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| Product | Description | |
|---|---|---|
| BMP Inhibitor II, DMH1 (ALK2/3 Inhibitor, DMH1, Bone Morphogenetic Protein Inhibitor, DMH1, 4- (6- (4-Isopropoxyphenyl) pyrazolo[1, 5-a]pyrimidin-3-yl) quinoline) | A cell-permeable pyrrazolopyrimidine compound that inhibits against R/VEGFR2, ALK2/BMPR-I, AMPK kinase activity (IC50=25.1, 148, and 234.6nM, respectively), while exhibiting much reduced or little effect toward ALK5/TGFbR-I, ZAPK, Syk, PKCth, PKA, or JAK3. Shown to block both BMP pathway-dependent dorsoventral development (EC100=2.5uM) and VEGF signaling-dependent intersomitic vessel formation (EC50=5uM) in zebrafish embryo in vivo. Commonly used in combination with AMPK activators AICAR and/or Metformin for studying AMPK-dependent cellular events in vitro and physiological responses in animals in vivo. Group: Biochemicals. Grades: Highly Purified. CAS No. 1206711-16-1. Pack Sizes: 5mg. US Biological Life Sciences. |  Worldwide |
| DMH-1 | DMH-1. Group: Biochemicals. Grades: Purified. CAS No. 1206711-16-1. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| DMH-1 | DMH-1 Inhibitor. Uses: Scientific use. Product Category: T1942. CAS No. 1206711-16-1. |  |
| DMH-1 | DMH-1 is a second-generation small-molecule BMP inhibitor based on dorsomorphin. It effectively inhibits ALK1/2/3. It was shown to induce neuronal differentiation in human-induced pluripotent stem cells (hiPSCs). Synonyms: DMH 1; 4-[6-(4-propan-2-yloxyphenyl)pyrazolo[1,5-a]pyrimidin-3-yl]quinoline. Grades: >98%. CAS No. 1206711-16-1. Molecular formula: C24H20N4O. Mole weight: 380.44. |  |
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