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Product | Description | |
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FK-506 Quick inquiry Where to buy Suppliers range | FK 506. CAS No. 104987-11-3. | |
FK-506 (Fujimycin, Tacrolimus) Quick inquiry Where to buy Suppliers range | FK-506 is a potent immunosuppressant and in vitro T cell proliferation blocker. It has been shown to disrupt calcineurin (also known as CaN or phosphatase 2B)-mediated signal transduction in T lymphocytes. The compound interacts with its FK506-binding protein-12 (FKBP12). The resulting complex, in turn, interferes with calcineurin substrate interaction. Group: Biochemicals. Alternative Names: Advagraf; FR 900506; Fujimycin; L 679934; Prograf; Protopic; TacroBell; Tacrolimus; Tsukubaenolide. Grades: Highly Purified. CAS No. 104987-11-3. Pack Sizes: 50mg, 100mg, 500mg, 1g. Molecular Formula: C44H69NO12, Molecular Weight: 804.02. US Biological Life Sciences. | Worldwide |
FK-506 (Fujimycin, Tacrolimus)-13C,D2 Quick inquiry Where to buy Suppliers range | FK-506 (Fujimycin, Tacrolimus)-13C,D2. Group: Biochemicals. Alternative Names: FK-506-13C,D2. Grades: Highly Purified. CAS No. 104987-11-3forunlabelled. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
Tacrolimus Quick inquiry Where to buy Suppliers range | FK-506 is a 23-membered macrolide lactone, it reduces peptidyl-prolyl isomerase activity by binding to the immunophilin FKBP12 (FK506 binding protein) creating a new complex. Uses: Drug. Synonyms: Prograf; Fujimycin; FK506; Protopy. Grades: >98%. CAS No. 104987-11-3. Molecular formula: C44H69NO12. Mole weight: 804.02. | |
Tacrolimus Quick inquiry Where to buy Suppliers range | Tacrolimus (also FK-506 or fujimycin, trade names Prograf, Advagraf, Protopic) is an immunosuppressive drug used mainly after allogeneic organ transplant to lower the risk of organ rejection. It achieves this by inhibiting the production of interleukin-2, a molecule that promotes the development and proliferation of T cells, which are vital to the bodys learned (or adaptive) immune response.Tacrolimus is also used in the treatment of other T cell-mediated diseases such as eczema (for which it is applied to the skin in a medicated ointment), severe refractory uveitis after bone marrow transplants, exacerbations of minimal change disease, Kimuras disease, and the skin condition vitiligo.Chemically it is a 23-membered macrolide lactone that was first discovered in 1987 from the fermentation broth of a Japanese soil sample that contained the bacterium Streptomyces tsukuba. Group: Main Products. Alternative Names: (2-propenyl)-, (3s-(3r*(e(1s*, 3s*, 4s*)), 4s*, 5r*, 8s*, 9e, 12r*, 14r*, 15s*, 16r*, 18s*;, 19s*, 26ar*))-;16-dimethoxy-4, 10, 12, 18-tetramethyl-8-3-(2-(4-hydroxy-3-methoxycyclohexyl)-1;19-epoxy-3h-pyrido(2, 1-c)(1, 4)oxaazacyclotricosine-1, 7, 20, 21(4h, 23h)-tetrone, 5, 6, 8, 11, 12, 13, 14, 15, 16, 17, 18, 19, 24, 25, 26, 26a-hexadecahydro-5, 19-dihydroxy-3-(2-(4-hydroxy-3-methoxycyclohexyl)-14, 16-dim;6, 8, 11, 12, 13, 14, 15, 16, 17, 18, 19, 24, 25, 26, 26a-hexadecahydro-5, 19-dihydroxy-5;fr900506;prograf;tsukubaenolide. Grades: 98%+. CAS No. 104987-11-3. Product ID: ACM104987113. Molecular formula: C44H69NO12. Mole weight: 804.02. IUPAC Name: FK506(Tacrolimus). Appearance: White or off-white crystalline powder. Boiling Point: 871.7ºC at 760 mmHg. Melting Point: 113-115ºC. Flash Point: 481ºC. Density: 1.19 g/cm³. |