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| Product | Description | |
|---|---|---|
| CT7001 hydrochloride | CT7001, also known as ICEC0942, is an orally bioavailable CDK7 inhibitor with IC50 value of 40nM. CDK7 phosphorylates the C-terminal domain (CTD) of RNA polymerase II (PolII) to enable transcription initiation, and also affects some transcriptional factor activities, resulting in suppression of types of cancers. Synonyms: ICEC0942 hydrochloride; (3R,4R)-4-[[[7-(benzylamino)-3-propan-2-ylpyrazolo[1,5-a]pyrimidin-5-yl]amino]methyl]piperidin-3-ol hydrochloride. CAS No. 1805789-54-1. Molecular formula: C22H31ClN6O. Mole weight: 430.97. |  |
| Samuraciclib | Samuraciclib Inhibitor. Uses: Scientific use. Product Category: T10898. CAS No. 1805789-54-1. |  |
| Samuraciclib hydrochloride | Samuraciclib hydrochloride (CT7001 hydrochloride) is a potent, selective, ATP-competitive and orally active CDK7 inhibitor, with an IC50 of 41 nM. Samuraciclib hydrochloride displays 45-, 15-, 230- and 30-fold selectivity over CDK1, CDK2 (IC50 of 578 nM), CDK5 and CDK9, respectively. Samuraciclib hydrochloride inhibits the growth of breast cancer cell lines with GI50 values between 0.2-0.3 μM. Samuraciclib hydrochloride has anti-tumor effects[1][2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: CT7001 hydrochloride; ICEC0942 hydrochloride. CAS No. 1805789-54-1. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-103712A. |  |
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