1,23:11,13-DIETHANO-2H,14H-[1,11]DIOXACYCLOEICOSINO[2,3-B:12,13-B]DIPYRIDINE; (1R,4aR,11R,12aS,13S,16aS,23R,24aS)-Eicosahydro-5H,17H-1,23:11,13-diethano-2H,14H-[1,11]dioxacycloeicosino[2. Product Category: Inhibitors. Appearance: off-white. CAS No. 88903-69-9. Molecular formula: C28H50N2O2. Mole weight: 446.71. Purity: 0.96. IUPACName: XESTOSPONGIN C. Density: 1.06g/cm³. Product ID: ACM88903699. Alfa Chemistry ISO 9001:2015 Certified. |  |
| Araguspongin B | Araguspongin B is a compound isolated from Pacific basin sponges. It shows notable vasodilatory properties. Araguspongin B antagonizes the calcium-releasing action of inositol 1,4,5-trisphosphate at the receptor level with an IC50 value of 0.6 μM in cerebral microsomes. It is nearly as potent as xestospongin C as an antagonist of the IP3 receptor. Grades: ≥90%. CAS No. 123000-02-2. Molecular formula: C28H50N2O2. Mole weight: 446.7. | |
| Xestospongin C | film. Group: Fluorescence/luminescence spectroscopy. |  |
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