2-(2-(2-aminoethoxy)ethoxy)acetic acid suppliers USA
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H2N-PEG2-CH2COOH belongs to a polyethylene glycol (PEG) linker covalently bound to E3 Ligase binding group (E3LB) and protein binding group (PB). H2N-PEG2-CH2COOH is a PEG derivative containing an amino group with a terminal carboxylic acid. The amino group is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc. The terminal carboxylic acid can be reacted with primary amine groups in the presence of activators (e.g. EDC, or DCC) to form a stable amide bond. PEG Linkers may be useful in the development of antibody drug conjugates and PROTACs. Synonyms: Amino-PEG2-CH2CO2H; Amino-PEG2-CH2COOH; Amino-PEG2-acetic acid. Grades: ≥95%. CAS No. 134978-97-5. Molecular formula: C6H13NO4. Mole weight: 163.17.
[2- (2-Aminoethoxy) ethoxy]acetic Acid
[2- (2-Aminoethoxy) ethoxy]acetic Acid is used in the development of chemically modified peptide nucleic acid (PNA) as a probe for qualitative and quantitative detection of DNA. It is also used in the preparation and studies of the biological activities of kappa agonist CovX-bodies. Group: Biochemicals. Grades: Highly Purified. CAS No. 134978-97-5. Pack Sizes: 250mg, 500mg. Molecular Formula: C6H13NO4, Molecular Weight: 163.169999999999. US Biological Life Sciences.
6-FAM-AEEAc-Stichodactyla helianthus Neurotoxin (ShK), a ShK analog containing a fluorescein-6-carboxyl group attached through an {2-[2-aminoethoxy]ethoxy}acetic acid (AEEAc) linker to the f-amino group of Arg1, selectively blocks the volt-gated T-lymphocyte K+ Kv1.3 channels, which is relevant to the pathogenesis of experimental autoimmune encephalomyelitis. It may be an effective tool for detecting the presence of T-lymphocytes with high expression of Kv1.3 channels in normal and diseased tissues. Synonyms: 6-FAM-AEEAc-ShK; Fluorescein-6-carbonyl-AEEAc-Arg-Ser-Cys-Ile-Asp-Thr-Ile-Pro-Lys-Ser-Arg-Cys-Thr-Ala-Phe-Gln-Cys-Lys-His-Ser-Met-Lys-Tyr-Arg-Leu-Ser-Phe-Cys-Arg-Lys-Thr-Cys-Gly-Thr-Cys-OH (Disulfide bridge: Cys3-Cys35, Cys12-Cys28, Cys17-Cys32). Grades: ≥95%. CAS No. 1927927-42-1. Molecular formula: C196H295N55O57S7. Mole weight: 4558.22.
Amino-PEG3-t-butyl acetate
NH2-PEG3-C1-Boc is a PROTAC linker, which refers to the alkyl/ether composition. PROTAC Linker 5 can be used in the synthesis of a series of PROTACs. NH2-PEG3-C1-Boc is a PEG derivative containing an amino group with a t-butyl protected carboxyl group. The amino group is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc. The t-butyl protected carboxyl group can be deprotected under acidic conditions. PEG Linkers may be useful in the development of antibody drug conjugates, PROTACs and drug delivery methods. Synonyms: NH2-PEG3-C1-Boc; PROTAC Linker 5; Amino-PEG3-CH2CO2-t-butyl ester; H2N-PEG3-CH2COOtBu; Acetic acid, 2-[2-[2-(2-aminoethoxy)ethoxy]ethoxy]-, 1,1-dimethylethyl ester. Grades: >95%. CAS No. 189808-70-6. Molecular formula: C12H25NO5. Mole weight: 263.33.
Amino-PEG4-CH2COOH
Amino-PEG4-CH2COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Amino-PEG4-CH2COOH is also a non-cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Uses: Designed for use in research and industrial production. Additional or Alternative Names: Amino-PEG4-acetic acid. Product Category: Amino PEG Linkers. Appearance: Liquid. CAS No. 195071-49-9. Molecular formula: C10H21NO6. Mole weight: 251.28. Purity: >90%. IUPACName: 2-[2-[2-[2-(2-Aminoethoxy)ethoxy]ethoxy]ethoxy]acetic acid. Canonical SMILES: C(COCCOCCOCCOCC(=O)O)N. Density: 1.156±0.06 g/cm3. Product ID: ACM195071499. Alfa Chemistry ISO 9001:2015 Certified.
Semaglutide-[Val-d8] Tetratrifluoroacetate
Semaglutide-[Val-d8] Tetratrifluoroacetate is the labelled salt of Semaglutide, which is a glucagon-like peptide-1 (GLP-1) receptor agonist used to treat type 2 diabetes. Synonyms: Semaglutide-d8 Tetratrifluoroacetate; L-histidyl-2-methylalanyl-L-a-glutamylglycyl-L-threonyl-L-phenylalanyl-L-threonyl-L-seryl-L-a-aspartyl-L-valyl-d8-L-seryl-L-seryl-L-tyrosyl-L-leucyl-L-a-glutamylglycyl-L-glutaminyl-L-alanyl-L-alanyl-N6-[N-(17-carboxy-1-oxoheptadecyl)-L-a-glutamyl-2-[2-(2-aminoethoxy)ethoxy]acetyl-2-[2-(2-aminoethoxy)ethoxy]acetyl]-L-lysyl-L-a-glutamyl-L-phenylalanyl-L-isoleucyl-L-alanyl-L-tryptophyl-L-leucyl-L-valyl-L-arginylglycyl-L-arginyl-Glycine, trifluoroacetic acid (1:4); H-His-Aib-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Val(D8)-Ser-Ser-Tyr-Leu-Glu-Gly-Gln-Ala-Ala-Lys(AEEAc-AEEAc-γ-Glu-17-carboxyheptadecanoyl)-Glu-Phe-Ile-Ala-Trp-Leu-Val-Arg-Gly-Arg-Gly-OH.4TFA. Molecular formula: C187H283D8N45O59.4C2HF3O2. Mole weight: 4577.78.
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