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| Product | Description | |
|---|---|---|
| 2',3'-cGMP | 2',3'-cGMP, a cyclic nucleotide with profound significance in the biomedical sector, takes center stage within this product description. Employed primarily as a research instrument, it facilitates an in-depth exploration of intracellular signaling cascades across diverse biological spectrums. Furthermore, 2',3'-cGMP assumes an indispensable role in overseeing cellular proliferation and differentiation. This versatile product harbors immense potential, warranting its employment in the realm of drug discovery. Synonyms: Guanosine- 2', 3'- cyclic monophosphate, sodium salt. Grade: ≥ 97 % by HPLC. CAS No. 15718-49-7. Molecular formula: C10H11N5O7P · Na. Mole weight: 367.2. |  |
| 2',3'-cGMP sodium | 2',3'-cGMP sodium, a cGMP analogue, is an intermediate of RNA catalytic cleavage by binase [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Guanosine 2',3'-cyclic monophosphate sodium salt. CAS No. 15718-49-7. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-N8245. |  |
| 2'- (N-Methylanthraniloyl) guanosine 3',5'-Cyclicmonophosphate, Sodium Salt (MANT-cGMP) | A blue fluorescent derivative of cGMP is a useful substrate the assay of cyclic nucleotide phosphdiesterase. Also inhibits calmodulin-dependent activation of cyclic nucleotide phosphodiesterase by peptide segments of HIV envelope glycoproteins has been monitored using MANT-cGMP.Fluorescence: max. Abs. 359nm; max. Em. 448nm; e x 10-3: 5.2. Group: Biochemicals. Alternative Names: Cyclic 3,5-(hydrogen phosphate) 2-[2-(methylamino)benzoate] Guanosine Monosodium Salt; MANT-cGMP. Grades: Highly Purified. CAS No. 221905-46-0. Pack Sizes: 5mg. US Biological Life Sciences. |  Worldwide |
| 2'-AEC-cGMP-Agarose | 2'-AEC-cGMP-Agarose is the protein kinase G activator cGMP immobilized on agarose by an aminoethylcarbamoyl spacer, which can be used in affinity chromatography of cyclic nucleotide-responsive proteins such as some phosphodiesterases. Synonyms: 2'- O- (2- Aminoethylcarbamoyl)guanosine- 3', 5'- cyclic monophosphate; immobilized on agarose gel. | |
| 2'-AEC-cGMP / EDA-cGMP | 2'-AEC-cGMP is a cGMP analogue used for immobilization as an affinity ligand or for coupling of labelling structures such as fluorophores. Synonyms: 2'- O- (2- Aminoethylcarbamoyl)guanosine- 3', 5'- cyclic monophosphate. Grade: ≥ 98% by HPLC. Molecular formula: C13H18N7O8P. Mole weight: 431.3. | |
| 2'-AHC-cGMP | 2'-AHC-cGMP is a cGMP analogue used for immobilization as an affinity ligand or for coupling of labelling structures such as fluorophores. Synonyms: 2'- O- (6- Aminohexylcarbamoyl)guanosine- 3', 5'- cyclic monophosphate. Grade: ≥ 98% by HPLC. CAS No. 1262749-60-9. Molecular formula: C17H26N7O8P. Mole weight: 487.4. | |
| 2'-AHC-cGMP-Agarose | 2'-AHC-cGMP-Agarose is the protein kinase G activator cGMP immobilized on agarose by an aminohexylcarbamoyl spacer which can be used in affinity chromatography of cyclic nucleotide-responsive proteins such as some phosphodiesterases. Synonyms: 2'- O- (6- Aminohexylcarbamoyl)guanosine- 3', 5'- cyclic monophosphate; immobilized on agarose gel. | |
| 2-AH-cGMP-Agarose | 2-AH-cGMP-Agarose is the second messenger cGMP immobilized on agarose by an aminohexyl spacer which can be used in affinity chromatography of cyclic nucleotide-responsive proteins such as protein kinases, phosphodiesterases and others. Synonyms: N2- (6- Aminohexyl)guanosine- 3', 5'- cyclic monophosphate; immobilized on agarose gel. | |
| 2'-[DY505-05]-AHC-cGMP | 2'-[DY505-05]-AHC-cGMP is a fluorescent cGMP analogue (λexc505 nm, λem530 nm) that can be used for phosphodiesterase studies. Synonyms: 2'- O- (6- [DY-505-05]- aminohexylcarbamoyl))guanosine- 3', 5'- cyclic monophosphate, sodium salt. Grade: ≥ 95% by HPLC. Molecular formula: C38H37N9O12P · Na. Mole weight: 865.7. | |
| 2-Me-cGMP | 2-Me-cGMP is an analogue of cGMP used for cGMP receptor mapping studies. Grade: ≥ 99% by HPLC. CAS No. 205368-54-3. Molecular formula: C11H13N5O7P · Na. Mole weight: 381.2. | |
| 2'-O-MB-cGMP | 2'-O-MB-cGMP is a precursor of cGMP. cGMP is released after the metabolism of 2'-O-MB-cGMP by esterases. Compared to cGMP, it has more lipophilic and membrane-permeant properties. Synonyms: 2'- O- Monobutyrylguanosine- 3', 5'- cyclic monophosphate, sodium salt. Grade: ≥ 97% by HPLC. CAS No. 58329-72-9. Molecular formula: C14H17N5O8P · Na. Mole weight: 437.3. | |
| 2'-O-Me-cGMP | 2'-O-Me-cGMP is a polar analogue of cGMP that activate neither protein kinase G nor Epac. It exhibits an inactive effect in patch clamp applications and can be used for receptor mapping studies. Synonyms: 2'- O- Methylguanosine- 3', 5'- cyclic monophosphate, sodium salt. Grade: ≥ 98% by HPLC. CAS No. 949909-73-3. Molecular formula: C11H13N5O7P · Na. Mole weight: 381.2. | |
| 2'-O-MS-cGMP | 2'-O-MS-cGMP is a cGMP analogue, which is used for coupling of ligands including proteins for ELISA. Synonyms: 2'- O- Monosuccinylguanosine- 3', 5'- cyclic monophosphate, free acid. Grade: ≥ 98% by HPLC. CAS No. 39118-26-8. Molecular formula: C14H16N5O10P. Mole weight: 445.3. | |
| 2'-O-MS-TME-cGMP | 2'-O-MS-TME-cGMP is an analogue of cGMP, which is used for radio-iodination in cGMP immunoassays. Synonyms: 2'- O- Monosuccinylguanosine- 3', 5'- cyclic monophosphate, tyrosylmethyl ester, sodium salt. Grade: ≥ 95% by HPLC. CAS No. 104872-93-7. Molecular formula: C24H26N6O12P · Na. Mole weight: 644.5. | |
| 2'-TAMRA-AEC-cGMP | 2'-TAMRA-AEC-cGMP is a fluorescent cGMP analogue (λexc555 nm, λem580 nm) that can be used for phosphodiesterase studies. Synonyms: 2'- O- (2- [Tetramethylrhodaminyl]aminoethylcarbamoyl)guanosine- 3', 5'- cyclic monophosphate, sodium salt. Grade: ≥ 95% by HPLC. Molecular formula: C38H37N9O12P · Na. Mole weight: 865.7. | |
| 2'-TAMRA-AHC-cGMP | 2'-TAMRA-AHC-cGMP is a fluorescent cGMP analogue (λexc555 nm, λem580 nm) that can be used for phosphodiesterase studies. Synonyms: 2'- O- (6- [Tetramethylrhodaminyl]aminohexylcarbamoyl)guanosine- 3', 5'- cyclic monophosphate, sodium salt. Grade: ≥ 95% by HPLC. Molecular formula: C42H45N9O12P · Na. Mole weight: 921.8. | |
| 8- (4-Chlorophenylthio) guanosine 3',5'-cyclic monophosphate sodium salt | 8- (4-Chlorophenylthio) guanosine 3',5'-cyclic monophosphate sodium salt. Group: Biochemicals. Alternative Names: 8-pCPT-cGMP. Grades: Highly Purified. CAS No. 51239-26-0. Pack Sizes: 5mg, 10mg, 25mg, 50mg. Molecular Formula: C16H14ClN5O7PS·Na. US Biological Life Sciences. | Worldwide |
| 8-[(6-Amino)hexyl]-amino-cGMP - MANT | 8-[(6-Amino)hexyl]-amino-cGMP - MANT is a modified form of cyclic guanosine monophosphate (cGMP) that has a MANT (2'(3')-O-(N'-methyl-anthraniloyl) fluorophore) attached to the amino group of the hexyl chain. Synonyms: 8-[(6-Amino)hexyl]-amino-guanosine-3',5'-cyclic monophosphate, labeled with MANT, Triethylammonium salt. Grade: ≥ 95% by HPLC. Molecular formula: C24H33N8O8P (free acid). Mole weight: 592.54 (free acid). | |
| 8-AET-cGMP | 8-AET-cGMP is a ligand in affinity chromatography and can be modified with fluorophores or other markers. Synonyms: 8- (2- Aminoethylthio)guanosine- 3', 5'- monophosphate. Grade: ≥ 98% by HPLC. CAS No. 115974-70-4. Molecular formula: C12H17N6O7PS. Mole weight: 420.4. | |
| 8-AET-cGMP-Agarose | 8-AET-cGMP-Agarose is the second messenger cGMP immobilized on agarose by an aminoethylthio spacer, which can be used in affinity chromatography of cyclic nucleotide-responsive proteins such as protein kinases, phosphodiesterases and others. Synonyms: 8- (2- Aminoethylthio)guanosine- 3', 5'- cyclic monophosphate; immobilized on agarose gel. | |
| 8-APT-cGMP | 8-APT-cGMP is an isozyme-selective stimulator of cGMP-dependent protein kinase I a with a prenference for type I a over I by a factor of 200. Synonyms: 8- (2- Aminophenylthio)guanosine- 3', 5'- monophosphate, sodium salt. Grade: ≥ 98% by HPLC. CAS No. 144509-87-5. Molecular formula: C16H16N6O7PS · Na. Mole weight: 490.4. | |
| 8-Br-2'-O-Me-cGMP | 8-Br-2'-O-Me-cGMP is an analogue of cGMP that does not activate both protein kinase G and Epac. It is often used as an inactive control versus 8-Br-cGMP. Synonyms: 8- Bromo- 2'- O- methylguanosine- 3', 5'- cyclic monophosphate, sodium salt. Grade: ≥ 98% by HPLC. Molecular formula: C11H12BrN5O7P · Na. Mole weight: 460.1. | |
| 8-Br-cGMP-AM | 8-Br-cGMP-AM is a precursor of 8-Br-cGMP, the PKG activator. The polar active analogue is released after the metabolism of 8-Br-cGMP-AM by esterases. Synonyms: 8- Bromoguanosine- 3', 5'- cyclic monophosphate, acetoxymethyl ester. Grade: ≥ 97% by HPLC for mixture of isomers. CAS No. 272445-71-3. Molecular formula: C13H15BrN5O9P. Mole weight: 496.2. | |
| 8-Br-PET-cGMP Sodium Salt | 8-Br-PET-cGMP Sodium Salt is a pkG cell-permeable activator. Synonyms: 2-Bromo-3,4-dihydro-6-phenyl-3-(3,5-O-phosphinico-β-D-ribofuranosyl)-9H-imidazo[1,2-a]purin-9-one Sodium Salt. CAS No. 185246-29-1. Molecular formula: C18H14BrN5NaO7P. Mole weight: 546.2. | |
| 8-OH-cGMP | 8-OH-cGMP is a cyclic guanosine monophosphate (cGMP) analog used in biomedical research. It acts as a second messenger in signal transduction pathways. 8-OH-cGMP is mainly utilized for studying the role of cGMP in various cellular processes, including smooth muscle relaxation, cell proliferation, and neurotransmission. It is also commonly used to investigate the pathophysiology and potential therapeutic targets in diseases related to altered cGMP signaling, such as hypertension, cardiovascular disorders, and neurodegenerative diseases. Synonyms: 8- Hydroxyguanosine- 3', 5'- cyclic monophosphate. CAS No. 21082-28-0. Molecular formula: C10H11N5O8P · Na. Mole weight: 383.2. | |
| 8-pCPT-2'-O-Me-cGMP | 8-pCPT-2'-O-Me-cGMP is a PDE-stable, high lipophilic and membrane-permeant analogue. It can be used as a control since it has no activated effect on protein kinase G or Epac. Synonyms: 8- (4- Chlorophenylthio)- 2'- O- methylguanosine- 3', 5'- cyclic monophosphate, sodium salt. Grade: ≥ 98% by HPLC. CAS No. 625112-42-7. Molecular formula: C17H16ClN5O7PS · Na. Mole weight: 523.8. | |
| 8-pCPT-cGMP-AM | 8-pCPT-cGMP-AM is a precursor of 8-pCPT-cGMP, the PKG activator. 8-pCPT-cGMP is released after the metabolism of 8-pCPT-cGMP-AM by esterases. Synonyms: 8- (4- Chlorophenylthio)guanosine- 3', 5'- cyclic monophosphate, acetoxymethyl ester. Grade: ≥ 97% by HPLC for mixture of isomers. CAS No. 272445-72-4. Molecular formula: C19H19ClN5O9PS. Mole weight: 559.9. | |
| Cyclic GMP | Cyclic GMP (cGAMP) is an endogenous second messenger that triggers interferon production in response to cytoplasmic DNA. Cyclic GMP can activate the stimulator of interferon genes (STING), activating the signaling cascade that leads to the production of type I interferons and other immune mediators. Cyclic-GMP-AMP, a conjugate of cyclic GMP and AMP, can induce IRF3 phosphorylation and nuclear translocation, enhancing antiviral immune responses. cGMP may also activate PDE to degrade cAMP, inhibit myocardial calcium current I Ca , and regulate myocardial contractility. The derivative of cyclic GMP (cGMP), 8-Br-cGMP, has antiplatelet activity, and cyclic GMP can be used in the study of antiviral immunity and cardiovascular diseases [1] [2] [3] [4]. Uses: Scientific research. Group: Natural products. CAS No. 7665-99-8. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-113469. | |
| Cyclic GMP sodium | Cyclic GMP (cGAMP) sodium is an endogenous second messenger that triggers interferon production in response to cytoplasmic DNA. Cyclic GMP sodium can activate the stimulator of interferon genes (STING), activating the signaling cascade that leads to the production of type I interferons and other immune mediators. Cyclic-GMP-AMP, a conjugate of cyclic GMP and AMP, can induce IRF3 phosphorylation and nuclear translocation, enhancing antiviral immune responses. Cyclic GMP sodium may also activate PDE to degrade cAMP, inhibit myocardial calcium current I Ca , and regulate myocardial contractility. The derivative of Cyclic GMP sodium, 8-Br-cGMP, has antiplatelet activity, and Cyclic GMP sodium can be used in the study of antiviral immunity and cardiovascular diseases [1] [2] [3] [4]. Uses: Scientific research. Group: Natural products. CAS No. 40732-48-7. Pack Sizes: 5 mg; 10 mg; 25 mg. Product ID: HY-113469A. | |
| DB-cGMP | DB-cGMP, an exceedingly compelling analogue of cyclic guanosine monophosphate (cGMP), a pivotal secondary messenger in myriad biological processes, serves as an invaluable tool in biomedical research. With a primary focus on unraveling the intricate role of cGMP in signal transduction pathways, cellular proliferation, and apoptosis, it facilitates the understanding of diseases stemming from aberrant cGMP signaling. Synonyms: N2, 2'- O- Dibutyrylguanosine- 3', 5'- cyclic monophosphate, sodium salt. Grade: ≥ 97% by HPLC. CAS No. 51116-00-8. Molecular formula: C18H23N5O9P · Na. Mole weight: 507.4. | |
| Dibutyryl-cGMP sodium | Dibutyryl-cGMP sodium (Bt2cGMP sodium) is a cell-permeable cGMP analogue. Dibutyryl-cGMP sodium preferentially activates cGMP-dependent protein kinase (PKG). Dibutyryl-cGMP sodium inhibits the release of [ 3 H]-arachidonic acid from γ thrombin-stimulated human platelets. Dibutyryl-cGMP sodium induces peripheral antinociception via activation of ATP-sensitive K + channels [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Bt2cGMP sodium. CAS No. 51116-00-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-130354. | |
| Guanosine 3',5'-cyclic monophosphate | Cyclic guanosine monophosphate (Cyclic GMP) is a guanine nucleotide containing one phosphate group which is esterified to the sugar moiety in both the 3'-and 5'-positions. It is a cellular regulatory agent and has been described as a second messenger. Its levels increase in response to a variety of hormones, including acetylcholine, insulin, and oxytocin and it has been found to activate specific protein kinases. 3',5'-cyclic GMP is a 3',5'-cyclic purine nucleotide in which the purine nucleobase is specified as guanidine. It has a role as a plant metabolite, a human metabolite, a Saccharomyces cerevisiae metabolite, an Escherichia coli metabolite and a mouse metabolite. It is a guanyl ribonucleotide and a 3',5'-cyclic purine nucleotide. It is a conjugate acid of a 3',5'-cyclic GMP(1-). Synonyms: 3:5-CGMP; D-Guanosine 3',5'-cyclic monophosphate; 3',5'-cyclic GMP; 2-Amino-6-oxo-6,9-dihydro-1H-purine 3-oxide; guanine-3-N-oxide; 2-Amino-1,7-dihydro-6H-purin-6-one 3-oxide; Cyclic guanosine monophosphate. Grade: ≥98%. CAS No. 7665-99-8. Molecular formula: C10H12N5O7P. Mole weight: 345.21. | |
| Guanosine 3',5'-cyclic monophosphate,2'-O-anthraniloyl-,sodium salt | Guanosine 3',5'-cyclic monophosphate,2'-O-anthraniloyl-,sodium salt. Uses: Designed for use in research and industrial production. Additional or Alternative Names: ANT-CGMP, NA;ANT-CGMP SODIUM SALT;GUANOSINE 3',5'-CYCLIC MONOPHOSPHATE, 2'-O-ANTHRANILOYL-, SODIUM SALT;2'-O-anthraniloylguanosine 3':5'-cyclic monophosphate. Product Category: Heterocyclic Organic Compound. CAS No. 142702-30-5. Molecular formula: C17H16N6NaO8P. Mole weight: 486.31. Product ID: ACM142702305. Alfa Chemistry ISO 9001:2015 Certified. |  |
| Guanosine,8-bromo-,cyclic 3',5'-[hydrogen(R)-phosphorothioate](9ci) | Guanosine,8-bromo-,cyclic 3',5'-[hydrogen(R)-phosphorothioate](9ci). Uses: Designed for use in research and industrial production. Additional or Alternative Names: RP-8-BR-CGMPS;RP-8-BR-CGMPS, NA;RP-8-BR-CGMPS SODIUM SALT;RP-8-BROMOGUANOSINE-3',5'-CYCLIC MONOPHOSPHOROTHIOTE, SODIUM SALT;GUANOSINE 3',5'-CYCLIC MONOPHOSPHOROTHIOATE, 8-BROMO-, RP-ISOMER, SODIUM SALT;8-BROMOGUANOSINE 3',5'-CYCLIC MONOPHOSPHOTHIOATE, RP. Product Category: Heterocyclic Organic Compound. Appearance: White lyophilized powder. CAS No. 150418-07-8. Molecular formula: C10H11BrN5O6PS. Mole weight: 440.167. Density: 2.53 g/cm³. Product ID: ACM150418078. Alfa Chemistry ISO 9001:2015 Certified. | |
| Guanosine,N-(6-aminohexyl)-,cyclic 3',5'-(hydrogen phosphate)(9ci) | Guanosine,N-(6-aminohexyl)-,cyclic 3',5'-(hydrogen phosphate)(9ci). Uses: Designed for use in research and industrial production. Additional or Alternative Names: 2-AH-CGMP SODIUM SALT;N2-(6-AMINOHEXYL) GUANOSINE-3',5'-CYCLIC MONOPHOSPHATE SODIUM SALT;n2-(6-aminohexyl)guanosine-3',5'-cyclicmonophosphate(2-ah-cgmp). Product Category: Heterocyclic Organic Compound. Appearance: Crystallized or lyophilized solid. CAS No. 205368-58-7. Molecular formula: C16H25N6O7P. Mole weight: 466.36. Purity: 0.96. IUPACName: sodium;9-[(4aR,6R,7R,7aS)-7-hydroxy-2-oxido-2-oxo-4a,6,7,7a-tetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphinin-6-yl]-2-(6-aminohexylamino)-3H-purin-6-one. Canonical SMILES: C1C2C(C(C(O2)N3C=NC4=C3NC(=NC4=O)NCCCCCCN)O)OP(=O)(O1)[O-].[Na+]. Product ID: ACM205368587. Alfa Chemistry ISO 9001:2015 Certified. | |
| Phosphodiesterase 5A1 from Human, Recombinant | PDE5 regulates vascular smooth muscle contraction and is involved in NO-cGMP signaling in platelets to control aggregation. PDE5 may also be involved in the regulation of cGMP signaling in the brain and may modulate pressure-induced cardiac hypertrophy and fibrosis. N-terminal gst-tagged 126 kda full-length protein. Applications: Phosphodiesterase (pde) is an enzyme that is used to breaks phosphodiester bonds. pde5 is a molecular target for the treatment of erectile dysfunction and pulmonary hypertension. pde5 is used to find novel pde5 inhibitors. Group: Enzymes. Synonyms: CN5N; phosphodiesterase 5A, cGMP-specific; PDE5A1; PDE5A; 3',5'-cyclic-GMP phosphodiesterase, PDE 5A1. Phosphodiesterase. Mole weight: 126 kDa. Storage: -70°C. Form: Supplied as a solution in 20% glycerol containing 40 mM Tris-HCl, pH 8.0, 110 mM NaCl, 2.2 mM KCl, 0.04% TWEEN 20 and 3 mM DTT. Source: Sf9 cells. Species: Human. CN5N; phosphodiesterase 5A, cGMP-specific; PDE5A1; PDE5A; 3',5'-cyclic-GMP phosphodiesterase, PDE 5A1. Cat No: NATE-0527. |  |
| 1-(Methyl)-4-nitro-3-(2,2,3,3,3-D5-propyl)-1H-pyrazole-5-carboxylic Acid | 1-(Methyl)-4-nitro-3-(2,2,3,3,3-D5-propyl)-1H-pyrazole-5-carboxylic Acid is a labelled intermediate of Sildenafil (S435000), an orally active selective type 5 cGMP phosphodiesterase inhibitor. Group: Biochemicals. Grades: Highly Purified. CAS No. 1175992-94-5. Pack Sizes: 1mg, 10mg. Molecular Formula: C8H6D5N3O4, Molecular Weight: 218.22. US Biological Life Sciences. | Worldwide |
| 1-Methyl-4-nitro-5-propyl-1H-pyrazole-3-carboxamide | Intermediate in the preparation of Iso Viagra and pyrazolopyrimidinone cGMP PDE5 inhibitors for the treatment of sexual dysfunction. Group: Biochemicals. Grades: Highly Purified. CAS No. 247583-72-8. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| 1-Methyl-4-nitro-5-propyl-1H-pyrazole-3-carboxylic Acid | Intermediate in the preparation of Iso Viagra and pyrazolopyrimidinone cGMP PDE5 inhibitors for the treatment of sexual dysfunction. Group: Biochemicals. Grades: Highly Purified. CAS No. 247583-71-7. Pack Sizes: 25mg. US Biological Life Sciences. | Worldwide |
| 1-Methyl-5-propyl-1H-pyrazole-3-carboxylic Acid | Intermediate in the preparation of Iso Viagra, Sidenafil analogs and pyrazolopyrimidinone cGMP PDE5 inhibitors for the treatment of sexual dysfunction. Group: Biochemicals. Grades: Highly Purified. CAS No. 247583-70-6. Pack Sizes: 100mg. US Biological Life Sciences. | Worldwide |
| 1-(Methyl-d3)-4-nitro-3-(2,2,3,3,3-D5-propyl)-1H-pyrazole-5-carboxylic Acid | 1-(Methyl-d3)-4-nitro-3-(2,2,3,3,3-D5-propyl)-1H-pyrazole-5-carboxylic Acid is a labelled intermediate of Sildenafil (S435000), an orally active selective type 5 cGMP phosphodiesterase inhibitor. Group: Biochemicals. Grades: Highly Purified. CAS No. 1175993-00-6. Pack Sizes: 1mg, 10mg. Molecular Formula: C8H3D8N3O4, Molecular Weight: 221.24. US Biological Life Sciences. | Worldwide |
| 2-AEA-cAMP | 2-AEA-cAMP is a ligand for affinity chromatography of cAMP and cGMP binding proteins. It can be modified with fluorophores and other markers. Synonyms: 2- (2- Aminoethylamino)adenosine- 3', 5'- cyclic monophosphate. Grade: ≥ 98% by HPLC. CAS No. 66311-12-4. Molecular formula: C12H18N7O6P. Mole weight: 387.3. | |
| 2'-AEC-cAMP | 2'-AEC-cAMP is a ligand for affinity chromatography of cAMP and cGMP binding proteins. It is often modified with fluorophores and other markers. Synonyms: 2'- O- (2- Aminoethylcarbamoyl)adenosine- 3', 5'- cyclic monophosphate. Grade: ≥ 98% by HPLC. CAS No. 403497-54-1. Molecular formula: C13H18N7O7P. Mole weight: 415.3. | |
| 2'-dcGMP | 2'-dcGMP is an analogue of cGMP, which is a protein kinase G inactive agent. Synonyms: 2'- Deoxyguanosine- 3', 5'- cyclic monophosphate, sodium salt. Grade: ≥ 98% by HPLC. CAS No. 93919-42-7. Molecular formula: C10H11N5O6P · Na. Mole weight: 351.2. | |
| 2-Ethoxy-5-[(4-methyl-1-piperazinyl)sulfonyl)]-benzaldehyde | 2-Ethoxy-5-[(4-methyl-1-piperazinyl)sulfonyl)]-benzaldehyde is an intermediate in the synthesis of Sildenafil (S435000), an orally active selective type 5 cGMP phosphodiesterase inhibitor. Group: Biochemicals. Grades: Highly Purified. CAS No. 332374-42-2. Pack Sizes: 50mg, 500mg. Molecular Formula: C14H20N2O4S, Molecular Weight: 312.38. US Biological Life Sciences. | Worldwide |
| 2'-NH2-cAMP | 2'-NH2-cAMP is often used in affinity chromatography of cAMP and cGMP binding proteins for its amino group used as a ligand, which do not require an intact 2'-OH group. Synonyms: 2'- Amino- 2'- deoxyadenosine- 3', 5'- cyclic monophosphate, sodium salt. Grade: ≥ 98% by HPLC. CAS No. 85819-83-6. Molecular formula: C10H12N6O5P · Na. Mole weight: 350.2. | |
| 3-(6,7-dihydro-1-methyl-7-oxo-3-propyl-1H-pyrazolo[4,3-d]pyrimidin-5-yl)-4-ethoxy-N-[2-(methylamino)ethyl]-Benzenesulfonamide | 3-(6,7-dihydro-1-methyl-7-oxo-3-propyl-1H-pyrazolo[4,3-d]pyrimidin-5-yl)-4-ethoxy-N-[2-(methylamino)ethyl]-Benzenesulfonamide is a Sildenafil derivative. Sildenafil is an orally active type 5 cGMP phosphodiesterase inhibitor. Group: Biochemicals. Grades: Highly Purified. CAS No. 466684-88-8. Pack Sizes: 25mg, 100mg. Molecular Formula: C20H28N6O4S, Molecular Weight: 448.54. US Biological Life Sciences. | Worldwide |
| 3-Bromo-4-fluoro-benzoic Acid Ethyl Ester | 3-Bromo-4-fluoro-benzoic Acid Ethyl Ester is used to prepare 2,3-diarylpyrrole inhibitors of parasite cGMP-dependent protein kinase as novel anticoccidial agents. It is also used to synthesize Aminopyrazole Inhibitors for c-Jun N-terminal Kinase 3 (JNK3) over p38. Group: Biochemicals. Grades: Highly Purified. CAS No. 23233-33-2. Pack Sizes: 1g, 5g. Molecular Formula: C9H8BrFO2, Molecular Weight: 247.06. US Biological Life Sciences. | Worldwide |
| 3-Isobutyl-1-methylxanthine - CAS 28822-58-4 | A cell-permeable, non-specific inhibitor of cAMP and cGMP phosphodiesterases (IC?? = 2-50 μM). Group: Fluorescence/luminescence spectroscopy. |  |
| 3-Isobutyl-1-methylxanthine (IBMX) | A cell-permeable, non-specific inhibitor of cAMP and cGMP phosphodiesterases (IC50=2-50uM). Also acts as an adenosine receptor antagonist. Reported to inhibit TNF-a expression in adipocyte precursor cells. Group: Biochemicals. Grades: Highly Purified. CAS No. 28822-58-4. Pack Sizes: 250mg, 1g. US Biological Life Sciences. | Worldwide |
| 3-O-Methylquercetin | 3-O-Methylquercetin is an inhibitor of cAMP and CGMP-phosphodiesterase ( PDE ) with IC 50 at 13.8 μM and 14.3 μM, respectively. 3-O-Methylquercetin is an inhibitor of β-secretase with an IC 50 of 6.5 μM. 3-O-Methylquercetin has a neuroprotective effect against neuronal death caused by oxidative damage. 3-O-Methylquercetin has strong antiviral activity against poliovirus, coxsackie virus and human rhinovirus. 3-O-Methylquercetin has anti-inflammatory and trachea-relaxing effects and can be used in the study of inflammatory diseases and asthma [1] [2] [3] [4] [5] [6]. Uses: Scientific research. Group: Natural products. CAS No. 1486-70-0. Pack Sizes: 1 mg; 5 mg. Product ID: HY-N1860. | |
| 4-Amino-1-methyl-5-propyl-1H-pyrazole-3-carboxamide | Intermediate in the preparation of Iso Viagra and pyrazolopyrimidinone cGMP PDE5 inhibitors for the treatment of sexual dysfunction. Group: Biochemicals. Grades: Highly Purified. CAS No. 247583-78-4. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| 6-AE-cAMP | 6-AE-cAMP is often used as a ligand for affinity chromatography of cAMP and cGMP binding proteins. Synonyms: N6- (2- Aminoethyl)adenosine- 3', 5'- cyclic monophosphate. Grade: ≥ 98% by HPLC. CAS No. 66311-08-8. Molecular formula: C12H17N6O6P. Mole weight: 372.3. | |
| 8-AEA-cAMP | 8-AEA-cAMP is a ligand for affinity chromatography of cAMP and cGMP binding proteins. It can be modified with fluorophores and other markers. Synonyms: 8- (2- Aminoethyl)aminoadenosine- 3', 5'-cyclic monophosphate. Grade: ≥ 98% by HPLC. CAS No. 61363-29-9. Molecular formula: C12H18N7O6P. Mole weight: 387.3. | |
| 8-AET-cAMP | 8-AET-cAMP is a ligand for affinity chromatography of cAMP and cGMP binding proteins. It is often modified with fluorophores or other markers. Synonyms: 8- (2- Aminoethylthio)adenosine- 3', 5'- cyclic monophosphate. Grade: ≥ 98% by HPLC. CAS No. 53546-96-6. Molecular formula: C12H17N6O6PS. Mole weight: 404.3. | |
| Adenosine 3,5-cyclic Monophosphate, 8-(4-Chlorophenylthio)-, Sodium Salt (8-CPT-cAMP, Na) | Cell-permeable cAMP analog that activates both protein kinase A and protein kinase G. Directly activates Epac, a Rap1 guanine-nucleotide exchange factor. Also acts as a potent inhibitor of cGMP-specific phosphodiesterase (IC50=900nM). Inhibits cAMP-specific phosphodiesterase at much higher concentrations (IC50=25uM). Group: Biochemicals. Grades: Highly Purified. CAS No. 93882-12-3. Pack Sizes: 10mg. Molecular Formula: C??H??ClN?O?PS · Na. US Biological Life Sciences. | Worldwide |
| Amrinone | Amrinone is a selective cAMP phosphodiesterase (PDE-3) inhibitor with positive inotropic and vasodilatory activity. It is a simple, non-glycoside cardiotonic agent. It provides protection against ischemia-reperfusion injury in kidney, liver, and heart. It has the ability to stimulate calcium ion influx into the cardiac cell. It is used in the treatment of congestive heart failure. It increases cardiac contractility as a vasodilator. It acts by inhibiting the breakdown of both cAMP and cGMP by the phosphodiesterase (PDE3) enzyme. It is a drug that may improve the prognosis in patients with congestive heart failure. It has been shown to increase the contractions initiated in the heart by high gain calcium induced calcium release (CICR). It was developed by Sanofi and has been listed. Uses: Amrinone is a simple, non-glycoside cardiotonic agent. it provides protection against ischemia-reperfusion injury in kidney, liver, and heart. it is used in the treatment of congestive heart failure. it increases cardiac contractility as a vasodilator. Synonyms: Inamrinone; Wincoram; Inocor; Cordemcura; Win-40680; Win40680; 3-Amino-5-pyridin-4-yl-1H-pyridin-2-one. Grade: 98%. CAS No. 60719-84-8. Molecular formula: C10H9N3O. Mole weight: 187.20. | |
| Ataciguat | Ataciguat (HMR-1766) is a nitric oxide-independent soluble guanylate cyclase (sGC) activator. Ataciguat is able to activate the ferric heme-iron redox form of sGC that stimulate the production of cyclic GMP (cGMP). Ataciguat exhibits vasodilator effects[1][2][3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: HMR-1766. CAS No. 254877-67-3. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-17500. | |
| Atrial natriuretic factor (1-28) (human, porcine) | Atrial natriuretic factor (1-28) (human, porcine) is a 28 amino acid peptide corresponding to the rat protein sequence. It is an endogenous peptide synthesized in myoendocrine cells of the heart from which it is released into the circulation. It has effects on the renal and cardiovascular systems that decrease vasoconstriction, increase sodium excretion and inhibit renin secretion. It decreases plasma renin activity and cAMP levels in anesthetized rats and increases cGMP levels at 8 μg/kg. It also inhibits arginine vasopressin-induced increase in mean arterial blood pressure in spontaneously hypertensive and control rats when administered intracerebroventricularly at a dose of 150 ng. It produces diuretic, natriuretic and vasodilatory effects through stimulation of guanylate cyclase-linked NPR-A receptors. It plays an important role in blood volume and blood pressure regulation. Synonyms: ANF 1-28; hANF; Atrial Natriuretic Peptide human. CAS No. 91917-63-4. Molecular formula: C127H205N45O39S3. Mole weight: 3080.46. | |
| Atrial Natriuretic Peptide (ANP) (1-28), rat | Atrial natriuretic factor (1-28) (rat) is a 28 amino acid peptide corresponding to the rat protein sequence. It is an endogenous peptide synthesized in myoendocrine cells of the heart from which it is released into the circulation. It has effects on the renal and cardiovascular systems that decrease vasoconstriction, increase sodium excretion and inhibit renin secretion. It decreases plasma renin activity and cAMP levels in anesthetized rats and increases cGMP levels at 8 μg/kg. It also inhibits the arginine vasopressin-induced increase in mean arterial blood pressure in spontaneously hypertensive and control rats when administered intracerebroventricularly at a dose of 150 ng. It produces diuretic, natriuretic and vasodilatory effects through stimulation of guanylate cyclase-linked NPR-A receptors. It plays an important role in blood volume and blood pressure regulation. Uses: Vasodilator agents. Synonyms: Atrial natriuretic factor (1-28) (rat); rANP; Atrial Natriuretic Peptide rat; Cardiodilatin-126; Atrial Natriuretic Factor (1-28) (mouse, rabbit, rat); rANF (1-28); H-Ser-Leu-Arg-Arg-Ser-Ser-Cys(1)-Phe-Gly-Gly-Arg-Ile-Asp-Arg-Ile-Gly-Ala-Gln-Ser-Gly-Leu-Gly-Cys(1)-Asn-Ser-Phe-Arg-Tyr-OH; L-seryl-L-leucyl-L-arginyl-L-arginyl-L-seryl-L-seryl-L-cysteinyl-L-phenylalanyl-glycyl-glycyl-L-arginyl-L-isole. Grade: ≥95%. CAS No. 88898-17-3. Molecular formula: C128H205N45O39S2. Mole weight: 3062 | |
| Avanafil | Avanafil (TA-1790) is a potent and selective phosphodiesterase-5 (PDE-5) inhibitor with IC 50 values of 5.2 nM, 630 nM, 5700 nM, 6200 nM, 12000 nM, 27000 nM, 51000 nM and 53000 nM for PDE-5, PDE-6, PDE-4, PDE-10, PDE-8, PDE-7, PDE-2 and PDE-1, respectively. Avanafil activates NO/cGMP/PKG signaling-pathway to decrease loss in BMD, bone atrophy, and oxidative stress. Avanafil inhibits cyclic guanosine monophosphate (cGMP) hydrolysis and thus increases cGMP levels. Avanafil can be used for the research of erectile dysfunction and osteoporosis [1] [2] [3]. Uses: Scientific research. Group: Natural products. Alternative Names: TA1790. CAS No. 330784-47-9. Pack Sizes: 10 mM * 1 mL; 100 mg; 250 mg; 500 mg; 1 g. Product ID: HY-18252. | |
| BPIPP | BPIPP is a non-competitive guanylyl cyclase (GC) and adenylyl cyclase (AC) inhibitor. It downregulates cAMP and cGMP synthesis, suppresses cGMP accumulation in a variety of cell lines (IC50 = 3.4 - 11.2 μM), inhibits GC-stimulated Cl- transport in vitro, and suppresses toxin-induced intestinal fluid accumulation in vivo. BPIPP may be a useful treatment of diarrhea. Uses: Potential treatment of diarrhea. Synonyms: 5-(3-Bromophenyl)-5,11-dihydro-1,3-dimethyl-1H-indeno[2',1':5,6]pyrido[2,3-d]pyrimidine-2,4,6(3H)-trione. Grade: ≥99% by HPLC. CAS No. 325746-94-9. Molecular formula: C22H16BrN3O3. Mole weight: 450.28. | |
| Cenderitide | Cenderitide is a potent agonist of particulate guanylyl cyclase receptor (pGC). Cenderitide is a natriuretic peptide (NP) composed of C-type natriuretic peptide (CNP) fused to the C-terminus of Dendroaspis natriuretic peptide (DNP). Cenderitide activates both pGC-A and pGC-B , activates the second messenger cGMP , suppresses aldosterone , and preserves GFR without reducing blood pressure. Cenderitide can be used for heart failure research [1] [2] [3]. Uses: Scientific research. Group: Peptides. CAS No. 507289-11-4. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P3624. | |
| cGMP-dependent protein kinase | CGMP is required to activate this enzyme. The enzyme occurs as a dimer in higher eukaryotes. The C-terminal region of each polypeptide chain contains the catalytic domain that includes the ATP and protein substrate binding sites. This domain catalyses the phosphorylation by ATP to specific serine or threonine residues in protein substrates. The enzyme also has two allosteric cGMP-binding sites (sites A and B). Binding of cGMP causes a conformational change that is associated with activation of the kinase. Group: Enzymes. Synonyms: 3':5'-cyclic GMP-dependent protein kinase; cGMP-dependent protein kinase Iβ; guanosine 3':5'-cyclic monophosphate-dependent protein kinase; PKG; PKG 1α; PKG 1β; PKG II; STK23. Enzyme Commission Number: EC 2.7.11.12. CAS No. 141588-27-4. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3131; cGMP-dependent protein kinase; EC 2.7.11.12; 141588-27-4; 3':5'-cyclic GMP-dependent protein kinase; cGMP-dependent protein kinase Iβ; guanosine 3':5'-cyclic monophosphate-dependent protein kinase; PKG; PKG 1α; PKG 1β; PKG II; STK23. Cat No: EXWM-3131. | |
| Dendroaspis Natriuretic Peptide | Dendroaspis Natriuretic Peptide, a 38-amino acid peptide originally isolated from the venom of the green mamba snake (Dendroaspis angusticeps), is structurally homologous to the natriuretic peptide family. It contains a 17-amino acid disulfide ring similar to ANP, BNP and CNP that mediate biological action through particulate guanylyl cyclase receptors and generation of guanosine monophosphate (cGMP). Synonyms: DNP; H-Glu-Val-Lys-Tyr-Asp-Pro-Cys-Phe-Gly-His-Lys-Ile-Asp-Arg-Ile-Asn-His-Val-Ser-Asn-Leu-Gly-Cys-Pro-Ser-Leu-Arg-Asp-Pro-Arg-Pro-Asn-Ala-Pro-Ser-Thr-Ser-Ala-OH (Disulfide bridge: Cys7-Cys23); L-alpha-Glutamyl-L-valyl-L-lysyl-L-tyrosyl-L-alpha-aspartyl-L-prolyl-L-cysteinyl-L-phenylalanylglycyl-L-histidyl-L-lysyl-L-isoleucyl-L-alpha-aspartyl-L-arginyl-L-isoleucyl-L-asparaginyl-L-histidyl-L-valyl-L-seryl-L-asparaginyl-L-leucylglycyl-L-cysteinyl-L-prolyl-L-seryl-L-leucyl-L-arginyl-L-alpha-aspartyl-L-prolyl-L-arginyl-L-prolyl-L-asparaginyl-L-alanyl-L-prolyl-L-seryl-L-threonyl-L-seryl-L-alaninecyclic(7-23)-disulfide. Grade: ≥95% by HPLC. CAS No. 255721-52-9. Molecular formula: C180H282N56O56S2. Mole weight: 4190.64. | |
| Desethyl Sildenafil | A metabolite of Sildenafil , an orally active selective type 5 cGMP phosphodiesterase inhibitor. Group: Biochemicals. Alternative Names: 5- [2-Hydroxy-5- (4- methyl piperazinylsulphonyl) phenyl] 1- methyl -3-n-propyl -1, 6-dihydro-7H-pyrazolo [4, 3-d] pyramidin-7-one; 5- [2-Hydroxy-5- [ [4- (methyl) -1-piperazinyl] sulfonyl] phenyl] -1, 6-dihydro-1-methyl-3-propyl-7H-pyrazolo [4, 3-d] pyrimidin-7-one. Grades: Highly Purified. CAS No. 139755-91-2. Pack Sizes: 2.5mg. US Biological Life Sciences. | Worldwide |
| Desethyl Sildenafil-d3 | A labeled metabolite of Sildenafil , an orally active selective type 5 cGMP phosphodiesterase inhibitor. Group: Biochemicals. Alternative Names: 5-[2-Hydroxy-5- (4-methyl-d3-piperazinylsulphonyl) phenyl]1-methyl-3-n-propyl-1, 6-dihydro-7H-pyrazolo[4, 3-d]pyramidin-7-one; 5- [2-Hydroxy-5- [ [4- (methyl-d3) -1-piperazinyl] sulfonyl] phenyl] -1, 6-dihydro-1-methyl-3-propyl-7H-pyrazolo [4, 3-d] pyrimidin-7-one. Grades: Highly Purified. CAS No. 1346603-75-5. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| EHNA hydrochloride | EHNA hydrochloride is a selective inhibitor of cGMP-stimulated phosphodiesterase (PDE2) (IC50 = 0.8 - 4 μM) and also an inhibitor of adenosine deaminase. EHNA inhibits spontaneous differentiation of human ESCs in feeder-free conditions and directed neuronal differentiation. Uses: Antiviral agents. Synonyms: (2S,3R)-3-(6-aminopurin-9-yl)nonan-2-ol hydrochloride. Grade: >98%. CAS No. 58337-38-5. Molecular formula: C14H23N5O.HCl. Mole weight: 313.83. | |
| Enoximone | Enoximone is an inotropic vasodilating agent and a selective and orally active phosphodiesterase III (PDE3) inhibitor with an IC 50 of 5.9 μM. Enoximone induces vasodilatation and increases intracellular levels of cAMP by inhibiting cGMP-inhibited PDE. Enoximone also exhibits PDE4 inhibitory effect with an IC 50 of 21.1 μM for myocardial PDE4A. Enoximone has the potential for congestive heart failure research and has bronchodilatory, antiasthma and anti-inflammatory effects [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 77671-31-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg. Product ID: HY-B1639. | |
| GS 389 | GS 389 is a novel tetrahydroisoquinoline analog which significantly increased cGMP levels in the rat aorta and inhibited cGMP phosphodiesterase from the rabbit brain. Uses: A novel tetrahydroisoquinoline analog. Synonyms: GS 389; GS-389; GS389. 6,7-dimethoxy-1-[(4-methoxyphenyl)methyl]-1,2,3,4-tetrahydroisoquinoline. Grade: ≥98%. CAS No. 41498-37-7. Molecular formula: C19H23NO3. Mole weight: 313.39. | |
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