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| Product | Description | |
|---|---|---|
| Topotecan | Topotecan has been used as a positive control for the identification and analysis of HIF-1α and VEGF inhibitors in human glioma cells under hypoxic conditions. It has also been used for in vitro apoptosis assays in PA317 cells. Synonyms: 1H-Pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione, 10-[(dimethylamino)methyl]-4-ethyl-4,9-dihydroxy-, (4S)-; (4S)-10-[(Dimethylamino)methyl]-4-ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione; 1H-Pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione, 10-[(dimethylamino)methyl]-4-ethyl-4,9-dihydroxy-, (S)-; (S)-Topotecan; 10-Hydroxy-9-[(dimethylamino)methyl]-(20S)-camptothecin; 9-(N,N-Dimethylaminomethyl)-10-hydroxycamptothecin; Evotopin; Hycamptamine; Hycamptin; Nogitecan; NSC 609699; Potactasol; SKF 104864; SKF-S 104864; TopoCED; Topophore C; Topotecan lactone; ZINC 1611274. Grade: ≥95%. CAS No. 123948-87-8. Molecular formula: C23H23N3O5. Mole weight: 421.45. |  |
| Topotecan | Topotecan is a pyranoindolizinoquinoline used as an antineoplastic agent. It is a derivative of camptothecin and works by binding to the topoisomerase I-DNA complex and preventing religation of these 328 single strand breaks. It has a role as an EC 5.99.1.2 (DNA topoisomerase) inhibitor and an antineoplastic agent. Alternative Names: Topotecan lactone. Hycamptamine. Hycamptin. CAS No. 123948-87-8. Product ID: API123948878. Molecular formula: C23H23N3O5. Mole weight: 421.4. EINECS: 687-471-1. SMILES: CCC1(C2=C(COC1=O)C(=O)N3CC4=CC5=C(C=CC(=C5CN(C)C)O)N=C4C3=C2)O. Appearance: Light Yellow to Yellow Solid. Category: Anti-Tumor APIs. |  |
| Topotecan | Topotecan (SKF 104864A; NSC 609669) is an orally active and potent Topoisomerase I inhibitor. Topotecan induces cell cycle arrest in G0/G1 and S phases and promotes apoptosis. Topotecan shows anticancer activity [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: SKF 104864A; NSC 609669. CAS No. 123948-87-8. Pack Sizes: 1 mg. Product ID: HY-13768. |  |
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