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| Product | Description | |
|---|---|---|
| (+)-Igmesine hydrochloride | Igmesine is a selective σ1 receptor ligand (KD = 19.1 nM), with nearly no activity at σ2 receptors (IC50 > 1000 nM). It was developed by Pfizer. Igmesine inhibits the NMDA-induced increase in cGMP in a concentration-dependent manner and IC50 value is approximately 100 nM. Igmesine can weekly inhibit brain 5-HT uptake in vitro. It exhibits neuroprotective and antidepressant effects. No developments were reported for the treatment of Cognition disorders, Diarrhoea and Major depressive disorder. Uses: Cognition disorders; diarrhoea; major depressive disorder. Synonyms: Igmesine HCl; CI-1019; JO-1784; CI 1019; JO 1784; CI1019; JO1784; (+)-(E)-N-(Cyclopropylmethyl)-alpha-ethyl-N-methyl-alpha-(3-phenyl-2-propenyl)benzenemethanamine hydrochloride. Grades: 98%. CAS No. 130152-35-1. Molecular formula: C23H30ClN. Mole weight: 355.94. |  |
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