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| Product | Description | |
|---|---|---|
| 2',3'-cGMP | 2',3'-cGMP, a cyclic nucleotide with profound significance in the biomedical sector, takes center stage within this product description. Employed primarily as a research instrument, it facilitates an in-depth exploration of intracellular signaling cascades across diverse biological spectrums. Furthermore, 2',3'-cGMP assumes an indispensable role in overseeing cellular proliferation and differentiation. This versatile product harbors immense potential, warranting its employment in the realm of drug discovery. Synonyms: Guanosine- 2', 3'- cyclic monophosphate, sodium salt. Grades: ≥ 97 % by HPLC. CAS No. 15718-49-7. Molecular formula: C10H11N5O7P · Na. Mole weight: 367.2. |  |
| 2',3'-cGMP sodium | 2',3'-cGMP sodium, a cGMP analogue, is an intermediate of RNA catalytic cleavage by binase [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Guanosine 2',3'-cyclic monophosphate sodium salt. CAS No. 15718-49-7. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-N8245. |  |
| 2'- (N-Methylanthraniloyl) guanosine 3',5'-Cyclicmonophosphate, Sodium Salt (MANT-cGMP) | A blue fluorescent derivative of cGMP is a useful substrate the assay of cyclic nucleotide phosphdiesterase. Also inhibits calmodulin-dependent activation of cyclic nucleotide phosphodiesterase by peptide segments of HIV envelope glycoproteins has been monitored using MANT-cGMP.Fluorescence: max. Abs. 359nm; max. Em. 448nm; e x 10-3: 5.2. Group: Biochemicals. Alternative Names: Cyclic 3,5-(hydrogen phosphate) 2-[2-(methylamino)benzoate] Guanosine Monosodium Salt; MANT-cGMP. Grades: Highly Purified. CAS No. 221905-46-0. Pack Sizes: 5mg. US Biological Life Sciences. |  Worldwide |
| 8-[(6-Amino)hexyl]-amino-cGMP - ATTO-532 | 8-[(6-Amino)hexyl]-amino-cGMP - ATTO-532 is a fluorescent dye with excitation/emission at 532/555 nm. It can be employed as a labeling agent for real-time imaging of cGMP signaling pathways and visualization of specific drug targets in various in vitro and in vivo biomedical studies. Synonyms: 8-[(6-Amino)hexyl]-amino-guanosine-3',5'-cyclic monophosphate, labeled with ATTO 532, Triethylammonium salt. Grades: ≥ 95% by HPLC. Molecular formula: C45H55N10O16PS2 (free acid). Mole weight: 1086.30 (free acid). | |
| 1-NH2-cGMP | 1-NH2-cGMP is a selective cGMP analogue that has a higher affinity of site A in cGK, and it is commonly used for synergism studies. Synonyms: 1- Aminoguanosine- 3', 5'- monophosphate, sodium salt. Grades: ≥ 98% by HPLC. CAS No. 78033-42-8. Molecular formula: C10H12N6O7P · Na. Mole weight: 382.2. | |
| 2'-AEC-cGMP-Agarose | 2'-AEC-cGMP-Agarose is the protein kinase G activator cGMP immobilized on agarose by an aminoethylcarbamoyl spacer, which can be used in affinity chromatography of cyclic nucleotide-responsive proteins such as some phosphodiesterases. Synonyms: 2'- O- (2- Aminoethylcarbamoyl)guanosine- 3', 5'- cyclic monophosphate; immobilized on agarose gel. | |
| 2'-AEC-cGMP / EDA-cGMP | 2'-AEC-cGMP is a cGMP analogue used for immobilization as an affinity ligand or for coupling of labelling structures such as fluorophores. Synonyms: 2'- O- (2- Aminoethylcarbamoyl)guanosine- 3', 5'- cyclic monophosphate. Grades: ≥ 98% by HPLC. Molecular formula: C13H18N7O8P. Mole weight: 431.3. | |
| 2'-AHC-cGMP | 2'-AHC-cGMP is a cGMP analogue used for immobilization as an affinity ligand or for coupling of labelling structures such as fluorophores. Synonyms: 2'- O- (6- Aminohexylcarbamoyl)guanosine- 3', 5'- cyclic monophosphate. Grades: ≥ 98% by HPLC. CAS No. 1262749-60-9. Molecular formula: C17H26N7O8P. Mole weight: 487.4. | |
| 2'-AHC-cGMP-Agarose | 2'-AHC-cGMP-Agarose is the protein kinase G activator cGMP immobilized on agarose by an aminohexylcarbamoyl spacer which can be used in affinity chromatography of cyclic nucleotide-responsive proteins such as some phosphodiesterases. Synonyms: 2'- O- (6- Aminohexylcarbamoyl)guanosine- 3', 5'- cyclic monophosphate; immobilized on agarose gel. | |
| 2-AH-cGMP-Agarose | 2-AH-cGMP-Agarose is the second messenger cGMP immobilized on agarose by an aminohexyl spacer which can be used in affinity chromatography of cyclic nucleotide-responsive proteins such as protein kinases, phosphodiesterases and others. Synonyms: N2- (6- Aminohexyl)guanosine- 3', 5'- cyclic monophosphate; immobilized on agarose gel. | |
| 2'-[DY505-05]-AHC-cGMP | 2'-[DY505-05]-AHC-cGMP is a fluorescent cGMP analogue (λexc505 nm, λem530 nm) that can be used for phosphodiesterase studies. Synonyms: 2'- O- (6- [DY-505-05]- aminohexylcarbamoyl))guanosine- 3', 5'- cyclic monophosphate, sodium salt. Grades: ≥ 95% by HPLC. Molecular formula: C38H37N9O12P · Na. Mole weight: 865.7. | |
| 2-Me-cGMP | 2-Me-cGMP is an analogue of cGMP used for cGMP receptor mapping studies. Grades: ≥ 99% by HPLC. CAS No. 205368-54-3. Molecular formula: C11H13N5O7P · Na. Mole weight: 381.2. | |
| 2'-O-MB-cGMP | 2'-O-MB-cGMP is a precursor of cGMP. cGMP is released after the metabolism of 2'-O-MB-cGMP by esterases. Compared to cGMP, it has more lipophilic and membrane-permeant properties. Synonyms: 2'- O- Monobutyrylguanosine- 3', 5'- cyclic monophosphate, sodium salt. Grades: ≥ 97% by HPLC. CAS No. 58329-72-9. Molecular formula: C14H17N5O8P · Na. Mole weight: 437.3. | |
| 2'-O-Me-cGMP | 2'-O-Me-cGMP is a polar analogue of cGMP that activate neither protein kinase G nor Epac. It exhibits an inactive effect in patch clamp applications and can be used for receptor mapping studies. Synonyms: 2'- O- Methylguanosine- 3', 5'- cyclic monophosphate, sodium salt. Grades: ≥ 98% by HPLC. CAS No. 949909-73-3. Molecular formula: C11H13N5O7P · Na. Mole weight: 381.2. | |
| 2'-O-MS-cGMP | 2'-O-MS-cGMP is a cGMP analogue, which is used for coupling of ligands including proteins for ELISA. Synonyms: 2'- O- Monosuccinylguanosine- 3', 5'- cyclic monophosphate, free acid. Grades: ≥ 98% by HPLC. CAS No. 39118-26-8. Molecular formula: C14H16N5O10P. Mole weight: 445.3. | |
| 2'-O-MS-TME-cGMP | 2'-O-MS-TME-cGMP is an analogue of cGMP, which is used for radio-iodination in cGMP immunoassays. Synonyms: 2'- O- Monosuccinylguanosine- 3', 5'- cyclic monophosphate, tyrosylmethyl ester, sodium salt. Grades: ≥ 95% by HPLC. CAS No. 104872-93-7. Molecular formula: C24H26N6O12P · Na. Mole weight: 644.5. | |
| 2'-TAMRA-AEC-cGMP | 2'-TAMRA-AEC-cGMP is a fluorescent cGMP analogue (λexc555 nm, λem580 nm) that can be used for phosphodiesterase studies. Synonyms: 2'- O- (2- [Tetramethylrhodaminyl] aminoethylcarbamoyl) guanosine- 3', 5'- cyclic monophosphate, sodium salt. Grades: ≥ 95% by HPLC. Molecular formula: C38H37N9O12P · Na. Mole weight: 865.7. | |
| 2'-TAMRA-AHC-cGMP | 2'-TAMRA-AHC-cGMP is a fluorescent cGMP analogue (λexc555 nm, λem580 nm) that can be used for phosphodiesterase studies. Synonyms: 2'- O- (6- [Tetramethylrhodaminyl] aminohexylcarbamoyl) guanosine- 3', 5'- cyclic monophosphate, sodium salt. Grades: ≥ 95% by HPLC. Molecular formula: C42H45N9O12P · Na. Mole weight: 921.8. | |
| 4-N3-PET-8-Br-cGMP | 4-N3-PET-8-Br-cGMP is an analogue used for photoaffinity labelling of cGMP-responsive receptors, and an isozyme-selective activator of cGMP-dependent protein kinase I α and &beta. Synonyms: β- (4- Azidophenyl)- 1, N2- etheno- 8- bromoguanosine- 3', 5'- cyclic monophosphate, sodium salt. Grades: ≥ 97% by HPLC. Molecular formula: C18H13BrN8O7P · Na. Mole weight: 587.2. | |
| 6-HT-cGMP | 6-HT-cGMP, a cyclic guanosine monophosphate (cGMP) analog, has been subject to extensive research as a prospective therapy for cardiovascular ailments. With vasoconstriction being a leading cause of such diseases, extensive studies have shown that 6-HT-cGMP act as a vasodilator. Animal models have indicated that it can increase coronary blood flow, giving it potential clinical implications. Furthermore, 6-HT-cGMP is promising in the treatment of erectile dysfunction. A comprehensive understanding of its properties and mechanisms is imperative as it shows great potential in treating these prevalent conditions. Synonyms: 6- Hexylthioguanosine- 3', 5'- cyclic monophosphate. Molecular formula: C16H23N5O6PS · Na. Mole weight: 467.4. | |
| 8- (4-Chlorophenylthio) guanosine 3',5'-cyclic monophosphate sodium salt | 8- (4-Chlorophenylthio) guanosine 3',5'-cyclic monophosphate sodium salt. Group: Biochemicals. Alternative Names: 8-pCPT-cGMP. Grades: Highly Purified. CAS No. 51239-26-0. Pack Sizes: 5mg, 10mg, 25mg, 50mg. Molecular Formula: C16H14ClN5O7PS·Na. US Biological Life Sciences. | Worldwide |
| 8-[(6-Amino)hexyl]-amino-cGMP | 8-[(6-Amino)hexyl]-amino-cGMP, a derivative of cyclic guanosine monophosphate (cGMP), displays potential for therapeutic use in diseases like hypertension and erectile dysfunction. This analogue's efficacy lies within its ability to enhance smooth muscle relaxation and trigger vasodilation. With the potential to alleviate the symptoms of these ailments, 8-[(6-Amino)hexyl]-amino-cGMP offers a promising avenue for further study and development. Synonyms: 8-[(6-Amino)hexyl]-amino-guanosine-3',5'-cyclic monophosphate, Sodium salt. Grades: ≥ 95% by HPLC. Molecular formula: C16H26N7O7P (free acid). Mole weight: 459.39 (free acid). | |
| 8-[(6-Amino)hexyl]-amino-cGMP - 6-JOE | 8-[(6-Amino)hexyl]-amino-cGMP - 6-JOE is a compound ingeniously devised to regulate the multifarious signaling pathways orchestrating cellular multiplication and programmed cell death. Synonyms: 8-[(6-Amino)hexyl]-amino-guanosine-3',5'-cyclic monophosphate, labeled with 6-JOE, Triethylammonium salt. Grades: ≥ 95% by HPLC. Molecular formula: C39H37Cl2N6O16P (free acid). Mole weight: 946.14 (free acid). | |
| 8-[(6-Amino)hexyl]-amino-cGMP - ATTO-425 | 8-[(6-Amino)hexyl]-amino-cGMP - ATTO-425 is a fluorescent probe used to measure cyclic guanosine monophosphate (cGMP) levels in biological systems. It is a valuable tool in studying diseases such as pulmonary hypertension and erectile dysfunction where cGMP regulation is disrupted. Synonyms: 8-[(6-Amino)hexyl]-amino-guanosine-3',5'-cyclic monophosphate, labeled with ATTO 425, Triethylammonium salt. Grades: ≥ 95% by HPLC. Molecular formula: C38H51N8O12P (free acid). Mole weight: 842.84 (free acid). | |
| 8-[(6-Amino)hexyl]-amino-cGMP - ATTO-488 | 8-[(6-Amino)hexyl]-amino-cGMP - ATTO-488, a fluorescent probe, has multifaceted applications in biomedicine research. One of its primary functions is monitoring cyclic guanosine monophosphate (cGMP) levels, which helps in understanding the signals that govern critical cellular activities. In addition, researchers use it to explore cell signaling mechanisms in the context of various diseases such as hypertension, cardiovascular diseases, and related disorders. All in all, this innovative probe represents the vanguard of medical research looking to investigate complex biological systems. Synonyms: 8-[(6-Amino)hexyl]-amino-guanosine-3',5'-cyclic monophosphate, labeled with ATTO 488, Triethylammonium salt. Grades: ≥ 95% by HPLC. Molecular formula: C41H47N10O16PS2 (free acid). Mole weight: 1030.24 (free acid). | |
| 8-[(6-Amino)hexyl]-amino-cGMP - ATTO-495 | 8-[(6-Amino)hexyl]-amino-cGMP - ATTO-495, a biochemical tool renowned for its high potency, has been prudently curated for biomedical research. This efficacious molecule is often employed to investigate the impacts of intracellular cyclic nucleotide signaling pathways, with its remarkably sensitive fluorophore, ATTO-495, facilitating the detection and visualization of the molecule in cellular environments. The versatility of the product sees its usability extend to numerous studies relating to complex medical conditions such as hypertension, cardiovascular disorders, and devastating cancer, among others. Synonyms: 8-[(6-Amino)hexyl]-amino-guanosine-3',5'-cyclic monophosphate, labeled with ATTO 495. Grades: ≥ 95% by HPLC. Molecular formula: C37H49N10O8P (free acid). Mole weight: 792.82 (free acid). | |
| 8-[(6-Amino)hexyl]-amino-cGMP - ATTO-540Q | 8-[(6-Amino)hexyl]-amino-cGMP - ATTO-540Q is a fluorescently labeled cyclic guanosine monophosphate (cGMP) derivative, utilized in compound for visualization and detection of cGMP signaling pathways. This compound aids in studying cardiovascular diseases, such as hypertension and heart failure, where cGMP dysregulation is implicated. It enables precise monitoring and quantification of cGMP levels, facilitating comprehensive understanding of its role in disease progression and drug design. Synonyms: 8-[(6-Amino)hexyl]-amino-guanosine-3',5'-cyclic monophosphate, labeled with ATTO 540Q, Triethylammonium salt. Grades: ≥ 95% by HPLC. Molecular formula: C16H26N7O7P - ATTO 540Q (free acid). Mole weight: 999.39 (free acid). | |
| 8-[(6-Amino)hexyl]-amino-cGMP - ATTO-550 | 8-[(6-Amino)hexyl]-amino-cGMP - ATTO-550 is a fluorescent probe whose purpose is monitoring of intracellular cGMP levels in living cells. This product is employed in studies connected to the cGMP signaling pathway and finding treatments of cardiovascular and metabolic ailments. The said properties of this fluorescent probe make it a crucial tool in biomedical research and scientific studies investigating intracellular processes in living systems, proving its worth in observing and studying cellular functions in utmost detail. Synonyms: 8-[(6-Amino)hexyl]-amino-guanosine-3',5'-cyclic monophosphate, labeled with ATTO 550, Triethylammonium salt. Grades: ≥ 95% by HPLC. Molecular formula: C16H26N7O7P - ATTO 550 (free acid). Mole weight: 1034.39 (free acid). | |
| 8-[(6-Amino)hexyl]-amino-cGMP - ATTO-580Q | 8-[(6-Amino)hexyl]-amino-cGMP - ATTO-580Q, a fluorescent probe, is frequently utilized in research to visualize real-time cGMP signaling. With its advantages in investigating the effects of drugs that alter cGMP levels and its role in the progression of diseases such as heart failure and hypertension, this probe offers significant value in scientific research. Synonyms: 8-[(6-Amino)hexyl]-amino-guanosine-3',5'-cyclic monophosphate, labeled with ATTO 580Q, Triethylammonium salt. Grades: ≥ 95% by HPLC. Molecular formula: C16H26N7O7P - ATTO 580Q (free acid). Mole weight: 1135.39 (free acid). | |
| 8-[(6-Amino)hexyl]-amino-cGMP - ATTO-590 | 8-[(6-Amino)hexyl]-amino-cGMP - ATTO-590 is a high-performance fluorescent marker widely employed in biomedical research to investigate complex cGMP signaling pathways. This exceptionally stable product binds uniquely to cGMP, yielding accurate measurements of intracellular cGMP concentrations and providing valuable insight into its subcellular localization. Consequently, this state-of-the-art technology enables researchers to more thoroughly investigate diseases like hypertension and heart failure. Synonyms: 8-[(6-Amino)hexyl]-amino-guanosine-3',5'-cyclic monophosphate, labeled with ATTO 590. Grades: ≥ 95% by HPLC. Molecular formula: C53H62N9O11P (free acid). Mole weight: 1032.10 (free acid). | |
| 8-[(6-Amino)hexyl]-amino-cGMP - ATTO-594 | 8-[(6-Amino)hexyl]-amino-cGMP - ATTO-594 is a fluorescent probe widely employed for the visualization of cyclic guanosine monophosphate (cGMP) signaling pathways in cells and tissues. This compound aids in studying the role of cGMP in various biological processes and diseases, including cardiovascular disorders, neuronal signaling and smooth muscle relaxation. Synonyms: 8-[(6-Amino)hexyl]-amino-guanosine-3',5'-cyclic monophosphate, labeled with ATTO 594, Triethylammonium salt. Grades: ≥ 95% by HPLC. Molecular formula: C16H26N7O7P - ATTO 594 (free acid). Mole weight: 1246.39 (free acid). | |
| 8-[(6-Amino)hexyl]-amino-cGMP - ATTO-612Q | 8-[(6-Amino)hexyl]-amino-cGMP - ATTO-612Q, a fluorescent probe, designed to assist biomedical research in investigating guanylyl cyclase enzyme activity and cGMP-related signaling pathways, as well as studying the pathogenesis of cardiovascular diseases and cancer. The intricacies of this product are profound whilst remaining highly practical, offering a truly unique insight into its potential. Synonyms: 8-[(6-Amino)hexyl]-amino-guanosine-3',5'-cyclic monophosphate, labeled with ATTO 612Q, Triethylammonium salt. Grades: ≥ 95% by HPLC. Molecular formula: C16H24N7O7P - ATTO 612Q (free acid). Mole weight: 1131.39 (free acid). | |
| 8-[(6-Amino)hexyl]-amino-cGMP - ATTO-620 | 8-[(6-Amino)hexyl]-amino-cGMP - ATTO-620 is a fluorescent dye used to label proteins and peptides. It is commonly used in the biomedical industry to study protein function and localization, as well as in drug discovery to identify potential targets and inhibitors. Synonyms: 8-[(6-Amino)hexyl]-amino-guanosine-3',5'-cyclic monophosphate, labeled with ATTO 620, Triethylammonium salt. Grades: ≥ 95% by HPLC. Molecular formula: C16H26N7O7P - ATTO 620 (free acid). Mole weight: 952.39 (free acid). | |
| 8-[(6-Amino)hexyl]-amino-cGMP - ATTO-633 | 8-[(6-Amino)hexyl]-amino-cGMP - ATTO-633, a fluorescent dye with high sensitivity and specificity, plays a significant role in biomedical research. It is widely used to label and trace intracellular signaling pathways which are linked to cyclic guanosine monophosphate (cGMP). This dye finds profound applications in pulmonary hypertension, erectile dysfunction, and other cardiovascular diseases. It offers an exceptional investigative tool to explore the signaling pathways associated with these ailments. Synonyms: 8-[(6-Amino)hexyl]-amino-guanosine-3',5'-cyclic monophosphate, labeled with ATTO 633, Triethylammonium salt. Grades: ≥ 95% by HPLC. Molecular formula: C16H26N7O7P - ATTO 633 (free acid). Mole weight: 992.39 (free acid). | |
| 8-[(6-Amino)hexyl]-amino-cGMP - ATTO-647N | 8-[(6-Amino)hexyl]-amino-cGMP - ATTO-647N is a fluorescent probe used for imaging guanylyl cyclase and monitoring cGMP signaling pathways in biological systems. This product can also be utilized in the diagnosis and treatment of disorders related to the activation or inhibition of guanylyl cyclase and cGMP. Synonyms: 8-[(6-Amino)hexyl]-amino-guanosine-3',5'-cyclic monophosphate, labeled with ATTO 647N, Triethylammonium salt. Grades: ≥ 95% by HPLC. Molecular formula: C16H26N7O7P - ATTO 647N (free acid). Mole weight: 1086.39 (free acid). | |
| 8-[(6-Amino)hexyl]-amino-cGMP - ATTO-655 | 8-[(6-Amino)hexyl]-amino-cGMP - ATTO-655, a fluorescent probe that selectively interacts with cyclic GMP, offers a unique opportunity to gain insights into the spatiotemporal regulation of this crucial second messenger in living cells. By illuminating the intricacies of cyclic GMP signaling, this probe promises to unlock the secrets of a wide range of diseases, from cardiovascular disorders to cancer. Witness the power of precision science with this cutting-edge technology. Synonyms: 8-[(6-Amino)hexyl]-amino-guanosine-3',5'-cyclic monophosphate, labeled with ATTO 655, Triethylammonium salt. Grades: ≥ 95% by HPLC. Molecular formula: C16H26N7O7P - ATTO 655 (free acid). Mole weight: 968.39 (free acid). | |
| 8-[(6-Amino)hexyl]-amino-cGMP - ATTO-665 | 8-[(6-Amino)hexyl]-amino-cGMP - ATTO-665 is a fluorescent-labeled nucleotide used in biomedicine to study guanosine cyclic monophosphate (cGMP)-related signaling pathways. It has been used in studies looking at nitric oxide (NO) signaling and the cyclic GMP-protein kinase G (PKG) pathway, which are involved in regulating smooth muscle relaxation. Additionally, it has potential therapeutic applications in treating cardiovascular diseases and pulmonary hypertension. Synonyms: 8-[(6-Amino)hexyl]-amino-guanosine-3',5'-cyclic monophosphate, labeled with ATTO 665. Grades: ≥ 95% by HPLC. Molecular formula: C16H26N7O7P - ATTO 665 (free acid). Mole weight: 1063.39 (free acid). | |
| 8-[(6-Amino)hexyl]-amino-cGMP - ATTO-680 | 8-[(6-Amino)hexyl]-amino-cGMP - ATTO-680 is a fluorescent labeling molecule used in the biomedical industry for research purposes. It can be used to visualize and track intracellular signaling processes involving cGMP in various cell types, as well as for studying cardiovascular diseases and vascular dysfunction related to nitric oxide (NO) signaling. Synonyms: 8-[(6-Amino)hexyl]-amino-guanosine-3',5'-cyclic monophosphate, labeled with ATTO 680, Triethylammonium salt. Grades: ≥ 95% by HPLC. Molecular formula: C16H26N7O7P - ATTO 680 (free acid). Mole weight: 966.39 (free acid). | |
| 8-[(6-Amino)hexyl]-amino-cGMP - ATTO-700 | 8-[(6-Amino)hexyl]-amino-cGMP - ATTO-700, a fluorescent probe widely used in molecular and cellular biology applications, offers remarkable capabilities in visualizing and monitoring cGMP-mediated signaling pathways in live cells and tissues. With its highly sensitive and specific cGMP detection, it is an invaluable tool for investigating an array of diseases linked with dysfunctional cGMP signaling, such as cardiovascular diseases and erectile dysfunction. Utilizing this state-of-the-art technology yields infinite possibilities for expanding our knowledge of the intricacies of cellular communication and signaling. Synonyms: 8-[(6-Amino)hexyl]-amino-guanosine-3',5'-cyclic monophosphate, labeled with ATTO 700, Triethylammonium salt. Grades: ≥ 95% by HPLC. Molecular formula: C16H26N7O7P - ATTO 700 (free acid). Mole weight: 1006.39 (free acid). | |
| 8-[(6-Amino)hexyl]-amino-cGMP - ATTO-740 | 8-[(6-Amino)hexyl]-amino-cGMP - ATTO-740, a fluorescent probe, is a valuable tool in biomedical research for investigating the function of guanylyl cyclases and soluble guanylate cyclases. Notably, this versatile probe can be used to study the mechanisms underlying cardiovascular diseases and neuronal disorders, thereby offering the potential for significant scientific breakthroughs and medical advancements. Its reliability and efficacy make it a highly sought-after compound for researchers across diverse fields. Synonyms: 8-[(6-Amino)hexyl]-amino-guanosine-3',5'-cyclic monophosphate, labeled with ATTO 740, Triethylammonium salt. Grades: ≥ 95% by HPLC. Molecular formula: C16H26N7O7P - ATTO 740 (free acid). Mole weight: 908.39 (free acid). | |
| 8-[(6-Amino)hexyl]-amino-cGMP - ATTO-MB2 | 8-[(6-Amino)hexyl]-amino-cGMP - ATTO-MB2 is a fluorescent probe used in biomedicine to detect cGMP, an important signaling molecule involved in numerous cellular processes. This probe can be used in various applications including in vitro assays, imaging techniques, and drug discovery research related to cGMP-dependent pathways such as cardiovascular diseases and erectile dysfunction. Synonyms: 8-[(6-Amino)hexyl]-amino-guanosine-3',5'-cyclic monophosphate, labeled with ATTO-MB2, Triethylammonium salt. Grades: ≥ 95% by HPLC. Molecular formula: C35H45N10O8PS (free acid). Mole weight: 796.83 (free acid). | |
| 8-[(6-Amino)hexyl]-amino-cGMP - ATTO-Rho12 | 8-[(6-Amino)hexyl]-amino-cGMP - ATTO-Rho12, a fluorescent nucleotide analog, is a versatile and indispensable tool utilized in biomedical research for the monitoring of nitric oxide signaling and cGMP. Its exceptional ability to act as a molecular probe in investigating spatiotemporal dynamics of cGMP signals and their correlation with physiological and pathological processes such as vasodilation, neurotransmission, and various cancers has been a game-changer in the scientific community. This product is essential for any researcher looking to make groundbreaking discoveries and uncover the secrets of these vital signaling pathways. Synonyms: 8-[(6-Amino)hexyl]-amino-guanosine-3',5'-cyclic monophosphate, labeled with ATTO Rho12, Triethylammonium salt. Grades: ≥ 95% by HPLC. Molecular formula: C57H75N10O10P (free acid). Mole weight: 1090.54 (free acid). | |
| 8-[(6-Amino)hexyl]-amino-cGMP - ATTO-Rho14 | 8-[(6-Amino)hexyl]-amino-cGMP - ATTO-Rho14 is a powerful fluorescent probe widely utilized in the biomedical industry. This compound plays a crucial role in studying cellular signaling pathways, particularly those involving cGMP. It enables visualize cGMP dynamics and monitor the effects of drugs or diseases on its regulation. With its exceptional fluorescence properties is aTTO-Rho14 facilitates accurate and efficient analysis, contributing to developments in drug discovery and disease understanding. Synonyms: 8-[(6-Amino)hexyl]-amino-guanosine-3',5'-cyclic monophosphate, labeled with ATTO Rho14, Triethylammonium salt. Grades: ≥ 95% by HPLC. Molecular formula: C57H67Cl4N10O10P (free acid). Mole weight: 1222.35 (free acid). | |
| 8-[(6-Amino)hexyl]-amino-cGMP - ATTO-Rho6G | 8-[(6-Amino)hexyl]-amino-cGMP - ATTO-Rho6G is a vital tool used in biomedical research to study cellular signaling pathways specifically designed to detect and visualize the presence and activity of the signaling molecule cyclic guanosine monophosphate (cGMP) in live cells. Synonyms: 8-[(6-Amino)hexyl]-amino-guanosine-3',5'-cyclic monophosphate, labeled with ATTO Rho6G, Triethylammonium salt. Grades: ≥ 95% by HPLC. Molecular formula: C47H59N10O10P (free acid). Mole weight: 954.42 (free acid). | |
| 8-[(6-Amino)hexyl]-amino-cGMP - ATTO-Thio12 | 8-[(6-Amino)hexyl]-amino-cGMP, a cyclic nucleotide analog, serves as a vital tool in biomedical research to investigate the part played by cyclic nucleotides in cell signaling. It additionally holds potential in studying modulation of intracellular pathways that contribute to the onset of cardiovascular ailments, such as hypertension and heart failure. To help visualize this versatile compound in live cells, ATTO-Thio12, a prominent fluorescent label, can be employed. Synonyms: 8-[(6-Amino)hexyl]-amino-guanosine-3',5'-cyclic monophosphate, labeled with ATTO Thio12. Grades: ≥ 95% by HPLC. Molecular formula: C45H55N10O9PS (free acid). Mole weight: 943.02 (free acid). | |
| 8-[(6-Amino)hexyl]-amino-cGMP - Biotin | 8-[(6-Amino)hexyl]-amino-cGMP - Biotin is a distinctive compound widely employed in the biomedical field, facilitating the investigation of cyclic guanosine monophosphate (cGMP) signaling. Augmented by the incorporation of biotin, this remarkable substance boasts remarkable efficacy in affording researchers with an elevated precision in detection and visualization techniques. Synonyms: 8-[(6-Amino)hexyl]-amino-guanosine-3',5'-cyclic monophosphate - Biotin, Triethylammonium salt. Grades: ≥ 95% by HPLC. Molecular formula: C26H40N9O9PS (free acid). Mole weight: 685.69 (free acid). | |
| 8-[(6-Amino)hexyl]-amino-cGMP - Cy3 | 8-[(6-Amino)hexyl]-amino-cGMP - Cy3, a fluorescent cGMP analog, is a potent visualizing tool of cGMP signaling pathways for live-cell imaging. Demonstrating remarkable sensitivity as a reporter of cGMP levels, this compound has been pivotal in exploring the intricacies of hypertension and heart failure as well as functioning as a multifaceted investigative substrate in a plethora of diseases. Synonyms: 8-[(6-Amino)hexyl]-amino-guanosine-3',5'-cyclic monophosphate, labeled with Cy3, Triethylammonium salt. Grades: ≥ 95% by HPLC. Molecular formula: C47H62N9O14PS2 (free acid). Mole weight: 1072.15 (free acid). | |
| 8-[(6-Amino)hexyl]-amino-cGMP - Cy5 | 8-[(6-Amino)hexyl]-amino-cGMP - Cy5 is a state-of-the-art biomedical innovation, serving the purpose of visualizing and tracing the intricate signaling pathway of cGMP within living cells. Harnessing the power of fluorescent dye Cy5, this revolutionary creation facilitates dynamic, real-time surveillance of cGMP signaling. This holistic understanding of cGMP's involvement in an array of physiological and pathological phenomena, including cardiovascular disorders, pulmonary hypertension is and erectile dysfunction, renders this compound an indispensable tool for rigorous scientific inquiry and medical investigations. Synonyms: 8-[(6-Amino)hexyl]-amino-guanosine-3',5'-cyclic monophosphate, labeled with Cy5, Triethylammonium salt. Grades: ≥ 95% by HPLC. Molecular formula: C49H64N9O14PS2 (free acid). Mole weight: 1098.19 (free acid). | |
| 8-[(6-Amino)hexyl]-amino-cGMP - DYQ-660 | 8-[(6-Amino)hexyl]-amino-cGMP - DYQ-660 is an extensively studied compound impeding the functioning of cGMP-dependent protein kinase. Synonyms: 8-[(6-Amino)hexyl]-amino-guanosine-3',5'-cyclic monophosphate, labeled with DYQ 660, Triethylammonium salt. Grades: ≥ 95% by HPLC. Molecular formula: C55H68N9O12PS (free acid). Mole weight: 1110.23 (free acid). | |
| 8-[(6-Amino)hexyl]-amino-cGMP - DYQ-661 | DYQ-661 - 8-[(6-Amino)hexyl]-amino-cGMP is a highly potent and remarkably specific regulator of the intricate cyclic guanosine monophosphate (cGMP) signaling cascade within the biomedical realm. Synonyms: 8-[(6-Amino)hexyl]-amino-guanosine-3',5'-cyclic monophosphate, labeled with DYQ 661, Triethylammonium salt. Grades: ≥ 95% by HPLC. Molecular formula: C55H67N9O15PS2 (Anion). Mole weight: 1189.28 (Anion). | |
| 8-[(6-Amino)hexyl]-amino-cGMP - MANT | 8-[(6-Amino)hexyl]-amino-cGMP - MANT is a modified form of cyclic guanosine monophosphate (cGMP) that has a MANT (2'(3')-O-(N'-methyl-anthraniloyl) fluorophore) attached to the amino group of the hexyl chain. Synonyms: 8-[(6-Amino)hexyl]-amino-guanosine-3',5'-cyclic monophosphate, labeled with MANT, Triethylammonium salt. Grades: ≥ 95% by HPLC. Molecular formula: C24H33N8O8P (free acid). Mole weight: 592.54 (free acid). | |
| 8-[(6-Amino)hexyl]-amino-cGMP - Texas Red | 8-[(6-Amino)hexyl]-amino-cGMP - Texas Red is a highly sophisticated and advanced fluorescent probe that has revolutionized the field of biomedical research. Its exceptional properties allow for the imaging and detection of intracellular nitric oxide (NO) production, opening up a whole new realm of possibilities for NO signaling pathway visualization in numerous diseases like cancer, inflammation, and cardiovascular disorders. The diversity of applications for this remarkable probe truly exemplifies its unrivaled potential in medical research. Synonyms: 8-[(6-Amino)hexyl]-amino-guanosine-3',5'-cyclic monophosphate, labeled with Texas Red, Triethylammonium salt. Grades: ≥ 95% by HPLC. Molecular formula: C53H65N10O14PS2 (free acid). Mole weight: 1161.25 (free acid). | |
| 8-AET-cGMP | 8-AET-cGMP is a ligand in affinity chromatography and can be modified with fluorophores or other markers. Synonyms: 8- (2- Aminoethylthio)guanosine- 3', 5'- monophosphate. Grades: ≥ 98% by HPLC. CAS No. 115974-70-4. Molecular formula: C12H17N6O7PS. Mole weight: 420.4. | |
| 8-AET-cGMP-Agarose | 8-AET-cGMP-Agarose is the second messenger cGMP immobilized on agarose by an aminoethylthio spacer, which can be used in affinity chromatography of cyclic nucleotide-responsive proteins such as protein kinases, phosphodiesterases and others. Synonyms: 8- (2- Aminoethylthio)guanosine- 3', 5'- cyclic monophosphate; immobilized on agarose gel. | |
| 8-APT-cGMP | 8-APT-cGMP is an isozyme-selective stimulator of cGMP-dependent protein kinase I a with a prenference for type I a over I by a factor of 200. Synonyms: 8- (2- Aminophenylthio)guanosine- 3', 5'- monophosphate, sodium salt. Grades: ≥ 98% by HPLC. CAS No. 144509-87-5. Molecular formula: C16H16N6O7PS · Na. Mole weight: 490.4. | |
| 8-Br-2'-O-Me-cGMP | 8-Br-2'-O-Me-cGMP is an analogue of cGMP that does not activate both protein kinase G and Epac. It is often used as an inactive control versus 8-Br-cGMP. Synonyms: 8- Bromo- 2'- O- methylguanosine- 3', 5'- cyclic monophosphate, sodium salt. Grades: ≥ 98% by HPLC. Molecular formula: C11H12BrN5O7P · Na. Mole weight: 460.1. | |
| 8-Br-cGMP-AM | 8-Br-cGMP-AM is a precursor of 8-Br-cGMP, the PKG activator. The polar active analogue is released after the metabolism of 8-Br-cGMP-AM by esterases. Synonyms: 8- Bromoguanosine- 3', 5'- cyclic monophosphate, acetoxymethyl ester. Grades: ≥ 97% by HPLC for mixture of isomers. CAS No. 272445-71-3. Molecular formula: C13H15BrN5O9P. Mole weight: 496.2. | |
| 8-Br-PET-cGMP Sodium Salt | 8-Br-PET-cGMP Sodium Salt is a pkG cell-permeable activator. Synonyms: 2-Bromo-3,4-dihydro-6-phenyl-3-(3,5-O-phosphinico-β-D-ribofuranosyl)-9H-imidazo[1,2-a]purin-9-one Sodium Salt. CAS No. 185246-29-1. Molecular formula: C18H14BrN5NaO7P. Mole weight: 546.2. | |
| 8-[Fluo]-AHT-PET-cGMP | 8-[Fluo]-AHT-PET-cGMP is a fluorescent cGMP analogue (λexc494 nm, λem517 nm), which can be used for receptor studies. It has the potential to be a CNG channel inhibitor. Synonyms: 8-(6-[Fluoresceinyl]aminohexylthio)-β-phenyl-1,N2-ethenoguanosine-3',5'-cyclic monophosphate, sodium salt. Grades: ≥ 95% by HPLC. Molecular formula: C45H39N7NaO12PS2. Mole weight: 987.9. | |
| 8-NBD-cGMP | 8-NBD-cGMP is a fluorescent activator of both isozymes I α and I β of cGMP-dependent protein kinase. 8-NBD-cGMP fluoresces strongly in hydrophobic environments. Synonyms: 8- (2-[7-Nitro-4-benzofurazanyl]aminoethylthio) guanosine-3', 5'-cyclic monophosphate, sodium salt. Grades: ≥ 95% by HPLC. CAS No. 115993-88-9. Molecular formula: C18H17N9NaO10PS. Mole weight: 605.41. | |
| 8-OH-cGMP | 8-OH-cGMP is a cyclic guanosine monophosphate (cGMP) analog used in biomedical research. It acts as a second messenger in signal transduction pathways. 8-OH-cGMP is mainly utilized for studying the role of cGMP in various cellular processes, including smooth muscle relaxation, cell proliferation, and neurotransmission. It is also commonly used to investigate the pathophysiology and potential therapeutic targets in diseases related to altered cGMP signaling, such as hypertension, cardiovascular disorders, and neurodegenerative diseases. Synonyms: 8- Hydroxyguanosine- 3', 5'- cyclic monophosphate. CAS No. 21082-28-0. Molecular formula: C10H11N5O8P · Na. Mole weight: 383.2. | |
| 8-pCPT-2'-O-Me-cGMP | 8-pCPT-2'-O-Me-cGMP is a PDE-stable, high lipophilic and membrane-permeant analogue. It can be used as a control since it has no activated effect on protein kinase G or Epac. Synonyms: 8- (4- Chlorophenylthio)- 2'- O- methylguanosine- 3', 5'- cyclic monophosphate, sodium salt. Grades: ≥ 98% by HPLC. CAS No. 625112-42-7. Molecular formula: C17H16ClN5O7PS · Na. Mole weight: 523.8. | |
| 8-pCPT-cGMP-AM | 8-pCPT-cGMP-AM is a precursor of 8-pCPT-cGMP, the PKG activator. 8-pCPT-cGMP is released after the metabolism of 8-pCPT-cGMP-AM by esterases. Synonyms: 8- (4- Chlorophenylthio)guanosine- 3', 5'- cyclic monophosphate, acetoxymethyl ester. Grades: ≥ 97% by HPLC for mixture of isomers. CAS No. 272445-72-4. Molecular formula: C19H19ClN5O9PS. Mole weight: 559.9. | |
| 8-pCPT-PET-cGMP | 8-pCPT-PET-cGMP is an activator of cyclic GMP-dependent protein kinase as well as an inhibitor of the retinal type cGMP-gated ion channel, thus it can be used for distinction between kinase and ion channel mediated effects. It effects against mammalian cyclic nucleotide-dependent phosphodiesterases. Compared to 8-Br-PET-cGMP, 8-pCPT-PET-cGMP is much more lipophilic and membrane-permeant. Synonyms: 8- (4- Chlorophenylthio)- β- phenyl- 1, N2- ethenoguanosine- 3', 5'- cyclic monophosphate, sodium salt. Grades: ≥ 98% by HPLC. Molecular formula: C24H18ClN5O7PS · Na. Mole weight: 609.9. | |
| Cyclic GMP | Cyclic GMP (cGAMP) is an endogenous second messenger that triggers interferon production in response to cytoplasmic DNA. Cyclic GMP can activate the stimulator of interferon genes (STING), activating the signaling cascade that leads to the production of type I interferons and other immune mediators. Cyclic-GMP-AMP, a conjugate of cyclic GMP and AMP, can induce IRF3 phosphorylation and nuclear translocation, enhancing antiviral immune responses. cGMP may also activate PDE to degrade cAMP, inhibit myocardial calcium current I Ca , and regulate myocardial contractility. The derivative of cyclic GMP (cGMP), 8-Br-cGMP, has antiplatelet activity, and cyclic GMP can be used in the study of antiviral immunity and cardiovascular diseases [1] [2] [3] [4]. Uses: Scientific research. Group: Natural products. CAS No. 7665-99-8. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-113469. | |
| Cyclic GMP sodium | Cyclic GMP (cGAMP) sodium is an endogenous second messenger that triggers interferon production in response to cytoplasmic DNA. Cyclic GMP sodium can activate the stimulator of interferon genes (STING), activating the signaling cascade that leads to the production of type I interferons and other immune mediators. Cyclic-GMP-AMP, a conjugate of cyclic GMP and AMP, can induce IRF3 phosphorylation and nuclear translocation, enhancing antiviral immune responses. Cyclic GMP sodium may also activate PDE to degrade cAMP, inhibit myocardial calcium current I Ca , and regulate myocardial contractility. The derivative of Cyclic GMP sodium, 8-Br-cGMP, has antiplatelet activity, and Cyclic GMP sodium can be used in the study of antiviral immunity and cardiovascular diseases [1] [2] [3] [4]. Uses: Scientific research. Group: Natural products. CAS No. 40732-48-7. Pack Sizes: 5 mg; 10 mg; 25 mg. Product ID: HY-113469A. | |
| DB-cGMP | DB-cGMP, an exceedingly compelling analogue of cyclic guanosine monophosphate (cGMP), a pivotal secondary messenger in myriad biological processes, serves as an invaluable tool in biomedical research. With a primary focus on unraveling the intricate role of cGMP in signal transduction pathways, cellular proliferation, and apoptosis, it facilitates the understanding of diseases stemming from aberrant cGMP signaling. Synonyms: N2, 2'- O- Dibutyrylguanosine- 3', 5'- cyclic monophosphate, sodium salt. Grades: ≥ 97% by HPLC. CAS No. 51116-00-8. Molecular formula: C18H23N5O9P · Na. Mole weight: 507.4. | |
| Dibutyryl-cGMP sodium | Dibutyryl-cGMP sodium (Bt2cGMP sodium) is a cell-permeable cGMP analogue. Dibutyryl-cGMP sodium preferentially activates cGMP-dependent protein kinase (PKG). Dibutyryl-cGMP sodium inhibits the release of [ 3 H]-arachidonic acid from γ thrombin-stimulated human platelets. Dibutyryl-cGMP sodium induces peripheral antinociception via activation of ATP-sensitive K + channels [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Bt2cGMP sodium. CAS No. 51116-00-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-130354. | |
| DMACM-caged 8-Br-cGMP | DMACM-caged 8-Br-cGMP is a fluorescent precursor of 8-bromo cyclic cGMP. 8-Br-cGMP and a fluorescent coumarin analogue are released by irradiation. It is much more lipophilic and membrane-permeant. Synonyms: (7- Dimethylaminocoumarin- 4- yl)methyl- 8- bromoguanosine- 3', 5'- monophosphate. Grades: ≥ 98% by HPLC. Molecular formula: C22H22BrN6O9P. Mole weight: 634.3. | |
| Guanosine 3',5'-cyclic monophosphate,2'-O-anthraniloyl-,sodium salt | Guanosine 3',5'-cyclic monophosphate,2'-O-anthraniloyl-,sodium salt. Uses: Designed for use in research and industrial production. Additional or Alternative Names: ANT-CGMP, NA;ANT-CGMP SODIUM SALT;GUANOSINE 3',5'-CYCLIC MONOPHOSPHATE, 2'-O-ANTHRANILOYL-, SODIUM SALT;2'-O-anthraniloylguanosine 3':5'-cyclic monophosphate. Product Category: Heterocyclic Organic Compound. CAS No. 142702-30-5. Molecular formula: C17H16N6NaO8P. Mole weight: 486.31. Product ID: ACM142702305. Alfa Chemistry ISO 9001:2015 Certified. |  |
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