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| Product | Description | |
|---|---|---|
| 1-Piperazinehexanoic acid-thalidomide | 1-Piperazinehexanoic acid-thalidomide is a conjugate of E3 ligase ligand and linker that serve as a key intermediate for the synthesis of complete JMV7048 (HY-162704) [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2819682-33-0. Pack Sizes: 5 mg; 10 mg; 25 mg. Product ID: HY-162737. |  |
| (R)-Thalidomide | (R)-Thalidomide ((R)-(+)-Thalidomide) is the R-enantiomer of Thalidomide. (R)-Thalidomide has psychomotor stabilizing properties [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: (R)-(+)-Thalidomide. CAS No. 2614-6-4. Pack Sizes: 5 mg; 10 mg. Product ID: HY-14658B. | |
| (R)-(+)-Thalidomide | (R)-(+)-Thalidomide. Group: Biochemicals. Alternative Names: (R)-(+)-2-(2,6-Dioxo-3-piperidinyl)-1H-iso-indole-1,3(2H)-dione; (R)-Thalidomide; NSC 91729. Grades: Highly Purified. CAS No. 2614-6-4. Pack Sizes: 1mg, 2mg, 5mg, 10mg, 25mg. Molecular Formula: C13H10N2O4. US Biological Life Sciences. |  Worldwide |
| R-Thalidomide | The R-enantiomer of Thalidomide which interacts directly with the protein cereblon (CRBN; IC50=8.5 nM), a ubiquitously-expressed E3 ligase. Synonyms: (R)-Thalidomide; (+)-Thalidomide; (R)-(+)-thalidomide; D-Thalidomide; 2614-06-4; R-(+)-Thalidomide; Thalidomide, (R)-; QN61H68KLK; 2-[(3R)-2,6-dioxopiperidin-3-yl]isoindole-1,3-dione; CHEBI:61917; Phthalimide, N-(2,6-dioxo-3-piperidyl)-, D-(+)-; (R)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione; 1H-Isoindole-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-, (R)-; 2-[(3R)-2,6-dioxopiperidin-3-yl]-2,3-dihydro-1H-isoindole-1,3-dione; 2-[(3R)-2,6-dioxopiperidin-3-yl]-1H-isoindole-1,3(2H)-dione; 2-[(3~{R})-2,6-bis(oxidanylidene)piperidin-3-yl]isoindole-1,3-dione; NSC 91729; NSC-91729; (R)-(D)-Thalidomide. Grades: > 95%. CAS No. 2614-6-4. Molecular formula: C13H10N2O4. Mole weight: 258.24. |  |
| (R)-(+)-Thalidomide ((R)-(+)-2-(2,6-Dioxo-3-piperidinyl)-1H-iso-indole-1,3(2H)-dione) | Optically active isomer of Thalidomide, which inhibits FGF-induced angiogenesis. Inhibits replication of human immunodeficiency virus type 1. Teratogenic sedative. Group: Biochemicals. Alternative Names: (R)-(+)-2-(2,6-Dioxo-3-piperidinyl)-1H-iso-indole-1,3(2H)-dione. Grades: Highly Purified. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
| (S)-(-)-Thalidomide ((S)-(-)-2-(2,6-Dioxo-3-piperidinyl)-1H-iso-indole-1,3(2H)-dione) | Optically active isomer of Thalidomide, which inhibits FGF-induced angiogenesis. Inhibits replication of human immunodeficiency virus type 1. Teratogenic sedative. Group: Biochemicals. Alternative Names: (S)-(-)-2-(2,6-Dioxo-3-piperidinyl)-1H-iso-indole-1,3(2H)-dione. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| (±)-Thalidomide ((RS)-2-(2,6-dioxopiperidin-3-yl)-1H-isoindole-1,3(2H)-dione) | Cell-permeable. A teratogen and sedative-hypnotic with inherent anti-inflammatory properties. A selective inhibitor of tumor necrosis factor a (TNF-a) synthesis. Thalidomide initiates its teratogenic effects by binding to cereblon (CRBN), a thalidomide-binding protein, and inhibiting the associated ubiquitin ligase activity. Group: Biochemicals. Grades: Highly Purified. CAS No. 50-35-1. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| FHD-609 | FHD-609 is a PROTAC degrader and inhibitor of BRD9 ( Bromodomain-containing protein 9 ). FHD-609 targets to ncBAF , can be used for research of wide range of cancers that contain a mutation in a BAF complex subunit. FHD-609 in combination with Telomelysin or INO5401, may play a role in adrenocortical carcinoma (ACC) treatment. (Blue: BRD9 ligand-6 (HY-49393), Black: linker (HY-168309); Pink: (S)-Deoxy-thalidomide-Br (HY-168308) ) [1] [2] [3] [4] [5]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2676211-64-4. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-153367. | |
| (S)-Thalidomide | (S)-Thalidomide ((S)-(-)-Thalidomide) is the S-enantiomer of Thalidomide. (S)-Thalidomide has immunomodulatory, anti-inflammatory, antiangiogenic and pro-apoptotic effects [1] [2] [3]. (S)-Thalidomide induces teratogenic effects by binding to cereblon (CRBN) [4]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: (S)-(-)-Thalidomide. CAS No. 841-67-8. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-14658A. | |
| 1,2-Dibromo-4,5-dimethylbenzene | 1,2-Dibromo-4,5-dimethylbenzene is used as a reagent in the synthesis of Thalidomide (T338850); an inhibitor of FGF-induced angiogenesis and replication of human immunodeficiency virus type 1. Also a teratogenic sedative and immunomodulatory agent used primarily in combination with dexamethasone to treat multiple myeloma. Group: Biochemicals. Grades: Highly Purified. CAS No. 24932-48-7. Pack Sizes: 1g, 5g. Molecular Formula: C8H8Br2, Molecular Weight: 263.959999999999. US Biological Life Sciences. | Worldwide |
| 2-(2-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)ethoxy)ethoxy)acetaldehyde | 2-(2-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)ethoxy)ethoxy)acetaldehyde. Uses: Designed for use in research and industrial production. Additional or Alternative Names: Thalidomide-O-PEG2-CH2-Ald. Product Category: E3 Ligase Ligand. CAS No. 2286368-58-7. Molecular formula: C19H20N2O8. Mole weight: 404.3707. IUPACName: 2-[2-[2-[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-4-yl]oxyethoxy]ethoxy]acetaldehyde. Product ID: PR2286368587. Alfa Chemistry ISO 9001:2015 Certified. |  |
| 2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)acetic acid | 2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)acetic acid. Uses: Designed for use in research and industrial production. Additional or Alternative Names: Thalidomide-O-COOH; E3 ligase Ligand 3; Thalidomide-Acid. Product Category: PROTAC Library. CAS No. 1061605-21-7. Molecular formula: C15H12N2O7. Mole weight: 332.265. IUPACName: 2-[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-4-yl]oxyacetic acid. Product ID: PR1061605217. Alfa Chemistry ISO 9001:2015 Certified. | |
| 2-(2-(2-aminoethoxy)ethoxy)-N-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl)acetamide | 2-(2-(2-aminoethoxy)ethoxy)-N-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl)acetamide. Uses: Designed for use in research and industrial production. Additional or Alternative Names: Thalidomide-amido-PEG2-NH2. Product Category: PROTAC Library. CAS No. 2380273-72-1. Molecular formula: C19H22N4O7. Mole weight: 418.4006. IUPACName: 2-[2-(2-aminoethoxy)ethoxy]-N-[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-4-yl]acetamide. Product ID: PR2380273721. Alfa Chemistry ISO 9001:2015 Certified. | |
| 2-(2,6-dioxopiperidin-3-yl)-4-(2-(2-(2-hydroxyethoxy)ethoxy)ethoxy)isoindoline-1,3-dione | 2-(2,6-dioxopiperidin-3-yl)-4-(2-(2-(2-hydroxyethoxy)ethoxy)ethoxy)isoindoline-1,3-dione. Uses: Designed for use in research and industrial production. Additional or Alternative Names: Thalidomide-O-PEG3-alcohol. Product Category: E3 Ligase Ligand. CAS No. 2286368-57-6. Molecular formula: C19H22N2O8. Mole weight: 406.3866. IUPACName: 2-(2,6-dioxopiperidin-3-yl)-4-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]isoindole-1,3-dione. Product ID: PR2286368576. Alfa Chemistry ISO 9001:2015 Certified. | |
| 2-(2,6-dioxopiperidin-3-yl)-4-fluoro-2,3-dihydro-1H-isoindole-1,3-dione | 2-(2,6-dioxopiperidin-3-yl)-4-fluoro-2,3-dihydro-1H-isoindole-1,3-dione. Uses: Designed for use in research and industrial production. Additional or Alternative Names: Thalidomide 4-fluoride. Product Category: PROTAC Library. CAS No. 835616-60-9. Molecular formula: C13H9FN2O4. Mole weight: 276.22. IUPACName: 2-(2,6-dioxopiperidin-3-yl)-4-fluoroisoindole-1,3-dione. Product ID: PR835616609. Alfa Chemistry ISO 9001:2015 Certified. | |
| 2-(2,6-dioxopiperidin-3-yl)-5-fluoro-2,3-dihydro-1H-isoindole-1,3-dione | 2-(2,6-dioxopiperidin-3-yl)-5-fluoro-2,3-dihydro-1H-isoindole-1,3-dione. Uses: Designed for use in research and industrial production. Additional or Alternative Names: Thalidomide 5-fluoride. Product Category: PROTAC Library. CAS No. 835616-61-0. Molecular formula: C13H9FN2O4. Mole weight: 276.22. IUPACName: 2-(2,6-dioxopiperidin-3-yl)-5-fluoroisoindole-1,3-dione. Product ID: PR835616610. Alfa Chemistry ISO 9001:2015 Certified. | |
| 2-(2,6-dioxopiperidin-3-yl)-5-fluoro-6-(piperazin-1-yl)-2,3-dihydro-1H-isoindole-1,3-dione | 2-(2,6-dioxopiperidin-3-yl)-5-fluoro-6-(piperazin-1-yl)-2,3-dihydro-1H-isoindole-1,3-dione. Uses: Designed for use in research and industrial production. Additional or Alternative Names: Thalidomide-Piperazine 5-fluoride. Product Category: PROTAC Library. CAS No. 2222114-22-7. Molecular formula: C17H17FN4O4. Mole weight: 360.3397. Purity: 0.99. IUPACName: 2-(2,6-dioxopiperidin-3-yl)-5-fluoro-6-piperazin-1-ylisoindole-1,3-dione. Product ID: PR2222114227. Alfa Chemistry ISO 9001:2015 Certified. | |
| 2-(2,6-dioxopiperidin-3-yl)-5-methylisoindoline-1,3-dione | 2-(2,6-dioxopiperidin-3-yl)-5-methylisoindoline-1,3-dione. Uses: Designed for use in research and industrial production. Additional or Alternative Names: Thalidomide-5-methyl. Product Category: PROTAC Library. CAS No. 40313-92-6. Molecular formula: C14H12N2O4. Mole weight: 272.2561. IUPACName: 2-(2,6-dioxopiperidin-3-yl)-5-methylisoindole-1,3-dione. Product ID: PR40313926. Alfa Chemistry ISO 9001:2015 Certified. | |
| 2,3-Naphthalic Anhydride | 2,3-Naphthalic anhydride is used as a reagent to synthesize analogues of Thalidomide (T338850), an inhibitor of tumor necrosis factor that was once abandoned because it caused birth defects, but is currently used as an inhibitor of angiogenesis in patients with multiple myeloma. Group: Biochemicals. Grades: Highly Purified. CAS No. 716-39-2. Pack Sizes: 100mg, 1g. Molecular Formula: C12H6O3. US Biological Life Sciences. | Worldwide |
| 3-(2-(2-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)ethoxy)ethoxy)ethoxy)propanoic acid | 3-(2-(2-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)ethoxy)ethoxy)ethoxy)propanoic acid. Uses: Designed for use in research and industrial production. Additional or Alternative Names: Pomalidomide-PEG3-CO2H; Thalidomide-NH-PEG3-propionic acid. Product Category: PROTAC Library. CAS No. 2138440-82-9. Molecular formula: C22H27N3O9. Mole weight: 477.4645. IUPACName: 3-[2-[2-[2-[[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-4-yl]amino]ethoxy]ethoxy]ethoxy]propanoic acid. Product ID: PR2138440829. Alfa Chemistry ISO 9001:2015 Certified. | |
| 3-(2-Aminoethoxy) Thalidomide | 3-(2-Aminoethoxy) Thalidomide is a derivative of Thalidomide (T338850), Inhibits FGF-induced angiogenesis. Inhibits replication of human immunodeficiency virus type 1. Teratogenic sedative. There is now a growing clinical interest in Thalidomide, and it is introduced as an immunomodulatory agent used primarily in combination with dexamethasone to treat multiple myeloma. Group: Biochemicals. Grades: Highly Purified. CAS No. 390367-50-7. Pack Sizes: 5mg, 10mg. Molecular Formula: C15H15N3O5, Molecular Weight: 317.3. US Biological Life Sciences. | Worldwide |
| 3-(2-Aminoethoxy) Thalidomide SF-1-088 Amide | 3-(2-Aminoethoxy) Thalidomide SF-1-088 Amide is a potential small molecule inhibitor of Stat3 and Stat5-SH2 domain. Useful in the treatment of human cancers. Antileukemia agent. Derivative of Thalidomide (T338850), Inhibits FGF-induced angiogenesis. Inhibits replication of human immunodeficiency virus type 1. Teratogenic sedative. There is now a growing clinical interest in Thalidomide, and it is introduced as an immunomodulatory agent used primarily in combination with dexamethasone to treat multiple myeloma. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 1mg, 2mg. Molecular Formula: C49H53N5O12S, Molecular Weight: 936.04. US Biological Life Sciences. | Worldwide |
| 3-(4-Amino-1,3-dihydro-5-hydroxy-1-oxo-2H-isoindol-2-yl)-2,6-piperidinedione | 3-(4-Amino-1,3-dihydro-5-hydroxy-1-oxo-2H-isoindol-2-yl)-2,6-piperidinedione is a related compound of Lenalidomide (L328000), an immunomodulatory drug and an analog of Thalidomide. Group: Biochemicals. Grades: Highly Purified. CAS No. 1421593-78-3. Pack Sizes: 5mg, 10mg. Molecular Formula: C13H13N3O4, Molecular Weight: 275.26. US Biological Life Sciences. | Worldwide |
| 3-[4- (Aminomethyl) benzyloxy] Thalidomide | 3-[4- (Aminomethyl) benzyloxy] Thalidomide is a derivative of Thalidomide (T338850), Inhibits FGF-induced angiogenesis. Inhibits replication of human immunodeficiency virus type 1. Teratogenic sedative. There is now a growing clinical interest in Thalidomide, and it is introduced as an immunomodulatory agent used primarily in combination with dexamethasone to treat multiple myeloma. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 5mg, 10mg. Molecular Formula: C21H19N3O5, Molecular Weight: 393.39. US Biological Life Sciences. | Worldwide |
| 3-[4- (Aminomethyl) benzyloxy] Thalidomide SF-1-088 | 3-[4- (Aminomethyl) benzyloxy] Thalidomide SF-1-088 is a potential small molecule inhibitor of Stat3 and Stat5-SH2 domain. Useful in the treatment of human cancers. Antileukemia agent. Derivative of Thalidomide (T338850), Inhibits FGF-induced angiogenesis. Inhibits replication of human immunodeficiency virus type 1. Teratogenic sedative. There is now a growing clinical interest in Thalidomide, and it is introduced as an immunomodulatory agent used primarily in combination with dexamethasone to treat multiple myeloma. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 1mg, 2mg. Molecular Formula: C53H55N5O10S, Molecular Weight: 954.1. US Biological Life Sciences. | Worldwide |
| 3-Amino-2,6-piperidinedione 2,2,2-Trifluoroacetate | 3-Amino-2,6-piperidinedione 2,2,2-Trifluoroacetate is an intermediate in the synthesis of Thalidomide-d4 (T338852), a labelled Thalidomide, which inhibits FGF-induced angiogenesis. Inhibits replication of human immunodeficiency virus type 1. Teratogenic sedative. Group: Biochemicals. Grades: Highly Purified. CAS No. 590365-46-1. Pack Sizes: 1g, 10g. Molecular Formula: C7H9F3N2O4, Molecular Weight: 242.15. US Biological Life Sciences. | Worldwide |
| 4-[(2-(2-aminoethoxy)ethyl)amino]-2-(2,6-dioxopiperidin-3-yl)-2,3-dihydro-1H-isoindole-1,3-dione | 4-[(2-(2-aminoethoxy)ethyl)amino]-2-(2,6-dioxopiperidin-3-yl)-2,3-dihydro-1H-isoindole-1,3-dione. Uses: Designed for use in research and industrial production. Additional or Alternative Names: Thalidomide-NH-PEG1-NH2. Product Category: PROTAC Library. CAS No. 2138439-12-8. Molecular formula: C17H20N4O5. Mole weight: 360.3645. Purity: >98%. IUPACName: 4-[2-(2-aminoethoxy)ethylamino]-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione. Product ID: PR2138439128. Alfa Chemistry ISO 9001:2015 Certified. | |
| 4-[(5-aminopentyl)amino]-2-(2,6-dioxopiperidin-3-yl)-2,3-dihydro-1H-isoindole-1,3-dione | 4-[(5-aminopentyl)amino]-2-(2,6-dioxopiperidin-3-yl)-2,3-dihydro-1H-isoindole-1,3-dione. Uses: Designed for use in research and industrial production. Additional or Alternative Names: Thalidomide-NH-C5-NH2 (hydrochloride). Product Category: PROTAC Library. CAS No. 2093386-39-9. Molecular formula: C18H22N4O4. Mole weight: 358.3917. IUPACName: 4-(5-aminopentylamino)-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione;hydrochloride. Product ID: PR2093386399. Alfa Chemistry ISO 9001:2015 Certified. | |
| 4-[(6-aminohexyl)amino]-2-(2,6-dioxopiperidin-3-yl)-2,3-dihydro-1H-isoindole-1,3-dione | 4-[(6-aminohexyl)amino]-2-(2,6-dioxopiperidin-3-yl)-2,3-dihydro-1H-isoindole-1,3-dione. Uses: Designed for use in research and industrial production. Product Category: PROTAC Library. CAS No. 2093386-50-4. Molecular formula: C19H24N4O4. Mole weight: 372.4183. Purity: >95%. IUPACName: 4-(6-aminohexylamino)-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione;hydrochloride. Product ID: PR2093386504. Alfa Chemistry ISO 9001:2015 Certified. Categories: Thalidomide-NH-C6-NH2. | |
| 4-[(8-aminooctyl)amino]-2-(2,6-dioxopiperidin-3-yl)-2,3-dihydro-1H-isoindole-1,3-dione | 4-[(8-aminooctyl)amino]-2-(2,6-dioxopiperidin-3-yl)-2,3-dihydro-1H-isoindole-1,3-dione. Uses: Designed for use in research and industrial production. Additional or Alternative Names: Thalidomide-NH-C8-NH2. Product Category: PROTAC Library. CAS No. 1957236-36-0. Molecular formula: C21H28N4O4. Mole weight: 400.4714. IUPACName: 4-(8-aminooctylamino)-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione. Product ID: PR1957236360. Alfa Chemistry ISO 9001:2015 Certified. | |
| BODIPY FL Thalidomide | BODIPY FL Thalidomide. Uses: Designed for use in research and industrial production. CAS No. 2740620-18-0. Purity: 0.95. Product ID: ACM2740620180. Alfa Chemistry ISO 9001:2015 Certified. | |
| CC-3052 | CC-3052, a thalidomide analogue, reduces persistent activation of the TNF-α system in HIV without markedly impairing neutrophil viability. Synonyms: CC-3052; CC 3052; CC3052; methyl (2R)-2-(3,4-dimethoxyphenyl)-3-(3-oxo-1H-isoindol-2-yl)propanoate. Grades: >98%. CAS No. 216884-02-5. Molecular formula: C20H21NO5. Mole weight: 355.38. | |
| CPS-11 | CPS-11 (N-(Hydroxymethyl)thalidomide) a Thalidomide (HY-14658) analogue, is a potent anti-cancer agent. CPS-11 inhibits NF-κB , activates NFAT , and repress cytokine expression through elevated ROS. CPS-11 exhibits a wider activity spectrum and higher potency against MM (multiple myeloma) cell lines [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: N-(Hydroxymethyl)thalidomide. CAS No. 145945-21-7. Pack Sizes: 1 mg; 5 mg. Product ID: HY-117987. | |
| Iberdomide | Iberdomide (CC-220) is an orally active and potent cereblon (CRBN) E3 ligase modulator (CELMoD) with an IC 50 of ~150?nM for cereblon-binding affinity. Iberdomide, a derivative of Thalidomide (HY-14658), has antitumor and immunostimulatory activities [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: CC-220. CAS No. 1323403-33-3. Pack Sizes: 10 mM * 1 mL; 2 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-101291. | |
| Lenalidomide | Lenalidomide (CC-5013), a derivative of Thalidomide, acts as molecular glue. Lenalidomide is an orally active immunomodulator. Lenalidomide (CC-5013) is a ligand of ubiquitin E3 ligase cereblon (CRBN) , and it causes selective ubiquitination and degradation of two lymphoid transcription factors, IKZF1 and IKZF3, by the CRBN-CRL4 ubiquitin ligase. Lenalidomide (CC-5013) specifically inhibits growth of mature B-cell lymphomas, including multiple myeloma, and induces IL-2 release from T cells [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: CC-5013. CAS No. 191732-72-6. Pack Sizes: 10 mM * 1 mL; 100 mg; 500 mg; 1 g; 5 g. Product ID: HY-A0003. | |
| Lenalidomide hemihydrate | Lenalidomide hemihydrate (CC-5013 hemihydrate) is a derivative of Thalidomide and functions as an orally active immunomodulator. It acts through cereblon-mediated selective ubiquitination and degradation of IKZF1 and IKZF3 lymphocyte transcription factors, inhibiting the growth of mature B-cell lymphomas including multiple myeloma, and inducing interleukin-2 (IL-2) release from T cells. Synonyms: Revlimid hemihydrate; CC-5013 hemihydrate. Grades: >98%. CAS No. 847871-99-2. Molecular formula: C26H28N6O7. Mole weight: 268.27. | |
| Lenalidomide hydrochloride | Lenalidomide hydrochloride (CC-5013 hydrochloride) is a derivative of Thalidomide and functions as an orally active immunomodulator. It acts through cereblon-mediated selective ubiquitination and degradation of IKZF1 and IKZF3 lymphocyte transcription factors, inhibiting the growth of mature B-cell lymphomas including multiple myeloma, and inducing interleukin-2 (IL-2) release from T cells. Synonyms: Revlimid hydrochloride; CC-5013 hydrochloride; CC5013 hydrochloride; CC 5013 hydrochloride. Grades: >98%. CAS No. 1243329-97-6. Molecular formula: C13H14ClN3O3. Mole weight: 295.72. | |
| Lenalidomide (Standard) | Lenalidomide (Standard) is the analytical standard of Lenalidomide. This product is intended for research and analytical applications. Lenalidomide (CC-5013), a derivative of Thalidomide, acts as molecular glue. Lenalidomide is an orally active immunomodulator. Lenalidomide (CC-5013) is a ligand of ubiquitin E3 ligase cereblon (CRBN) , and it causes selective ubiquitination and degradation of two lymphoid transcription factors, IKZF1 and IKZF3, by the CRBN-CRL4 ubiquitin ligase. Lenalidomide (CC-5013) specifically inhibits growth of mature B-cell lymphomas, including multiple myeloma, and induces IL-2 release from T cells [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 191732-72-6. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-A0003R. | |
| NX-2127 | NX-2127 (compound 28) is an orally active PROTAC deggrader, targeting to Brutons Tyrosine Kinase (Btk). NX-2127 inhibits proliferation of BTK C481S mutant TMD8 cells, more effectively than Ibrutinib (HY-10997). NX-2127 catalyzes the degradation of Ikaros (IKZF1) and Aiolos (IKZF3) with of 25 nM and 54 nM, respectively. NX-2127 stimulates T cell activation and increases IL-2 production in primary human T Cells [1] [2]. NX-2127 is composed of PROTAC target protein ligand (red part) BTK ligand 10 (HY-168302), E3 ligase ligand (blue part) Thalidomide 5-fluoride (HY-W087383) and PROTAC Linker (black part) (S)-4-(1-(Pyrrolidin-3-ylmethyl)piperidin-4-yl)aniline (HY-168303). Among which, the conjugate of E3 ubiquitin ligase ligand + Linker compose of Thalidomide-pyrrolidine-C-piperidine-Ph-NH2 (HY-168304). Uses: Scientific research. Group: Signaling pathways. CAS No. 2416131-46-7. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-153220. | |
| Pomalidomide-PEG1-C2-NH2 | Pomalidomide-PEG1-C2-NH2 is a crosslinker-E3 ligase ligand conjugate consisting of an E3 ligase ligand pomalidomide and a PEGylated crosslinker with terminal amine for reactivity with a carboxyl group on the target ligand. It has been used as a degrader building block in PROTAC for targeted protein degradation. Synonyms: Thalidomide-NH-PEG1-NH2; 4-((2-(2-aminoethoxy)ethyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione; 4-{[2-(2-Aminoethoxy)ethyl]amino}-2-(2,6-dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione; 1H-Isoindole-1,3(2H)-dione, 4-[[2-(2-aminoethoxy)ethyl]amino]-2-(2,6-dioxo-3-piperidinyl)-. Grades: ≥95%. CAS No. 2138439-12-8. Molecular formula: C17H20N4O5. Mole weight: 360.36. | |
| Pomalidomide-PEG2-C2-NH2 | Pomalidomide-PEG2-C2-NH2 is a crosslinker-E3 ligase ligand conjugate consisting of an E3 ligase ligand pomalidomide and a PEGylated crosslinker with terminal amine for reactivity with a carboxyl group on the target ligand. It has been used as a degrader building block in PROTAC for targeted protein degradation. Synonyms: Thalidomide-NH-PEG2-NH2; 4-((2-(2-(2-aminoethoxy)ethoxy)ethyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione; 4-({2-[2-(2-Aminoethoxy)ethoxy]ethyl}amino)-2-(2,6-dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione; 1H-Isoindole-1,3(2H)-dione, 4-[[2-[2-(2-aminoethoxy)ethoxy]ethyl]amino]-2-(2,6-dioxo-3-piperidinyl)-; 4-({2-[2-(2-aminoethoxy)ethoxy]ethyl}amino)-2-(2,6-dioxopiperidin-3-yl)-2,3-dihydro-1H-isoindole-1,3-dione; Thalidomide-NH-PEG2-C2-NH2. Grades: ≥95%. CAS No. 2093416-32-9. Molecular formula: C19H24N4O6. Mole weight: 404.42. | |
| rac Lenalidomide-13C5 | Labeled Lenalidomide. Immunomodulatory drug; analog of Thalidomide. Group: Biochemicals. Alternative Names: 3-(4-Amino-1,3-dihydro-1-oxo-2H-isoindol-2-yl)-2,6-piperidinedione-13C5; 1-Oxo-2-(2,6-dioxopiperidin-3-yl)-4-aminoisoindoline-13C5; CC-5013-13C5. Grades: Highly Purified. CAS No. 1219332-91-8. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| (R,S)-Lenalidomide, Free Base (3-(4-Amino-1,3-dihydro-1-oxo-2H-isoindol-2-yl)-2,6-piperidinedione, CC-5013, CDC-501, ENMD-0997, Revamid, Revimid) | Cell-permeable. An analog of thalidomide that was originally found based on its ability to effectively inhibit tumor necrosis factor production. Lenalidomide is 50,000 times more potent than thalidomide in inhibiting Tumor Necrosis Factor-a (TNF-a). Displays potent anti-tumor and anti-inflammatory effects as well as modulates and potentiates host immune responses against multiple myeloma. Group: Biochemicals. Grades: Highly Purified. CAS No. 191732-72-6. Pack Sizes: 25mg. US Biological Life Sciences. | Worldwide |
| tert-butyl (2-(2-(2-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)acetamido)ethoxy)ethoxy)ethyl)carbamate | tert-butyl (2-(2-(2-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)acetamido)ethoxy)ethoxy)ethyl)carbamate. Uses: Designed for use in research and industrial production. Additional or Alternative Names: Thalidomide-O-amido-PEG2-NHBoc. Product Category: PROTAC Library. CAS No. 1957235-73-2. Molecular formula: C26H34N4O10. Mole weight: 562.569. IUPACName: tert-butyl N-[2-[2-[2-[[2-[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-4-yl]oxyacetyl]amino]ethoxy]ethoxy]ethyl]carbamate. Product ID: PR1957235732. Alfa Chemistry ISO 9001:2015 Certified. Categories: SCHEMBL24819176. | |
| tert-butyl 4-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)piperazine-1-carboxylate | tert-butyl 4-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)piperazine-1-carboxylate. Uses: Designed for use in research and industrial production. Product Category: PROTAC Library. Molecular formula: C22H26N4O6. Mole weight: 442.465. Purity: >98%. Product ID: PR01140. Alfa Chemistry ISO 9001:2015 Certified. Categories: Thalidomide-piperazine-Boc. | |
| Thalidomide | Recruits SALL4 to cereblon-CRL4 ubiquitin ligase. Uses: Angiogenesis inhibitors; immunosuppressive agents; leprostatic agents; teratogens. Synonyms: alphaphthalimidoglutarimide. Nphthaloylglutamimide; Nphthalylglutamic acid imide. US brand names: Synovir; Thalomid. Foreign brand names: Contergan; Distaval; Kevadon; Neurosedyn; Pantosediv; Sedoval K17; Softenon Talimol; Abbreviation: THAL. Grades: ≥99% (HPLC). CAS No. 50-35-1. Molecular formula: C13H10N2O4. Mole weight: 258.23. | |
| Thalidomide | Thalidomide inhibits cereblon (CRBN), a part of the cullin-4 E3 ubiquitin ligase complex CUL4-RBX1-DDB1, with a K d of ?250 nM, and has immunomodulatory, anti-inflammatory and anti-angiogenic cancer properties. Thalidomide can work as molecular glue to potentiate substrate. Uses: Scientific research. Group: Signaling pathways. CAS No. 50-35-1. Pack Sizes: 10 mM * 1 mL; 200 mg; 500 mg. Product ID: HY-14658. | |
| (+/-)-Thalidomide | 1g Pack Size. Group: Bioactive Small Molecules, Research Organics & Inorganics. Formula: C13H10N2O4. CAS No. 50-35-1. Prepack ID 86297062-1g. Molecular Weight 258.23. See USA prepack pricing. |  |
| Thalidomide (2-(2,6-Dioxo-3-piperidinyl)-1H-iso-indole-1,3(2H)-dione) | Inhibits FGF-induced angiogenesis. Inhibits replication of human immunodeficiency virus type 1. Teratogenic sedative. Group: Biochemicals. Alternative Names: 2-(2,6-Dioxo-3-piperidinyl)-1H-iso-indole-1,3(2H)-dione. Grades: Highly Purified. Pack Sizes: 500mg. US Biological Life Sciences. | Worldwide |
| Thalidomide-4-O-C4-NH2 hydrochloride | Thalidomide-4-O-C4-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide (HY-14658) based cereblon ligand and a linker used in PROTAC technology. Uses: Scientific research. Group: Signaling pathways. CAS No. 2376990-29-1. Pack Sizes: 5 mg; 10 mg; 25 mg. Product ID: HY-130948B. | |
| Thalidomide-5-PEG3-NH2 hydrochloride | Thalidomide-5-PEG3-NH2 is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2761385-81-1. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-138786A. | |
| Thalidomide-d4 (2-(2,6-Dioxo-3-piperidinyl)-1H-iso-indole-1,3(2H)-dione-d4) | Labelled Thalidomide, which inhibits FGF-induced angiogenesis. Inhibits replication of human immunodeficiency virus type 1. Teratogenic sedative. Group: Biochemicals. Alternative Names: 2-(2,6-Dioxo-3-piperidinyl)-1H-iso-indole-1,3(2H)-dione-d4. Grades: Highly Purified. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| Thalidomide-O-amido-C6-NH2 (TFA) | Thalidomide-O-amido-C6-Amine trifluoroacetate is a PROTAC block consist of Thalidomide linked to alkyl with Amine functional group for conjugation reactions. Synonyms: Thalidomide-O-amido-C6-NH2 (TFA); Cereblon Ligand-Linker Conjugates 11 (TFA); E3 Ligase Ligand-Linker Conjugates 25 (TFA); Thalidomide-O-amido-C6-Amine Trifluoroacetate; N-(6-aminohexyl)-2-[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-4-yl]oxyacetamide;2,2,2-trifluoroacetic acid. CAS No. 1950635-14-9. Molecular formula: C23H27F3N4O8. Mole weight: 544.48. | |
| Thalidomide-O-amido-PEG2-C2-NH2 TFA | Thalidomide-O-amido-PEG2-C2-NH2 TFA is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and 2-unit PEG linker used in PROTAC technology. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Cereblon Ligand-Linker Conjugates 10 TFA; E3 Ligase Ligand-Linker Conjugates 24 TFA. CAS No. 1957235-75-4. Pack Sizes: 25 mg; 50 mg; 100 mg; 500 mg. Product ID: HY-112617A. | |
| Thalidomide-O-amido-PEG3-C2-NH2 hydrochloride | Thalidomide-O-amido-PEG3-C2-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and 3-unit PEG linker used in PROTAC technology [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2245697-84-9. Pack Sizes: 25 mg; 100 mg. Product ID: HY-107440A. | |
| Thalidomide-O-amido-PEG3-C2-NH2 TFA | Thalidomide-O-amido-PEG3-C2-NH2 TFA is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and 3-unit PEG linker used in PROTAC technology. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Cereblon Ligand-Linker Conjugates 3 TFA; E3 ligase Ligand-Linker Conjugates 14 TFA. CAS No. 1957236-21-3. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-103611. | |
| Thalidomide-piperazine hydrochloride | Thalidomide-piperazine hydrochloride has the potential for the research of leprosy and multiple myeloma. Thalidomide-piperazine hydrochloride used as a tool in developmental biology leads to important discoveries in the biochemical pathways of limb development [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2228029-82-9. Pack Sizes: 25 mg; 50 mg. Product ID: HY-132971. | |
| Thalidomide-Piperazine-Piperidine hydrochloride | Thalidomide-Piperazine-Piperidine hydrochloride is a synthesized E3 ligase ligand-linker conjugate. Thalidomide-Piperazine-Piperidine hydrochloride incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2599846-44-1. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-138783A. | |
| Thalidomide, propargyl | Thalidomide, propargyl is a cereblon-recruiting ligand consisting of an E3 ubiquitin ligase thalidomide conjugated to an alkyne linker ready for a target protein ligand. It has been used in PROTAC technology for target protein degradation. Synonyms: 2-(2,6-Dioxo-3-piperidinyl)-4-(2-propyn-1-yloxy)-1H-isoindole-1,3(2H)-dione. Grades: ≥98%. CAS No. 2098487-39-7. Molecular formula: C16H12N2O5. Mole weight: 312.28. | |
| Thalidomide-pyrrolidine hydrochloride | Thalidomide-pyrrolidine hydrochloride (compound 18) is an E3 ligase ligand , and can be used for synthesis of PROTACs [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2616553-35-4. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-W248665A. | |
| Zomiradomide | KT-413 (example I-3) is an orally active PROTAC-class IRAK degrader [1]. KT-413 consists of a target protein ligand (red part) PROTAC IRAK4 ligand-5 (HY-168311), an E3 ubiquitin ligase ligand (blue part) Thalidomide-4-Br (HY-W039116), and a PROTAC linker (black part) 2-(2-Azaspiro[3.3]heptan-6-yl)ethanamine (HY-168313). E3 ubiquitin ligase and linker can form Thalidomide-NH-C2-2-azaspiro[3.3]heptane (HY-168312). The active control for the target protein ligand is RSL3-4-Me (HY-169375). Uses: Scientific research. Group: Signaling pathways. Alternative Names: KT-413. CAS No. 2655656-99-6. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-153368. | |
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