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EPZ004777 hydrochloride Quick inquiry Where to buy Suppliers range | EPZ004777 selectively inhibits cellular H3K79 methylation and inhibits expression of key MLL fusion target genes. Following DOT1L inhibition, EPZ004777 selectively inhibits proliferation of MLL-Rearranged cell lines and MLL-AF9-transformed murine hematopoietic cells. In addition, EPZ004777 also induces differentiation and apoptosis in MLL-rearranged cells. EPZ004777 selectively inhibits proliferation of MLL-AF10 and CALM-AF10-transformed murine bone marrow cells. DOT1L inhibition by EPZ004777 results in significantly decreased proliferation, decreased expression of MLL-AF6 target genes, and cell cycle arrest of MLL-AF6-transformed cells. Synonyms: EPZ 004777 hydrochloride; EPZ-004777 hydrochloride; EPZ004777 hydrochloride. Grades: >98%. CAS No. 1380316-03-9. Molecular formula: C28H42ClN7O4. Mole weight: 576.13. |